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Baek Moon Seong,Baek Ae-Rin,Hong Sang-Bum,Bae Soohyun,Park Hye Kyeong,Kim Changhwan,Lee Hyun-Kyung,Cho Woo Hyun,Kim Jin Hyoung,Chang Youjin,Lee Heung Bum,Gil Hyun-Il,Shin Beomsu,Yoo Kwang Ha,Moon Jae 대한의학회 2023 Journal of Korean medical science Vol.38 No.41
Background: There is insufficient data on the benefits of empiric antibiotic combinations for hospital-acquired pneumonia (HAP). We aimed to investigate whether empiric antipseudomonal combination therapy with fluoroquinolones decreases mortality in patients with HAP. Methods: This multicenter, retrospective cohort study included adult patients admitted to 16 tertiary and general hospitals in Korea between January 1 and December 31, 2019. Patients with risk factors for combination therapy were divided into anti-pseudomonal non-carbapenem β-lactam monotherapy and fluoroquinolone combination therapy groups. Primary outcome was 30-day mortality. Propensity score matching (PSM) was used to reduce selection bias. Results: In total, 631 patients with HAP were enrolled. Monotherapy was prescribed in 54.7% (n = 345) of the patients, and combination therapy was prescribed in 45.3% (n = 286). There was no significant difference in 30-day mortality between the two groups (16.8% vs. 18.2%, P = 0.729) or even after the PSM (17.5% vs. 18.2%, P = 0.913). After the PSM, adjusted hazard ratio for 30-day mortality from the combination therapy was 1.646 (95% confidence interval, 0.782–3.461; P = 0.189) in the Cox proportional hazards model. Moreover, there was no significant difference in the appropriateness of initial empiric antibiotics between the two groups (55.0% vs. 56.8%, P = 0.898). The proportion of multidrug-resistant (MDR) pathogens was high in both groups. Conclusion: Empiric anti-pseudomonal fluoroquinolone combination therapy showed no survival benefit compared to β-lactam monotherapy in patients with HAP. Caution is needed regarding the routine combination of fluoroquinolones in the empiric treatment of HAP patients with a high risk of MDR.
핵연료집합체 지지격자의 혼합날개 형상이 임계열유속에 미치는 영향
신창환(ChangHwan Shin),추연준(YeonJun Choo),문상기(SangKi Moon),천세영(SeYoung Chun),전태현(TaeHyun Chun) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
Freon CHF experiments are carried out to investigate the CHF enhancements by mixing vane shapes of spacer grids in nuclear fuel assembly. The experiments were performed for a wide range mass flux, 50~3000 ㎏/㎡s. Three kinds of spacer grids in 5×5 rod bundles are tested: no mixing vane grids, hybrid mixing vane grids, and split mixing vane grids. The CHF performances are compared along with the data belong to the PWR operating conditions based on a water equivalence through a fluid-to-fluid modeling method. The average of the data in this range is 16.4% for 37 data of hybrid vane grid and 12.5% for 24 data of split vane. In the lower mass flux, however, the split vane grid shows slightly higher performance than the hybrid vane grid.
김현수,Jeong Moon Yang,Changhwan Lim 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.4
We investigated the temperature characteristic of a longitudinally-pumped Yb:YAG disk laser to determine the geometric size required for optimal base-surface cooling. We found the worst ratio of disk thickness to pump beam size, which resulted in the worst cooling condition. The results showed that the disk temperature did not strongly depend on the disk diameter, but did strongly depend on the disk thickness and the pump beam size. We investigated the temperature characteristic of a longitudinally-pumped Yb:YAG disk laser to determine the geometric size required for optimal base-surface cooling. We found the worst ratio of disk thickness to pump beam size, which resulted in the worst cooling condition. The results showed that the disk temperature did not strongly depend on the disk diameter, but did strongly depend on the disk thickness and the pump beam size.