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      • KCI등재

        기후변화에 따른 보건 분야의 취약성 평가

        이재범(Jae-Bum Lee), 이현주(Hyun-Ju Lee), 문경정(Kyung Jung Moon), 홍성철(Sung-Chul Hong), 김덕래(Deok-Rae Kim), 송창근(Chang-Keun Song), 홍유덕(You-Deog Hong) 한국대기환경학회 2012 한국대기환경학회지 Vol.28 No.1

        Adaptation of climate change is necessary to avoid unexpected impacts of climate change caused by human activities. Vulnerability refers to the degree to which system cannot cope with impacts of climate change, encompassing physical, social and economic aspects. Therefore the quantification of climate change impacts and its vulnerability is needed to identify vulnerable regions and to setup the proper strategies for adaptation. In this study, climate change vulnerability is defined as a function of climate exposure, sensitivity, and adaptive capacity. Also, we identified regions vulnerable to ozone due to climate change in Korea using developed proxy variables of vulnerability of regional level. 18 proxy variables are selected through delphi survey to assess vulnerability over human health sector for ozone concentration change due to climate change. Also, we estimate the weighting score of proxy variables from delphi survey. The results showed that the local regions with higher vulnerability index in the sector of human health are Seoul and Daegu, whereas regions with lower one are Jeollanam-do, Gyeonggi-do, Gwangju, Busan, Daejeon, and Gangwon-do. The regions of high level vulnerability are mainly caused by their high ozone exposure. We also assessed future vulnerability according to the Intergovernmental Panel on Climate Change (IPCC) Special Report on Emissions Scenarios (SRES) A2, A1FI, A1T, A1B, B2, and B1 scenarios in 2020s, 2050s and 2100s. The results showed that vulnerability increased in all scenarios due to increased ozone concentrations. Especially vulnerability index is increased by approximately 2 times in A1FI scenarios in the 2020s. This study could support regionally adjusted adaptation polices and the quantitative background of policy priority as providing the information on the regional vulnerability of ozone due to climate change in Korea.

      • SCOPUSKCI등재

        ORIGINAL ARTICLE : Causes and Predictive Factors Associated with “Diagnosis Changed” Outcomes in Patients Notified as Tuberculosis Cases in a Private Tertiary Hospital

        ( Byung Ju Kang ), ( Kyung Wook Jo ), ( Tai Sun Park ), ( Jung Wan Yoo ), ( Sei Won Lee ), ( Chang Min Choi ), ( Yeon Mok Oh ), ( Sang Do Lee ), ( Woo Sung Kim ), ( Dong Soon Kim ), ( Tae Sun Shim ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6

        Background: The aim of our study was to evaluate the “diagnosis changed” rate in patients notified as tuberculosis (TB) on the Korean TB surveillance system (KTBS). Methods: A total of 1,273 patients notified as TB cases on the KTBS in one private tertiary hospital in 2011 were enrolled in the present study. Patients were classified into three groups: “diagnosis maintained”, “diagnosis changed” (initially notified as TB, but ultimately diagnosed as non-TB), and “administrative error” (notified as TB due to administrative errors). Results: Excluding 17 patients in the “administrative error” group, the “diagnosis maintained” and “diagnosis changed” groups included 1,097 (87.3%) and 159 patients (12.7%), respectively. Common causes of “diagnosis changed” were nontuberculous mycobacterial (NTM) disease (51.7%, 61/118), and pneumonia (17.8%) in cases notified as pulmonary TB, and meningitis (19.5%, 8/41) and Crohn`s disease (12.2%) in cases notified as extrapulmonary TB. Being older than 35 years of age (odds ratio [OR], 2.18) and a positive acid-fast bacilli stain (OR, 1.58) were positive predictors and a TB-related radiological finding (OR, 0.42) was a negative predictor for a “diagnosis changed” result via multivariate logistic regression analysis in pulmonary TB cases. Conclusion: Because of a high “diagnosis changed” rate in TB notifications to the KTBS, the TB incidence rate measured by the KTBS may be overestimated. Considering the worldwide trend toward increased NTM disease, the “diagnosis changed” rate may increase over time. Thus, when reporting the annual TB notification rate in Korea, the exclusion of “diagnosis changed” cases is desirable.

      • SCOPUSKCI등재

        Causes and Predictive Factors Associated with "Diagnosis Changed" Outcomes in Patients Notified as Tuberculosis Cases in a Private Tertiary Hospital

        Kang,,Byung,Ju,Jo,,Kyung-Wook,Park,,Tai,Sun,Yoo,,Jung-Wan,Lee,,Sei,Won,Choi,,Chang-Min,Oh,,Yeon-Mok,Lee,,Sang-Do,Kim,,Woo,Sung,Kim,,Dong,Soon,Shim,,Tae,Sun The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6

        Background: The aim of our study was to evaluate the "diagnosis changed" rate in patients notified as tuberculosis (TB) on the Korean TB surveillance system (KTBS). Methods: A total of 1,273 patients notified as TB cases on the KTBS in one private tertiary hospital in 2011 were enrolled in the present study. Patients were classified into three groups: "diagnosis maintained", "diagnosis changed" (initially notified as TB, but ultimately diagnosed as non-TB), and "administrative error" (notified as TB due to administrative errors). Results: Excluding 17 patients in the "administrative error" group, the "diagnosis maintained" and "diagnosis changed" groups included 1,097 (87.3%) and 159 patients (12.7%), respectively. Common causes of "diagnosis changed" were nontuberculous mycobacterial (NTM) disease (51.7%, 61/118), and pneumonia (17.8%) in cases notified as pulmonary TB, and meningitis (19.5%, 8/41) and Crohn's disease (12.2%) in cases notified as extrapulmonary TB. Being older than 35 years of age (odds ratio [OR], 2.18) and a positive acid-fast bacilli stain (OR, 1.58) were positive predictors and a TB-related radiological finding (OR, 0.42) was a negative predictor for a "diagnosis changed" result via multivariate logistic regression analysis in pulmonary TB cases. Conclusion: Because of a high "diagnosis changed" rate in TB notifications to the KTBS, the TB incidence rate measured by the KTBS may be overestimated. Considering the worldwide trend toward increased NTM disease, the "diagnosis changed" rate may increase over time. Thus, when reporting the annual TB notification rate in Korea, the exclusion of "diagnosis changed" cases is desirable.

      • KCI우수등재

        스포츠생리학 : 운동중지가 비만남자청소년의 콜레스테롤 대사에 미치는 영향

        윤석창(YoonSeok-Chang), 성봉주(SungBong-JU) 한국체육학회 2000 한국체육학회지 Vol.39 No.4

        본 연구는 8주 수영 training 후 8주 운동중지(detraining)가 비만청소년의 콜레스테롤 대사에 미치는 영향을 파악하기 위하여 체지방율이 30% 이상인 비만 남자청소년(n=12)을 대상으로 6명씩 두 집단(운동집단, 통제집단)으로 나누었다. 운동집단(n=6)에게는 자발적 식이제한(2,000kcal/day)을 병행한 수영을 8주간 실시하게 한 후, 8주간 식이 제한과 운동처치를 하지 않았다 통제집단(n=6)은 16주 동안 아무런 처치를 하지 않았다. 운동집단의 수영 Training 은 주당 3일, 1회 60분, 운동강도는 분당심박수가 130~160(회/분)으로 설정하여 실시하였다. 측정은 처치 전, 4주, 8주, 12주, 16주 후에 5번 실시하였고, 측정항목은 신장(Height), 체중(Body Weight), 총콜레스테롤(TC), 중성지방 (TG), 저밀도지단백콜레스테롤(LDL-C), 고밀도지단백콜레스테롤(HDL-C), 지단백분획치 (TC/HDL-C) 등의 항목으로 한정하였으며, 실험결과 다음과 같은 결론을 얻었다.첫째, 운동그룹은 8주 수영 Training 후 TC에서 유의한 변화가 나타나지 않았다. 또한 연이은 8주 Detraining 후에도 TC에서 유의한 변화가 나타나지 않았다.둘째, 운동그룹은 8주 수영 Training 후 TG에서 유의한 변화가 나타나지 않았다. Detraining 후에는 4 · 8주에서 TG의 유의한 증가가 나타났다.셋째, 운동그룹은 8주 수영 Training 후 LDL-C에서 유의한 변화가 나타나지 않았다. 8주 Detraining 후에도 LDL-C에서 유의한 변화가 나타나지 않았다.넷째, 운동그룹은 8주 수영 Training 후 HDL-C에서 유의한 변화가 나타나지 않았고 8주 Detraining 후에도 유의한 변화가 나타나지 않았다.다섯째, 운동그룹은 8주 수영 Training 후 TC/HDL-C에서 유의한 변화가 나타나지 않았고 8주 Detraining 후에도 유의한 변화가 나타나지 않았다.자발적 식이제한을 동반한 8주 수영 운동 후 8주 운동중지는 콜레스테롤 대사에서 유의한 변화가 나타나지 않았다. 그러나 중성지방에서만 민감한 변화를 나타내었다. The purpose of this study is to investigate the effect of 8-week detraining after 8-week swimming on the spontaneous caloric restriction and the changes of the cholesterol metabolism in obese adolescents. 12 males were selected as the experimental objects for this study. They were over 30% Body fat, without risk factor during training and never attended in any obese therapy course before. The exercise regimen was composed of the spontaneous caloric restriction and the schedule of swimming program, 1 hrs/day, 3 days/week The intensity of the swimming program was respectively at 60~80%HRmax(130~160 beat/min).. The calorie restrict regimen was about 2,000kcal/day. The variable was measured to the TC, TG, HDL-C, LDL-C, TC/HDL at pre-test 4W, 8VV, 12W(4-week detraining), 16W(8 weeks detraining). The Independant & Paired t-test Measure was used and Tukey was treated for the post hoc testing(p<0.05).The results was as following;(1) The TC of the exercise group after 8-week swimming was not changed significantly. The TC after 8-week detraining was not changed significantly.(2) The TG of the exercise group after 8-week swimming was not changed significantly. The TG after 4 and 8-week detraining was increased significantly.(3) The LDL-C of the exercise group after 8-week swimming was not changed significantly. The LDL-C after 8-week detraining was not changed significantly.(4) The HDL-C of the exercise group after 8-week swimming was not changed significantly. The HDL-C after 8-week detraining was not changed significandy.(5) The TC/HDL-C of the exercise group after 8-week swimming was not changed significantly. The TC/HDL-C after 8-week detraining was not changed significantly.8-week detraining after 8-week swimming on the spontaneous caloric restriction dose not give significant change in cholesterol metabolism. But the TG level showed sensitive change.

      • KCI등재후보

        아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

        최철웅(Cheol Ung Choi), 나승운(Seung-Woon Rha), 김선원(Sun Won Kim), 나진오(Jin Oh Na), 임홍의(Hong Euy Lim), 김진원(Jin Won Kim), 김응주(Eung Ju Kim), 한성우(Seong Woo Han), 박창규(Chang Gyu Park), 서홍석(Hong Seog Seo), 오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

      • KCI등재

        펠던크라이스 기법, 탄성밴드 운동 및 복합운동 적용이 현대무용전공자의 체간근력에 미치는 영향

        김채수(Kim Chae-Soo), 권혜영(Kwon Hye-Young), 이원재(Lee Won-Jae), 조창모(Jo Chang-Mo), 김진환(Kim Jin-Hwan), 주성범(Ju Sung-Bum), 이미경(Lee Mi-Kyoung) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.1

        This study is carried out to examine the effect of applying Feldenkrais method, elastic band training and combined training on trunk muscle. The subjects of this study were 32 modern dance majors and they were divided into four groups which consists of 8 peoples each, Feldenkrais method group(modern dance + Feldenkrais method), elastic band training group(modern dance + elastic band training), combined training group(modern dance + Feldenkrais method + elastic band training), and control group(modern dance). Measurement variables which are trunk muscle were measured before training, and after 4 and 8 weeks training and the results are as follow: In the left muscle strength change at Centaur 0°, Feldenkrais method group, elastic band training group and combined training group showed significant increase after 8 weeks training compared to before training. In the right muscle strength change, Feldenkrais method group and combined training group had significant increase after 8 weeks training. In the left muscle strength change at Centaur 45°, Feldenkrais method group and combined training group showed significant increase after 8 weeks training compared to before training and after 4 weeks training. Also elastic band training group showed significant increase after 8 weeks training compared to before training. In the right muscle strength change, Feldenkrais method group and elastic band training group significantly increased after 8 weeks training compared to before training. In the left muscle strength change at Centaur 90°, Feldenkrais method group and combined training group showed significant increase after 4 and 8 weeks training compared to before training. In the right muscle strength change, Feldenkrais method group showed significant increase after 4 and 8 weeks training compared to before training, and elastic band training group significantly increased after 8weeks training compared to before training. In the left muscle strength change at Centaur 135°, there was no significant changes. In the right muscle strength change, elastic band training group and combined training group showed significant increase after 8 weeks training compared to before training. In the left muscle strength change at Centaur 180°, combined training group showed significant increase after 4 and 8 weeks training compared to before training. In the right muscle strength change, combined training group showed significant increase after 4 and 8 weeks training compared to before training. From above results, applying 8 weeks regular program of Feldenkrais method, elastic band training and combined training to modern dance majors showed positive changes on improvement of trunk muscle strength and physical strength. Also this study implemented to verify the effects of trunk muscle strength and body balance through supplementary training program, and showed the effects in the training group and control group after 8 weeks trunk muscle strengthening program. Feldenkrais method, elastic band training and combined training are very effective to improve trunk muscle strength of modern dance majors so that continuous implementation and application of these effective training program shall be provided for strengthening trunk muscle.

      • KCI등재

        Thermographic Assessment on Temperature Change of Eye Surface in Cataract Surgery Observation

        Chang,Won,Park,Young-Ju,An,Hyojin,Kim 대한시과학회 2018 대한시과학회지 Vol.20 No.4

        목적: 백내장 환자를 대상으로 수술 전과 후의 안구표면의 온도변화 양상을 열화상카메라의 서모그래피를 이용하여 연구 하고자 하였다. 방법: 본 연구는 백내장 수술을 받은 환자 50-79세까지 75명 75안의 환자 군을 대상으로 하였다. 과거에 굴절교정수술, 각막관련 수술을 받은 자와 콘택트렌즈를 사용하는 자, 눈물관 이상자, 전신질환 치료 약물을 복용하는 자 등 눈물분비와 눈물막에 영향을 줄 수 있는 자는 연구 대상자에서 제외하였고 눈물막파괴시간 검사(Tear Break Up Time, BUT), 쉬르머 검사(Schirmer's Test), 맥모니테스트(Mcmonnies questionnaire)를 시행한 후 열화상카메라(Cox CX series, Answer., Korea)를 이용하여 안구표면의 온도변화를 실시간으로 측정하였다. 결과: 전체 대상자의 술 전 안구표면 온도는 35.20±0.54 ℃이었고 술 후에는 35.30±0.53 ℃로 표면온도가 상승하였으나 유의한 차이를 보이지 않았다. 안구표면 온도변화는 술전에서 -0.12±0.08 △(℃/sec)에서 술 후 -0.18±0.07 △(℃/sec)로 통계학적으로 유의한 결과를 나타냈다. 연령 별 비교에서는, 50 대군은 백내장 술 전 대상자의 안구표면 온도변화가 -0.14±0.09 △(℃/sec)에서 -0.19±0.05 △(℃/sec)으로 나타났고 60 대군에서는 -0.12±0.08 △(℃/sec)에서 -0.15±0.07 △(℃/sec)으로 나타났으며 70 대군에서는 술 전 대상자의 안구표면 온도변화는 -0.12±0.08 △(℃/sec)에서 -0.18±0.07 △(℃/sec)으로 전 연령에서 모두 유의한 안구표면 온도변화를 보였다. 결론: 백내장 술 후에는 안구건조증 평가지표가 모두 감소하였고 안구표면 온도변화가 유의함을 보였다. 안구표면의 서모그래피 기술은 비침습적으로 안구건조증을 평가하는데 용이하였고 객관적으로 수치화할 수 있는 장점이 있어 다양한 안구건조증 연구에 활용 될 것으로 기대된다. Purpose : The purpose of this study was to investigate the temperature changes of the ocular surface before and after cataract surgery using thermography of a thermal imaging camera. Methods : The study included 75 patients (75 eyes) aged from 50 to 79 years who underwent cataract surgery. In the past, those who underwent corneal-related surgery, wearing contact lens, disorder of tear secretion and taking medication for systemic disease were excluded from this study. The temperature changes of the eyeball surface were measured using a thermal imager (Cox CX series, Answer, Korea) following Tear Break Up Time (TBUT) test, Mcmonnies questionnaire and Schirmer's Test in real time, Results : While the temperature of preoperative ocular surface was 35.20 ± 0.54 ℃ and that of postoperative temperature was 35.30 ± 0.53 ℃, the difference was not significant. The temperature changes in the ocular surface were statistically significant at -0.12 ± 0.08 △ (℃ / sec) before the surgery and -0.18 ± 0.07 △ (℃ / sec) after the surgery. In comparison of the age groups, it was shown that the changes in the surface temperature before the surgery were from -0.19 ± 0.05 △ (℃ / sec) to -0.14 ± 0.09 △ (℃ / sec) in the 50s group, and from -0.12 ± 0.08 △ (℃ / sec) to -0.15 ± 0.07 △ (℃ / sec) in 60s group , and -0.18 ± 0.07 △ (℃) to -0.12 ± 0.08 △ / sec) in the 70s group, showing significant changes in the ocular surface temperature at all ages. Conclusion : Following the cataract surgery, all the indicators of dry eye syndrome were decreased, and eye surface temperature changes were significant. The thermography technique of the ocular surface would be expected to be useful for the evaluation of various dry eye syndromes because it is easy to evaluate dry eye syndrome noninvasively and can be quantified.

      • Ether麻醉가 肺의 微細形態學的 構造에 미치는 影響

        朱昌洙,洪錫宰 慶北大學校 醫科大學 1974 慶北醫大誌 Vol.15 No.1

        白鼠를 實驗動物로 하여 ether吸入麻醉를 單回 또는 數回에 亘하여 反復 施行하고 肺組織에 惹起되는 變化를 光學 및 電子顯微鏡的으로 檢索한 結果를 要約하면 다음과 같다. 1) 光學顯微鏡的으로는, 肺組織에서 充血, 間質性水腫, 肺胞隔壁의 肥厚, 肺胞細胞의 數的 增加等의 變化가 輕한 程度로 認定되었으며 이러한 變化는 單回麻醉보다는 反復麻醉에 있어서 더욱 著明하였다. 2) 電子顯微鏡的으로는, ether麻醉를 30分間 單回實施한 直後에는 Ⅱ型肺胞細胞의 osmiophilic inclusion body에 數的 增加, 大小不同, density의 減少 및 空泡化가 甚한 程度로 惹起되었고, 이러할 封入體가 肺胞腔內로 脫出하여 遊離狀態로 있는 것도 相當數로 볼 수 있었으며, 4時間後에는 上記한 바와 같은 變化들이 顯著하게 減少되었고, 12時間後에는 osmiophilic inclusion body에서 輕微한 數的增加와 大小不同을 나타냈을 뿐이며 空泡化는 볼 수 없고 density는 오히려 輕度로 增加되어 있었으며 거의 正常으로 恢復된 所見을 보였다. Ether麻醉를 15分間씩 連3日間 反復 施行한 實驗群에 있어서는, 最終麻醉 直後 및 4時間後에는 Ⅱ型 肺胞細胞의 osmiophilic inclusion body에서 輕度 乃至 中等度로 數的 增加와 大小不同 및 density의 增加를 볼 수 있었고 空泡化는 輕微하게 認定되었으며, 12時間後에는 上記한 變化들이 輕微해져서 거의 正常으로 恢復된 所見을 보였다. Ⅰ型 肺胞細胞 및 肺胞毛細血管에서는 兩實驗群에서 다 같이 特記할 만한 變化를 全혀 認定할 수 없었다. 3) 上記 實驗成績으로 보아 ether麻醉時에는 Ⅱ型 肺胞細胞의 osmiophilic inclusion body에 相當히 甚한 變性性變化가 惹起되나 이러한 變化는 可逆性變化로서 短時間에 恢復될 수 있는 것이라고 推定된다. This study was undertaken to investigate the ultrastructural changes of the lung with special reference to the alveolar lining cells of a rat with single and repeated ether anesthesia. Twenty healthy albino rats, weighing about 200gm average, were divided into 3 groups. Group 1. Control group. 2 rats: Untreated. Group 2. Single ether anesthesia group, 9 rats: Subjected to moderate anesthesia with ether for 30 minutes. Group 3. Repeated ether anesthesia group. 9 rats: Subjected to moderate anesthesia with ether for 15 minutes per day for 3 consecutive days. Experimental rats were sacrificed at 0 hour (3 rats), 4 hours(3 rats) and 12 hours (3 rats) after ether anesthesia from the group 2 and 3. Lungs were extirpated and examined using both light and electron microscopes. The result are as follows: 1) Light microscopic observation: Lungs showed mild congestion, interstitial edema, thickening of the alveolar septa, and increase of alveolar cells. These changes were more marked in the repeated anesthesia group than in the single anesthesia group. 2) Electron microscopic observation: Soon after single ether anesthesia, the type Ⅱ alveolar cells were crowded with variably sized osmiophilic inclusion bodies which were mostly vacuolated. Some of these inclusion bodies were extruded in to the alveolar lumen. After 4 hours, these changes were markedly diminished. After 12 hours, the osmiophilic inclusion bodies in the type Ⅱ alveolar cell showed almost normal pattern except slight increase of their density. Up to 4 hours after repeated ether bnesthesia, variably sized osmiophilic inclusion bodies were noted in the type Ⅱ alveolar cells. They were considerably increased in number. The density of the osmiophilic inclusion bodies was markedly increased. After 12 hours, type Ⅱ alveolar cells showed almost normal appearance except slight increase of the density in the osmiophilic inclusion bodies. The type Ⅰ alveolar cells and the capillary endothelial cells showed no remarkable changes in both experimental groups. 3) These results suggest that ether anesthesia induces severe changes of the osmiophilic inclusion body of type Ⅱ alveolar cells, but these changes are reversible and restored to normal within 12 hours.

      • KCI등재

        수영운동이 비만 청소년의 신체조성과 호르몬에 미치는 영향

        김창규,성봉주 한국운동과학회 1999 운동과학 Vol.8 No.3

        수영운동이 비만 청소년의 신체조성과 호르몬에 미치는 영향. 운동과학, 제8권 제3호, 447-460, 1999. 본 연구는 수영운동이 비만청소년의 신체조성과 호르몬에 미치는 영향을 파악하기 위하여 체지방율이 30%이상인 비만 남자청소년(n=12)을 대상으로 식단일지 작성을 통한 자발적 식이제한(2000㎉/day)을 병행하여 수영을 8주간 실시한 운동그룹(n=6)과 아무런 처치를 받지 않은 통제그룹(n=6)으로 나누어 실험을 진행하였다. 운동그룹의 수영운동은 주당 3일, 1회 60분, 운동강도는 분당심박수가 130∼160(회/분)으로 설정하여 실시하였다. 측정은 처치 전, 4주, 8주 후에 실시하였고, 측정항목은 신장(Height), 체중(Body Weight), 체지방율(%Body Fat), 체지방량(LBM), 체질량지수(BMI) 등의 신체조성 항목과 Leptin을 중심으로 한 성장호르몬(Growth Hormone)과 인슐린(Insullin) 등의 혈액 호르몬성분으로 한정하였으며, 실험결과 다음과 같은 결론을 얻었다. 첫째, 운동그룹은 8주 후 제지방율이 처치 전에 비해 통계적으로 유의하게 감소하였다. 둘째, 운동그룹은 4주 후 체질량지수가 처치 전에 비해 통계적으로 유의하게 감소하였다. 셋째, 운동그룹은 8주 후 체지방량이 통계적으로 유의하게 증가하였다. 넷째, 운동그룹의 Leptin 농도는 처치 전에 높게 나타났고, 8주 후에는 점차 낮게 변화하였지만 통계적으로 유의한 차이는 나지 않았다. 다섯째, 운동 그룹의 8주 후 인슐린은 처치 전에 비해 약간 증가하였으나 통계적으로 유의한 차이는 나지 않았다. 여섯째, 운동그룹의 성장호르몬은 4주에 악간 증가하다가 8주에는 급격한 감소를 나타내었으며 통계적으로도 유의한 차이가 나지 않았다. 즉, 성장호르몬은 불규칙한 변화를 나타내었다. 일곱째, 운동그룹과 통제그룹간의 호르몬 변인에서 4주에 인슐린, 8주에 성장호르몬에서 통계적으로 유의한 차이가 나타났다. 따라서 식이제한을 병행한 수영은 비만 청소년의 체지방율과 체질량지수의 감소와 제지방량 증가에 유의한 영향을 주었다. 그리고 통계적으로 유의한 차이가 나지 않았으나 8주 후 Leptin 농도가 처치 전에 비해 감소하였으며, 이러한 결과는 체지방 감소와 영향이 있는 것으로 사료된다. 비만인과 Leptin의 정확한 작용기전을 알아내기 위해서는 계속적인 후속연구가 진행되어야 할 것으로 사료된다. The Effects of Swimming exercise on body composition and hormone of obese adolescents. Exercise Science, 8(3): 447-460, 1999. The purpose of this study is to investigate the effect of swimming exercise on the spontaneous caloric restriction and the changes of the body composition and hormone in obese adolescents. 12 males were selected with the experimental objects for this study. They were over 30% Body fat, Without risk factor during training and never attended In any obese therapy course before. The exercise regimen was composed of the spontaneous caloric restriction and the schedule of swimming program, 1 hrs/day, 3 days/week. The intensity of the swimming program was respectively at 60∼80%/HR_max(130∼160 beat/min). The calorie restrict regimen was about 2,000㎉/day. The variable was measured to the %BodyFat, BMI, LBM, Leptin, Insulin, Growth-Hormone at pre-test, 4, 8 week. The Independanted & Paired t-test Measure was used and Tukey was treated for the post hoc testing(p<.05). The results was as following; (1) The %BodyFat of the exercise group was decreased from pre-test to 8week. The changes of the %BodyFat was significantly decrease from pre-test to 8 week(p<.01). (2) The BMI of the exercise group was decreased from pre-test to 4 week. The changes of the BMI was significantly decrease from pre-test to 4 week(p< .05). (3) The changes of the LBM of the exercise group was increased from pre-test to 8 week, and there was significantly different from pre-test to 8 week. (4) The leptin concentration of the exercise group was decreased from pre-test to 8 week. The changes of the leptin was not significantly different between from pre-test to 4 and pre-test to 8 week. (5) The Insulin concentration of the exercise group was increased a little from pre-test to 8 week The changes of the insulin was not significantly different Between from pre-test to 4 and pre-test to 8 week. (6) The Growth-Hormone concentration of the exercise group was changed in irregularity from pre-test to 8 week. The charges of the Growth-Hormone was not significantly different between from pre-test to 4 and pre-test to 8 week. (7) Total variable was not significantly different Between Exercise group and Control group in pre-test, 4 week and 8 week. The result of this study suggest that swimming exercise on the spontaneous caloric restriction was decrease on %BodyFat, BMI and Leptin and increase on LBM.

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