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          Case Report for a Refractory Recurrent Aphthous Stomatitis Treated with Jibaekpalmi-hwon

          Chang-Gue,Son 대한한의학회 2012 대한한의학회지 Vol.33 No.2

          Objectives: This report reports a clinical case of a patient with recurrent aphthous stomatitis (RAS) for 10 years who was completely cured using Korean medicine. Methods: A male patient with terribly severe RAS was hospitalized, and then treated with Jibaekpalmi-hwon, indirect moxibustion (KI 1 and CV 4) and acupuncture. The clinical outcome was observed by self-reported VAS measurement and macroscopy. Results: The severity of stomatitis became improved gradually and completely recovered during 17 hospital days, and RAS has not recurred for three months as an outpatient. The blood test including complement activity was in the normal range. Conclusions: This case report provides information about a therapeutic effect of Jibaekpalmi-hwon and Korean medicine on RAS.

        • KCI등재

          A Severe Hepatotoxicity by Antituberculosis Drug, and its Recovery in Oriental Hospital

          Chang-Gue,Son 대한한의학회 2016 대한한의학회지 Vol.37 No.2

          Objectives: To demonstrate a clinical course and feature of a female patient with a severe liver injury (DILI) during antituberculosis treatment for her intestinal tuberculosis, whom traditional Korean medicine completely recovered. Methods: A female patient with diagnosed as DILI by antituberculosis drugs had been treated with herbal drugs; and then the clinical outcome and biochemical parameters had been monitored. Result: A 45-year old female had taken antituberculosis drugs for about 2 months, and complained severe abdominal discomfort and dyspepsia. The RUCAM score was 10, which met the criteria for DILI (AST 584 IU/L, ALT 1212 IU/L, ALP 100 IU/L, and GGT 161 IU/L, total bilirubin 0.9 mg/dL). She had been treated with herbal drugs and acupuncture as inpatient and outpatient, and then her symptoms had been completely recovered with normalization of hepatic enzymes. Conclusion: This report provides a clinical characteristic for a severe hepatotoxicity induced by antituberculosis drugs, and showed an example of TKM-based application.

        • KCI등재

          Minireview for Chronic Fatigue Syndrome and its Medical Attention recently

          Chang-Gue,Son 대한한의학회 2019 대한한의학회지 Vol.40 No.4

          Objectives: Chronic fatigue syndrome (CFS) is a debilitating illness impairing seriously quality of life, while CFS would be an optimized target disorder of Korean medicine. This study aims to present the recent information especially in aspect of medical policy and new diagnosis criteria for CFS. Methods: The literature survey was conducted using the terms of “chronic fatigue syndrome”, “myalgic encephalomyelitis” and “fibromyalgia” in PubMed database and Google database in its entirety from January 2011 to February 2019. The in-depth review was made focusing on the changes in policy and medical perspective for CFS. Results: Recently large medical attentions and researches for CFS have been existed worldwide. By supporting of USA government, IOM made a report which leaded to a turning point in clinical practices and research in 2015. This report recommended a new name of CFS to systemic exertion intolerance disease (SEID), and new diagnostic criteria focusing on post-exertional malaise, unrefreshing sleep, cognitive impairment and orthostatic intolerance. The medical perspective also was changed into “a serious, chronic, complex, systemic disease” from a psychological-like disorder, and then UAS and EU governments sharply increased the research grants. Conclusions: This study provided practitioners in Korean medicine (KM) a core information about the recent changes in CFS-related perspectives. This review would be helpful for KM-derived researches or therapeutics development for CFS.

        • KCI등재
        • KCI등재

          A Case of Non-alcoholic Steatohepatitis Treated with Herbal Medicine

          Chang-Gue,Son 대한한의학회 2011 대한한의학회지 Vol.32 No.3

          Objective: To understand the characteristic of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), and study the traditional Korean medicine (TKM)-based strategies or therapeutics for them. Methods: A male patient with NASH was treated with only Oriental therapies, and then the clinical outcome was evaluated by serum biochemical parameters and radiographs. Result: The clinical and biochemical values of the patient fluctuated over three years according to the treatments and cessation of herbal medicines. Conclusion: NASH or NAFLD are now prevalent and these disorders could be targets of TKM, and this case report would provide useful information.

        • KCI등재

          Overview of RCT for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

          Chang-Gue,Son 대한한의학회 2011 대한한의학회지 Vol.32 No.3

          Objective: This study aimed to get information on the current status of therapies to date for non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH). Methods: All randomized clinical controlled trial (RCT)-derived papers for NAFLD or NASH were reviewed via PubMed Database. Results: 39 RCTs met the review criteria, of which 15 and 24 papers were for NAFLD and NASH, respectively. 83% of the papers were released since 2006, and 30 studies were conducted for western medicines, antioxidants and lifestyle intervention whereas nine trials were done using herbal medicine or acupuncture which showed positive outcome. Conclusions: NAFLD and NASH are new epidemic disorders which can be a target of traditional Oriental medicine. This study will be helpful for the Oriental medicine-based strategies or therapeutic development for them.

        • KCI등재
        • KCI등재

          Survey of Fatigue-Related Health Conditions of General Population in a Metropolis

          Chang-Gue,Son 대한한의학회 2011 대한한의학회지 Vol.32 No.6

          Objectives: To examine the overview of fatigue-related health conditions in the Korean general population. Methods: Data were collected from 2,203 adults (1,126 men and 1,077 women) via a self-reporting questionnaire and their sleeping, exercise, stress, physical problems, use of functional food, and fatigue status were analyzed. Results: The average sleeping hours was about 6.6 ± 2.0 hrs per day, and 24.3% of subjects didn't exercise (over 30 min) in a week. Around 16.5% of subjects were under severe stress, and 46.1% (36.9% male vs. 55.6% female) had had trouble with at least one form of physical distress including dyspepsia, headache or muscular pain. 45.4% (37.2% male vs. 53.9% female) of subjects used functional supplements. 46.3% (42.8% male vs. 50.0% female) of subjects complained of chronic fatigue, and they were significantly different compared with no-fatigue subjects regarding severe stress status (8.6% vs. 24.0%), frequency of physical distress (33.2% vs. 69.9%), and use of functional supplements (41.6% vs. 49.8%). Conclusion: This result first reports the features of fatigue-related health conditions including prevalence of chronic fatigue in the Korean population. This data could be helpful to develop fatigue-focused traditional Korean medicine in the future.

        • KCI등재

          Original Articles : Resuscitation ; Emergency Coronary Angiography and Effects on Survival in Resuscitated Patients after Out-of-Hospital Cardiac Arrest

          ( Chang Gue Lee ), ( Kyoung Mi Lee ), ( In Byung Kim ) 대한응급의학회 2014 大韓應急醫學會誌 Vol.25 No.5

          Purpose: The aim of this study is to evaluate the clinical characteristics and outcomes of patients with cardiac arrest without obvious extracardiac cause who underwent emergency angiography to determine the factors related to significant coronary artery disease in patients in whom coronary angiography was performed. We also addressed the issues around the survival benefit of coronary angiography and subsequent coronary intervention. Methods: In total 91 patients during the period between 2004 and 2012 were included in the study. Clinical characteristics and coronary angiographic data were collected retrospectively. The success measurement of the study was set as survival at the time of hospital discharge. Results: In comparison of the demographic and clinical variables of patients with and without emergency coronary angiography, only the electrocardiogram differed significantly between the two groups. Fifty four patients underwent an emergency coronary angiography, which was performed later for the remaining seven patients. Acute coronary lesions were observed in 38 patients (62%). Findings of electrocardiograms before and after return of spontaneous circulation (ROSC) were not statistically significant in relation to the prevalence of a culprit lesion. Neither an emergency coronary angiography nor successful coronary intervention showed correlation with survival at the time of hospital discharge. A shorter duration to return of spontaneous circulation, an initial shockable rhythm, and the absence of shock were found to be independent factors affecting discharge of patients alive in the overall study population (n=91). Conclusion: Considering the angiographic findings, neither the presence of a shockable rhythm nor ST-segment elevation myocardial infarction (STEMI) before and after ROSC were factors favouring acute coronary artery disease. The emergency coronary angiography did not show correlation with survival at hospital discharge in patients with a resuscitated cardiac arrest without non-cardiac cause. Factors positively related to survival should be considered when deciding on coronary angiography in order to identify patients in whom routine angiography is futile (e.g., the delay for return of spontaneous circulation and presence of shock).

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