국내산 중하(Metapenaeus joyneri) 내 주알레르겐 규명 : 가열 및 소화액에 의한 변화

윤성호,김현아,김현미,최정희,서창희,남동호,김윤근,민경업,박해심 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

통근자료와 GIS를 이용한 서울대도시권 도시 간 상호작용 분석

김지소(Kim Jyso),장훈(Chang Hoon),임업(Lim Up) 대한토목학회 2009 대한토목학회논문집 D Vol.29 No.2D

대도시권의 공간구조 변화를 예측하고 문제를 미연에 방지하기 위해서는 도시공간구조의 시간적, 공간적 변화의 특성을 파악하는 것이 중요하다. 통근ㆍ통학 자료는 대도시권내에서 나타나는 필연적이며 규칙적인 통행에 대한 것으로 도시공간변화를 자세히 규명하는데 유용한 변수이며 최근 그 중요성이 높아지고 있다. 따라서 본 연구에서는 중력모델을 이용한 서울대 도시권 통근ㆍ통학자 자료 분석을 통해 서울시와 주변 도시 간 상호작용을 분석하였다. 그 결과, 서울과 주변 도시 간 상호 작용은 시간의 경과에 따라 강화되고 있음이 확인되었고, 도시 간 상호작용은 거리와 밀접한 연관을 갖는 것으로 검증되었으며, 서울과 강한 상호작용을 보이는 도시들이 대체로 서울 이남에 분포하고 있어 서울대도시권이 불균형적으로 개발되고 있음이 확인되었다. To predict the urban growth trend and to prevent the metropolitan problems, it is important to track the spatio-temporal changes in the urban spatial structure. Commuting is inevitable and regular activities emerging in the metropolitan region. Therefore, it can be a useful to examine the interregional interaction and the urban spatial change. The purpose of this study is to investigate the urban interaction between Seoul and cities around Seoul Metropolitan Region, and GIS functions helped analysis and visualized results. An analysis of current commuting data using the Gravity Model suggests that the interaction between Seoul and its peripheral cities has been intensified from 1990 to 2000 and that the urban interaction was closely related to the distance. And the southward distribution of the cities having a strong interaction with Seoul accounts for the imbalance in growing of Seoul Metropolitan Region.

한국인 중.고등학생의 체격, 체형 및 그 성장에 관한 연구

이영춘,김종석,박희명,채의업,주영은,이륭창,류호열,김규수,김정묵,최경숙,이열희,이태호,우원형,신현찬,박원학,Lee, Young-Choon,Kim, Chong-Suk,Park, Hi-Myung,Chae, E-Up,Choo, Young-Eun,Lee, Yung-Chang,Ryoo, Ho-Yul,Kim, Kyu-Soo,Kim, Chung-Muk,Choi, Kyu 대한생리학회 1970 대한생리학회지 Vol.4 No.1

Measurement and analysis of the physical status (height, body weight, breast girth, sitting height. length of leg, length of thigh, thigh girth, crural length, length of arm, brachial length, antebrachial girth and skinfold thickness), physical types and the growth were made to the 360 Korean middle and high school boys aged between 12 and 17 years in Taegu City. The physical status was evaluated and expressed as dispersion and the Physical type as percentage of each status to height, and the growth was analysed by the growth formula. The results are as follows; 1) The increase of the volumes of Physical status was slowest between 12 and 13 years and fastest between 13 and 14 years in general. 2) The increase of the volumes of thigh girth and antebrachial girth showed a linear pattern until 16 years. 3) The coefficient of variation was largest in skinfold thickness $(16.3{\sim}28.4%)$ followed by body weight $(10.0{\sim}14.3%)$, antebrachial girth $(4.8{\sim}19.60%)$ and length of thigh$(6.3{\sim}13.6%)$. The coefficients of variation in all the other status were similar $(4{\sim}7%)$. 4)The physical indices of body weight, breast girth, sitting height, length of thigh, thigh girth, antebrachial girth and skinfold thickness increased as age increased while the others decreased except the brachial length, which showed no significant change. 5) Ratio of growth quantity was largest in body weight followed by skinfold thickness, and the others were all similar. 6) Growth rate and specific growth rate decreased in the all the status analysed as age increased except in the skinfold thickness in which an increase was noted. 7) Growth gradient was increased along the increase of age in breast girth, sitting height, crural length, brachial length and in skinfold thickness. However a decrease was observed in the other status except in the body weight which was decreased until 15 years of age and increased thereafter.

가스연료 엔진의 운전변수에 따른 탄화수소의 배출특성

김창업,김성수 신라대학교 자연과학연구소 2003 自然科學論文集 Vol.11 No.-

Measurements of the concentrations of individual exhaust hydrocarbon species have been made under various engine operating conditions with a 2-liter 4-cylinder engine for natural gas and LPG. Tests were performed at constant engine speed, 1800rpm for two compression ratios(8.6 and 10.6), with various operating parameters, such as excess air ratio(1.0~1.6), bmeps(250~800kPa) and spark timings(BTDC 10~55). It was found that the natural gas gave the less ozone formation than LPG in various operating conditions. This was accomplished by reducing the emissions of propylene(C_3H_6), which has relatively high MIR factor, and propane(C_3H_*) that originally has large portion of LPG. In addition, the natural gas show lower values in the SR and BSRs. Higher compression ratio showed higher NMHC emissions. However, SR decreased since fuel species of HC emissions increase. BSRs showed almost same values under high bmep, over 500kPa for both fuels. This means that effect of increasing of NMGC emissions and effect of decreasing of SRs with higher bmep affect each other simultaneously. With advanced spark timing, BSRs of LPG were increased while those of natural gas showed almost constant values.

解放後 濟州硏究槪觀(Ⅱ) : 歷史·考古分野

金宗業,權仁赫,高昌錫,金容完 제주대학교 탐라문화연구소 1983 탐라문화 Vol.0 No.2

한국인의 Phenylketonuria에 대한 연구

고병업,김창세 최신의학사 1974 最新醫學 Vol.17 No.10

Plasma phenylalanine measurement of primary school pupils, amounts to 19,726 presumably esti?mated, in Korean have performed by the fluorometric method. Mean values of plasma phenylalanine concentration are 0.98 ±0.47 mg/100 ml by arithmatic, and are 0.92±0.42 mg/100 ml, 0.90±0.38 mg/ 100 ml in males and 0.93±0.42 mg/100ml in females by means of probability graph method. Values of males are slightly lower than those of females. The pupils having 2 mg/100 ml or more have had within normal limits in point of hematologic and urinary findings. Three of those have taken phenylalanine tolerance test, in which they appeared as normal disappearance of phenylalanine from blood as control group. In point of rate constants, however, one of three, case of Lee, appeared as a variant of phenylketonuria as described in Woolf et al. 60.51) Case of Lee showed that rate constant were progressively increeased with time but other 2 cases showed reverse tendency, progressively decreased.

골뱅이(Buccinum Undatum) 알레르기 : 감작률과 다른 음식물 항원과의 연관성 Sensitization rate and its relationship with other food allergens

이재영,윤성호,서유진,최정희,서창희,남동호,김윤근,민경업,박해심 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1

Background : The common whelk (Buccinum undatum) is one of the largest and most common snails in the North Atlantic. In Korea and Japan, common whelk is a popular eatable shellfish. Although shellfish has been known as the one of the most common causes of food allergy, there has been no published report on allergenecity and clinical significance of this sea snail. In this study, we determined the sensitization rate to common whelk and its relationship with other food allergens in allergy patients. Method : We carried out the skin prick test (SPT) with commonly consumed food stuffs in Korea including common whelk in 1700 patients over 1 year. The specific IgE to common whelk were detected by enzyme-linked immunosorbent assay (ELISA). ELISA inhibition test using sensitized sera was conducted. Results : SPT to common whelk was positive (≥2+) in 83 (4.9%) patients studied. Twenty-four (38.7%) of 62 SPT-positive patients had high serum specific IgE to common whelk. ELISA inhibition test showed significant inhibitions by abalone as well as by common whelk and, minimal inhibition were noted by shrimp. Significant correlation was also noted in specific IgE levels between common whelk and abalone (r=0.58, F<.05). Conclusion : IgE-sensitization rate to common whelk was 4.9% in allergy patients. Further stuides are needed to evaluate the clinical significance of sensitized patients to common whelk, and to confirm a cross reactivity with abalone. (J Asthma Allergy Immunol 24 : 77-84, 2004)

Korean Ginseng-Induced Occupational Asthma and Determination of IgE Binding Components

Kim, Kyung-Mook,Kwon, Hyouk-Soo,Jeon, Sung-Gyu,Park, Chang-Han,Sohn, Seong-Wook,Kim, Duck-In,Kim, Sun-Sin,Chang, Yoon-Seok,Kim, Yoon-Keun,Cho, Sang-Heon,Min, Kyung-Up,Kim, You-Young The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.2

<P>A number of case reports on occupational asthma caused by herbal medicines have been issued, for example, on Sanyak, Chunkung, Banha, and Brazilian ginseng. Recently, cases of occupational asthma induced by Sanyak and Korean ginseng have been reported, but the pathogenic mechanisms involved are unknown. This study was carried out to evaluate the immunologic mechanism underlying Korean ginseng-induced occupational asthma. A patient engaged in Korean ginseng wholesale was referred for recurrent dyspnea, wheezing, and nasal symptoms, which were aggravated at work. Allergen bronchial provocation testing to Korean ginseng extract showed a typical immediate response, and skin prick testing to Korean ginseng extract also showed a strong positive response. Moreover, serum-specific IgE levels to Korean ginseng extract were significantly higher than in controls. Enzyme-linked immunosorbent assay (ELISA) inhibition tests showed a dose-dependent inhibition by Korean ginseng, but not by <I>Dermatophagoides farinae</I>, wheat flour, or Chinese balloon flower. Sodium dodecylsulfate-poly-acrylamide gel electrophoresis (SDS-PAGE) and immunoblotting revealed four specific Immunoglobulin E (IgE) binding components at 26, 30, 47, and 60 kDa, which were not bound by control sera. These results strongly suggest that occupation asthma induced by Korean ginseng is induced via an IgE-mediated mechanism.</P>

3차 의료기관을 방문한 천식 환자에서 아토피 유병률의 변화

박흥우(Heung Woo Park),김상헌(Sang Heon Kim),김상훈(Sang Hoon Kim),장윤혜(Yoon Hae Chang),정희(Hee Chung),이병재(Byung Jae Lee),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.1

N/A Background: The prevalence of atopy and atopy-related disease has been known to increase during the past decade. Objective : This study was desinged to evaluate the changes of atopy prevalence among asthmatic patients and the causative allergens. Method : A total of 698 asthmatic patients visiting Seoul National University Hospital in 1983, 1990 and 1997 was recruited. Skin prick test with common inhalant allergens was carried out and interpreted as positive when the mean wheal size formed by allergen was larger than 3 mm. Atopy was defined when skin reaction to one or more allegens was positive. Result. The prevalence of atopy among asthmatic patients was 54% in 1983, 48.8% in 1990 and 58% in 1997, respectively. The prevalence of atopy decreased as the age of patients in- creased. Recently, old asthmatic patients ( >55 years) showed a higher tendency to visit the tertiary referral hospital. When the data were analyzed according to age, the prevalence of atopy significantly increased among asthmatic patients aged 15-35 years, in whom the prevalence was 60.4% in 1988 and 81.3% in 1997 (p< 0.05). The positive rate of skin test to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen were significantly higher in 1997 than in 1983 (p < 0.05). Conclusion : The prevalence of atopy among asthmatic patients aged 15-85 years showed significant increase in 1997 compared to 1983. The changes of skin response to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen contributed to the increase of atopy.

Diagnostic Value of Clinical T Staging Assessed by Endoscopy and Stomach Protocol Computed Tomography in Gastric Cancer: The Experience of a Low-Volume Institute

Kim, Tae Hyeon,Kim, Jeong Jae,Kim, Seung Hyoung,Kim, Bong Soo,Song, Hyun Joo,Na, Soo Young,Boo, Sun Jin,Kim, Heung Up,Maeng, Young Hee,Hyun, Chang Lim,Kim, Kwang Sig,Jeong, In Ho The Korean Gastric Cancer Association 2012 Journal of gastric cancer Vol.12 No.4

Purpose: Clinical staging of gastric cancer appears to be important more and more for tailored therapy. This study aimed to verify the accuracy of clinical T staging in a low-volume institute. Materials and Methods: We retrospectively reviewed prospectively collected data of gastric cancer patients who underwent resection. A total of 268 patients of gastric cancer were enrolled from March 2004 to June 2012. These demographics, tumor characteristics, and clinical stages were analyzed for identification of diagnostic value of clinical T staging. Results: The predictive values for pT1 of endoscopy and computed tomography were 90.0% and 89.4%, respectively. In detail, the predictive values of endoscopy for pT1a, pT1b, and pT2 or more were 87%, 58.5%, and 90.6%, respectively. The predictive values of computed tomography for pT1a, pT1b, and pT2 or more were 68.8%, 73.9%, and 84.4%, respectively. The factors leading to underestimation of pT2 or more lesions by gastroscopy were the middle third location, the size greater than 2 cm, and younger age. Those for overestimation of pT1 lesion by computed tomography were male, age more than 70 years, elevated type, and size greater than 3 cm. Conclusions: Diagnostic accuracy of early gastric cancer was 90%, which is comparable to those of high volume center. In patients with early gastric cancer, limited gastrectomy or minimal invasive surgery can be safely introduced at a low volume center also. However, the surgeon of low-volume institute should consider the accuracy of clinical staging before extending the indication of limited treatment.