원발성 후복막 점액낭샘암종 1예

지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.

췌장 선방세포암 1예

이화정,지준호,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Acinar cell carcinoma is a rare tumor that represents 1~2% of al1 pancreatic cancers. Clinical and radiologic findings are inconclusive in this disease Acinar cell carcinoma is characterized by rapid progression and early metastasis, which lead to its poor prognosis. A 41-year-o1d man was admitted to our hospital for abdominal pain. Abdominal computed tomography (CT) and positron emission tomography-computed tomography (PET-CT) showed a splenic mass, which was being invaded by a pancreatic tail mass and which had increased ^(18)F-fluorodeoxyglucose (FDG) uptake Primary radical distal pancreatectomy and splenectomy were performed. Pathologic findings revealed an acinar cell carcinoma of the Pancreas The patient underwent a total gastrectomy three months later because of gastric recurrence Four months later, multiple hepatic metastases were discovered, and the patient underwent a left hepatectomy During treatment with capecitabine, there was no evidence of tumor progression for 14 months. We report a case of metastatic pancreatic acinar cell carcinoma, which did not progress for an extended period while the patient was being treated with capecitabme.

TNF-α로 유도된 혈관내피세포의 혈관염증에 미치는 오적산(五積散)의 억제 효과

한병혁 ( Byung Hyuk Han ),윤정주 ( Jung Joo Yoon ),김혜윰 ( Hye Yoom Kim ),안유미 ( You Mee Ahn ),홍미현 ( Mi Hyeon Hong ),손찬옥 ( Chan Ok Son ),나세원 ( Se Won Na ),이윤정 ( Yun Jung Lee ),강대길 ( Ho Sub Lee ),이호섭 대한본초학회 2018 大韓本草學會誌 Vol.33 No.4

Objectives : Ojeoksan, originally recorded in an ancient Korean medicinal book named “Donguibogam” and has been used for the treatment of circulation disorder of blood which was called blood accumulation (血積) in Korean medicine. Therefore, this study was carried out to investigate the beneficial effect of OJS on vascular inflammation in HUVECs. Methods : We evaluated the effect of OJS on the expression of cell adhesion molecules and protective role in HUVEC stimulated by TNF-α by using Western blot. Results : Pretreatment with OJS decreased the adhesion of HL-60 cells to TNF-α-induced HUVEC. OJS suppressed TNF-α-induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and endothelial cell selectin (E-selectin). Moreover, OJS significantly decreased TNF-α-induced production of intracellular reactive oxygen species (ROS); and inhibited the phosphorylation of IκB-α in the cytoplasm compared to the experimental group. Pretreatment with OJS inhibited the trans-location of NF-κB p65 to the nucleus. OJS also inhibited phosphorylation of MAPKs compared to the experimental group. OJS significantly increased the protein expression of Nrf2 and HO-1. Conclusions : Ojeoksan has a protective effect on vascular inflammation, and might be a potential therapeutic agent for early atherosclerosis.

다중 가설 추적 알고리듬의 성능 평가

정영헌,한찬호,최덕규 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(C)

The Multiple Hypotheses Tracking (MHT) algorithm has been shown to be one of the most cost- effective estimation schemes for hybrid systems. Its performance, however, could only evaluated via expensive Monte-Carlo simulations. An effective hybrid approach to the performance evaluation without recourse to simulations is presented here. This approach is based on a scenario-conditional performance measure of hybrid nature in the sense that it is a continuous-valued function of a discrete-valued random sequence. The performance measure is calculated efficiently in an off-line recursion.

Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis

Jung Kyung Hee,Kim Sang Eun,Go Han Gyeol,Lee Yun Ji,Park Min Seok,Ko Soyeon,Han Beom Seok,Yoon Young-Chan,Cho Ye Jin,Lee Pureunchowon,Lee Sang-Ho,Kim Kipyo,Hong Soon-Sun 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.6

According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney ferroptosis remain limited. In this study, we assessed the renoprotective effects of melatonin and zileuton as a novel therapeutic strategy against ferroptosis-mediated kidney injury and fibrosis. First, we identified RSL3-induced ferroptosis in renal tubular epithelial HK-2 and HKC-8 cells. Lipid peroxidation and cell death induced by RSL3 were synergistically mitigated by the combination of melatonin and zileuton. Combination treatment significantly downregulated the expression of ferroptosis-associated proteins, 4-HNE and HO-1, and upregulated the expression of GPX4. The expression levels of p-AKT and p-mTOR also increased, in addition to that of NRF2 in renal tubular epithelial cells. When melatonin (20 mg/kg) and zileuton (20 mg/kg) were administered to a unilateral ureteral obstruction (UUO) mouse model, the combination significantly reduced tubular injury and fibrosis by decreasing the expression of profibrotic markers, such as α-SMA and fibronectin. More importantly, the combination ameliorated the increase in 4-HNE levels and decreased GPX4 expression in UUO mice. Overall, the combination of melatonin and zileuton was found to effectively ameliorate ferroptosis-related kidney injury by upregulating the AKT/mTOR/ NRF2 signaling pathway, suggesting a promising therapeutic strategy for protection against ferroptosis-mediated kidney injury and fibrosis.

키토산 구슬을 이용한 가토 연골세포의배양

장의찬,김경환,저호중,이기현,정상인,손태일 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

Titanium isopropoxide의 가수분해에 의한 TiO₂ Power 합성

박찬웅,명중재,김호건 漢陽大學校 基礎科學硏究所 1995 基礎科學論文集 Vol.14 No.-

Isopropanol 내에서 titanium isopropoxide의 가수분해반응속도를 자외선분광법에 의하여 측정하였다. H₂O 농도 및 온도의 변화에 따른 반응속도상수를 Guggenheim method로 계산하였다. 이 실험 결과 titanium isopropoxide의 가수분해반응은 이분자 반응이 ?? mechanism 으로 관여하는 것으로 추정되었다. 또한 titanium isopropoxide의 가수분해에 의한 TiO₂ 분말합성에 있어서 pH 및 온도영향을 연구하였다. 합성된 분말과 소결체에 대하여 SEM, XRD, IR 및 입도분석을 통하여 characterization 하였다. TiO₂분말 합성결과 pH가 높을수록, 또한 반응온도가 높을수록 반응시간이 짧아졌으나, 낮은 온도에서 반응시킬 경우에 입자의 agglomeration이 적어짐을 알았다. 생성된 입자는 비정질의 gel 상태였으며, 소결시킨 후는 rutile, 또는 rutile과 anatase의 혼합물인 titanium dioxide인 것으로 나타났다. 소결하기 전의 TiO₂ 분말의 IR분석에서는 -OH, -CH₃ 등 유기물 그룹의 흡수 피크가 나타났으나 소결한 후의 시료에서는 그러한 피크가 나타나지 않았다. Rates of hydrolysis of titanium isopropoxide in isopropanol were investigated by UV spectroscopy. The change of reaction rate according to temperature and concentration of H₂O was calculated by Guggenheim method. From these results, it could be estimated that the hydrolysis of titanium isopropoxide was ?? mechanism involving both of titanium isopropoxide and H₂O. pH and temperature dependence of TiO₂ powder preparation were also investigated. Particle sizes and size distributions of dried powders were determined using size distribution analysis and SEM(scaning electron microscope), and the crystal phases in dried powder and in sintered powder were analyzed using powder XRD method. The reaction rate of TiO₂ powder preparation was faster at higher temperature and higher pH, however more agglomeration of particles occured at high temperature. The phase of dried powders was noncrystalline gel state but the sintering of the powder at 800℃ changed its phase to crystalline rutile or anatase. Absorption peaks of organic group such as -OH, -CH₃ in IR spectra of dried powder disappeared after sintering.

실리카흄을 흔입한 고강도 콘크리트 개발

홍창우,김태경,김경진,김성환,김남윤,심도식,이정호,윤청호,백민경,원치문,박제선,이주형,정경일 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

콘크리트 구조물이 대형화됨에 따라 설계단면이 증대되어 상대적으로 많은 경제적 손실을 부담하게 된다. 따라서 단면을 감소시키면서도 소요의 하중에 안전한 구조물을 건설하기 위해서는 우선적으로 구조물 건설에 기초가 되는 고품질, 고내구성의 고강도 콘크리트 개발이 절실히 요구된다 본 연구에서는 일정 시멘트비 및 혼화재 비율하에서 소요의 워커빌리티가 확보되는 고강도 콘크리트를 시간과 온도의 변화에 따라 증기 양생하여, 압축, 인장, 휨강도 뿐만 아니라 파괴특성을 실험적으로 연구하였다. 시료 제작시 시멘트 입자 사이의 공극 및 불연속 영역을 충전하여 고밀도화하기 위한 콘크리트용 혼화재로 시멘트 비표면적이 상당히 작은 초미립 분말인 실리카흄을 이용하였다. 또한 AE감수제 및 고성능 유동화제를 사용하여 혼화재의 첨가에 의하여 발생될 수 있는 워커빌리티의 감소를 방지하였다. 실험결과에 의하면 일정 양생 지속 시간하에서 온도의 증가에 따라 콘크리트의 압축, 인장 및 휨강도가 전반적으로 증가하였다. 동일하게 일정 온도하에서 양생 지속시간이 커짐에 따라 강도들이 증가됨을 알 수 있었다. 따라서 상대적으로 높은 온도와 긴 지속 양생 조건하에서 파괴에 대한 저항력이 크게 나타났다. The compressible, tensible, and flexibleresistance of the high strength concrete is analyzed by the experimentation in the present study. For the test, we cure several samples with the silica fume as a mixture being become dense the spaces between the particle of cement under the variation of both the temperature and the curing-interval. Then, the superplasticizer and the ezcon are also used to satisfy the required workability for construction. The compressible, tensible, and flexible resistances to a stress are increased as increasing the temperature and the time interval for the curing. Therefore it is concluded that the overal fractural and mechanical properties is improved by mixing the silica fume into the cement.

윈도우 환경에서 음성인식을 이용한 인터넷 검색기 구현

임중혁,원호준,백인찬,권영헌,이건상 한양대학교 이학기술연구소 1999 이학기술연구지 Vol.1 No.-

본논문에서는 Window 상에서 웹브라우저 검색어로 영문 알파벳을 인식하도록 하였다. 음성의 특징 벡터로는 10차원의 LPC, cepstrum, LSF(Line Spectrum Frequency) 계수와, 규격화된 필터뱅크 에너지를 사용하였으며 인식 알고리즘으로는 MSVQ 모델을 사용하였다. 인식 대상 어휘는 26개의 알파벳을 사용하였으며 실험결과 필터뱅크 에너지를 사용한 인식결과가 가장 우수한 것으로 나타났다. This paper represents the speech recognizer of English alphabet for the internet explorer in Windows. We use 10-dimensional LPC, cepstrum, LSF coefficients and normalized filter bank energies as the speech feature vectors and MSVQ model as the recognition algorithm. As the results the recognizer using the normalized filter bank energies shows the better performance than that using the other feature vectors.

스피커 특성 및 오차경로의 온라인 인식을 이용한 새로운 적응 능동소음제어

한찬호,최덕규,정영헌 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

In active noise control system, the error path transfer function is much more likely to change rapidly due to in temperature or flow rate. The loudspeaker response also changes due to aging and the other factors. Therefore, an improved solution to obtaining both the loudspeaker and the error path transfer functions on an on-line basis is required. In this paper, a new filtered-X least mean square(LMS) algorithm considering the loudspeaker and the error path characteristics is proposed for active noise control system. The transfer functions of the loudspeaker and the error path are obtained by an adaptively estimated error signal and the error path output signal on an on-line basis. In the computer simulation using the sinusoidal and the practical duct noise, the proposed algorithm reduces noise level about 29.1dB and 10.4dB, respectively. We observed an improvement of about 2.5dB in noise level compared with that obtained using the Eriksson's filtered-X LMS algorithm.