http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ma, R. C. W.,Hu, C.,Tam, C. H.,Zhang, R.,Kwan, P.,Leung, T. F.,Thomas, G. N.,Go, M. J.,Hara, K.,Sim, X.,Ho, J. S. K.,Wang, C.,Li, H.,Lu, L.,Wang, Y.,Li, J. W.,Wang, Y.,Lam, V. K. L.,Wang, J.,Yu, W.,Ki Springer-Verlag 2013 Diabetologia Vol.56 No.6
<P><B>Aims/hypothesis</B></P><P>Most genetic variants identified for type 2 diabetes have been discovered in European populations. We performed genome-wide association studies (GWAS) in a Chinese population with the aim of identifying novel variants for type 2 diabetes in Asians.</P><P><B>Methods</B></P><P>We performed a meta-analysis of three GWAS comprising 684 patients with type 2 diabetes and 955 controls of Southern Han Chinese descent. We followed up the top signals in two independent Southern Han Chinese cohorts (totalling 10,383 cases and 6,974 controls), and performed in silico replication in multiple populations.</P><P><B>Results</B></P><P>We identified <I>CDKN2A/B</I> and four novel type 2 diabetes association signals with <I>p</I> < 1 × 10<SUP>−5</SUP> from the meta-analysis. Thirteen variants within these four loci were followed up in two independent Chinese cohorts, and rs10229583 at 7q32 was found to be associated with type 2 diabetes in a combined analysis of 11,067 cases and 7,929 controls (<I>p</I><SUB>meta</SUB> = 2.6 × 10<SUP>−8</SUP>; OR [95% CI] 1.18 [1.11, 1.25]). In silico replication revealed consistent associations across multiethnic groups, including five East Asian populations (<I>p</I><SUB>meta</SUB> = 2.3 × 10<SUP>−10</SUP>) and a population of European descent (<I>p</I> = 8.6 × 10<SUP>−3</SUP>). The rs10229583 risk variant was associated with elevated fasting plasma glucose, impaired beta cell function in controls, and an earlier age at diagnosis for the cases. The novel variant lies within an islet-selective cluster of open regulatory elements. There was significant heterogeneity of effect between Han Chinese and individuals of European descent, Malaysians and Indians.</P><P><B>Conclusions/interpretation</B></P><P>Our study identifies rs10229583 near <I>PAX4</I> as a novel locus for type 2 diabetes in Chinese and other populations and provides new insights into the pathogenesis of type 2 diabetes.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00125-013-2874-4) contains peer-reviewed but unedited supplementary material, which is available to authorised users.</P>
Vincent C.H. Chung,Charlene H.L. Wong,Claire C.W. Zhong,Yan Yin Tjioe,Ting Hung Leung,Sian M. Griffiths 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.1
Background: With increasing burden of chronic non-communicable diseases (NCD), ageing becomes a global public health concern, and the World Health Organization Western Pacific Region has no exception. To address the NCD challenge, priority should be given to promote healthy ageing across the life-course. As traditional and complementary medicine (T&CM) is popular within the Region, it is of policy interest to explore possibilities of applying T&CM for promoting healthy ageing. Methods: We first summarized sources of clinical evidence supporting the use of T&CM. We then searched publications through MEDLINE from its inception to April 2020 to identify studies focusing on the perception of T&CM among older people. Finally, taking current evidence base and patient choice into account, we generated policy recommendations for of integrating T&CM into health systems. Result: Experiences from countries with different income levels suggested that promoting evidence-based T&CM as self-care modalities would be the most efficient way of maximizing impact among the older population, especially via a train the trainer approach. Meanwhile, popularity of natural products in the Region mandates policy makers to implement appropriate regulation and quality assurance, and to establish pharmacovigilance to detect potential harm. The role of pharmacists in advising patients on self-medication using natural products needs to be strengthened. Conclusion: Policy-makers will benefit from continued global dialogue and sharing of experience in T&CM policy development and implementation. Harmonizing regulatory frameworks for natural products at regional and global levels, including mutual recognition of regulatory approval, to improve standards and protect patients could be a priority.
Scheduling a single machine with parallel batching to minimize makespan and total rejection cost
He, C.,Leung, J.Y.T.,Lee, K.,Pinedo, M.L. North Holland ; Elsevier Science Ltd 2016 Discrete Applied Mathematics Vol.204 No.-
We consider the problem of scheduling a set of n jobs on a single machine with parallel batching and with rejection being allowed. Two bi-criteria problems are considered: (a) minimize the makespan subject to the constraint that the total rejection cost does not exceed a given threshold, and (b) minimize the total rejection cost subject to the constraint that the makespan does not exceed a given threshold. For the case of a batching machine with infinite capacity (i.e., the batch size allowed on the machine is larger than or equal to the number of jobs), we assume that the jobs have release dates. We present an O(n<SUP>2</SUP>)-time 2-approximation algorithm for problem (a) and, in addition, we present dynamic programming algorithms and fully polynomial-time approximation schemes for both problems (a) and (b). For the case of a batching machine with finite capacity (i.e., the batch size allowed on the machine is less than the number of jobs), we assume that the jobs have identical release dates. We propose approximation algorithms for (a) and present dynamic programming algorithms and fully polynomial-time approximation schemes for both problems (a) and (b).
Low Complexity Zero-Forcing Beamforming for Distributed Massive MIMO Systems in Large Public Venues
Li, Haoming,Leung, Victor C.M. The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.4
Distributed massive MIMO systems, which have high bandwidth efficiency and can accommodate a tremendous amount of traffic using algorithms such as zero-forcing beam forming (ZFBF), may be deployed in large public venues with the antennas mounted under-floor. In this case the channel gain matrix H can be modeled as a multi-banded matrix, in which off-diagonal entries decay both exponentially due to heavy human penetration loss and polynomially due to free space propagation loss. To enable practical implementation of such systems, we present a multi-banded matrix inversion algorithm that substantially reduces the complexity of ZFBF by keeping the most significant entries in H and the precoding matrix W. We introduce a parameter p to control the sparsity of H and W and thus achieve the tradeoff between the computational complexity and the system throughput. The proposed algorithm includes dense and sparse precoding versions, providing quadratic and linear complexity, respectively, relative to the number of antennas. We present analysis and numerical evaluations to show that the signal-to-interference ratio (SIR) increases linearly with p in dense precoding. In sparse precoding, we demonstrate the necessity of using directional antennas by both analysis and simulations. When the directional antenna gain increases, the resulting SIR increment in sparse precoding increases linearly with p, while the SIR of dense precoding is much less sensitive to changes in p.
Receiver-oriented load-balancing and reliable routing in wireless sensor networks
Chen, Min,Leung, Victor C. M.,Mao, Shiwen,Kwon, Taekyoung John Wiley Sons, Ltd. 2009 WIRELESS COMMUNICATIONS AND MOBILE COMPUTING Vol.9 No.3
<P>Routing protocols in wireless sensor networks (WSNs) typically employ a transmitter-oriented approach in which the next hop node is selected based on neighbor or network information. This approach incurs a large overhead when the accurate neighbor information is needed for efficient and reliable routing. In this paper, a novel receiver-oriented load-balancing and reliable routing (RLRR) protocol is proposed. In RLRR, an intermediate node solicits next hop candidates, each of which is to respond with its own backoff time dubbed a temporal gradient (TG). In this way, the next hop is selected without any central coordination on a packet-by-packet basis. Thus, each node needs not maintain any neighbor information. The remaining energy level used to determine the TG is always accurate and up-to-date. Furthermore, neighbor nodes whose hop count is less than the soliciting node participate in the next-hop selection process with loop-free operation guarantee. Comprehensive simulations are carried out to show that RLRR achieves relatively longer network lifetime and higher reliability than other existing schemes. Copyright © 2007 John Wiley & Sons, Ltd.</P>