남자 알코올 의존 환자의 기질적 특성에 관한 연구

김성곤,민영기,이덕기,김미영,송영상,권도훈,고영훈,박제민,정병선 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.1

목 적: 본 연구의 목적은 한국인 남자 알코올 의존 환자의 기질적 특성을 Temperament and Character Inventory(TCI)를 이용하여 조사하는 것이다. 방 법: DSM-Ⅳ 진단 기준에 맞는 알코올 의존 환자 30명과 정상인 36명을 대상으로 연구학적 특성을 조사하고, 기질적 특성을 한글판 TCI를 이용하여 조사하였다. 모든 대상자의 나이는 30~60세였다. 결 과: 1) 두 군간 평균 나이는 유의한 차이가 없었으나, 교육 정도와 결혼을 유지하고 있는 비율 및 취업률은 알코올 의존군이 정상 대조군에 비해 유의하게 낮았다. 2) 알코올 의존군에서는 정상 대조군에 비해 Harm Avoidance(HA) 점수와 Self-transcendence(ST)점수는 유의하게 높았으며, Self-directiveness(SD)점수는 유의하게 낮았다. 3) 알코올 의존군 내에서의 각 척도들 간의 상관관계는, HA와 SD 점수, HA와 Persistence(PE) 점수, ST와 SD 점수는 각각 유의한 음의 상관관계, ST와 PE 점수, SD 점수와 Cooperativeness(CO) 점수, Reward Dependence(RD)와 CO 점수는 양의 상관관계를 보였다. 결 론: 이러한 본 연구의 결과는 한국인 남성에서 수줍음을 잘 타며, 걱정도 많고, 염세적이고 쉽게 피로해지는 기질적 특성이 알코올 의존과 연관성이 있음을 의미한다. Objectives : The purpose of this study was to assess the temperament of male parients with alcohol dependence. Methods : The subjects were 30 patients who met DSM-Ⅳ criteria for alcohol dependence and 36 normal controls. All subjects completed Temperament and Character Inventory(TCI) which was developed by Cloninger. Results : 1) The educational level, marital status, and occupation in alcohol dependence group were significantly lower than those of normal control group, but there was no difference in the age between two groups. 2) Among the scores of TCI, the score of harm avoidance(HA) and self-transcendence(ST) were significantly higher in the alcohol dependence group than in the normal control group. 3) In the alcohol dependence group, a significant negative correlation among the scores of TCI was between HA and SD, HA and Persistence(PE), ST and SD, and positive correlation between ST and PE, SD and Cooperativeness(CO), Reward Dependence(RD) and CO. Conclusion : These results suggest that shy, fearful, pessimistic and fatigable temperament are related to developing alcohol dependence in Korean males.

1,1,1,2-Tetrafluoroethane(HFC-134a)과 Propane(HC-290)의 2성분계 기-액 평형 측정

진현상,박지영,이병권,양대륙,임종성 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

혼합물을 냉매로 사용할 경우, 냉매의 성능 평가를 위해 기-액 상평형 데이터가 필수적으로 요구된다. 본 연구에서는 HFC-134a와 propane의 이성분계 상평형 데이터를 얻기 위해 273.15, 283.15, 283.15, 303.15, 313.15, 323.15K의 조건에서 실험을 실행하였다. 상평형 실험 장치로는 circulation type의 장치를 사용하였다. 실험데이터는 Peng-Robinson-Stryjek-Vera(PRSV)상태방정식과 NRTL excess Gibbs free energy model을 결합한 식에 다섯 개의 혼합법칙(Huron-Vidal original and modified equation)들을 이용하여 상관관계를 알아보았다. PRSV 상태방정식을 이용하여 얻은 데이터는 실험 데이터와 만족할 만한 일치를 볼 수 있었다. 실험은 실행한 모든 온도에서 공비점이 형성하는 것을 확인하였다. Vapor-liguid equilibrium(VLE) data are essential when using mixtures as a refrigerant. The VLE data of binary mixture containing 1, 1, 1, 2-tetrafluoroethane and propane were measured at 273.15, 283.15, 293.15, 303.15, 313.15 and 323.15K using circulation type experimental apparatus. The experimental data were correlated with five mixing rules combined with the Peng-Robinson-Stryjek-Vera equation of state. We compared the data obtained by using the PRSV EOS with experimental data and a satisfactory consistency of model predictions with experimental data were obtained. Azeotropic behavior has been observed in all these mixtures.

Ce_(0.8)Zr_(0.2)O₂ 촉매를 이용한 Dimethyl Carbonate 합성에서 탈수제 첨가의 영향

한기보,전진혁,박노국,이종대,류시옥,이태진,이병권,안병성 한국공업화학회 2004 응용화학 Vol.8 No.1

The effect of dehydrating agent in DMC(dimethyl carbonate) synthesis from methanol and carbon dioxide over Ce_(0.8)Zr_(0.2)O₂ catalyst was studied in this work. Ce_(0.8)Zr_(0.2)O₂ catalyst having the best activity among Ce_(1-x)Zr_(x)O₂ catalysts was selected. We could supposed that the addition of dehydrating agents improved the DMC yield by H₂O elimination. When the dehydrating agents such as Na_(2)SO₄ or K₂SO₄ was added into the synthesis of DMC, the formation amount of DMC increased to about 0.8∼0.9 mmol through the elimination of formed H₂O as by-product.

CFC 대체냉매

김재덕,임종성,이병권 한국공업화학회 2002 공업화학 Vol.13 No.6

오존층 파괴물질에 관한 몬트리얼의정서에 의해 CFC냉매의 규제가 시작된 이후 새로 개발된 CFC대체냉매에 관한 연구현황과 주요 합성방법을 정리하여 기술하였다. 대체냉매로는 HFC-134a와 R-407C, R-410A 등의 HFC계 혼합냉매, 탄화수소, 이산화탄소 등 자연냉매 등이 많이 사용되고 있다. HFC-134a, HFC-125, HFC-143a, HFC-32 등 현재 많이 사용되는 HFC계 대체냉매의 제조방법은 이미 많은 연구가 진행되었고 차세대 냉매의 개발 및 제조연구는 현재도 계속 이루어지고 있다. Research trend and synthesis methods of alternative of CFC refrigerants which is banned by Montreal protocol that depletes the ozone layer. HFC-134a, HFC mixtures, such as R-407C, R-410A, natural refrigerants, such as hydrocarbons, carbon dioxide etc., were promising replacement of CFC. Many researches on manufacturing methods of HFCs including HFC-134a, HFC-125, HFC-143a, HFC-32, etc. were well carried out. The research on the development and manufacturing techniques of next generation refrigerant is on - going now.

고삼투압성 비케톤성 상태의 예후인자

안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.

Helicobacter pylori 제균치료에 Rebamipide (Mucosta) 의 유용성

이재동,이문호,이강문,남승우,안병민,이동수,정현용,정일권,노임환 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.5

Bakground/Aims: Eradication of Helicobacter pylori infection is highly efficacious in preventing the recurrence of peptic ulcer. Rebamipide (Mucosta) is known to have the ability to inhibit neutrophil activity, to reduce the production of inflammatory cytokines, to scavenge oxygen radical, and to stimulate prostaglandin production. This study was designed to evaluate the effect of rebamipide on the eradication of H. pylori, and decrease of the infilatration of inflammatory cells. Methods: Eighty two patients with gastric or duodenal ulcers with H. pylori infection were allocated to two treatment groups. The patients were treated either with omeprazole 40 mg, clarithromycin 1.0 g, amoxicillin 2.0 g, rebamipide 300 mg (OCAR group) or omeprazole 40 mg, clarithromycin 1.0 g, amoxicillin 2.0 g (OCA group) for two weeks. Results: H. pylori was eradicated 56 out of 62 patients (90%) in OCAR group and 16 out of 20 patients (80%) in OCA group. The infiltration of inflammatory cells decreased in both treatment groups. No significant side effects had been noticed. Conclusions: The results of the present study suggest that rebamipide may be useful to decrease gastric mucosal inflammation in peptic ulcer disease. However, further detailed study will be reqiured to determine the potentially beneficial effect whether rebamipide can prevent the recurrence of peptic ulcer diseases with H. pylori infection.

Implantable small device enabled with magnetic actuation for on-demand and pulsatile drug delivery

Lee, Seung Ho,Kim, Byung Hwi,Park, Chun Gwon,Lee, Cheol,Lim, Byung Yoon,Choy, Young Bin Elsevier 2018 Journal of controlled release Vol.286 No.-

<P><B>Abstract</B></P> <P>We prepared an implantable device of small volume (SID) that is enabled with on-demand, pulsatile drug release. The device was designed to be actuated via a magnetic field; hence, there was no need for a battery. The device was actuated when the magnet was applied from the outside and infused the drug solution outward via the outlet ports in the device. When there was no external magnetic field, no drug was released. In this work, we varied the amount of delivered drug by varying the number of outlet ports. Thus, as the number of outlet ports increased from one to three, the average amount of drug release per actuation increased from 60.7 ± 1.79 μg to 122.6 ± 1.27 μg. In addition, when the SID with three outlet ports (SID3) was actuated once and thrice, the amount of drug release increased from 123.0 ± 6.99 μg to 357.3 ± 9.70 μg, respectively, which was reproducible over 30 days. When the SID3 was implanted in living animals for 30 days, plasma drug concentration was measured to be 92–146 ng ml<SUP>−1</SUP> or 210–363 ng ml<SUP>−1</SUP> when the device was actuated once or three consecutive times, respectively.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

군입영 대상자의 HBsAg 양성률과 anti-HCV 항체 양성률의 변화

이원철,이동수,박영민,이영석,이강문,정규원,안병민,맹광호,김록권 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.4

Background/Aims: Before the introduction of the HBV vaccination programs, the positivity of HBsAg among the general population was reported to be around 8% in Korea. Although recent reports revealed somewhat decreased values, a wide range of variation exists according to the authors. Major movements to control HBV infection include the programs such as the introduction of HBV vaccination in 1983, mass inoculation of the elementary school children since 1988 and inclusion of type B hepatitis in 1995 in Class III legal epidemics. The purpose of the present study was to examine the changing trend of the positivities of HBsAg, HBeAg and anti-HCV in army draftees in Korea since we believed that they are an ideal study group with a set of fixed variables such as gender and age. Methods: From January 1, 1993 to December 31, 1999, we evaluated a total of 498,206 male army draftees for serum ALT, HBsAg, HBeAg and anti-HCV antibody. HBsAg (Genedia, Yongin, Korea) and HBeAg (Amrad, Austrailia) were examined by EIA and Immunochromatography, respectively. Anti-HCV antibody was tested by 3rd generation EIA (Genedia, Yongin, Korea). Serum ALT was determined by autoanalyser, Polystat 2000 (Hitachi, Japan). Results: The majority of the draftees were 20 years old (68.8%). The positivity of HBsAg gradually decreased from 5.8% in 1993 to 4.3% in 1999(mean 4.8%). The positivity of HBeAg among the asymptomatic HBsAg carriers ranged from 47.9% to 55.6%(mean 51.8%). The positivity of anti-HCV antibody was seen in the range from 0.09% to 0.29%(mean 0.18%), and 84.5% showed normal ALT. The positivity of HBsAg among the anti-HCV positive subjects was 6.6%. Conclusion: The HBsAg positivity has significantly(p=0.001) decreased for the past 7 years. However, the positivity of anti-HCV antibody showed no significant pattern of change during the same period. (Korean J Hepatol 2000;6:474-480)

Production of Hydrogen by Autothermal Reforming of Propane over Ni/<i>δ</i>-Al₂O₃

Lee, Hae Ri,Lee, Kwi Yeon,Park, Nam Cook,Shin, Jae Soon,Moon, Dong Ju,Lee, Byung Gwon,Kim, Young Chul American Scientific Publishers 2006 Journal of nanoscience and nanotechnology Vol.6 No.11

<P>The performance of Ni/<I>δ</I>-Al2O3 catalyst in propane autothermal reforming (ATR) for hydrogen production was investigated in the present study. The catalysts were characterized using XRD, TEM, and SEM. The activity of the Ni/<I>δ</I>-Al2O3 catalyst manufactured by the water-alcohol method was better than those of the catalysts manufactured by the impregnation and chemical reduction methods. The Ni/<I>δ</I>-Al2O3 catalysts were modified by the addition of promoters such as Mg, La, Ce, and Co, in order to improve their stability and yield. Hydrogen production was the largest for the Ni-Co-CeO2/Al2O3 catalyst.</P>

두통(頭痛)의 남녀(男女) 차이(差異)에 관한 임상적(臨床的) 고찰(考察) -《동의보감(東醫寶鑑),기(氣)》의 용약법(用藥法)을 중심(中心)으로-

이병권 ( Byung Gwon Lee ),감철우 ( Chul Woo Kam ),박동일 ( Dong Il Park ),김원일 ( Won Il Kim ),권경만 ( Kyoung Man Kwon ),김광록 ( Koang Lok Kim ),이수영 ( Su Young Lee ),배수현 ( Su Hyun Bae ),강나루 ( Na Ru Kang ) 경락경혈학회 2011 Korean Journal of Acupuncture Vol.28 No.2

Objectives: The Aim of this study was to investigate the clinical characteristics of male and female patients who have been suffered from headaches. The investigation was undertaken based on Qi-section(Methods of prescribing oriental herbal medicine) from DongEuiBoGam ( ). Methods: A statistical survey was conducted to compare the difference in clinical characteristics between male and female patients experiencing headaches. Oriental medical Diagnosis was used to classify all parients under the following categories; Qi-deficiency (氣虛), Jing-dificiency (精 ), Food-stagnation (食積), Damp-accumulation (痰飮), Qi-stagnation (氣滯). Patients were treated using acupuncture therapy and herbal medicines. Results: 1. The ratio between male and female patients was about 1:3. 2. It showed that periods of illness were longer in female patients than in male patients. 3. The total number of treatments received was higher in female patients than in male patients. 4. Statistically, most female patients had Metopodynia and Migraines(Rt.), while male patients suffered mostly from Laryngalgia. 5. Male patients had feelings of strain in the head and female patients had splitting headaches. 6. Musculo-skeletal System and General Symptoms were frequently observed in male patients. Digestive System and Nervous System were frequently observed in female patients. 7. Results from oriental medical Diagnosis showed that male patients mostly had Qi-deficiency, Jing-deficiency while the majority of female patients had Food-stagnation, Damp-accumulation, Qi-stagnation. 8. The recovery time for male patients was shorter than it was for female patients. The recurrence rate of the headaches were higher for female patients. Prognosis was better than in female patients in comparison to male patients. Conclusions: The statistical survey conducted was based on Qi-section of DongEuiBoGam. It had significant differences in clinical characteristics between male & femal patients.