[논문]Operational Characteristics of CO2 Laser Adopted by Superposing-Discharge

Hee-Je Kim,Hyun-Ju Chung,Byoung-Dae Min,Jong-Han Joung,Sung- lun Park 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

오늘날 현저한 CO2 레이저의 응용 추세에 발맞추어 보다 다양한 형태의 출력 제어 기술이 대두되고 있다. 본연구에서는multi-Pulse Superposing-Discharge 기술을 이용하여 다양한형태의 CO2 레이저의 펄스를 성형 하였다. 펄스 성형을 위한 방법으로 PIC one-chip microprocessor를 이용하여 삼중 PFN 모률의 SCR을 각각 고유의 지연시간을 가지도록 제어하였다. 실험에 사용된 삼중 PFN 모률의 전원 회로는 각각 캐패시터 인덕터,SCR,고압 펄스 트랜스 그리고 고압 트랜스 2차측에 브릿지 정류기로 구성 하였다. 고압 펼스 트랜스의 1차측을 제어하므로서 PFN 모률의 동작을 저 전압에서 수행 할 수 있다. 트랜스의 2차측에 연결된 전파 정류기는 펄스 에너지를 부하에 지속적으로 전달한다. 본 연구에서는 삼중 PFN 모률의 각각의 SCR을 다른 시간 가격을 두고 트리거 하므로서 다양한 Long pulse shaping을 실현하였다. 또한 약 250-1000μs 의 주기를 가지는 다양한 펄스형 레이저 빔을 얻었다.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

RBL-2H3 세포에서 Spermine에 의한 히스타민 유리와 칼슘유입에 미치는 상백피의억제효과

채옥희,강경진,신인호,김영기,이무삼,전병득 대한해부학회 1994 Anatomy & Cell Biology Vol.27 No.2

羚羊角散이 鎭痙, 解熱, 鎭痛, 鎭靜 및 GABAergic system에 미치는 영향

김진희,문병순,성강경 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

This study has been carried out to investigate the effects of Youngyanggaksan(YGS) extrac on the anticonvulsive, antipyretic, anlgestic, sedative and GABAergic system of experimental animals. The results of this study were as follows: 1. YGS extract prolonged significantly the beginning time to convulsion and time to death induced by strychnine. 2. YGS extract prolonged significantly the time to death induced by electrical shock of ECT unit (3sec, 200F, 25mA). 3. On the experiment of hypothermic effects of YGS extract on the rectal temperature of rats, YGS extract decreased significantly the rectal temperature of rats. 4. On the experiment of antipyretic effects of YGS extract on the febrile induced by the subcutneous injection of 150 ㎍/kg emdptpxin in rats, YGS extract decreased significantly the rectal temperature of rats. 5. On the experiment of analgesic effects of YGS extract on the writing syndrome induced by intraperitoneal injection 0.7% acetic acid 1ml/100g in rats, the writing syndrome was reduced significantly by administration of YGS extract. 6. On the experiment of sedative effects of YGS extract on spontaneous motor activity measured by wheel cage method in mice, the spontaneous motor activity was reduced significantly by administration of YGS extract. 7. On the experiment of effects of YGS extract on the activity of GABA-transaminase(GABA-T) in rat brains after 21 days of oral administration of YGS extract, the activity of GABA-T was reduced significantly by administration of YGS extract. 8. On the experiment of effects of YGS extract on the activity concentration of GABA in rat brains after 21 days of oral administration of YGS extract, the activity concentration of GABA was reduced significantly by administration of YGS extract. 9. On the experiment of effects of YGS extract on the activity of GAD in rat brains after 21 days of oral administration of YGS extract, the activity of GAD was reduced significantly by administration of YGS extract. According to the those results, Youngyanggaksan extract reveals the effects on the anticonvulsive, antipyretic, anlgesic, sedative and GABAergic system.

흰쥐에서 부신 적출이 양성 가속도(+Gz) 노출에 의한 위산분비 감소에 미치는 영향

윤신희,김대중,박병옥 공군본부 의무감실 1992 항공의학 Vol.40 No.1-2

폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

廣告 메세지의 談論 分析 : 헤드라인 形式別 이웃관계 效果를 中心으로

金昞希 西原大學校 經營科學硏究所 2001 經營硏究 Vol.10 No.1

UASB 공정에 의한 슬러리형 돈사폐수의 처리

원철희,김병욱,한동준,임재명 한국물환경학회 2004 한국물환경학회지 Vol.20 No.6

This research examined the treatment efficiency and methane production rate in treating slurry-type swine waste using UASB (upflow anaerobic sludge blanket) reactor. The UASB reactor was operated at an organics volumetric loading rate (VLR) of 2.6-15.7 ㎏COD/㎥/day. A stepwise increase of the VLR resulted in a temporary deterioration in the COD removal rate in UASB reactor but recovered quickly. The COD removal rate were 65-70% for VLR up to 5 ㎏COD/㎥/day. When organics VLR was 10 ㎏COD/㎥/day, the COD removal rate decreased sharply and there was loss of 17.537g of the seeding biomass due to sludge washout. This result indicated that the UASB system cannot be adapted to more than 10 ㎏COD/㎥/day of VLR. As the organic load increased from 2.6 to 15.7 ㎏ COD/㎥/d, the biogas production rate varied from 3.2 to 10.8 L/d and the methane conversion rate of the organic matter varied from 0.30 to 0.23 ㎥CH₄/㎏ COD_(removed). The methane content showed the range of 70.1-81.5% during the experimental period. The volatile solids (VS) removal efficiency was similar at the low VLR (< 5 ㎏COD/㎥/day), but it decreased sharply at the high VLR (> 5 ㎏COD/㎥/day). The VS reduction rate was, moreover, large those of COD. The result shows that hydraulic retention time above 2 days is essential in case of treating wastewater containing 1% of solids.

광릉수목원 혼합림에서 복사 에너지의 계절 변화 특성

김연희,조경숙,김현탁,엄향희,최병철 한국대기환경학회 2003 한국대기환경학회지 Vol.19 No.3

The measurement of the radiation energy, trunk temperature, leaf area index(LAI), air temperature,vapor pressure, and precipitation has been conducted under a mixed forest at Kwangneung Arboretum during the period of 2001. Characteristics of the diurnal and seasonal variation of the radiative energy were investigated. The aerodynamic roughness length was determined as about 1.6m and the mean albedo was about 0.1. The downward shortwave radiation was linearly correlated with the net radiation and its correlation coefficient was about 0.96. From this linear relation, the heating coefficient was calculated and its annual mean value was about 0.21. The albedo and heating coefficient was varied with season, surface characteristics, and meteorogical conditions. The diurnal and seasonal variations of radiation energy were discussed in terms of the surface characteristics and meteorological conditions. In the daytime, during clear skies, net raditaion was cominated by the shortwave radiation. In presence of clouds and fog, the radiation energy was diminished. At night, the net radiation was entirely dominated due to the net longwave radiation. There was no distinct diurnal variation in net radiation flux during the overcast or rainy days. The net radiation was strongest in spring and weakest in winter. The seasonal development in leaf area was also reflected in a strong seasonal pattern of the radiation energy balance. The timing, duration, and maximum leaf area and trunk temperature were found to be an important control on radiation energy budget. The trunk temperature was either equal or warmer than air temperature during most of the growing season because the canopy could absorb a substantial amount of sunlight. After autumn(after the middle of October), the trunk temperature was consistently cooler than air temperature.

노동복지의 국가별 접근유형에 관한 비교연구 : 북유럽,미국,일본을 중심으로

이병훈,류만희 한국산업노동학회 2002 산업노동연구 Vol.8 No.2

이 논문에서는 북유럽 국가(스웨덴과 노르웨이), 미국, 그리고 일본을 중심으로 노동복지에 대한 국가별 정책적 접근유형을 비교하고 있다. 스웨덴·노르웨이는 강력한 노동조합운동의 정치적 영향력과 사민당 정부의 보편주의적 사회복지정책기조를 배경으로 제한적인 비중의 민간 기업복지 조차 국가복지로 '도약'하여 수렴됨으로써 국가복지 수렴형의 노동복지체제로 특징지을 수 있다. 반면에, 미국의 경우에는 실리주의 노선의 노동조합운동 전통과 국가복지 확대에 대한 정부의 미온적인 정책입장 등으로 인해 민간 기업복지 중심의 시장의존적인 노동복지체제, 즉 기업들의 시장지배력에 연동되어 노동자들에 대한 부가급여의 제공수준이 결정되는 기업복지 주도형의 복지모델이 고착화도어 왔다. 그 결과, 스칸디나비아국가에서는 노동자계층 내부의 복지격차는 원천적으로 억제될 수 있었던 것에 반해, 미국에서는 이러한 노동복지의 격차문제가 방치되거나 오히려 확대되는 것을 정책적으로 조장하기까지 하고 있다. 일본의 경우에는 전후 경제성장연대의 기간에는 민간 기업복지 중심의 노동복지체계가 구축되었으나, 1980년대 이후 복지격차를 완화하기 위한 정책적 노력의 일환으로 사회보장체계의 점진적 확대적용을 통한 법정화된 기업복지의 비중 중대와 중소기업근로자복지서비스센터에 대한 설립 및 운영의 지원이 이루어지면서 준공공복지의 영역이 확대되어 취약한 국가복지를 보완하고 있는 것으로 드러났다. 이 글의 결론에서는 일본의 준 공공복지 보완모델이 국내 노동자계층내부의 복지격차를 해소하기 위한 현실적인 대안이 될 수 있다는 점을 제언하고 하고 있다. This study compares and classifies national policy approaches to labor welfare among Northern European states(i.e. Sweden and Norway), US, and Japan. In Sweden and Norway, the labor welfare regime is categorized as the “state welfare-convergency” model, in that the limited private company welfare has been frog-leaped and converged into the public state welfare against the backdrop of labor union’s strong political influence and the SDP-led government’s univeralistic welfare policy. By contrast, the “private company welfare-driven” model, in which the level of welfare compensation, given to workers, is primarily determined by the market power of companies, has been forged in the US, because of the tradition of business unionism and the government’s inactive position on the expansion of public state welfare. As a consequence, the welfare gap in the working class has to a large extent been constrained in those Scandinavian countries, whereas the discrepancy of labor welfare in the US has been taken for granted and even widened by the government’s policy to encourage the diffusion of private welfare packages. In Japan, where the private company welfare-dominated model was formed during the post-war period of economic development, the semi-public welfare system has since 1980s been expanded by assisting the weak state welfare with the government’s policy to gradually increase companies’ legal contribution of social welfare and promote the establishment and operation of non-government labor welfare service centers for workers of small-sized companies. It is suggested as a conclusion that the “semi-public welfare-aided” model, illustrated in Japan, need to be considered as a meaningful policy approach for resolving the widening discrepancy of labor welfare among workers in Korea.