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RISS 인기검색어
- 검색키워드
- 저자 : Borea, Pier Andrea (검색결과 2 건)
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Control of quorum sensing signals and emerging contaminants in electrochemical membrane bioreactors
Borea, Laura,Naddeo, Vincenzo,Belgiorno, Vincenzo,Choo, Kwang-Ho Elsevier 2018 Bioresource technology Vol.269 No.-
<P><B>Abstract</B></P> <P>The present study investigated the influence of electric field on the removal of quorum sensing (QS) and emerging contaminants using an electrochemical membrane bioreactor (eMBR). A significant reduction of N-octanoyl-L-homoserine lactone signal molecules (∼76%) was achieved in the eMBR, with respect to the level observed in the conventional MBR as the control. Furthermore, the intermittent electric current supply (0.5 mA/cm<SUP>2</SUP>) was found to be effective for the removal of atrazine and estrone. The degradation of key pharmaceutical compounds, such as diclofenac, carbamazepine, and amoxicillin, was also possible, confirming the applicability of the eMBR system for removing the priority chemical compounds of public health concern.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Influence of the electric field on QS activity in the eMBR was first investigated. </LI> <LI> Pharmaceuticals, atrazine and estrone removals by eMBR were evaluated. </LI> <LI> A reduction of C8-HSL concentration in the eMBR was found. </LI> <LI> EPSp and TEP were examined as a function of C8-HSL QS signal molecule. </LI> <LI> EPSp, TEP and C8-HSL concentrations over time were modelled using linear regression. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Amelioration of Cerebral Ischemic Injury by a Synthetic Seco-nucleoside LMT497
Ryu, Sangwoo,Kwon, Joonha,Park, Hyeon,Choi, In-Young,Hwang, Sunyoung,Gajulapati, Veeraswamy,Lee, Joo Young,Choi, Yongseok,Varani, Katia,Borea, Pier Andrea,Ju, Chung,Kim, Won-Ki The Korean Society for Brain and Neural Science 2015 Experimental Neurobiology Vol.24 No.1
<P>Recently, we reported that the A3 adenosine receptor (A<SUB>3</SUB>AR) agonist LJ529 (2-chloro-N<SUP>6</SUP>-(3-iodobnzyl)-5'-N-methylcarbamoyl-4'-thioadenosine) reduces cerebral ischemic injury via inhibition of recruitment of peripheral inflammatory cells into ischemic brain lesion. A3AR agonists, however, are known to possess anti-platelet activity, which may deter the combination therapy with tissue plasminogen activator for the therapy of cerebral ischemic stroke. Thus, the present study investigates the neuroprotective/anti-ischemic effect of a synthetic seco-nucleoside, LMT497 ((<I>S</I>)-2-((<I>R</I>)-1-(2-chloro-6-(3-iodobenzylamino)-9<I>H</I>-purin-9-yl)-2-hydroxyethoxy)-3-hydroxy-<I>N</I>-methylpropanamide) with little anti-platelet activity. LMT497 neither showed A<SUB>3</SUB>AR binding activity nor anti-platelet activity. In our present study LMT497 significantly attenuated the injury/death of cortical neurons exposed to oxygen-glucose deprivation (OGD) followed by re-oxygenation (R). LMT497 significantly reduced the ascending cellular level of reactive oxygen species under ischemic conditions by increasing the superoxide dismutase (SOD) levels. LMT497 also inhibited the migration of microglia which mediates inflammatory responses in ischemia. In rats subjected to middle cerebral artery occlusion (MCAO, 1.5 h) followed by reperfusion, LMT497 largely reduced brain infarction volume, and edema, and improved neurological score. Therapeutic efficacy of LMT497 was obtained by twice treatments even at 10 h and 18 h after the onset of ischemia. Collectively, LMT497 could be a therapeutic drug candidate with a wide therapeutic time window for the treatment of cerebral ischemic stroke.</P>
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