Cyclosporin에 의한 치은증식증의 치험 2례

김종배,박효상,김창환,이용규,최봉주,장학원 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2

Cyclosporin is a relatively new immunosuppressive agent which has been used to prevent organ transplant rejection, to treat type-I diabetes mellitus and several other autoimmune disorders. It is anticipated that the therapeutic use of cyclosporin will increase progressively in the future to treat numerous other disorders. As its clinical use broadens, it will needed for health professionals to be familiar with the beneficial effects as well as some of the undesirable side effects of cyclosporin therapy. A side effect of this drug in dentistry appears to be pronounced gingival hyperplasia. Cyclosporin induced gingival hyperplasia is indistinguishable from gingival hyperplasia induced by phenytoin and nifedipine in clinical and histopathologic finding. We experienced two cases of gingival hyperplasia secondary to cyclosporin therapy in patients, 48-year old & 28-year old females who received a kidney allograft transplant. Clinical examinations revealed a severely overgrown and inflammed gingiva. Surgical excision of the excess tissue was accomplished under local anesthesia. On follow-up check, gingival hyperplasia in a 48-year old patient whose oral hygiene was very poor showed successive recurrence after three times surgical excision, another patient who could control oral hygiene thoroughly showed good healing. Conclusively, it seems to be very important to control oral hygiene thoroughly to decrease occurrence and recurrence of cyclosporin-induced gingival hyperplasia.

물과 Micelle 용액에서 Benzaldehyde의 전기화학적 환원에 대한 연구

金日光,金潤根,金峯元,印權植 圓光大學校 基礎自然科學硏究所 1988 基礎科學硏究誌 Vol.7 No.3

The electrochemical reduction of benzaldehyde in 10% ethanol-water solution contained surfactants has been studied by direct current (DC) differential pulse (DP) polarography, cyclic voltammetry (CV) and controlled potential coulometry (CPC). A totally irreversible electrode reaction processes of benzaldehyde reduction proceeded by one electron transfer to form anion radical which undergoes both protonation and a second one electron reduction to give benzyl alcohol as a major product. The cathodic reduction wave was seperated by inhibition of sodium lauryl sulfate due to selectivity and effect of anionic charged micelle. The possible reduction mechanism with controlled pH range was suggested.

β-Cyclodextrine과 Micelle의 비수용액에서 Nitrobenzyl chlorides의 전기화학적 환원에 관한 연구

金日光,金峰元 圓光大學校 基礎自然科學硏究所 1984 基礎科學硏究誌 Vol.3 No.2

The electrochemical reduction of nitrobenzyl chloride in micelle and β-cyclodextrine acetonitrile solution has been examined by DC. DP. polarography and cyclic voltammetry. The polarographic reduction wave on the chloride functional group of nitrobenzyl chlorides shown to be eliminate in the anionic surfactant NaLS solution. In the β-cyclodextrine solution, on the other hand, nitro functional group of nitrobenzyl chlorides(gust) complexion does with β-cyclodextrine (host) with the aromatic ring inside the apolar cavity of the torus, result in dramatic eliminates on the nitro functional group reduction wave. o,m,p-nitrobenzyl chlorides are initially on one-electron process which give the corresponding anion radical and the anion radical is rapidly decomposed to give the neutral radical. Those neutral radical dimerises as a major product although some o,p-nitrotoluene is also produced by hydrogen atom abstraction from the solvent, in a β-cyclodextrine at low voltage. But in the NaLS solution produced some aminotoluene because of its charge repulsion effect.

상부위장관 출혈을 일으킨 Warfarin Sodium에 의한 위점막내 혈종 1예

이봉규,김태원,박찬국,김만우 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2

A case of warfarin sodium-induced intramural hematoma and upper gastrointestinal bleeding is described, and the literature on this adverse effect is reviewed. A 83-year-old woman who has been receiving warfarin came to a emergency room because of hematemesis. She had a history of cerebral infarction. Physical examination was anemic conjunctiva, no abdominal mass and melena. The emergency gastroscopic finding was submucosal mass. Her hemoglobin and hematocrit concentration had falled to 6.7g/㎗ and 20%, Her prothrombin time (PT) was 130 sec and partial prothrombin time (aPTT) was 133 sec. The patient underwent an emergency exploratory laparotomy. The name of operation was hemigastrectomy with gastrojejunostomy(Billorth-Ⅱ). The pathology report indicated the presence of submucosal hematoma formation with mucosal ischemic necrosis and mucosal ulceration and regenerating epithelium.

4-nitro-N-(triphenyl phosphoranylidene)의 전기화학적 환원에 관한 연구

최창진,김일광,이기학,전병영,김봉원 圓光大學校 基礎自然科學硏究所 1984 基礎科學硏究誌 Vol.3 No.2

The electrochemical reduction of 4-nitro-N-(triphenyl-phosphoranylidene) in nonaqueous media has been examined by polarography, cyclic voltammetry and controlled-potential coulometry. The reduction of 4-nitro-N-(triphenylphosphoranylidene) proceeds by a one electron-transfer to form anion radical which undergoes both protonation and a second one electron reduction followed by cleavage of a phosphorous-phenyl bond was also observed after reduction of triphenylphosphine oxide which is one of the major products of the chemical reaction which follow the primary electrode process.

Urea 박테리아 전극에 관한 연구

인권식,최창진,김봉원,손무정,김인탁 圓光大學校 基礎自然科學硏究所 1987 基礎科學硏究誌 Vol.6 No.2

Proteus vulgaris 를 ammonia와 carbon dioxide gas-sensor에 고정시켜 감응도와 재현성이 우수한 요소에 대한 박테리아 전극을 직접 제조하여 pH, 온도, 완충용액, 박테리아의 양, 여러 가지 아미노산 및 무기염류에 대한 영향과 전극의 수명 등에 관하여 조사하였다. 먼저 ammonia-박테리아 전극은 25℃에서 pH 7.4인 0.05M phosphate 완충용액을 사용하였을 때가 최적이었으며, 7.0 ×10 exp (-4) -3.0 ×10 exp (-2)M 내에서 직선을 나타내었고, 이때 감응도는 116.7mV/decade였다. 한편, carbon dioxide-박테리아 전극은 30℃, pH7.0, 0.1M phosphate 완충용액에서 가장 우수한 감응을 보였다. 이 경우는 7.0 ×10 exp (-4) - 5.0 ×10 exp (-2)M 내에서 45.4 - 45.7mV/decade를 나타내었다. 이들 두 전극중에서 carbon deoxide-박테리아 전극을 이용하여 요소를 정량한다면 방해물질들의 방해가 최소화되었다. 실제 임상적 응용에서 분광 광도법과 비교한 결과 실험과정이 간단하고 편리하여 신속하게 많은 양의 시료분석이 가능하다. Bio-electrodes for urea have been constructed by immobilizing the Proteus vulgaris on ammonia and carbon dioxide gas-sensors. The bacteria containing urease convert each molecule of urea into two molecules of ammonia and one molecule of carbon dioxide gas. Ammonia-bacterial electrode based on ammonia gas-sensor has linearity in the range of 7.0 ×10 exp (-4) - 3.0 ×10 exp (-2)M urea in pH 7.4, 0.05M phosphate buffer solution at 25℃. While carbon dioxide-bacterial electrode based on carbon dioxide gas-sensor has linearity in the range of 7.0 ×10 exp (-4) - 5,0 ×10 exp (-2)M urea in pH 7.0, 0.1M phosphate buffer solution at 30℃. These electrodes were investigated for the effects of pH, temperature, buffer solutions, bacterial amounts and interferences, and life time. As the clinical applications, urea in urine was determined by these devices and was compared with spectrophotometric method. As the results, those methods were by far more simple and rapid than these method.

Acceleration tests: Degradation of anode-supported planar solid oxide fuel cells at elevated operating temperatures

Kim, Sun Jae,Choi, Moon-Bong,Park, Mansoo,Kim, Hyoungchul,Son, Ji-Won,Lee, Jong-Ho,Kim, Byung-Kook,Lee, Hae-Weon,Kim, Seung-Goo,Yoon, Kyung Joong Elsevier 2017 Journal of Power Sources Vol.360 No.-

<P><B>Abstract</B></P> <P>As the solid oxide fuel cell (SOFC) technology matures, durability under real operating conditions is considered as one of the most critical issues for commercialization. The severe conditions encountered in practical operation include a large temperature gradient and generation of local hot spots within stacks. Herein, we report the degradation mechanisms of anode-supported planar SOFCs supplied by Posco Energy at elevated operating temperatures. A simple comparison of the voltage reduction rates at different operating temperatures does not appropriately represent the degree of degradation, because the rapid deterioration of the cell components at high temperatures is compensated for by the fast reaction and transport kinetics. A combination of impedance interpretation and post-mortem analysis reveals the major degradation processes that are distinctively accelerated by increasing temperature, including the chemical interaction between the cathode and electrolyte, the enlargement of the interfacial pores, the coarsening of the fine particles in the composite electrodes, the formation of interfacial cracks and Cr poisoning. Systematic analysis presented in this study provides guidelines for counteracting the unexpected temperature increase, and the database established under various extreme conditions would form the groundwork for achieving the lifetime goals of commercial SOFC systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Long-term stability of solid oxide fuel cells are evaluated at various temperatures. </LI> <LI> The impedance spectra are analyzed using the distribution of the relaxation time technique. </LI> <LI> The major degradation processes accelerated by increasing temperature are clarified. </LI> </UL> </P>

식도 궤양을 동반한 Behcet 병 1예

김경수,여향순,임연근,조철현,김원영,이승욱,윤봉한,김광현,강명원 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.2

Behcet's disease is a recurrent and multisystemic disorder which usually persists over many years and is classified under vasculitic syndrome. A classic triad in this disorder is composed of a recurrent oral ulcer, genital ulceration and uveitis. While intestinal Behcet's disease most commonly affects the ileoecal region, dysphagia associated with esophageal ulceration is very uncommon. A 34-year-old-female patient visited our hospital because of dysphagia, epigastric pain and fever. The patient had ulcers on the oral mucosa, soft palate and extemal genitalia. Multiple irregularly marginated ulcers surrounded with hyperemic edematous mucosa were found on the middle and distal esophagus and lesser curvature of the stomach by an esophagogastroduodenoscopic examination. The pathologic findings were non-specific ulcers with necrotizing vasculitis in the vulva and with suspicious vasculitis in the esophagus. So she was diagnosed to have a Behcets disease and was treated with steroid and sulfasalazine. In this study we report a case of esophageal involvement of Behcet's disease with a review of the literature.

Alpha-Fetoprotein이 증가한 만성 간질환의 임상적 특성

김창민,홍석일,조희준,이영현,김봉석,홍원선,이진오,김유철,강태웅,김서운 대한소화기학회 1992 대한소화기학회지 Vol.24 No.4

In an attempt to investigate the factors influencing the specificity of serum level of alphafetoprotein (AFP) for hepatocellular carcinoma, serum levels of AFP were analyzed in 33 patients treated at the department of gastroenterology in the Korea Cancer Center Hospital between January 1989 and December 1991. All patients entered into the study had chronic liver disease with increased serum level of AFP, more than 50 ng/ml. Clinical and; laboratory parameters, such as HBsAg, Anti-HCV, GOT and GPT and image studies with ultraonograpy and computed tomography were sequentially evaluated, every two or three months, in 2Z' patients. Among 33 patients, 30 had liver cirrhosis and three had chronic hepatitis. The median level of serum AFP was 189 ng/ml in 33 patients. Thirty (90.9%) out of 33 patients were positive for HBsAg. Anti-HCV was tested in 14 patients, among whom four (28.6%) were positive. No significant correlation was observed between serum AFP levels and age, sex or positive rates for HBsAg, anti-HCV and cirrhosis. In 32 among 33 patients, no evidence of the development of hepatocellar carcinoma was found after the follow-up period of six to 36 months, when hepatocellar carcinoma teas diagnosed as the space occupying lesion in the liver by ultrasonograpy and computed tomography. Another one patient was also suggested not to develop hepatocellar carcinoma, when clinically evaluated, because liver function and serum AFP level were markedly improved. The follow-up period in 22 patients was determined as the period until the AFP level decreased below the cut-off value, 50 ng/ml, or the end of study period. The serum AFP level and liver function were sequentially tested during the median follow-up period of 7.5 months (range, 3-30), demonstrating that the median serum AFP level significantly decreased from 376.6 ng/ ml to 57.6 ng/ml (p$lt;0.05). With the decrease in serum AFP levels, serum levels of GOT and GPT also decreased (p$lt;0.01). In 20 out of 22 patients, serum level of AFP decreased to less than 50% of the inital level of AFP after the follow-up period. In eight and seven patients, serum levels of AFP decreased to the normal level, less than 20 ng/ml, after tile median follow-up period of 14.5 months (range, 5-30) and 20-49 ng/ml during 4.5 months (range, 3.11), respectively. In two patients, however, change in the serum AFP levels was not observed. In seven patients who had the initial serum AFP level of more than 100 ng/ml and tested serum AFP level and liver function test every two months. serum levels of AFP, GOT and GPT concurrently decreased during the follow-up period. These results demonstrating that serum AFP level increased in benign liver diseases, such as liver cirrhosis and chronic hepatitis, suggest that, in order to increase the clinical usefulness of serum level of AFP for the diagnosis of hepatocellular carcinoma, serum AFP level should be reevaluated for the specificity for hepatocellular carcinoma according to the cut-off value. Because serum AFP level decreased in most of the patients after the follow-up period, tit is also suggested that AFP elevated in benign liver disease might be different from that in hepatocellular carcinoma in molecular characteristics.

[화학]장미조직센서를 이용한 요소의 정량

김봉원(Bong-Weon Kim),전영국(Young-Guk Jeon),정진갑(Chin-Kap Chung) 한국분석과학회 1993 분석과학 Vol.6 No.3