Mechanical evaluation of polymer microneedles for transdermal drug delivery: In vitro and in vivo

Rui Xuan Liu,Yu Ting He,Ling Liang,Liu Fu Hu,Yue Liu,Rui-xing Yu,Bo Zhi Chen,Yong Cui,Xin Dong Guo 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-

In this study, we reported two types of PMNs based on polylactic acid (PLA) and polyvinyl alcohol (PVA),respectively. Parafilm M film, porcine skin, and rats’ models were operated to evaluate the mechanicalproperties in vitro and in vivo to find optimal parameters for efficient insertion. Insertion depth was measuredusing Digital Force Gauge by changing insertion force and speed, respectively. Results showed thatincreasing the insertion force and speed used for PMNs application led to a significant increase in thedepth of insertion. A force of 18 N under a speed of 330 mm/min was the optimal condition for insertingPMNs array into ParafilmM film and porcine skin. In addition, PLA-MNs exhibited higher robustness andenhanced homogeneity in insertion depth compared with PVA-MNs, but PVA-MNs were able to reachmuch deeper insertion depth. Moreover, Sprague Dawley (SD) rat experiments confirmed the effectivenessof optimal insertion parameters for transdermal drug delivery. This study illustrated not only thedevelopment of novel PMNs but also the mechanical evaluation for the design of PMNs.

The effect of HCP on the formation of twin boundaries and dislocations in Ni–Co alloys

Ma Rui-bo,Zhou Li-li,Liang Yong-chao,Chen Qian,Tian Ze-an,Liu Rang-su,Mo Yun-fei,Gao Ting-hong,Xie Quan 한국물리학회 2021 Current Applied Physics Vol.29 No.-

In this study, molecular dynamics (MD) was used to simulate the rapid solidification process of Ni47Co53 and Ni48Co52 alloys at a cooling rate of 1012 K/s. The effects of HCP on the formation of twin boundaries and dislocations in two Ni–Co alloys are studied. It is found that the difference of HCP clusters is the main effect that producing discrepancies on microstructure of two alloys. The number of HCP clusters accounted for 9.23% in Ni47Co53 alloy. They are regularly arranged to form the number of single-layer twin boundaries, and each twin boundary ends in a dislocation. The FCC and HCP structures coexist in the same atomic layers, which is easy to create dislocations. The relatively standard FCC crystal and only 0.32% HCP clusters are formed in Ni48Co52 alloy at 300 K. That small amount of HCP clusters are dispersed on the surface, and cause the formation of dislocation in the border with FCC clusters.

Design of a Bidirectional DC/AC Converter with Battery Charging/Discharging/Standing Balance Control

Liang-Rui Chen,Bo-Rui Xu,Chuan-Sheng Liu,Shao-wei Peng,Chia-Hsuan Wu 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

Battery cells connected in series have been widely used in high-voltage and high-power applications. In this paper, a single-phase battery energy storage system with battery balance charging, battery balance discharging, and power factor correction capabilities was developed. A prototype suitable for a single-phase 110V power supply was designed and implemented for verification. To verify its performance, three 48V/7Ah battery modules were used as normal batteries, and a 48V/5Ah battery module was used as a retired battery. The experimental results showed that the battery energy storage system has excellent battery balancing capability. Compared with that of the conventional system without balanced control, the balancing performance of the proposed system is increased by about 15.25% and 26.92%, respectively, when the system was operated in the converter and rectifier modes. In addition, the proposed system also had battery fault tolerance, and was compatible with recycled batteries and an independent power supply.

Time-varying H∞ Control for Discrete-time Switched Systems with Admissible Edge-dependent Average Dwell Time

Rui-Hua Wang,Bing-Xin Xue,Jing-Bo Zhao 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.8

The problem of H∞ control for discrete-time switched systems is investigated via admissible edgedependent average dwell time (AED-ADT) method in this paper. By virtue of a convex combination of positive definite matrices, a novel multiple piecewise convex Lyapunov function (MPCLF) is designed, which can relax the restricted conditions of Lyapunov functions at switching points and interval interior points. Based on the MPCLF approach, the time-varying H∞ state feedback controllers, guaranteeing that the corresponding closed-loop system is globally uniformly exponentially stable (GUES) with a prescribed H∞ performance, are established for the considered switched system. Finally, three numerical examples are provided to illustrate the effectiveness of the proposed approaches.

Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation

Rui Shi,Jia-Wen Xu,Zi-Ting Xiao,Ruo-Fei Chen,Yi-Lin Zhang,Jia-Bi Lin,Ke-Ling Cheng,Gu-Yi Wei,Pei-Bo Li,Wen-Liang Zhou,Wei-Wei Su 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.9

Naringin and its aglycone, naringenin, occur naturally in our regular diet and traditional Chinese medicines. This study aimed to detect an effective therapeutic approach for cough variant asthma (CVA) through evaluating the relaxant effect of these two bioactive herbal monomers as antitussive and antiasthmatic on rat tracheal smooth muscle. The relaxant effect was determined by measuring muscular tension with a mechanical recording system in rat tracheal rings. Cytosolic Ca2+ concentration was measured using a confocal imaging system in primary cultured tracheal smooth muscle cells. In rat tracheal rings, addition of both naringin and naringenin could concentration dependently relax carbachol (CCh)-evoked tonic contraction. This epithelium-independent relaxation could be suppressed by BaCl2, tetraethylammonium, and iberiotoxin (IbTX), but not by glibenclamide. After stimulating primary cultured tracheal smooth muscle cells by CCh or high KCl, the intracellular Ca2+ increase could be inhibited by both naringin and naringenin, respectively. This reaction was also suppressed by IbTX. These results demonstrate that both naringin and naringenin can relax tracheal smooth muscle through opening big conductance Ca2+-activated K+ channel, which mediates plasma membrane hyperpolarization and reduces Ca2+ influx. Our data indicate a potentially effective therapeutic approach of naringin and naringenin for CVA.

Molecular Structure Design of Sizing Agent and Its Influence on the Mechanical Properties of CF Reinforced Composite

Bo Wu,Rui Wang,Guo Zheng,Cun Zhou 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1

In this article, phosphate modified epoxy resin (PAEK) and polyethylene oxide (PEO) were used as the mainmonomers to fabricate a composite sizing agent (TPP) for carbon fiber (CF) surface treatment. The effects of TPP sizing onthe surface morphology, activity and wettability of CF were studied by FE-SEM, XPS and contact angle. In addition, frictioncoefficients, fuzz amount and the mechanical properties of CF filaments, as well as the interlaminar shear strength (ILSS) ofCF composites were analyzed. The results indicate that the defects of CF surface were completely repaired by TPPmolecules, the content of active groups increased by 24.8 % and the contact angle and the spreading time of EP on CF surfacereached respective minimum values of 43.5 o and 15 s, meanwhile, the friction coefficient and the fuzz amount of the treatedCF surface are reduced in the sizing quantity range of 3.0-4.0 mg/g. Thus, there were 36.1 % and 24.3 % enhancement in thebreaking strength and elongation of CF filament. In addition, the ILSS of composite prepared with TPP treated CFs wasincreased from 12.81 to 28.55 MPa.

Genetic variation and phylogenetic relationships of the ectomycorrhizal Floccularia luteovirens on the Qinghai-Tibet Plateau

Rui Xing,Qing-bo Gao,Fa-qi Zhang,Peng-cheng Fu,Jiu-li Wang,Hui-ying Yan,Shi-long-Chen 한국미생물학회 2017 The journal of microbiology Vol.55 No.8

Floccularia luteovirens, as an ectomycorrhizal fungus, is widely distributed in the Qinghai-Tibet Plateau. As an edible fungus, it is famous for its unique flavor. Former studies mainly focus on the chemical composition and genetic structure of this species. However, the phylogenetic relationship between genotypes remains unknown. In this study, the genetic variation and phylogenetic relationship between the genotypes of F. luteovirens in Qinghai-Tibet Plateau was estimated through the analysis on two protein-coding genes (rpb1 and ef-1α) from 398 individuals collected from 24 wild populations. The sample covered the entire range of this species during all the growth seasons from 2011 to 2015. 13 genotypes were detected and moderate genetic diversity was revealed. Based on the results of network analysis, the maximum likelihood (ML), maximum parsimony (MP), and Bayesian inference (BI) analyses, the genotypes H-1, H-4, H-6, H-8, H-10, and H-11 were grouped into one clade. Additionally, a relatively higher genotype diversity (average h value is 0.722) and unique genotypes in the northeast edge of Qinghai- Tibet plateau have been found, combined with the results of mismatch analysis and neutrality tests indicated that Southeast Qinghai-Tibet plateau was a refuge for F. luteovirens during the historical geological or climatic events (uplifting of the Qinghai-Tibet Plateau or Last Glacial Maximum). Furthermore, the present distribution of the species on the Qinghai-Tibet plateau has resulted from the recent population expansion. Our findings provide a foundation for the future study of the evolutionary history and the speciation of this species.

Semantic Similarity Computation Based on Multi-Features Fusion

Bo Ma,Yating Yang,Fan Zhao,Rui Dong,Xi Zhou 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.5

Semantic similarity is a core technique of many NLP research fields. However, state-of-the-art metrics for semantic similarity computation often operate at different levels, e.g., words or sentences. In this paper, semantic similarity computation metrics are firstly introduced and the quality is measured in order to determine their advantages and limitations; then a new semantic similarity metric based on multi-features fusion is proposed. Distributed representations of words are used for alignment-based disambiguation operation, and Wikipedia tags are used to enhance the performance of our approach. The proposed metric is unsupervised, and can be applied at different levels e.g., single words or entire documents. The metric is evaluated on both English and Chinese datasets, it is shown that the precision and recall scores are higher than metrics which simply using knowledge base or distributed representation of words.

Retraction Note: Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma

Bo Wang,Yun Su,Qun Yang,Decheng Lv,Wei-Guo Zhang,Kai Tang,Hong Wang,Rui Zhang,Yang Liu 한국분자세포생물학회 2020 Molecules and cells Vol.43 No.10

Retraction Note: Mol. Cells 2015; 38(5): 432-440 https://doi.org/10.14348/molcells.2015.2327 This article has been retracted at the request of the corresponding author of this paper with the consent of the other authors. The authors sincerely apologize for any inconvenience this retraction may have caused.

Overexpression of Long Non-Coding RNA HOTAIR Promotes Tumor Growth and Metastasis in Human Osteosarcoma

Bo Wang,Yun Su,Qun Yang,Decheng Lv,Wei-Guo Zhang,Kai Tang,Hong Wang,Rui Zhang,Yang Liu 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.5

Human osteosarcoma usually presented a high tendency to metastatic spread and caused poor outcomes, however, the underlying mechanism was still largely unknown. In the present study, using a series of in vitro experiments and an animal model, we investigated the roles of HOX antisense intergenic RNA (HOTAIR) during the proliferation and invasion of osteosarcoma. According with our results, HOTAIR was commonly overexpressed in osteosarcoma, which significantly correlated with advanced tumor stage, highly histological grade and poor prognosis. In vitro and in vivo experiments demonstrated that knockdown of HOTAIR could notably suppress cellular proliferation, inhibit invasion and decrease the secretion of MMP2 and MMP9 in osteosarcoma. Collectively, our results suggested that HOTAIR might be a potent therapeutic target for osteosarcoma.