Iridin abrogates LPS-induced inflammation in L6 skeletal muscle cells by inhibiting NF-κB and MAPK signaling pathway

BHOSALE PRITAM BHAG-WAN,하상은,김훈환,아부살리야 아부야시르,박민영,김곤섭,Kim Jin-A 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3

Background Iridin is a glycoside form of fl avonoids isolated from Belamcanda chinensis , and Iris fl orentina has numerous biological properties, including antitumor, antiproliferative, anti-infl ammatory and antioxidant properties. Infl ammatory diseases are an essential health concern and have a growing incidence worldwide, so developing safe drugs remains an important objective. Objective In the present study, we evaluated iridin's anti-infl ammatory eff ect on LPS-stimulated skeletal muscle cells (L6). The anti-infl ammatory action of iridin elucidated through NF-κB (nuclear factor-kappa B) and MAPK (mitogen-activated protein kinases) pathway in LPS-stimulated L6 cells. Results Determination of cytotoxicity was examined by MTT assay. The expression level of cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS) was evaluated by western blot analysis. To elucidate the underlying mechanism, NF-κB and MAPKs proteins were investigated by immunoblot. Iridin could decrease the phosphorylation of NF-κB and MAPK proteins in LPS-induced L6 cells. Conclusion The results showed that iridin inhibited the phosphorylation of NF-κB and MAPK proteins and infl ammatory cytokines COX-2 and iNOS in LPS-induced L6 cells. Based on fi ndings in this work, iridin possesses anti-infl ammatory action on L6 cells and could be considered for an attractive candidate for anti-infl ammation.

Ignition of boron-based green hypergolic fuels with hydrogen peroxide

Bhosale, Vikas K.,Jeong, Junyeong,Kwon, Sejin Elsevier 2019 Fuel Vol.255 No.-

<P><B>Abstract</B></P> <P>Exploring novel green hypergolic fuels ignited with hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) offers a number of opportunities in space propulsion with regard to replacing conventional toxic propellant combinations. The green hypergolic fuels, BH bond-rich zwitterions and ionic liquids (ILs) were synthesized; their hypergolic reactivity was investigated with 95% H<SUB>2</SUB>O<SUB>2</SUB>. Remarkably, ammonia borane (AB) and 1-ethyl-3-methyl imidazolium borohydride ([EMIM][BH<SUB>4</SUB>]) exhibited the lowest ignition delay times of 8.1 and 18.5 ms, respectively. For a comprehensive application, the reactivity of liquid and hybrid fuel blends were studied. A liquid fuel blend, [EMIM][BH<SUB>4</SUB>] and methyl imidazolium borane (MIMB) (1:1, w/w) exhibited the ignition delay time of about 35 ms. Further, a solid hybrid fuel blend consisting of 40% AB-paraffin revealed a hypergolic ignition delay time of 9.2 ms. Additionally, the gas phase heat of formation and specific impulse were calculated using G09 and NASA-CEC-71 programs, respectively. The specific impulse of AB was 273 s, which is higher than the stated hypergolic zwitterions. Hence, the BH bond-rich zwitterions and ILs are promising choices for new generation green hypergolic liquid and hybrid rocket propulsion.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hypergolic BH bond encased ionic liquids and zwitterionic fuels were synthesized. </LI> <LI> The reactivity of hypergolic fuels with 95% H<SUB>2</SUB>O<SUB>2</SUB> was explored. </LI> <LI> We investigate the hypergolic fuel blends for hybrid and bipropellant rocket applications. </LI> <LI> Boron-based green fuels and hydrogen peroxide can be the alternatives for conventional toxic propellant combinations. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Organic small molecules and polymers as an electrode material for rechargeable lithium ion batteries

Bhosale, Manik E.,Chae, Sudong,Kim, Ji Man,Choi, Jae-Young The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.41

<P>Organic electrode materials are promising for electrochemical energy storage devices because they have a high theoretical capacity, structural diversity, and flexibility. In addition, they are light weight, inexpensive, and environmentally benign. Organic electrode materials are a promising alternative to conventional inorganic materials. Various organic materials, such as conducting polymers, organodisulfides, nitroxyl radical polymers, and conjugated carbonyl compounds, have been studied as electrode materials for lithium batteries. Among them, small organic carbonyl compounds and polymers containing carbonyls have been widely studied as electrode materials because of their high theoretical capacity, fast redox kinetics, and structural diversity. However, these materials have intrinsic drawbacks, such as solubility in electrolyte media and a low conductivity. Herein, methods to solve these problems by increasing the polarity are discussed. The polarity of small molecules could be increased by forming salts. In addition, the conductivity could be enhanced using a chemical doping strategy or forming a composite with a conductive additive. This review provides guidance for the design of a new type of organic material for next-generation rechargeable batteries.</P>

Multi-criteria Vertical Handoff Decision Algorithm Using Hierarchy Modeling and Additive Weighting in an Integrated WLAN/WiMAX/UMTS Environment- A Case Study

( Sahana Bhosale ),( Rohin Daruwala ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.1

Multi-criteria decision making (MCDM) algorithms play an important role in ensuring quality of service in an integrated HetNets (Heterogeneous Networks). The primary objective of this paper is to develop a multi-criteria vertical handoff decision algorithm (VHDA) for best access network selection in an integrated Wireless Local Area Network (WLAN)/ Universal Mobile Telecommunications System (UMTS)/ Worldwide Interoperability for Microwave Access (WiMAX) system. The proposed design consists of two parts, the first part is the evaluation of an Analytic Hierarchy Process (AHP) to decide the relative weights of handoff decision criteria and the second part computes the final score of the weights to rank network alternatives using Simple Additive Weighting (SAW). SAW ranks the network alternatives in a faster and simpler manner than AHP. The AHP-SAW mathematical model has been designed, evaluated and simulated for streaming video type of traffic. For other traffic type, such as conversational, background and interactive, only simulation results have been discussed and presented in brief. Simulation results reveal that the hierarchical modelling and computing provides optimum solution for access network selection in an integrated environment as obtained results prove to be an acceptable solution to what could be expected in real life scenarios.

Evaluating and Selecting a Supplier in a Healthcare Supply Chain using the Technique for Order Performance by Similarity to Ideal Solution under Intuitionistic Fuzzy Environment

Trupti Bhosale,Hemant Umap 한국지능시스템학회 2024 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.24 No.1

Supplier selection is an important aspect of effective supply chain management (SCM) and has implications in risk mitigation, profitability, and cultivating robust supplier-buyer relationships. In this dynamic and competitive landscape, it is essential to implement multi-criteria decision making (MCDM) methods. Therefore, we employ the technique for order performance by similarity to ideal solution (TOPSIS), an MCDM technique, to evaluate the best supplier. Our approach incorporates fuzzy intuitionistic data and leverages the insights of decision-makers. Seven essential criteria, namely, supplier relationships, patient demand, quality, profitability, delivery time, post-delivery service, and patient cost, are integral to this assessment. This methodology is particularly valuable in situations that require swift supplier selection and those that cater to the urgent supplier needs of pharmacists. While our focus was on a specific context, the adaptability of this approach enables researchers to customize it for their respective fields by incorporating pertinent criteria based on expert inputs. Supplier evaluation within the healthcare sector, focusing on sector-specific metrics such as antibiotic drug selection, remains a relatively unexplored area. To address this issue, we present a comprehensive framework to select antibiotic drug suppliers.

Preparation of amorphous carvedilol polymeric microparticles for improvement of physicochemical properties

Priyanka Bhosale,Yogesh Pore,Fahim Sayyad 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.6

The aim of the present study was to enhance the physicochemical properties of poorly aqueous soluble carvedilol (CRV) by preparing its microparticles in presence and/or in absence of a hydrophilic carrier. The polymeric microparticles of CRV were prepared with polyvinylpyrrolidone K30 with or without addition of adsorbents like Aerosil200 and/or Sylysia350 by using spray drying technique. The dissolution profiles revealed that the drug and polymer ratio and colloidal silica both played critical role in solubility enhancement. The spray dried microparticles and drug alone were characterized by differential scanning calorimetry (DSC), X-ray powder diffraction, Fourier transformation infrared spectroscopy (FTIR), particle size analysis and scanning electron microscopy (SEM). DSC analysis showed that CRV transformed from the crystalline state to amorphous state by spray drying, confirmed by disappearance of its melting peak. The results of the X-ray analysis were in agreement with the thermal analysis data. It did not show characteristic crystalline drug peaks which confirmed that the amorphous form of CRV was present in the CRV loaded microparticles. FTIR analysis demonstrated hydrogen bonding interaction with an absence of significant chemical interaction between CRV and polymer. Spherical microparticles were yielded with smooth surfaces as observed by SEM. All in all, this work reveals that spray drying is a suitable technique for preparation of microparticles with improved physicochemical properties of CRV.

Feeding Longer Frames for Efficient Video Denoising Model

Kavita Arjun Bhosale,Sang-Hyo Park 한국정보과학회 2022 Journal of Computing Science and Engineering Vol.16 No.4

Recently, deep video denoising networks have shown substantially higher denoising performance with considerably lower computing times. However, due to the various characteristics of video motion, such models may not be able to denoise long-term frames. In this paper, we propose a method that takes longer input frames and feeds them to the existing architecture. In particular, the proposed method can effectively extract temporal information from frames that are dependent on each other over a long period of time. To demonstrate the performance of the proposed method, we implemented our method on the state-of-the-art video denoising model. Through the extensive experiments, the proposed method showed better performance in terms of quality metrics than the existing one, even with a higher noise level, resulting in considerably lower computing times.

Seismic control of structures using sloped bottom tuned liquid dampers

Amardeep D. Bhosale,Mohan M. Murudi 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.64 No.2

Earlier numerous studies have been done on implementation of Tuned Liquid Damper (TLD) for structural vibration control by many researchers. As per current review there is no significant study on a sloped bottom TLD. TLD‟s are passive devices. A TLD is a tank rigidly attached to the structure and filled partially by liquid. When fundamental linear sloshing frequency is tuned to structure‟s natural frequency large sloshing amplitude is expected. In this study set of experiments are conducted on flat bottom and sloped bottom TLD at beach slope 20º, 30º and 45º, for different types of structures, mass ratio, and depth ratio to investigate the overall effectiveness of TLD and specific effect of TLD parameters on structural response. This experimental study shows that a properly designed TLD reduces structural response. It is also observed that effectiveness of TLD increases with increase in mass ratio. In this experimental study an effectiveness of sloped bottom TLD with beach slope 30º is investigated and compared with that of flat bottom TLD in reducing the structural response. It is observed from this study that efficiency of sloped bottom TLD in reducing the response of structure is more as compared to that of flat bottom TLD. It is shown that there is good agreement between numerical simulation of flat bottom and sloped bottom TLD and its experimental results. Also an attempt has been made to investigate the effectiveness of sloped bottom TLD with beach slope 20º and 45º.

Ignition performance of green hypergolic fuels with hydrogen peroxide

Vikas Khandu Bhosale,Junyeong Jeong(정준영),Sejin Kwon(권세진) 한국추진공학회 2019 한국추진공학회 학술대회논문집 Vol.2019 No.5

Ionic liquids (ILs) have been emerged as a green hypergolic fuel for space propulsion. They are ultra-fast igniting with white fuming nitric acid, red fuming nitric acid and nitrogen tetroxide oxidizers. However, these oxidizers are corrosive and generate toxic fumes, therefore, require the safety precautions during handling. Therefore, the hypergolic combination of an environment friendly oxidizer, hydrogen peroxide and ILs fuel has been investigated. ILs, 1-ethyl-3-methyl imidazolium cyanoborohydride ([EMIM][BH3CN]) and 1-allyl-3-ethyl imidazolium cyanoborohydride ([AEIM][BH3CN]) exhibited longer ignition delay time with 95% hydrogen peroxide. Hence, the ignition delay (ID) time was monitored by addition of metal and non-metal additives in IL, [EMIM][BH3CN]. The additive, 15% 1,3-dimethyl imidazole copper iodide in IL, [EMIM][BH3CN] exhibited an ID time about 36 ms. In addition, the effect of temperature on hypergolic ignition behavior of ILs were also studied. The environment friendly hypergolic ILs propellant combination can be the alternatives to conventional toxic hydrazine based propellant combination.

Crack Propagation Analysis of Synthetic vs. Steel vs. Hybrid Fibre-Reinforced Concrete Beams Using Digital Image Correlation Technique

Aniket B. Bhosale,S. Suriya Prakash 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.6

Improvement in fracture behaviour of fibre-reinforced concrete (FRC) due to the inclusion of various types and combinations of fibres is widely reported. The fracture behaviour of FRC needs to be fully understood for the optimum use of these fibres in structural elements. Fracture behaviours of synthetic fibre-reinforced concrete (SynFRC), hybrid fibre-reinforced concrete (HFRC) and steel fibre-reinforced concrete (SFRC) are investigated in this study using digital image correlation (DIC) technique. This work focuses on improvement in the structural performance of FRC through a comprehensive study of the change in the crack length, crack opening and fracture process zone (FPZ) due to different fibres addition and their combinations. Three distinct fibre dosages of 0.50%, 0.75%, and 1.00%, of macro-polyolefin fibres, hooked end steel fibres and their hybrid combination are regarded as research parameters. Test outcomes indicate that HFRC offers higher post-cracking resistance when compared to SynFRC. SFRC showcases superior fracture performance than that of HFRC and SynFRC. Full-field strain measurements from DIC are used to measure the crack openings at different load levels during the fracture tests. Results of DIC analysis show good agreement with experimental measurements. Continuous monitoring of strain contours using DIC reveals the effective engagement of fibres along the depth at higher dosages for HFRC when compared to that of SynFRC. Also, HFRC had longer cracks than SFRC at a particular load.