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      • KCI등재후보

        Antioxidant Activity of Aqueous Extract of Coscinium fenestratum in STZ-Nicotinamide Induced Diabetic Rats

        I.S.R.Punitha1,,Nalini Bhat3,,K.Rajendran1,,Arun Shirwaikar2,,Annie Shirwaikar1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3

        The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of theexperimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase insuperoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was alsoobserved in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The resultssuggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.

      • Lack of Association of a Common Polymorphism in the 3'-UTR of Interleukin 8 with Non Small Cell Lung Cancer in Kashmir

        Bhat, Imtiyaz Ahmad,Pandith, Arshid A.,Bhat, Bashir A.,Naykoo, Niyaz A.,Qasim, Iqbal,Rasool, Roohi,Aziz, Sheik Aejaz,Shah, Zafar Amin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

        Background: Chronic inflammation is considered as an important factor in the pathogenesis of lung cancer. The presence of inflammatory cells and higher levels of pro-inflammatory cytokines in the tumor microenvironment and their surrounding tissues is gaining much importance in research. Materials and Methods: One hundred ninety NSCLC cases and 200 age, smoking and sex matched controls were evaluated for association of IL-8 -251 (rs4073) and IL-8 -845 (rs2227532) in our population. Restriction fragment length polymorphism (RFLP) was used followed by direct sequencing for the detection of SNPs. Results: The IL-8 -845 polymorphism was not found in our population. No significant association was observed between the IL-8 -251 AT genotypes and IL-8 -25 AA genotypes and NSCLC (p=0.05) in our population. The IL-8 -251 A allele was also non-significant (p=0.05) in NSCLC patients. Conclusions: In conclusion, this report reveals lack of association between IL-8 - 251 A/T polymorphism and NSCLC in our Kashmir Valley population.

      • Polymorphic Variation in Glutathione-S-transferase Genes and Risk of Chronic Myeloid Leukaemia in the Kashmiri Population

        Bhat, Gulzar,Bhat, Ashaqullah,Wani, Aadil,Sadiq, Nida,Jeelani, Samoon,Kaur, Rajinder,Masood, Akbar,Ganai, Bashir Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

        Cancer is a complex disease and the genetic susceptibility to it could be an outcome of the inherited difference in the capacity of xenobiotic metabolizing enzymes. Glutathione-S-transferases (GSTs) are phase II metabolizing enzymes whose various genotypes have been associated with increased risk of different types of cancer. Null mutations caused by the deletion of the entire gene result in the absence of the enzymatic activity and increase in the risk of developing cancer including chronic myeloid leukaemia (CML). In the present case-control study we evaluated the effect of null mutations in GSTM1 and GSTT1 genes on the risk of developing CML. The study included 75 CML patients (43 males and 32 females; age (mean ${\pm}$ S.D) $42.3{\pm}13.4$ years) and unrelated non-malignant controls (76 male and 48 females; age (mean ${\pm}$ S.D) $41.5{\pm}12.9$). The distribution of GSTM1 and GSTT1 genotypes in CML patients and controls was assessed by multiplex-PCR method. Logistic regression was used to assess the relationship between GSTM1 and GSTT1 genotypes and risk of CML. Chi-square test was used to evaluate the trend in modulating the risk to CML by one or more potential high risk genotype. Although GSTM1 null genotype frequency was higher in CML patients (41%) than in the controls (35%), it did not reached a statistical significance (OD = 1.32, 95% CI: 0.73-2.40; P value = 0.4295). The frequency of GSTT1 null genotypes was higher in the CML patients (36%) than in the controls (21%) and the difference was found to be statistically significant (OD = 2.12, 95% CI: 1.12-4.02; P value = 0.0308). This suggests that the presence of GSTT1genotype may have protective role against the CML. We found a statistically significant (OD = 3.09, 95% CI: 1.122-8.528; P value = 0.0472) interaction between the GSTM1 and GSTT1 null genotypes and thus individuals carrying null genotypes of both GSTM1 and GSTT1 genes are at elevated risk of CML.

      • KCI등재후보

        Implications of Impacts of Climate Change on Forest Product Flows and Forest Dependent Communities in the Western Ghats, India

        Indu K Murthy,Savithri Bhat,Vani Sathyanarayan,Sridhar Patgar,Beerappa M,PR Bhat,DM Bhat,Ranjith Gopalakrishnan,Mathangi Jayaraman,Madhushree Munsi,Ravindranath NH,Khalid MA,Prashant M,Sudha Iyer,Ragh 강원대학교 산림과학연구소 2014 Journal of Forest Science Vol.30 No.2

        The tropical wet evergreen, tropical semi evergreen and moist deciduous forest types are projected to be impacted by climate change. In the Western Ghats region, a biodiversity hotspot, evergreen forests including semi evergreen account for 30% of the forest area and according to climate change impact model projections, nearly a third of these forest types are likely to undergo vegetation type change. Similarly, tropical moist deciduous forests which account for about 28% of the forest area are likely to experience change in about 20% of the area. Thus climate change could adversely impact forest biodiversity and product flow to the forest dependent households and communities in Uttara Kannada district of the Western Ghats. This study analyses the distribution of non- timber forest product yielding tree species through a network of twelve 1-ha permanent plots established in the district. Further, the extent of dependence of communities on forests is ascertained through questionnaire surveys. On an average 21% and 28% of the tree species in evergreen and deciduous forest types, respectively are, non-timber forest product yielding tree species, indicating potential high levels of supply of products to communities. Community dependence on non-timber forest products is significant, and it contributes to Rs. 1199 and Rs. 3561/household in the evergreen and deciduous zones, respectively. Given that the bulk of the forest grids in Uttara Kannada district are projected to undergo change, bulk of the species which provide multiple forest products are projected to experience die back and even mortality. Incorporation of climate change projections and impacts in forest planning and management is necessary to enable forest ecosystems to enhance resilience.

      • KCI등재

        Implications of Impacts of Climate Change on Forest Product Flows and Forest Dependent Communities in the Western Ghats, India

        Murthy, Indu K.,Bhat, Savithri,Sathyanarayan, Vani,Patgar, Sridhar,M., Beerappa,Bhat, P.R.,Bhat, D.M.,Gopalakrishnan, Ranjith,Jayaraman, Mathangi,Munsi, Madhushree,N.H., Ravindranath,M.A., Khalid,M., Institute of Forest Science 2014 Journal of Forest Science Vol.30 No.2

        The tropical wet evergreen, tropical semi evergreen and moist deciduous forest types are projected to be impacted by climate change. In the Western Ghats region, a biodiversity hotspot, evergreen forests including semi evergreen account for 30% of the forest area and according to climate change impact model projections, nearly a third of these forest types are likely to undergo vegetation type change. Similarly, tropical moist deciduous forests which account for about 28% of the forest area are likely to experience change in about 20% of the area. Thus climate change could adversely impact forest biodiversity and product flow to the forest dependent households and communities in Uttara Kannada district of the Western Ghats. This study analyses the distribution of non-timber forest product yielding tree species through a network of twelve 1-ha permanent plots established in the district. Further, the extent of dependence of communities on forests is ascertained through questionnaire surveys. On an average 21% and 28% of the tree species in evergreen and deciduous forest types, respectively are, non-timber forest product yielding tree species, indicating potential high levels of supply of products to communities. Community dependence on non-timber forest products is significant, and it contributes to Rs. 1199 and Rs. 3561/household in the evergreen and deciduous zones, respectively. Given that the bulk of the forest grids in Uttara Kannada district are projected to undergo change, bulk of the species which provide multiple forest products are projected to experience die back and even mortality. Incorporation of climate change projections and impacts in forest planning and management is necessary to enable forest ecosystems to enhance resilience.

      • SCOPUSKCI등재

        Inhibition Effect of Nevirapine an Antiretroviral on the Corrosion of Mild Steel Under Acidic Condition

        Bhat, J. Ishwara,Alva, Vijaya D.P. Korean Chemical Society 2011 대한화학회지 Vol.55 No.5

        Corrosion inhibition of mild steel by nevirapine, an antiretroviral has been investigated using potentiodynamic polarization, electrochemical impedance spectroscopy technique and weight loss methods. The experimental results suggested, nevirapine is a good corrosion inhibitor for mild steel in 1M hydrochloric acid medium and the inhibition efficiency increased with increase in inhibitor concentration. The kinetic parameters for corrosion process and thermodynamic parameters for adsorption process were calculated and discussed. The adsorption of the inhibitor on the surface of mild steel followed Langmuir adsorption isotherm.

      • SCIESCOPUSKCI등재

        Grains and Roughage Production and Its Utilization in Asian-Australasian Region - Review -

        Bhat, P.N.,Bansil, P.C. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.3

        Asian-Australasian region comprises of 82 countries spread over varying agro economic zones, habitats and ecosystems varying from dry hot to humid tropics and cold deserts. The literacy standards vary from very low to almost 100 percent. On the basis of economic development there are 4 countries Japan, Australia, New Zealand and Korea which are developed countries, rest are in varying states of development and growing economically very rapidly. Based on Agro ecosystems and farming practices, we have chosen four countries for indepth study in this paper namely China, Thailand, Indonesia and India. They represent 70% of the bovine and poultry population of the region. This paper makes a comparative study of the grain and roughage production and utilization at present and in 2000 A.D. by examining information on feed rates demand patterns and feed requirements in these four countries keeping in view the size and growth of bovine and poultry population and dietary pattern of the people. It has been observed, there has so far been no country level detailed study on the livestock feed requirements. Apart from conceptual discrepancies, most of the estimates given in various reports brought out by the national governments and international agencies do not have any scientific basis. Hence an inter-country comparison is virtually impossible on the basis of the available information. We have however, attempted to analyse the dietary pattern in the different countries, feedgrains requirements, availability of feed based on the information available from the various published and unpublished reports. We have given an inter-country comparison of feed rate and feed requirements which, however, needs to be tested by carrying out a micro level study in each selected country.

      • SCOPUSKCI등재

        Inhibiting Effect of Nicotinic Acid Hydrazide on Corrosion of Aluminum and Mild Steel in Acidic Medium

        Bhat, J. Ishwara,Alva, Vijaya D.P. Korean Chemical Society 2014 대한화학회지 Vol.58 No.1

        The corrosion behavior of aluminum and mild steel in hydrochloric acid medium was studied using a nicotinic acid hydrazide as inhibitor by potentiodynamic polarization, electrochemical impedance spectroscopy technique and gravimetric methods. The effects of inhibitor concentration and temperature were investigated. The experimental results suggested, nicotinic acid hydrazide is a good corrosion inhibitor for both aluminum and mild steel in hydrochloric acid medium and the inhibition efficiency increased with increase in the inhibitor concentration. The polarization studies revealed that nicotinic acid hydrazide exhibits mixed type of inhibition. The inhibition was assumed to occur via adsorption of the inhibitor molecules on the aluminum and mild steel surface and inhibits corrosion by blocking the reaction sites on the surface of aluminum.

      • Mesoporous architecture of TiO2 microspheres via controlled template assisted route and their photoelectrochemical properties

        Bhat, T. S.,Mali, S. S.,Korade, S. D.,Shaikh, J. S.,Karanjkar, M. M.,Hong, C. K.,Kim, J. H.,Patil, P. S. Springer Science + Business Media 2017 Journal of materials science. Materials in electro Vol.28 No.1

        <P>Anatase titanium dioxide (TiO2) microspheres were successfully synthesized via a controlled chemical route using carbon spheres as sacrificial templates. The morphology has been controlled by varying the deposition time of carbonaceous (c) spheres from 4 to 16 h with the interval of 4 h, which affect the size of TiO2 spheres. The structural, morphological, optical, compositional and photoelectrochemical properties of the TiO2 thin films were studied. X-ray diffraction (XRD) pattern confirms the formation of anatase TiO2 with the tetragonal crystal structure. Field emission scanning electron microscopy analysis revealed that the synthesized anatase TiO2 microspheres has average diameter of similar to 330-510 nm. The blueshift in optical absorption is observed due to Mie scattering. The indirect optical band gap energy of TiO2 was varied over 3.05-3.16 eV, with the increase in deposition time. The HRTEM and SAED results show the polycrystalline nature of the sample which is in good agreement with the XRD. The anatase TiO2 hollow spheres with mesoporous walls and high specific surface area i.e. 41 m(2) g(-1) was obtained using this simple method. The films were photoelectrochemically active with maximum current density 531 mu A/cm(2) under 100 mW/cm(2) illuminations.</P>

      • SCISCIESCOPUS

        Substantially enhanced photoelectrochemical performance of TiO<sub>2</sub> nanorods/CdS nanocrystals heterojunction photoanode decorated with MoS<sub>2</sub> nanosheets

        Bhat, Swetha S.M.,Pawar, Sachin A.,Potphode, Darshna,Moon, Chang-Ki,Suh, Jun Min,Kim, Changyeon,Choi, Seokhoon,Patil, Dipali S.,Kim, Jang-Joo,Shin, Jae Cheol,Jang, Ho Won Elsevier 2019 Applied Catalysis B Vol.259 No.-

        <P><B>Abstract</B></P> <P>Two-dimensional (2D) MoS<SUB>2</SUB> nanosheets (NSs) modified 1D TiO<SUB>2</SUB> nanorods/0D CdS nanocrystals (NCs) heterojunction has been fabricated by all solution process as a potential anode for photoelectrochemical (PEC) water splitting applications. This heterojunction photoanode shows high photocurrent density of 3.25 mA/cm<SUP>2</SUP> at 0.9 V vs. RHE (0 V vs. Ag/AgCl) compared to the pristine TiO<SUB>2</SUB>/CdS photoanode. The influence of MoS<SUB>2</SUB> NSs on PEC performance of TiO<SUB>2</SUB>/CdS/MoS<SUB>2</SUB> heterojunction has been systematically investigated. We demonstrate that MoS<SUB>2</SUB> NSs transfer holes from CdS and facilitate further charge separation in TiO<SUB>2</SUB>/CdS. Time resolved photoluminescence measurement reveals increase in photoluminescence lifetime due to the presence of MoS<SUB>2</SUB> NSs in TiO<SUB>2</SUB>/CdS/MoS<SUB>2</SUB> resulting in enhanced PEC activity. This work suggests that 1D TiO<SUB>2</SUB>/0D CdS/2D MoS<SUB>2</SUB> heterojunction prototype is an interesting system where MoS<SUB>2</SUB> NSs can be utilized to improve charge separation in photoanodes. This study would pave the way towards designing new heterojunction functional materials for efficient PEC applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Photoanodes were fabricated by all solution process. </LI> <LI> Enhanced photoelectrochemical performance of TiO<SUB>2</SUB> 1D/0D CdS/MoS<SUB>2</SUB> 2D triple heterojunction photoanode was achieved. </LI> <LI> The heterojunction photoanode shows high photocurrent density of 3.25 mA/cm<SUP>2</SUP> at 0.9 V vs. RHE (0 V vs. Ag/AgCl). </LI> <LI> Role of MoS<SUB>2</SUB> nanosheets on the improved photoelectrochemical performance has been investigated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Decoration of solution-processed MoS<SUB>2</SUB> nanosheets on TiO<SUB>2</SUB> nanorods/CdS nanocrystals photoanode substantially improves the photoelectrochemical performance. The heterojunction photoanode TiO<SUB>2</SUB>/CdS/MoS<SUB>2</SUB> with ZnS shows high photocurrent density of 3.25 mA/cm<SUP>2</SUP> at 0 V vs. Ag/AgCl (0.9 V vs. RHE).</P> <P>[DISPLAY OMISSION]</P>

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