급성기 뇌혈관장애에서 고혈압의 치료

김범생 대한고혈압학회 1997 대한고혈압학회지 Vol.3 No.2

뇌졸중에서 고혈압 치료제 선택

김범생 대한고혈압학회 1995 대한고혈압학회지 Vol.1 No.2

加工食品에 出現하는 害虫類의 生態調査 : 湖南地方을 中心으로 한 菓子害虫類의 實態

文範洙,吉奉燮 圓光大學校 1981 論文集 Vol.15 No.1

1. 1978년 호남지방에서 발생된 과자해충은 화랑곡나방, 톱가슴머리대장, 곡식나방, 줄알락명나방, 수시렁이, 기타등 6 종이었다. 2. 과자의 분류별 해충발생 빈도는 초컬릿류, 캔디류, 비스킷류, 스넥류, 빵류의 순이었다. 3. 과자제조 후 대체로 스넥류는 3개월, 초컬릿류는 4개월, 비스킷류는 6개월, 캔디류는 9개월 경과후에 해충이 발생되었다. 4. 과자류 해충의 발생은 제품의 유통과정에서의 침입에 기안하는 것으로 추정된다. 5. 화랑곡나방은 1년에 3회발생하며 8월중순경이 그 최성기이고, 이때 과자류에 가장 심한 피해를 주었다. 6. 화랑곡나방은 초저녁 활동형곤충으로서 오후 9시경에 많이 활동하고, 또 음성 주지성, 음성 주광성을 나타냈다. 7. 화랑곡나방의 배우행동은 발작→유인자세→날개치기→교접단계로 구분되며 1마리당 평균 산란수는 188개였다. 8. 화랑곡나방 유충의 혈구는 Prohemocyte, Plasmatocyte, Granular cell, Spherule cell, Adipohemocyte가 관찰되었고 이 중 Adipohemocyte가 가장 많이 나타났다. 9. 현재 시판되는 과자 포장지는 Al박을 포함해서 거의 대부분이 화랑곡나방 유충에 의해서 구멍이 뚫릴 수 있었다. 6 Species of insects probably injurious to confectionery were found out in Honam area in 1978. Above all, the number of Plodia interpunctella Hu"bner was the largest and that of oryzaephilus surinamensis Linne was next to it. And Nemapogon granella, Ephestia. cautella Walker, Dermestes ater Degree, others(Parasitic bee sp) occurred respectively. Confection insects were collected from a kind of chocolates most of all, and a kind of candy, biscuits, snacks, breads were next to it. In general, after confectionery was produced, the insects took place in a kind of snacks after three months had passed, in a kind of chocolates after for moths, in a kind of biscuits after six months, in a kind of candy after nine months respectively. we postulated. that occurrence of the vermin was caused by the flow course of the products. Indian mea1 moths.(Plodia interaunctella) occurred three times in a year, and they showed peak time in the middle of August. Indian meal moth moved actively in early evening and it appeared negative geotaxis, also negative phototaxis. Mating behavior of Indian meal moth was as following steps: introduction→calling pose→wing vibration→copulation. Also average egg-laying of a moth were 188. Indian meal moths had had prohemocyte, plasmatocyte, granular cell, spherule cell, adipohemocyte in their blood. Among them, adipohemocyte was examined very much. The packing paper of confectionery including aluminium foil which had sold these days could almost be bored holes by larva of Indian meal moth.

IT 투자가 기업의 생산성에 미치는 효과

박범조 단국대학교 산업연구소 2002 산업연구 Vol.23 No.-

마가린中의 微量成分의 檢出(第1報) : 薄層크로마토그라피에 依한 着色劑의 定性 Identification of colouring matters by thin-layer chromatography

文範洙,金榮錫 國立保健硏究院 1967 국립보건연구원보 Vol.4 No.-

ARCH모형 : 확장, 추정 및 검정 Extensions, Estimation and Testing

박범조 단국대학교 경영경제연구소 1997 經營, 經濟硏究 Vol.1 No.-

The purpose of this survey paper is to provide a brief account of the important theoretical developments in the autoregressive conditional heteroskedasticity (ARCH) models. This paper begins with the specification of univariate parametric ARCH models and the extensions of ARCH models such as generalized ARCH, ARCH in mean and exponential ARCH. In addition, motivated in part by recent results on kernel estimation, a nonparametric conditional variance model is also presented. Next this paper discusses estimation and testing for ARCH models.

알쯔하이머병 환자의 뇌혈류 장애 : Statistical Parametric Mapping을 이용한 Tc-99m ECD SPECT 분석 Statistical Parametric Mapping analysis of Tc-99m ECD SPECT

양동원,김범생,손영민,박정욱,정용안,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2

Background and Objectives . Alzheimer's disease (AD) is the most common cause of the dementia Pathologic and functional changes of AD are known to be unevenly distributed in the brain. This study investigates changes of cerebral blood flow (CBF) in patients with AD to determine brain regions with hypoperfusion that reflects progression of disease. Methods. Tc-99m-ECD single photon emission computed tomography (SPECT) was performed to measure regional CBF and statistical parametric mapping (SPM) 99 soft ware was used for the automated and objective approach to analyze SPECT image data. Twenty-five patients with mild to moderate dementia who met NINCDS-ADRDA critena for AD (male 11 female 14) and 17 age-matched normal control subjects were studied. The severity of AD was measured by clinical dementia rating (CDR) scale Results. SPM analysis of SPECT images revealed that CBF in the anterior cingulate gyrus left superior panetal cortex left medial frontal cortex left infenor temporal cortex. right thalamus and left hippocampus was significantly decreased in AD patients compared with normal controls (corrected p<0.05). The reduction of CBF according to CDR was localized in the left hippocampus and infenor temporal cortex right antenor and postenor ciagulate cortex and right superior panetal cortex (uncorrected p<0.01). Conclusions : Our data suggest that the cognitive dysfunction of AD is strongly related with functional abnormality in discrete brain areas 99m-Tc ECD SPECT with SPM analysis could be used as a useful functional imaging tool in AD study.

풍촌 석회암의 소성에 관한 연구

이재장,노범식,장경호,정수현 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

본 연구는 여러 가지 용도에 적합한 생석회를 생산하기 위하여 풍촌 석회석을 대상으로 소성시험을 하였다. 시료의 형상은 주로 정방형이나 때로는 구형을 나타내며, 배색 내지 회백색을 띈다. 소성시험에 사용한 시료의 크기는 45∼50㎜ 이며, 소화시험에서는 3.3mm(6mesh) 이하로 분쇄하여 소성하였다. 시료의 광물학적 특성을 보기위하여 편광현미경 관찰, X-ray 분석, 열분석을 하였다. 시료는 거의 순수한 CaCO₃이었으며, 600℃ 부터 열분해가 시작되어 850℃에서 완결되었다. 화학분석 결과 CaO 98.27%인 잠재적 순도를 갖는 생석회를 얻을 수 있음을 알 수 있다. 대략 50 ㎜ 정도의 석회석은 전기로의 온도가 실온에서 1,050℃에 도달하였을 때 99%이상이 소성되었다. 이 때 얻어진 생석회는 거의 순 백색이며 갈라짐이 없었다. 소화시험 결과 ASTM C-110에 의하면 반응성이 우수한 생석회인 것을 알 수 있으며, 1분 이내의 상승온도는 63℃ 이었다. In this study, the calcination characteristics of Pungchon limestone was investigated to produce the optimum quick lime for various uses. The shape of limestone sample was mainly cubic, but sometimes longish. Approximate size range for the calcination tests was from 45 to 50 mm. For the slaking test, it was crushed by cobbing method and screened by 3.3 mm(6 mesh) screen. Mineralogical studies of the sample were carried out to investigate textures, X-ray diffraction analysis and thermal analysis. The result of chemical analysis shows a very high grade limestone with a CaO potential of 98.27%. Approximate 50 mm size's of limestone, about 250 g was calcined more than 99% when the calcination temperature arrived at 1,050 ℃ from room temperature in the electric laboratory furnace. Lumpy lime in nearly white colour with nearly no cracks was observed during calcining test. and during calcination process the limestone places kept their shape. Slaking test(ASTM C-110 ) results indicate a high reactivity product. In slaking, a 63℃ temperature rise was achieved within the first one minutes.

피질하 혈관성 치매 환자에서 단광자방출단층촬영과 Statistical Parametric Mapping을 이용한 뇌혈류 흐름의 분석 : Adaptation of Statistical Parametric Mapping

양동원,김범생,김의녕,손형선,김상윤 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: Subcortical vascular dementia(SVaD) is relatively homogeneous subtype of VaD, but the mechanisms of cognitive dysfunction of subcortical VaD are not completely understood yet This study investigated the changes of cerebral blood flow(CBF) in patients with SVaD and the contribution of the white matter hyperintensity(WMHI) and clinical severity to CBF changes. Methods: 99mTc-ethyl cysteinate dimer single photon emission computed tomography(SPECT) was performed to measure the regional CBF and statistical parametric mapping(SPM)99 software was applicated to automated and objective analysis of the SPECT image data Twenty three patients (male 12, female 11) of mild to moderate dementia who met both the criteria of the DSM-IV and probable or possible NINDS-AIREN for VaD and have subcortical white matter changes and lacunar infarction on brain MRI and seventeen normal control subjects (male 7, female 10) were evaluated The severity of the WMHI was measured by semi-quantitative scale method proposed by Mantyla. The seventy of dementia was measured by clinical dementia rating (CDR) scale Results: SPM analysis of SPECT image revealed significantly reduced regional CBF in the right thalamus, left caudatd nucleus, cingulate, bilateral superior temporal, and left ventral subcallosal gyri in SVaD patients when it compared to normal controls (corrected p<0 001). Among four WMHIs, only the WMHI was associated with the small CBF reduction in the left superior temporal gyrus (uncorrected p<0 01) The reduction of CBF according to the severity of dementia was noted in the anterior and posterior association areas (uncorrected p<0 01). Conclusions: our study suggests that cognitive dysfunction of SVaD may be related with CBF reduction in the above mentioned brain areas, which probable are not associated with the severity of periventncular WMHI and dementia.

리튬-필로카르핀 경련모델의 특징 : 행동양상, 뇌파, Fos단백의 발현 및 신경병리학적 변화 Behaviors, Electroencephalography, Fos Expression, and Neuropathologic changes

김영인,이광수,김범생,김용재,천명훈,김명석 대한신경과학회 1996 대한신경과학회지 Vol.14 No.1