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Berrin Unsal,Isil Saygun,Ozlem Daltaban,Belgin Bal,Erol Bolu 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.1
Purpose: The aim of this preliminary study was to determine the possible relationship between alkaline phosphatase (ALP) levels in the gingival crevicular fluid (GCF) and periodontal disease in men with hypergonadotropic hypogonadism (HH). Materials and Methods: A total of 41 patients were divided into four groups. 9 with HH and periodontitis (P/HH), 11 with HH and gingivitis (G/HH), 12 with systemically healthy and periodontally healthy (H/C) and 9 with systemically healthy and periodontitis (P/C). The clinical evaluation of patients was based on the following parameters; the plaque index (PI), gingival index (GI), probing depths (PD) and attachment level (AL). The levels of ALP in the GCF were measured by enzyme-linked immunosorbent assay (ELISA). Results: No significant difference could be detected in the mean clinical parameter data between the P/HH and P/C groups (p>0.05). The periodontitis patients in both groups (P/C and P/HH) had higher mean probing depths than the H/C and G/HH patients (p<0.001). The concentrations and total amounts of ALP in the GCF were significantly higher in both periodontitis groups compared to healthy and gingivitis groups (p<0.01). The serum ALP levels were significantly higher in the P/HH group when compared to the other groups (p<0.001). Conclusion: The findings of this study suggested that HH could be implicated as a contributing factor to the progress of periodontal disease.
Duran, Berrin,Yurttas, Leyla,Duran, Murat The Korean Electrochemical Society 2021 Journal of electrochemical science and technology Vol.12 No.3
Two arylamino substituted mercaptoimidazole derivatives namely 4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione (I1) and 4,5- dimethyl-1-((p-chlorophenyl)amino)- 1H-imidazole-2(3H)-thione (I2) were synthesized and investigated as corrosion inhibitors for carbon steel in 0.5 M HCl solution by means of electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, ATR-FTIR spectroscopy and SEM. The results showed that the investigated mercaptoimidazole derivatives act as mixed type inhibitors and inhibition efficiency follows the I2>I1 order. Adsorption of inhibitors on metal surface was found to obey the Langmuir adsorption isotherm. Thermodynamic parameters revealed that adsorption of the inhibitors has both physisorption and chemisorption adsorption mechanism. Electrochemical test results were supported by quantum chemical parameters obtained from DFT calculations.
Investigation of Supporting Electrolyte Effect on Supercapacitor Properties of Poly(Carbazole) Films
Duran, Berrin,Unver, Irem Cakmakci,Bereket, Gozen The Korean Electrochemical Society 2020 Journal of electrochemical science and technology Vol.11 No.1
In this study poly(carbazole) films deposited on stainless steel have been investigated as electrode material for supercapacitor applications. Poly(carbazole) films were electrodeposited using cyclic voltammetry in presence of lithium, sodium and tetrabutylammonium perchlorate salts. Poly(carbazole) films doped with perchlorate anions having different counter cations were characterized by SEM, ATR-FTIR and solid state conductivity measurements. Capacitive behaviours of PCz coated steel electrodes were tested by cyclic voltammetry, charge-discharge analysis and electrochemical impedance spectroscopy. It was found that counter cation of the dopant is significantly effective on the capacitive performance on the obtained PCz films and the PCz film synthesized from lithium perchlorate has the better capacitive performance than the poly(carbazole)s synthesized from sodium perchlorate and tetrabutylammonium perchlorate salts.
Ayse Erdem Yayla,Berrin Goktug Kadioglu,Ayse Aydin,Osman Aktas 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.4
ObjectiveHuman papillomaviruses (HPVs) are among the agents responsible for infection and cancer of the skin and mucousmembranes in the human body. The aim of this study was to investigate the frequency and type distribution of HPVsin married female patients with gynecological complaints, who had visited the Maternity Hospital in Erzurum, Turkey. MethodsIn this study, 263 cervical swab samples were taken from married women using the Pap smear method and wereinvestigated for positive reactivity against HPV. The L1 gene region of HPV was investigated using molecular methods. For this purpose, polymerase chain reaction (PCR) assays and sequence analysis of positive samples were performed. Phylogenetic analyses were performed using a bioinformatics approach after sequencing. ResultsHPV-DNA was detected in 17 (6.5%) samples. Highest positive reactivity to HPV-DNA was found in the 35–44 agegroup at 9.2%. Fourteen out of seventeen positive samples were included in the phylogenetic analysis. All isolatesclustered in the Alphapapillomavirus genus. Six samples were found to be HPV 70 positive, four were HPV 16 positive,and the rest were HPV 54, 72, 81, and 114 positive. When genotyping data were evaluated according to the riskgroup, we found that 28.6% of the 14 samples were found to be high risk-HPV, and 71.4% were low risk-HPV. ConclusionAs per our knowledge, this is the first report on the phylogenetic analysis of HPV genotypes isolated from women inTurkey. The prevalence of low- and-high risk HPV was determined in married women in Erzurum, and these resultscontribute to the epidemiological data on the distribution of HPV types for this region.
The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis
Isler, Sila Cagri,Unsal, Berrin,Soysal, Fatma,Ozcan, Gonen,Peker, Elif,Karaca, Inci Rana Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.3
Purpose: The decontamination procedure is a challenging aspect of surgical regenerative therapy (SRT) of peri-implantitis that affects its success. The purpose of the present study was to determine the impact of additional topical gaseous ozone therapy on the decontamination of implant surfaces in SRT of peri-implantitis. Methods: A total of 41 patients (22 males, 19 females; mean age, $53.55{\pm}8.98years$) with moderate or advanced peri-implantitis were randomly allocated to the test group (ozone group) with the use of sterile saline with additional ozone therapy or the control group with sterile saline alone for decontamination of the implant surfaces in SRT of peri-implantitis. Clinical and radiographic outcomes were evaluated over a period of 12 months. Results: At the 12-month follow-up, the plaque and gingival index values were significantly better in the ozone group (P<0.05). Probing depth decreased from $6.27{\pm}1.42mm$ and $5.73{\pm}1.11mm$ at baseline to $2.75{\pm}0.7mm$ and $3.34{\pm}0.85mm$ at the end of the 12-month observation period in the ozone and control groups, respectively. Similarly, the clinical attachment level values changed from $6.39{\pm}1.23mm$ and $5.89{\pm}1.23mm$ at baseline to $3.23{\pm}1.24mm$ and $3.91{\pm}1.36mm$ at the 12-month follow-up in the ozone and control groups, respectively. According to the radiographic evidence, the defect fill between baseline and 12 months postoperatively was $2.32{\pm}1.28mm$ in the ozone group and $1.17{\pm}0.77mm$ in the control group, which was a statistically significant between-group difference (P<0.05). Conclusions: Implant surface decontamination with the additional use of ozone therapy in SRT of peri-implantitis showed clinically and radiographically significant. Trial registry at ClinicalTrials.gov, NCT03018795.
Umut Can Oz,Berrin Küçüktürkmen,Burcu Devrim,Ongun Mehmet Saka,Asuman Bozkir 한국고분자학회 2019 Macromolecular Research Vol.27 No.9
Alendronate sodium (AS) which supresses the activity of osteoclastic cells and leads to the inhibition of bone resorption, is one of the most clinically preferred drug for the treatment of osteoporosis. The purpose of this research is to develop an optimization method for AS loaded poly(lactide-co-glycolide) (PLGA) nanoparticle formulation which is prepared by nanoprecipitation method and is intended for local application to provide enhanced guided bone regeneration. Nanoparticle formulation parameters including AS content, polymer/surfactant ratio and organic to aqueous phase ratio were optimized to evaluate their effects on particle size, polydispersity index (PDI), zeta potential and entrapment efficiency by using central composite experimental design (CCD). Morphology of nanoparticles was visualized with transmission electron microscopy (TEM) and interaction between nanoparticle components was analyzed by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The developed quadratic model showed high correlation (R2>0.89) between predicted response and evaluated parameters. Spherical nanoparticles with mean particle size of <84 nm and encapsulation efficiency with >34.68% were produced with the optimized nanoparticle preparation method. The optimization of AS encapsulating PLGA nanoparticles by utilizing CCD method, allowed us to prepare the nanoparticle formulation with optimum properties with less experiments. Consequently, this optimized model can be applied to predict the characteristics of nanoparticles prepared with nanoprecipitation method by using PLGA polymer.
The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis
Sila Cagri Isler,Berrin Unsal,Fatma Soysal,Gonen Ozcan,Elif Peker,Inci Rana Karaca 대한치주과학회 2018 Journal of Periodontal & Implant Science Vol.48 No.3
Purpose: The decontamination procedure is a challenging aspect of surgical regenerative therapy (SRT) of peri-implantitis that affects its success. The purpose of the present study was to determine the impact of additional topical gaseous ozone therapy on the decontamination of implant surfaces in SRT of peri-implantitis. Methods: A total of 41 patients (22 males, 19 females; mean age, 53.55±8.98 years) with moderate or advanced peri-implantitis were randomly allocated to the test group (ozone group) with the use of sterile saline with additional ozone therapy or the control group with sterile saline alone for decontamination of the implant surfaces in SRT of peri-implantitis. Clinical and radiographic outcomes were evaluated over a period of 12 months. Results: At the 12-month follow-up, the plaque and gingival index values were significantly better in the ozone group (P<0.05). Probing depth decreased from 6.27±1.42 mm and 5.73±1.11 mm at baseline to 2.75±0.7 mm and 3.34±0.85 mm at the end of the 12-month observation period in the ozone and control groups, respectively. Similarly, the clinical attachment level values changed from 6.39±1.23 mm and 5.89±1.23 mm at baseline to 3.23±1.24 mm and 3.91±1.36 mm at the 12-month follow-up in the ozone and control groups, respectively. According to the radiographic evidence, the defect fill between baseline and 12 months postoperatively was 2.32±1.28 mm in the ozone group and 1.17±0.77 mm in the control group, which was a statistically significant between-group difference (P<0.05). Conclusions: Implant surface decontamination with the additional use of ozone therapy in SRT of peri-implantitis showed clinically and radiographically significant. Trial registry at ClinicalTrials.gov, NCT03018795.