8주간의 유산소 운동과 Circuit Weight Training이 비만여성의 렙틴, 혈중지질, 심박수 및 신체조성 성분에 미치는 영향

김상범,김창환,김병완 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This study is designed to investigate the effects of 8 week combined exercise of aerobics & circuit might training on serum leptin, serum lipid level, heart rate and body composition in obese women. For this study, 8 obese women in 40s who were the members of D Fitness Club in Daejeon were recruited. Fasting blood sample was collected from anticubital vein before and after 8 week training. They practiced the aerobic exercise with treadmill for 30 minutes at the level of 80% HRmax, and practiced CWT for 20 minutes a clay, CWT consits of the 7 weight machines and the one free weight by using her own weight at the level of 60~70% 1RM. The results were as follows: The result shows that there was a statistically significant decrease in body weight and %body fat, whereas there was no significant difference in lean body mass in accordance with the period, The survey reveals that there was a statistically significant decrease in the case of HRrest, but there was a statistically significant increase in PEI by using Harvard Step Test for the ability of heart recovery. The study indicates that the subjects showed a significant decrease in TC, LDL-C, TG and glucose, but there was no significant difference in HDL-C, Though there was a slight decrease in Leptin, there was no statistically significant difference in it.

부산지역 강하먼지 중 불용성 중금속 함유량

이용범,황용식,이창희,박명희,이채관,강동묵,김정원,전병일,문덕환 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1

■ Objectives The purpose of this study was to estimate qualitatively various bulk deposition flux of insoluble heavy metal components by applying regional and seasonal distribution. our institution from January 1980 to December 31th, 2001. ■ Materials and Methods Dustfall particles were collected by the modified American dust jar (wide inlet bottle type) at 6 sampling sites in Pusan area from March, 1999 to February, 2000. Five chemical species (Cd, Cr, Mn, Ni and Pb) were analyzed by AAS(Perkin-Elmer 4100ZL). ■ Results The mean values of each heavy metal concentrations were Cd for 3.947 g/㎢/month, Cr for 0.191 ㎏/㎢/month, Mn for 0.375 ㎏/㎢/month, Ni for 0.176 ㎏/㎢/month, and Pb for 0.823 ㎏/㎢/month. ■ Conclusions Insoluble heavy metal amount of regional variations were found in order of industrial zone, coastal zone, commercial zone, agricultural zone and residential zone.

원저 : 집단치료를 통한 비만환자의 체중감량이 삶의 질에 미치는 영향

강준구 ( Joon Gu Kang ),이창범 ( Chang Beom Lee ),이혜순 ( Hye Soon Lee ),배상철 ( Sang Cheol Bae ),최웅환 ( Woong Hwan Choi ) 대한비만학회 2005 The Korean journal of obesity Vol.14 No.3

연구배경: 집단치료를 받고 있는 비만환자에서 체중 감량을 하였을 때 나타나는 삶의 질 변화를 수량화된 척도로 알아보고자 이 연구를 시행하였다. 방법: 2003년부터 2004년까지 한양대학교 구리병원 내분비내과에서 체중감량 치료 방법에 동의한 9명의 환자를 대상으로 조사하였다. 체중감량의 목표는 첫 내원시 체중의 10%로 정하였다. 건강관련 삶의 질 측정도구(Health-related quality of life instrument)를 치료 시작 전과 후에 측정하였다. 일반적 건강 프로필로서 건강 관련 삶의 질을 측정하는 KSF-36 (Korean Medical Outcomes Study 36-Item Short Form)을 사용하였다. 결과: 1. 대상환자의 임상적 특성과 비만 치료 전후의 변화 연구대상 환자 9명은 모두 목표 체중감량에 성공하였다. 개별적 특성은, 전원 여성이었고 전체 환자의 평균값은 연령 59.3±2.0세, 신장 160.0±9.1㎝, 체중 70.9±2.0㎏, BMI 28.8±0.9㎏/㎡이었다 (Table 1). 20주간의 식사요법, 운동요법, 약물요법, 행동그룹치료 후 체중 63.6±2.9㎏ (P<0.05), BMI 25.9±1.1 ㎏/㎡ (P<0.05)로 감소하였다. 2. 건강관련 삶의 질 측정 비만환자의 평균 KSF-36 전반적 건강값 (Global)은 49.43±5.25 (38.8~56.4)에서 57.62±8.10 (50.3~65.8)로 수치상의 증가만을 보이나 체부 통증 (bodily pain)이 36.25±21.34 (30~70)에서 33.75±13.03 (20~50)로 (P<0.05), 정신적 건강 (mental health)이 47.50±20.33 (16~84)에서 62.00±10.69 (48~80)으로 (P<0.05)으로 향상되었다. 결론: 집단치료를 받고 있는 비만환자에서 체중 감량을 하였을 때 삶의 질 향상을 가져올 수 있음을 알 수 있었다. 그러므로 앞으로 더 많은 숫자의 환자를 대상으로 한 대규모 연구가 필요할 것으로 생각된다. Background: This study was to exam the effect of weigh reduction after group therapy on the quality of life of patients with obesity. Methods: The participants of this study were 9 women with obesity who visitied the Hanyang University Hospital Obesity Clinic. Data were collected for 2 years from 2003 to 2004. Weight, height, abdominal circumference, and BMI were measured before and after group therapy which consisted of medical and behavior therapy. And also KSF-36 (Korean Medical Outcomes Study 36-Item Short Form) was used as a Health-related quality of Life instrument. Results: In use of KSF-36, Global score before and after treatment showed no significant change (49.43±5.25 (38.8~56.4) vs 57.62±8.10 (50.3~65.8)) but bodily pain (36.25±21.34 (30~70) vs 33.75±13.03 (20~50), P<0.05) and mental health (47.50±20.33 (16~84) vs 62.00±10.69 (48~80), P<0.05) showed significant changes. Conclusion: According to the result of this study, in group therapy of patients with obesity, weigh reduction improved the quality of Life.

항정신병 약물이 Cyclooxygenase-2 유전자 발현과 Prostaglandin E_2 농도에 미치는 영향

김종우,조성욱,범재명,윤도준,장환일,송지영 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : Cyclooxygenase(COX) is the central enzyme in the biosynthetic pathway to prostaglandins from arachidonic acids. The action mechanism of nonsteroidal anti-inflammatory drugs is through inhibition of COX activity and prostanoid biosynthesis including prostaglandin E_2(PGE_2). The antipsychotic drugs are known having an analgesic effects, however its mechanisms of actions of action to pain control was not still clearly proved. In the present study, the effects of antipsychotic drugs(chlorpromazie and clozapine) on the production of PGE_2 and the expression of COX-2mRNA and protein in P815 cell line were studied. Methods : For that purpose, the methods of RT-PCR, western blot and prostagalndin E_2 enzymeimmunoassay were applied. Results : The results showed tha tin P815 cells treated with chlorpromazine, the level of COX2 mRNA was significantly decreased compared to the control cells. And total cellular PGE_2 levels were significantly decreased after treatment with chlorpromazine and clozapine. Conclusion : These results suggest that antipsychotic drugs have revealed their analgesic effect through the inhibition of COX-2 activity and PGE_2 production. And also, these results partly supports the excess theory of prostaglangdins in the pathogenesis of schizophrenia.

위의 유암종과 선종의 병발 1례

장재식,강혁주,이중현,서영범,윤병구,김용섭,이구,서정일,양창헌,이창우,김정란,윤환중 東國大學校醫學硏究所 2000 東國醫學 Vol.7 No.-

유암종은 전신에 퍼져 잇는 장크롬친화성 세포에서 기원하는데 위의 유암종은 비교적 드문 질환으로 모든 유암종의 1.9~2.2%에 해당하며 위에 발생하는 종양의 1% 미만에서 보고되고 있다. 유암종은 일반적으로 증상이 비특이적이고 면역조직화학검사에 의해서 진단되기 때문에 과거에는 드물게 발견되었으나 최근 내시경 기기 및 술기의 발전과 검사 빈도의 증가 및 면역조직화학검사의 발달로 진단율이 증가 추세에 있으며, 드물지만 유암종에서 선암과 공존하는 예들이 보고되고 있다. 저자들은 심와부 동통을 주소로 내원한 70세 남자 환자의 상부위장관내시경 검사에서 위체상부의 대만곡에서 0.4×0.4 cm 크기의 중간 함몰을 가진 Yamada 1형의 용종과 함께 전정부의 전벽에서 0.8×0.5 cm 크기의 융기된 점막 소견을 보여 조직학적으로 각각 위유암종 및 위선종임을 확진한 후 내시경적 용종 절제술로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carcinoid tumors are arisen from enterochromaffin cells, which are scattered throughout the body. These tumors are composed of variable numbers of cells that contain endocrine granules in their cytoplasm, which can be identified by immunohistochemistry and electron microscopy. Gastric carcinoid tumors are relatively rare tumor, the reported incidence being 1.9~2.2% of all carcinoid tumors and less than 1% of all gastric tumors. Sometimes, composite carcinoid tumors and adenocarcinoma is reported. We experienced a case of the coincidence of carcinoid tumor and adenoma at the other site of the stomach in a 70 year old male patient. Gastrofiberscope showed 0.4×0.4 cm sized Yamada type I polyp with central depression on the greater curvature of the proximal body and 0.8×0.5 cm sized focal slightly elevated mucosa on the anterior wall of the antrum. The endoscopic biopsy specimens revealed carcinoid tumor and tubular adenoma with moderate atypism, respectively. The carcinoid tumor and adenoma were removed by endoscopic polypectomy. According to the follow-up gastrofiberoscopy after 7 month later, both lesions were nearly normal mucosa except whitish atrophic change after polypectomy.

Influence of Growth Temperature on the Characteristics of Single-Junction p—i—n InGaP Solar Cells

Jung, Sang Hyun,Kim, Youngjo,Kim, Chang Zoo,Jun, Dong-Hwan,Kim, Kangho,Shin, Hyun-Beom,Choi, JeHyuk,Park, Won-Kyu,Lee, Jaejin,Kang, Ho Kwan American Scientific Publishers 2017 Journal of nanoscience and nanotechnology Vol.17 No.4

<P>Single-junction p-i-n InGaP solar cells are grown at various temperatures from 620 to 700 degrees C by low pressure metalorganic chemical vapor deposition on GaAs (001) substrates. The short circuit current density of the p-i-n InGaP solar cells increases by up to 38.8% when the growth temperature is reduced from 700 to 620 degrees C, while the open circuit voltage and fill factor show relatively small changes. The external quantum efficiency, especially, in the wavelength regime below 500 nm, is improved for the p-i-n InGaP solar cells grown at lower temperatures. The improvement might be attributed to the reduced absorption loss of the photons in the n-InGaP emitter region. The highest conversion efficiency of 11.01% is attributed from the p-i-n InGaP solar cell grown at 640 degrees C. Electron mobility and concentration of undoped InGaP layers are investigated as a function of the growth temperature and correlated with the p-i-n InGaP solar cell performance.</P>

내관(內關)(PC6).공손(公孫)(SP4) 자침이 정상인의 자율신경계에 미치는 영향 연구

유경환,임인환,김동현,나병조,이범준,박성욱,고창남,Rheu, Kyoung-Hwan,Im, In-Hwan,Kim, Dong-Hyun,Na, Byong-Jo,Lee, Beom-Jun,Park, Seong-Uk,Ko, Chang-Nam 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3

Objectives : This study was designed to investigate the effect of PC6 and SP4 on autonomic nerve system in healthy adults. Methods : 22 healthy adults were recruited and randomized into the study group or control group. The study group (real acupuncture group) was acupuncturcd on PC6 and SP4. The control group (sham acupuncture group) was acupunctured superficially near PC6 and SP4 but not the exact points. The subjects rested for 10 minutes, and were then acupunctured. After 15 minutes, acupuncture needles were removed and the subjects rested for another 15 minutes. Heart rate variability(HRV) was continuously measured during the study period by FM-150 (digital Holter ECG recorder). Results : In the real acupuncture group. LF(low frequency) significantly decreased during the acupuncture period(p<0.05). LF/HF ratio also had a significant decrease during acupuncture period and the decrease was maintained during the post-treatment period as compared with the pre-treatment period. In the sham acupuncture group. LF significantly increased during the acupuncture period but LF/HF ratio had no significant changes. Conclusions : The results suggest that acupuncture on PC6 and SP4 can increase parasympathetic activity and balance autonomic nervous system.

수직적 치조제 증강술후 발생하는 골흡수량에 관한 연구

전하룡(Ha-Ryong Jeon),김종원(Jong-Won Kim),권호범(Ho-Beom Kwon),이동환(Dong-Hwan Lee),홍종락(Jong-Rak Hong),김창수(Chang-Soo Kim) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.3

Purpose: This study presents radiographic and laboratory analysis and comparison of bone resorption rate of grafted endochondral bone and intramembranous bone on the aspect of height and volumetric change. Patients and Methods: 18 partially edentulous patients who needed alveolar ridge augmentation for implant placement during the years 2002 to 2004 were selected for this study. Group A consisted of 5 males & 3 females who were treated with intraoral(intramembranous) bone and Group B consisted of 8 males & 2 females who were treated with iliac(endochondral) bone. Non-standard periapical X-ray was taken at day 1, 2 month, 4 months, 8 months after the surgery. Resorption rate of grafted bone were measured on these X-rays and compared. Also we calculated volume of grafted bone with models which was fabricated at 1.5 months, 6 months. Results: There was bone resorption in both groups. Group B showed more bone resorption than Group A. In Group A, the resorption rate according to the radiographic measurements was 9.81 %, and resorption rate according to volumetric measurement was 16.5 %. In group B, the resorption rate according to the radiographic measurements was 15.9 %, and resorption rate according to volumetric measurement was 30.6 %. Significant difference is on radiographic resorption of post-op 2, 4, 8 months on two groups (P < 0.05). Also significant difference is on volume resorption on two groups (P < 0.05) Conclusion: We found that more bone resorption occurred with iliac(endochondral) bone and when we use intraoral bone, that bone can maintain their vitality for alveolar ridge augmentation.

Changes in Clinical Characteristics and Outcome of Patients with Hepatocellular Carcinoma (HCC) in a 16-Year Cohort

( Sang Il Choi ),( Joong-won Park ),( Bo Hyun Kim ),( Ju Hee Lee ),( Seung Duk Lee ),( In Joon Lee ),( Tae Hyun Kim ),( Seong Hoon Kim ),( Young Hwan Koh ),( Hyun Beom Kim ),( Eun Kyung Hong ),( Chang 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: In South Korea, an endemic area of hepatitis B virus (HBV), the incidence and mortality of HCC is gradually decreasing by HBV vaccination, antiviral treatment, early tumor detection, improved treatment options, and evidence-based guidelines. This study investigated the changes over time in the baseline characteristics and clinical outcomes of HCC patients at a single center. Methods: Patients initially diagnosed with and treated for HCC at the National Cancer Center between 2000 and 2015 (n=4291) were followed-up until February 2017. Difference in patient characteristics and outcomes were compared in patients diagnosed in 2000-2004 (n=1157), 2005-2009 (n=1678), and 2010-2015 (n=1456). Results: The median age of the patient cohort was 57 years (range 13-98) years, and most were male (3502, 81.6%). HBV infection was the most common etiology (74.7%). The percentage of patients with Child class A (69.1%, 79.9%, and 87.1%, respectively) and BCLC stage 0 (4.1%, 5.2%, and 9.8%, respectively) increased significantly over time. Median overall survival also increased significantly over time, from 14.4 months (95% confidence interval [CI] 12.0-16.8 months) in 2000-2004, to 22.9 months (95% CI, 20.3-25.5 months) in 2005-2009, to 53.6 months (95% CI, 45.7- 61.5 months) in 2010-2015 (p<0.001). OS of patients with modified UICC stage IV (3.6 vs. 4.7 vs 6.1 months, p<0.001) and with HBV etiology (12.7 vs 20.4 vs 64.5 months, p<0.001) was observed in patients diagnosed in 2000-2004, 2005-2009 and 2010-2015, respectively. Conclusions: Survival of patients with HCC has improved significantly over time in a single center in South Korea. Analysis is ongoing to determine the causes of the improved outcomes.

A Study on Model Converged Industry of the User Experience to Provide Value to User

Chang Beom Shin,Hye Min Lee,Young Hwan Pan 대한인간공학회 2015 대한인간공학회 학술대회논문집 Vol.2015 No.10

Objective: Recently, existing industry is diversifying rapidly. According to changing needs of the customers, the conventional service companies provide new services fused products and contents. Also, the companies of manufacture provide products to customers through services. Even more, this phenomenon is extended and deepened, it is underway around the world. Seeking a change in the servicesas to solve the ultimate needs of customers rather than simply providing customer service. Background: In this study, we defined a business model type delivered to the customers focusing on user value. In other words, we classify the type of fused different business models between industry and describe the characters in terms of user experience. Method: The Eco-system to provide user value to the customers, we defined PCS models by the three elements that are product, contents and service. And, we were mapped the various types of business models based on them. Results: We were separated seven kinds of business models based on the type of the PCS models. We could find that each model fused together and broke down the barrier between the industry, which provide new items and values to the users. Conclusion: Based on the results, we expect to be able to create user value business model as various fused methods in the future that more diversified social environment and user needs.