Some Properties of Fresh and Ripened Traditional Akcakatik Cheese

Bedia Ş,imş,ek,Yasin Tuncer 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.1

Akcakatik cheese (yogurt cheese) is produced by drying strained yogurt with or without adding cloves or black cumin. The main objective of this study was to detect the properties of both fresh and ripened Akcakatik cheeses and to compare them. For this purpose the biogenic amine content, volatile flavor compounds, protein degradation level, chemical properties and some microbiological properties of 15 Akcakatik cheese samples were investigated. Titratable acidity, total dry matter, NaCl, total nitrogen, water soluble nitrogen, ripened index, histamine, diacetyl and acetaldehyde levels were found to be higher in ripened cheese samples than in fresh cheese samples. On the other hand, the clove and black cumin ratios were found to be higher in the fresh cheese samples. Sodium dodecyl sulphate polyacrylamide gel electropherograms of cheese samples showed that protein degradation was higher in ripened cheese samples than in fresh samples, as expected. The dominant Lactic acid bacteria (LAB) flora of Akcakatik cheese samples were found to be Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus.

Methylene Tetrahydrofolate Reductase C677T Mutation and Left Ventricular Hypertrophy in Turkish Patients with Type 2 Diabetes Mellitus

( Hulya Yilmaz ),( Bedia Agachan ),( Arzu Ergen ),( Zeynep Ermis Karaalib ),( Turgay Isbir ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.2

This study was designed to investigate, in the Turkish population, the association of methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and left ventricular hypertrophy (LVH) in patients with type II diabetes mellitus. Our study included 249 patients with type II diabetes mellitus (102 men, 147 women) and 214 healthy volunteers as controls (91 men, 123 women). MTHFR C677T genotypes were determined by polymerase chain reaction, restriction fragment length polymorphism techniques. No differences were observed in the distribution of MTHFR genotypes or allele frequencies in the cases versus the controls. The frequency of the MTHFR-mutated allele (T) was 31.7% in the type II diabetes mellitus versus 31.1% of the controls. The homozygous mutation (T/T) in the MTHFR gene was identified in 12% of the type II diabetes mellitus versus 9.3% of the controls. Patients with the TT genotype showed a higher prevalence of LVH when compared to patients with the CC and CT genotypes (p = 0.01). The MTHFR gene C677T mutation may be a possible risk factor for the development of LVH in the type II diabetic patients

Nonlinear thermal buckling behavior of functionally graded plates using an efficient sinusoidal shear deformation theory

Bouiadjra, Rabbab Bachir,Bedia, E.A. Adda,Tounsi, Abdelouahed Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.48 No.4

Nonlinear behavior of functionally graded material (FGM) plates under thermal loads is investigated here using an efficient sinusoidal shear deformation theory. The displacement field is chosen based on assumptions that the in-plane and transverse displacements consist of bending and shear components, and the shear components of in-plane displacements give rise to the sinusoidal distribution of transverse shear stress through the thickness in such a way that shear stresses vanish on the plate surfaces. Therefore, there is no need to use shear correction factor. Unlike the conventional sinusoidal shear deformation theory, the proposed efficient sinusoidal shear deformation theory contains only four unknowns. The material is graded in the thickness direction and a simple power law based on the rule of mixture is used to estimate the effective material properties. The neutral surface position for such FGM plates is determined and the sinusoidal shear deformation theory based on exact neutral surface position is employed here. There is no stretching-bending coupling effect in the neutral surface-based formulation, and consequently, the governing equations and boundary conditions of functionally graded plates based on neutral surface have the simple forms as those of isotropic plates. The non-linear strain-displacement relations are also taken into consideration. The thermal loads are assumed as uniform, linear and non-linear temperature rises across the thickness direction. Closed-form solutions are presented to calculate the critical buckling temperature, which are useful for engineers in design. Numerical results are presented for the present efficient sinusoidal shear deformation theory, demonstrating its importance and accuracy in comparison to other theories.

Methylene Tetrahydrofolate Reductase C677T Mutation and Left Ventricular Hypertrophy in Turkish Patients with Type II Diabetes Mellitus

Yilmaz, Hulya,Agachan, Bedia,Ergen, Arzu,Karaalib, Zeynep Ermis,Isbir, Turgay Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.2

This study was designed to investigate, in the Turkish population, the association of methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and left ventricular hypertrophy (LVH) in patients with type II diabetes mellitus. Our study included 249 patients with type II diabetes mellitus (102 men, 147 women) and 214 healthy volunteers as controls (91 men, 123 women). MTHFR C677T genotypes were determined by polymerase chain reaction, restriction fragment length polymorphism techniques. No differences were observed in the distribution of MTHFR genotypes or allele frequencies in the cases versus the controls. The frequency of the MTHFR-mutated allele (T) was 31.7% in the type II diabetes mellitus versus 31.1% of the controls. The homozygous mutation (T/T) in the MTHFR gene was identified in 12% of the type II diabetes mellitus versus 9.3% of the controls. Patients with the TT genotype showed a higher prevalence of LVH when compared to patients with the CC and CT genotypes (p = 0.01). The MTHFR gene C677T mutation may be a possible risk factor for the development of LVH in the type II diabetic patients.

Vibration analysis of nonlocal porous nanobeams made of functionally graded material

Berghouti, Hana,Adda Bedia, E.A.,Benkhedda, Amina,Tounsi, Abdelouahed Techno-Press 2019 Advances in nano research Vol.7 No.5

In this work, dynamic behavior of functionally graded (FG) porous nano-beams is studied based on nonlocal nth-order shear deformation theory which takes into the effect of shear deformation without considering shear correction factors. It has been observed that during the manufacture of "functionally graded materials" (FGMs), micro-voids and porosities can occur inside the material. Thus, in this work, the investigation of the dynamic analysis of FG beams taking into account the influence of these imperfections is established. Material characteristics of the FG beam are supposed to be vary continuously within thickness direction according to a "power-law scheme" which is modified to approximate material characteristics for considering the influence of porosities. A comparative study with the known results in the literature confirms the accuracy and efficiency of the current nonlocal nth-order shear deformation theory.

Influence of the porosities on the free vibration of FGM beams

Hadji, L.,Adda Bedia, E.A. Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3

In this paper, a free vibration analysis of functionally graded beam made of porous material is presented. The material properties are supposed to vary along the thickness direction of the beam according to the rule of mixture, which is modified to approximate the material properties with the porosity phases. For this purpose, a new displacement field based on refined shear deformation theory is implemented. The theory accounts for parabolic distribution of the transverse shear strains and satisfies the zero traction boundary conditions on the surfaces of the beam without using shear correction factors. Based on the present refined shear deformation beam theory, the equations of motion are derived from Hamilton's principle. The rule of mixture is modified to describe and approximate material properties of the FG beams with porosity phases. The accuracy of the present solutions is verified by comparing the obtained results with the existing solutions. Illustrative examples are given also to show the effects of varying gradients, porosity volume fraction, aspect ratios, and thickness to length ratios on the free vibration of the FG beams.

An Investigation of SDF1/CXCR4 Gene Polymorphisms in Autism Spectrum Disorder: A Family-Based Study

Tayfun Kara,İ,smail Akaltun,Bedia Cakmakoglu,İ,lyas Kaya,Salih Zoroğ,lu 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.3

Objective-Autism spectrum disorders (ASD) have a complex pathophysiology including genetic, inflammatory and neurodevelopmental components. We aim to investigate the relationship between ASD and gene polymorphisms of stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor-4 (CXCR4), which may affect inflammatory and neurodevelopmental processes. Methods-101 children diagnosed with ASD aged 2–18 and their biological parents were included in the study. All participants were assessed using an information form and the Children were assessed using Childhood Autism Rating Scale (CARS). SDF-1 G801→A and CXCR4 C13→T polymorphisms were detected by genetic techniques. The results were evaluated using the transmission disequilibrium test (TDT) and haplotype relative risk (HRR). Results-Following TDT evaluation for CXCR4, the assumption of equality was not rejected (χ2=1.385, p=0.239). HRR for the C allele was 1.037 [HRR (95%CI)=0.937 (0.450-2.387), χ2=0.007, p=0.933] and HRR for the T allele was 0.965 [HRR (95%CI)=0.965 (0.419-2.221), χ2=1.219, p=0.270], but the findings were statistically insignificant. Based on TDT evaluation for SDF1, the assumption of equality cannot be rejected (χ2=0, p=0.999). HRR for the A allele was 0.701 [HRR (95%CI)=0.701 (0.372-1.319), χ2=1.219, p=0.270] and HRR for the G allele was 1.427 [HRR (95%CI)=1.427 (0.758-2.686), χ2=1.219, p=0.270], but the findings were statistically insignificant. Conclusion-The genetic screening of blood samples from mother, father and child trios could not show a significant association between SDF1/CXCR4 genes and ASD on the basis of TDT and HRR tests. More extensive genetic studies are now needed to investigate the relationship between SDF1/CXCR4 gene polymorphisms and ASD.

Influence of the porosities on the free vibration of FGM beams

L. Hadji,E.A. Adda Bedia 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3

In this paper, a free vibration analysis of functionally graded beam made of porous material is presented. The material properties are supposed to vary along the thickness direction of the beam according to the rule of mixture, which is modified to approximate the material properties with the porosity phases. For this purpose, a new displacement field based on refined shear deformation theory is implemented. The theory accounts for parabolic distribution of the transverse shear strains and satisfies the zero traction boundary conditions on the surfaces of the beam without using shear correction factors. Based on the present refined shear deformation beam theory, the equations of motion are derived from Hamilton’s principle. The rule of mixture is modified to describe and approximate material properties of the FG beams with porosity phases. The accuracy of the present solutions is verified by comparing the obtained results with the existing solutions. Illustrative examples are given also to show the effects of varying gradients, porosity volume fraction, aspect ratios, and thickness to length ratios on the free vibration of the FG beams.

Influence of material composition on buckling response of FG plates using a simple plate integral model

Karima Bakhti,Mohamed Sekkal,E.A. Adda Bedia,Abdelouahed Tounsi 국제구조공학회 2020 Smart Structures and Systems, An International Jou Vol.25 No.4

In this study, a simple two-dimensional shear deformation model is employed for buckling analysis of functionally graded (FG) plates. The proposed theory has a kinematic with integral terms which considers the influence of shear deformation without using "shear correction factors". The impact of varying material properties and volume fraction of the constituent on buckling response of the FG plate is examined and discussed. The benefit of this theory over other contributions is that a number of variables is reduced. The basic equations that consider the influence of transverse shear stresses are derived from the principle of virtual displacements. The analytical solutions are obtained utilizing the "Navier method". The accuracy of the proposed theory is proved by comparisons with the different solutions found in the literature.

A refined exponential shear deformation theory for free vibration of FGM beam with porosities

Hadji, Lazreg,Daouadji, T. Hassaine,Bedia, E. Adda Techno-Press 2015 Geomechanics & engineering Vol.9 No.3

In this paper, a refined exponential shear deformation theory for free vibration analysis of functionally graded beam with considering porosities that may possibly occur inside the functionally graded materials (FGMs) during their fabrication. For this purpose, a new displacement field based on refined shear deformation theory is implemented. The theory accounts for parabolic distribution of the transverse shear strains and satisfies the zero traction boundary conditions on the surfaces of the beam without using shear correction factors. Based on the present refined shear deformation beam theory, the equations of motion are derived from Hamilton's principle. The rule of mixture is modified to describe and approximate material properties of the FG beams with porosity phases. The accuracy of the present solutions is verified by comparing the obtained results with the existing solutions. Illustrative examples are given also to show the effects of varying gradients, porosity volume fraction, aspect ratios, and thickness to length ratios on the free vibration of the FG beams.