Effect of Pre-Procedural State-Trait Anxiety on Pain Perception and Discomfort in Women Undergoing Colposcopy for Cervical Cytological Abnormalities

Baser, Eralp,Togrul, Cihan,Ozgu, Emre,Esercan, Alev,Caglar, Mete,Gungor, Tayfun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Background: Colposcopy is the gold standard procedure for evaluating cervical cytological abnormalities. Although it is essentially a minimally invasive intervention, referral for colposcopy may cause significant distress on patients. In this study, we aimed to determine if pre-procedural anxiety levels have a significant association with procedure related pain and discomfort in women undergoing colposcopy for evaluation of abnormal cervical cytology. We also assessed the impact of various clinical factors on anxiety, pain and discomfort in these patients. Materials and Methods: This prospective study was performed at the gynecologic oncology department of Zekai Tahir Burak Women's Health Education and Research Hospital in Ankara, Turkey between January and June 2013. After taking informed consent, State-Trait Anxiety Inventory (STAI) form and a 14-item questionnaire were filled for women who were admitted to our outpatient colposcopy unit for evaluation of abnormal cervical cytology. STAI scores were calculated for each participant. Immediately after the procedure, visual analog scale (VAS) scores for procedure-related pain and discomfort were obtained. Associations between STAI and VAS scores were investigated using correlation analyses. The effect of various contributing factors on anxiety, pain and discomfort were evaluated with linear regression analysis. The p values less than 0.05 were considered statistically significant. Results: A total of 222 women met the inclusion criteria within the study period. Mean patient age was $38.5{\pm}9.6$. Median state and trait anxiety scores were 47 and 46, respectively. Median VAS scores for pain and discomfort were 4 for both variables. State anxiety had a significant correlation with procedure related discomfort (p=0.02). Colposcopy related pain VAS scores were significantly affected by state anxiety level, marital status and prior gynecological examination (p<0.05). Colposcopy related discomfort VAS scores were significantly affected by state anxiety level, marital status, prior gynecological examination and educational status. Conclusions: Additional measures should be implemented in women that carry higher risk for experiencing pain and discomfort. Social, cultural and lifestyle issues may also affect women's experiences during colposcopy, therefore further studies are needed to define specific determining factors in various populations.

Clinical Outcomes of Cases with Absent Cervical Dysplasia in Cold Knife Conization Specimens

Baser, Eralp,Ozgu, Emre,Erkilinc, Selcuk,Yalcin, Hakan,Cetinkaya, Nilufer,Sirvan, Levent,Erkaya, Salim,Gungor, Tayfun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Cold knife conization is a surgical procedure that allows both diagnosis and treatment of cervical lesions at the same time. It is mainly performed for indications of high-grade cervical intraepithelial neoplasia (CIN). In this study, we aimed to investigate the clinical outcome of cases without CIN in cold knife conization specimen, following a high-grade lesion (CIN2/3) in cervical biopsy. Materials and Methods: We performed a retrospective cohort study at a tertiary referral hospital between January $1^{st}$ 2008 and August $1^{st}$ 2012. Cases that underwent cold knife conization for CIN2/3 within the study period were included. Cone-negative (Group 1) and cone-positive (Group 2) cases were analyzed for various clinical parameters, and were compared in the 1-year post-conization period for histological recurrence and human papillomavirus (HPV) DNA status. Results: A total of 173 women underwent cold knife conization for CIN2/3 within the study period. Twenty-two cases (12.7%) were included in Group 1 and 151 cases (87.3%) in Group 2. There were no significant differences between the two groups in terms of age, gravidity, parity, menopausal status and HPV-DNA status (pre-conization and 1 year post-conization) (p>0.05). Recurrence rates were also similar between the groups (9.1% vs 9.9%, p>0.05). Conclusions: Clinical outcomes were similar in terms of histological recurrence and HPV persistence after 1 year of follow-up between cone-negative and cone-positive cases. Clinical follow-up of cone-negative cases should therefore be performed similar to cone-positive cases.

ON STRONG REVERSIBLE RINGS AND THEIR EXTENSIONS

Baser, Muhittin,Kwak, Tai Keun The Kangwon-Kyungki Mathematical Society 2010 한국수학논문집 Vol.18 No.2

P. M. Cohn called a ring R reversible if whenever ab = 0, then ba = 0 for $a,b{\in}R$. In this paper, we study an extension of a reversible ring with its endomorphism. An endomorphism ${\alpha}$ of a ring R is called strong right (resp., left) reversible if whenever $a{\alpha}(b)=0$ (resp., ${\alpha}(a)b=0$) for $a,b{\in}R$, ba = 0. A ring R is called strong right (resp., left) ${\alpha}$-reversible if there exists a strong right (resp., left) reversible endomorphism ${\alpha}$ of R, and the ring R is called strong ${\alpha}$-reversible if R is both strong left and right ${\alpha}$-reversible. We investigate characterizations of strong ${\alpha}$-reversible rings and their related properties including extensions. In particular, we show that every semiprime and strong ${\alpha}$-reversible ring is ${\alpha}$-rigid and that for an ${\alpha}$-skew Armendariz ring R, the ring R is reversible and strong ${\alpha}$-reversible if and only if the skew polynomial ring $R[x;{\alpha}]$ of R is reversible.

RIGIDNESS AND EXTENDED ARMENDARIZ PROPERTY

Baser, Muhittin,Kaynarca, Fatma,Kwak, Tai-Keun Korean Mathematical Society 2011 대한수학회보 Vol.48 No.1

For a ring endomorphism of a ring R, Krempa called $\alpha$ rigid endomorphism if $a{\alpha}(a)$ = 0 implies a = 0 for a $\in$ R, and Hong et al. called R an $\alpha$-rigid ring if there exists a rigid endomorphism $\alpha$. Due to Rege and Chhawchharia, a ring R is called Armendariz if whenever the product of any two polynomials in R[x] over R is zero, then so is the product of any pair of coefficients from the two polynomials. The Armendariz property of polynomials was extended to one of skew polynomials (i.e., $\alpha$-Armendariz rings and $\alpha$-skew Armendariz rings) by Hong et al. In this paper, we study the relationship between $\alpha$-rigid rings and extended Armendariz rings, and so we get various conditions on the rings which are equivalent to the condition of being an $\alpha$-rigid ring. Several known results relating to extended Armendariz rings can be obtained as corollaries of our results.

The McCoy Condition on Skew Polynomial Rings

Baser, M.,Kwak, T. K.,Lee, Y. Taylor Francis 2009 Communications in Algebra Vol.37 No.11

GENERALIZED SEMI COMMUTATIVE RINGS AND THEIR EXTENSIONS

Baser, Muhittin,Harmanci, Abdullah,Kwak, Tai-Keun Korean Mathematical Society 2008 대한수학회보 Vol.45 No.2

For an endomorphism ${\alpha}$ of a ring R, the endomorphism ${\alpha}$ is called semicommutative if ab=0 implies $aR{\alpha}(b)$=0 for a ${\in}$ R. A ring R is called ${\alpha}$-semicommutative if there exists a semicommutative endomorphism ${\alpha}$ of R. In this paper, various results of semicommutative rings are extended to ${\alpha}$-semicommutative rings. In addition, we introduce the notion of an ${\alpha}$-skew power series Armendariz ring which is an extension of Armendariz property in a ring R by considering the polynomials in the skew power series ring $R[[x;\;{\alpha}]]$. We show that a number of interesting properties of a ring R transfer to its the skew power series ring $R[[x;\;{\alpha}]]$ and vice-versa such as the Baer property and the p.p.-property, when R is ${\alpha}$-skew power series Armendariz. Several known results relating to ${\alpha}$-rigid rings can be obtained as corollaries of our results.

QUASI-ARMENDARIZ PROPERTY FOR SKEW POLYNOMIAL RINGS

Baser, Muhittin,Kwa, Tai Keun Korean Mathematical Society 2011 대한수학회논문집 Vol.26 No.4

The concept of the quasi-Armendariz property of rings properly contains Armendariz rings and semiprime rings. In this paper, we extend the quasi-Armendariz property for a polynomial ring to the skew polynomial ring, hence we call such ring a ${\sigma}$-quasi-Armendariz ring for a ring endomorphism ${\sigma}$, and investigate its structures, several extensions and related properties. In particular, we study the semiprimeness and the quasi-Armendariz property between a ring R and the skew polynomial ring R[x;${\sigma}$$] of R, and so these provide us with an opportunity to study quasi-Armendariz rings and semiprime rings in a general setting, and several known results follow as consequences of our results.

Sperm-Associated Antigen 9 is a Promising marker for Early Diagnosis of Endometrial Cancer

Baser, Eralp,Togrul, Cihan,Ozgu, Emre,Ayhan, Sevgi,Caglar, Mete,Erkaya, Salim,Gungor, Tayfun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: Sperm-associated antigen 9 (SPAG9) has been recently proposed as a novel biomarker for early diagnosis of several human tumors, including ovarian, cervical and breast cancers. Its clinical value remains to be clarified for endometrial cancer (EC). In this study, we investigated the utility of serum SPAG9 levels in diagnosis of EC and its association with important clinicopathological parameters. Materials and Methods: This cross-sectional study was performed at a tertiary women's referral center in Ankara, Turkey. Preoperative serum samples were collected from patients surgically treated for endometrial cancer between June 2012-April 2013. Similar aged women with a biopsy proven benign endometrium were used as controls. Serum SPAG9 levels were measured with an enzyme-linked immunosorbent assay (ELISA) method and assessed for links with clinicopathological factors. Receiver operating characteristic (ROC) curve analysis was performed to assess power of SPAG9 levels for EC prediction. P values less than 0.05 were considered statistically significant. Results: A total of 63 women with EC and 27 with benign endometrium were included in the study. Mean age in the EC group was $58.7{\pm}1.1$. Median SPAG9 levels in the EC and control groups were 18.3 (range, 12.7-53.8) and 14.1 (range, 4.3-65.3), respectively (p<0.001). A cut-off value of 17 ng/ml for SPAG9 predicted presence of malignant endometrium with 74% sensitivity and 83% specificity [Area under curve (AUC)=0.82, p<0.001]. SPAG9 levels did not demonstrate any significant association with histological type, FIGO stage, tumor grade, size, myometrial invasion, lymphovascular space invasion, cervical involvement, adnexal involvement, peritoneal cytology or lymph node status (all p>0.05). Conclusions: Testing for SPAG9 may be useful for early detection of EC in asymptomatic high-risk women. Its role in post-treatment follow-up and early detection of recurrence should be assessed in future trials.

RING ENDOMORPHISMS WITH THE REVERSIBLE CONDITION

Baser, Muhittin,Kaynarca, Fatma,Kwak, Tai-Keun Korean Mathematical Society 2010 대한수학회논문집 Vol.25 No.3

P. M. Cohn called a ring R reversible if whenever ab = 0, then ba = 0 for a, $b\;{\in}\;R$. Commutative rings and reduced rings are reversible. In this paper, we extend the reversible condition of a ring as follows: Let R be a ring and $\alpha$ an endomorphism of R, we say that R is right (resp., left) $\alpha$-shifting if whenever $a{\alpha}(b)\;=\;0$ (resp., $\alpha{a)b\;=\;0$) for a, $b\;{\in}\;R$, $b{\alpha}{a)\;=\;0$ (resp., $\alpha(b)a\;=\;0$); and the ring R is called $\alpha$-shifting if it is both left and right $\alpha$-shifting. We investigate characterizations of $\alpha$-shifting rings and their related properties, including the trivial extension, Jordan extension and Dorroh extension. In particular, it is shown that for an automorphism $\alpha$ of a ring R, R is right (resp., left) $\alpha$-shifting if and only if Q(R) is right (resp., left) $\bar{\alpha}$-shifting, whenever there exists the classical right quotient ring Q(R) of R.

INSERTION-OF-FACTORS-PROPERTY ON SKEW POLYNOMIAL RINGS

BASER, MUHITTIN,HICYILMAZ, BEGUM,KAYNARCA, FATMA,KWAK, TAI KEUN,LEE, YANG Korean Mathematical Society 2015 대한수학회지 Vol.52 No.6

In this paper, we investigate the insertion-of-factors-property (simply, IFP) on skew polynomial rings, introducing the concept of strongly ${\sigma}-IFP$ for a ring endomorphism ${\sigma}$. A ring R is said to have strongly ${\sigma}-IFP$ if the skew polynomial ring R[x;${\sigma}$] has IFP. We examine some characterizations and extensions of strongly ${\sigma}-IFP$ rings in relation with several ring theoretic properties which have important roles in ring theory. We also extend many of related basic results to the wider classes, and so several known results follow as consequences of our results.