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- 저자 : Baek-Vin Lim (검색결과 55 건)
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( Baek Vin Lim ),( Tae Soo Kim ),( Mal Soon Shin ) 한국운동영양학회 2013 Physical Activity and Nutrition (Phys Act Nutr) Vol.17 No.3
Depression is one of the most common psychiatric symptoms in hypothyroidism. Depression following hypothyroidism is closely associated with reduced activity of the serotonergic system. Physical exercise has positive effects for mental diseases such as depression. In the present study, we investigated the effects of treadmill exercise on the depressive-like symptom, 5-hydroxytryptamine (5-HT)and tryptophan hydroxylase (TPH) expression in the dorsal raphe nucleus of the rat pups with hypothyroidism. On the day of perinatal 14, pregnant rats were divided into two groups (n = 5 in each group): the pregnant control group and the pregnant methimazole (MMI)-treated group. For the induction of hypothyroidism in the rat pups, MMI was added to the drinking water, from the day of perinatal 14 to postnatal 49. After delivery, male rat pups born from the pregnant control group were assigned to the control group. Male rat pups born from the MMI-treated group were divided into the hypothyroidism-induction (HI) group and the hypothyroidism-induction with treadmill exercise (HIT) group (n = 10 in each group). The rat pups in the exercise group were forced to run on a treadmill for 30 min once a day for 4 weeks, starting on postnatal day 22. In the hypothyroidism-induced rat pups,5-HT synthesis and TPH expression was reduced in the dorsal raphe nucleus. Treadmill exercise alleviated hypothyroidism-induced depressive state by enhancing serotonergic related genes. These results suggest that treadmill exercise can be used as a therapeutic agent for hypothyroidism patients with depression.
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LIM, Baek-Vin,SHIN, Min-Chul,JANG, Mi-Hyeon,LEE, Taeck-Hyun,KIM, Young-Pyo,KIM, Hyun-Bae,LEE, Kwang-Sik,KIM, Hong,KIM, Ee-Hwa,KIM, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
Ginseng radix, the root of Panax Ginseng C. A. Meyer(Araliaceae), is one of the most famous Oriental medical herbs with various therapeutic applications. Aqueous extract of Ginseng radix has been used to treat a wide variety of dis-eases including anemia, diabetes mellitus, insomnia with neurasthenia, gastrntis, abnormality in blood pressure, dys-pepsia, overstrain, and fatigue Ginseng radix is known to possess various pharmacological effects, including hypoten-sive, cardiotonic, sedative, aphrodisiac, anti-aging, and anti-oxidant activities. Ginseng radix has also been used to re-store and enhance well-being in Oriental medicine, and these effects are described as increasing resistance against noxious or stressful influences without impairing physiological func-tions. In addition, it has been reported that Ginseng radix improves the learning capacities of animals.
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( Baek Vin Lim ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.2
The aqueous extract of red ginseng has traditionally been used as an ergogenic aid for endurance exercise. In the present study, the endurance in treadmill exercise and the concentration of 5-hydroxytryptamine (serotonin, 5-HT) and level of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, expression in dorsal raphe of rats were studied following treatment with red ginseng. In exercise groups, Sprague-Dawley rats were put on treadmill running for 30 min per day for 4 consecutive days. The speed of the treadmill used for measurement of the time to exhaustion was 20 m/min, the presumed equilibrium speed of running for the rats. In order to clarify the ergogenic mechanism of red ginseng, its effect of red ginseng on 5-HT synthesis and TPH expression in the dorsal raphe was investigated via immunohistochemistry in this study. Rats receiving red ginseng showed ncreased time to exhaustion for treadmill running, and red ginseng theatment inhibited exercise-induced increases n 5-HT synthesis and the expression of tryptophan hydroxylase in the dorsal raphe. These results suggest that the suppressive effect of red ginseng on 5-HT synthesis n the dorsal raphe during exercise is a possible ergogenic mechanism of red ginseng.
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Lim, Baek-Vin,Shin, Mal-Soon,Lee, Jae-Min,Seo, Jin-Hee 한국운동재활학회 2015 JER Vol.11 No.2
<P>Epilepsy is a common neurological disorder characterized by seizure and loss of neuronal cells by abnormal rhythmic firing of neurons in the brain. In the present study, we investigated the effect of treadmill exercise on gamma-aminobutyric acid (GABA)ergic neuronal loss in relation with neuronal activation using pilocarpine-induced epileptic rats. The rats were divided into four groups: control group, control and treadmill exercise group, pilocarpine-induced epilepsy group, and pilocarpine-induced epilepsy and treadmill exercise group. Epilepsy was induced by intraperitoneal injection of 320 mg/kg pilocarpine hydrochloride. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. In the present results, neuronal loss in the hippocampal CA1 region was increased after pilocarpine-induced seizure. Treadmill exercise inhibited hippocampal neuronal loss in the epileptic rats. Glutamic acid decarboxylase (GAD67) expression in the hippocampal CA1 region was reduced by pilocarpine-induced seizure. Treadmill exercise increased GAD67 expression in the epileptic rats. c-Fos expression in the hippocampal CA1 region was increased in response to epileptic seizure. Treadmill exercise inhibited c-Fos expression in the epileptic rats. Epileptic seizure increased brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) expressions in the hippocampus. Treadmill exercise suppressed BDNF and TrkB expressions in the epileptic rats. In the present study, treadmill exercise prevented GABAergic neuronal loss and inhibited neuronal activation in the hippocampal CA1 region through the down-regulation of BDNF-TrkB signaling pathway.</P>
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고온과 저온 환경에서의 트레드밀 운동이 흰쥐 해마에서 c-Fos 발현과 비복근에서의 HSP 70 발현에 미치는 영향
임백빈(Baek-Vin Lim) 한국생활환경학회 2009 한국생활환경학회지 Vol.16 No.6
In the present study was to examine the effect of treadmill exercise under heat and cold stress conditions on c-Fos expression in the hippocampus and HSP 70 expression in the gastrocnemius muscle. c-Fos expression represents neuronal activity and plays a crucial role in the brain development. Physical exercise is known to enhance neuronal plasticity and activity. Heat shock protein 70 (HSP 70) is the best characterized stress-responsive gene with enhanced expression and thought to be a protective factor against environmental stress in a cell. For this study, male Sprague-Dawley rats weighing 250±10 g (7 weeks in age) were used. The rats were randomly divided into six groups (n=10 in each group): the control in 4℃ group, the exercise in 4oC group, the control in 22℃ group, the exercise in 22℃ group, the control in 35℃ group, and the exercise in 35℃ group. The environmental temperature at 22℃ set as the normal conditions, 4℃ was as the cold stress conditions and 35℃ was as the heat stress conditions. In the cold conditions, the temperature was 4oC with relative humidity 40%. In the normal conditions, the temperature was 22℃ with relative humidity 40%. In the heat stress conditions, temperature was 35℃ with relative humidity 20%. Animals were sacrificed immediately after finishing the last session of treadmill exercise on the 5 weeks of the experiment. The present results showed that exposure under normal, cold and heat stress conditions exerted no signifiant effect on the c-Fos expression. However, the c-Fos expression in the hippocampus was increased by treadmill exercise, showing that cold stress and heat stress acted as the decreasing factor of c-Fos. The HSP 70 expression in the gastrocnemius was increased by treadmill exercise for 5 weeks under normal, cold and heat conditions, however, the increasing of HSP 70 was not appeared that exposure under the cold and heat stress conditions. The present study revealed that treadmill exercise exerted improvement effect on impairment of environmental stress through enhancing of c-Fos and increasing of HSP 70.
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임백빈(Baek-Vin Lim),고광욱(Kwang-Wook Koh),김희숙(Hee-Suk Kim),신용현(Yong-Hyun Shin) 한국보건교육건강증진학회 2014 보건교육건강증진학회지 Vol.31 No.3
Objectives: Although many cities have adopted Healthy Cities approach in Republic of Korea, few studies have been reported about city health profile. So we report a case of city health profile made of subjective indexes and objective indicators using available recent evidence. Methods: To assess subjective city health indexes, questionnaire survey was implemented to public officers and citizen adapting the ‘Signs of progress, signs of caution of 12 stage tool from Ontario Healthy Community Coalition. Based on recent literature objective city health indicators were collected for time-series comparison and for the comparison with those of larger province mainly using Korean Statistical Information Service. Results: Subjective city health indexes were successfully constructed in four areas including human health, environment, social and economic area. The score was especially low in environmental area. Specific items in each area for improvement were identified. Objective city health indicators were collected for three year time-series comparison and for the compared with those of larger province. Conclusions: City health profile comprised of subjective city health indexes and objective city health indicators could successfully be made from primary survey and secondary data in a medium-sized Korean city. That City health profile was useful in subsequent city health planning through participatory process.
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임백빈(Baek Vin Lim),박진국(Jin Kook Park),장명제(Myoung Jei Chang),신말순(Mal Soon Shin),김창주(Chang Ju Kim) 한국사회체육학회 2004 한국사회체육학회지 Vol.0 No.21
수영 운동이 쥐의 해마 치상회에 세포 생성에 미치는 영향을 5-bromo-2`-deoxyuridine(BrdU) 면역 조직화학법을 이용하여 연구하였다. 첫 번째 실험에서 수영 운동집단은 1분 수영군, 5분 수영군, 10분 수영군, 20분 수영군으로 나누어 3일간 수영운동을 실시하였다. 두 번째 실험은 1일 수영군, 3일 수영군, 7일 수영군, 14일 수영군으로 분류하여 1일 10분씩 수영운동을 실시하였다. 본 실험의 결과, 10분간의 수영 운동이 치상회의 세포생성을 가장 효과적으로 증가시켰으며, 또한 7일간의 수영 운동이 세포생성을 가장 많이 시키는 것으로 나타났다. 이러한 결과로 미루어보아 수영운동이 치상회의 세포생성을 증가시키는 운동요법으로 사용될 수 있을 것으로 생각된다.
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