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- 저자 : Baek-Vin Lim (검색결과 55 건)
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LIM, Baek-Vin,SHIN, Min-Chul,JANG, Mi-Hyeon,LEE, Taeck-Hyun,KIM, Young-Pyo,KIM, Hyun-Bae,LEE, Kwang-Sik,KIM, Hong,KIM, Ee-Hwa,KIM, Chang-Ju WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
Ginseng radix, the root of Panax Ginseng C. A. Meyer(Araliaceae), is one of the most famous Oriental medical herbs with various therapeutic applications. Aqueous extract of Ginseng radix has been used to treat a wide variety of dis-eases including anemia, diabetes mellitus, insomnia with neurasthenia, gastrntis, abnormality in blood pressure, dys-pepsia, overstrain, and fatigue Ginseng radix is known to possess various pharmacological effects, including hypoten-sive, cardiotonic, sedative, aphrodisiac, anti-aging, and anti-oxidant activities. Ginseng radix has also been used to re-store and enhance well-being in Oriental medicine, and these effects are described as increasing resistance against noxious or stressful influences without impairing physiological func-tions. In addition, it has been reported that Ginseng radix improves the learning capacities of animals.
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Baek Vin Lim,Choong Yeol Lee,Jin Oh Kang,Chang Ju Kim,Sonhae Cho 한의병리학회 2004 동의생리병리학회지 Vol.18 No.1
Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. Bee venom has been used for the treatment inflammatory disease. In the present study, the effects of bee venom on apoptosis and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils were investigated using immunohistochemistry for cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), caspase-3, and 5-bromo-2'-deoxyuridine (BrdU). It was shown that apoptotic cell death and cell proliferation in the hippocampal dentate gyrus were significantly increased following transient global ischemia in gerbils and that treatment of bee venom suppressed the ischemia-induced increase in apoptosis and cell proliferation in the dentate gyrus. The present results also showed that 1 mg/kg bee-venom treatment suppressed the ischemia-induced increasing apoptosis, cell proliferation, and COX-2 expression in the dentate gyrus. It is possible that the suppression of cell proliferation is due to the reduction of apoptotic cell death by treatment of bee venom. In the present study, bee venom was shown to possess anti-apoptotic effect in ischemic brain disease, and this protective effect of bee venom against ischemia-induced neuronal cell death is closely associated with suppression on caspase-3 expression.
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( Baek Vin Lim ),( Tae Soo Kim ),( Mal Soon Shin ) 한국운동영양학회 2013 Physical Activity and Nutrition (Phys Act Nutr) Vol.17 No.3
Depression is one of the most common psychiatric symptoms in hypothyroidism. Depression following hypothyroidism is closely associated with reduced activity of the serotonergic system. Physical exercise has positive effects for mental diseases such as depression. In the present study, we investigated the effects of treadmill exercise on the depressive-like symptom, 5-hydroxytryptamine (5-HT)and tryptophan hydroxylase (TPH) expression in the dorsal raphe nucleus of the rat pups with hypothyroidism. On the day of perinatal 14, pregnant rats were divided into two groups (n = 5 in each group): the pregnant control group and the pregnant methimazole (MMI)-treated group. For the induction of hypothyroidism in the rat pups, MMI was added to the drinking water, from the day of perinatal 14 to postnatal 49. After delivery, male rat pups born from the pregnant control group were assigned to the control group. Male rat pups born from the MMI-treated group were divided into the hypothyroidism-induction (HI) group and the hypothyroidism-induction with treadmill exercise (HIT) group (n = 10 in each group). The rat pups in the exercise group were forced to run on a treadmill for 30 min once a day for 4 weeks, starting on postnatal day 22. In the hypothyroidism-induced rat pups,5-HT synthesis and TPH expression was reduced in the dorsal raphe nucleus. Treadmill exercise alleviated hypothyroidism-induced depressive state by enhancing serotonergic related genes. These results suggest that treadmill exercise can be used as a therapeutic agent for hypothyroidism patients with depression.
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Lim, Baek-Vin,Shin, Mal-Soon,Lee, Jae-Min,Seo, Jin-Hee 한국운동재활학회 2015 JER Vol.11 No.2
<P>Epilepsy is a common neurological disorder characterized by seizure and loss of neuronal cells by abnormal rhythmic firing of neurons in the brain. In the present study, we investigated the effect of treadmill exercise on gamma-aminobutyric acid (GABA)ergic neuronal loss in relation with neuronal activation using pilocarpine-induced epileptic rats. The rats were divided into four groups: control group, control and treadmill exercise group, pilocarpine-induced epilepsy group, and pilocarpine-induced epilepsy and treadmill exercise group. Epilepsy was induced by intraperitoneal injection of 320 mg/kg pilocarpine hydrochloride. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. In the present results, neuronal loss in the hippocampal CA1 region was increased after pilocarpine-induced seizure. Treadmill exercise inhibited hippocampal neuronal loss in the epileptic rats. Glutamic acid decarboxylase (GAD67) expression in the hippocampal CA1 region was reduced by pilocarpine-induced seizure. Treadmill exercise increased GAD67 expression in the epileptic rats. c-Fos expression in the hippocampal CA1 region was increased in response to epileptic seizure. Treadmill exercise inhibited c-Fos expression in the epileptic rats. Epileptic seizure increased brain-derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) expressions in the hippocampus. Treadmill exercise suppressed BDNF and TrkB expressions in the epileptic rats. In the present study, treadmill exercise prevented GABAergic neuronal loss and inhibited neuronal activation in the hippocampal CA1 region through the down-regulation of BDNF-TrkB signaling pathway.</P>
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( Baek Vin Lim ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.2
The aqueous extract of red ginseng has traditionally been used as an ergogenic aid for endurance exercise. In the present study, the endurance in treadmill exercise and the concentration of 5-hydroxytryptamine (serotonin, 5-HT) and level of tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT synthesis, expression in dorsal raphe of rats were studied following treatment with red ginseng. In exercise groups, Sprague-Dawley rats were put on treadmill running for 30 min per day for 4 consecutive days. The speed of the treadmill used for measurement of the time to exhaustion was 20 m/min, the presumed equilibrium speed of running for the rats. In order to clarify the ergogenic mechanism of red ginseng, its effect of red ginseng on 5-HT synthesis and TPH expression in the dorsal raphe was investigated via immunohistochemistry in this study. Rats receiving red ginseng showed ncreased time to exhaustion for treadmill running, and red ginseng theatment inhibited exercise-induced increases n 5-HT synthesis and the expression of tryptophan hydroxylase in the dorsal raphe. These results suggest that the suppressive effect of red ginseng on 5-HT synthesis n the dorsal raphe during exercise is a possible ergogenic mechanism of red ginseng.
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임백빈(Baek Vin Lim),박진국(Jin Kook Park),장명제(Myoung Jei Chang),신말순(Mal Soon Shin),김창주(Chang Ju Kim) 한국사회체육학회 2004 한국사회체육학회지 Vol.0 No.21
수영 운동이 쥐의 해마 치상회에 세포 생성에 미치는 영향을 5-bromo-2`-deoxyuridine(BrdU) 면역 조직화학법을 이용하여 연구하였다. 첫 번째 실험에서 수영 운동집단은 1분 수영군, 5분 수영군, 10분 수영군, 20분 수영군으로 나누어 3일간 수영운동을 실시하였다. 두 번째 실험은 1일 수영군, 3일 수영군, 7일 수영군, 14일 수영군으로 분류하여 1일 10분씩 수영운동을 실시하였다. 본 실험의 결과, 10분간의 수영 운동이 치상회의 세포생성을 가장 효과적으로 증가시켰으며, 또한 7일간의 수영 운동이 세포생성을 가장 많이 시키는 것으로 나타났다. 이러한 결과로 미루어보아 수영운동이 치상회의 세포생성을 증가시키는 운동요법으로 사용될 수 있을 것으로 생각된다.
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수영이 흰쥐 해마 치상회에서 산화질소합성효소의 발현에 미치는 영향
임백빈 ( Baek Vin Lim ),박진국 ( Jin Kook Park ) 한국운동영양학회 2004 Physical Activity and Nutrition (Phys Act Nutr) Vol.8 No.3
The purpose of the present study was to investigate the effect of swimming on nitric oxide synthase expression in the hippocampal dentate gyrus of the Sprague-Dawley (SD) rats. The male SD rats weighing 250±10 g (6 weeks old) were used in the experiment. In the first part of the experiment (involving session duration-dependence swimming), the rats were divided into five groups to investigate an optimum duration of swimming exercise for the prevention of the NO-dependent neuronal damage: control group, 1-min-swimming group, 5-min-swimming group, 10-min-swimming group, and 20-min-swimming group (n = 10 in each group). In the second part of the experiment (involving training duration-dependence swimming), the rats were divided into five groups: control group to investigate an optimum program of swimming training for the prevention of the NO-dependent neuronal damage, I-day-swimming group, 3-day-swimming group, 7-day-swimming group, and 14-day-swimming group (n = 10 in each group). The rats in the session duration-dependence swimming groups were made to swim for 1 min, 5 min, 10 min, and 20 min once a day for 3 consecutive days, respectively. The rats in the program duration-dependence swimming groups were made to for 10 min once a day for 1 day, 3 days, 7 days, and 14 days, respectively. The swimming apparatus consisted of a swimming pool with 60 cm in height and 120 cm in diameter, which was filled with water at a temperature of 30-32℃ up to 45 cm from the bottom. With respect to the session-duration-dependence swimming groups. the two swimming groups of 10 min or longer duration significantly decreased the number of NADPH-d-positive cells in the dentate gyrus compared to either the control group (p = 0.001) or the I -min swimming group (p = 0.001) or the 5-min swimming group (p = ??). With respect to the program-duration swimming groups, all the swimming groups regardless of its training frequencies had significantly decreased NADPH-d-positive cells in the dentate gyrus compared to the control group (p = 0.03). In conclusion, these results of the current study suggest that a single bout of swimming lasting longer than 10 min, regardless of its frequency, may be an effective means for the prevention of NO-dependent neuronal damage.
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