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Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.
The Drastic development of Information technology has given us both opportunities and risks. So this kind of movement might be recognised as a socioeconomic revolution parallel to the Industrial Revolution. Most of all, as the population of Internet user is expanding, internet is regarded as a communication method to make and intensify connections among people rather than a library of information. This trend results in online communities where people are gathering along based on common interests not common places. The History of online community is at most 30 years. It began to prosper quite recently. Two attributes of online communities, double characteristics of network and community, have enabled the interaction without time and spacial constraints. Focused on e-commerce, the interaction among consumers as same community members can stimulate the production of information about product, price, stores, uses and so on. The interaction between consumers and business agents including producers and sellers can be accelerated on the internet more than in traditional markets of the real world. Self-help production of information by consumers has a great potential to increase the bargaining power of consumers. The intensified relationships with business agents based on their interaction can be another factor to change the old unbalanced status between them. Emerging online community might be the place to test the possibility of consumer driven market. Because it showed us some clues of friction free markets and presumption by consumers. This research is exploratory to predict the changes of relationship between consumers and business agents and delineate the future market based on the development of online community. To estimate the impact of online community on consumers' interest and market, further studies on korean online communities in full bloom are required.
Today, the new wave of information which results from the combination of computer and telecommunication has brought enormous changes throughout the society. As the changes of social system in the history have ranged from hunting to agricultural, and to finally industrial society, the society in the upcoming 21st century will be defined as 'the society of information' based on communication technology. The changes in the environment of the communication and the buying offer both new oppurtunities and the difficulties for consumer who have performed the activities in a traditional market environment. Under this circumstances, this study is to bring our attention to the problems and weaknesses of the consumer in the society of information. It is also to explore the causes and the forms of the problems. Finally, we propose some suggestions for consumer policies and the consumer education.
일차연접부위에서 악안면 영역에서 유래하는 유해자극의 전달 및 처리기전을 이해하고자 horseradish pe개xidase를 치수지배 구심성 신경섬유를 표식한 후 연수후각에서 미세구조 및 연절 양상을 분석하여 다음과 같은 결과를 얻었다. 표식종말은 소수의 큰 치밀소포가 관찰되는 종말 (S형) 및 다수의 치밀소포를 함유하는 종말 (LDCV형)등 2종류로 분류할 수 있었다. S형 및 LDCV형 표식종말의 연접양식은 유사하였으며, 다수의 표식종말이 1개 혹은 2개의 neurofile과 연접을 이루어 대단히 단순한 연접양상을 보였다. 표식종말은 가지돌기체 보다는 다수의 가지돌기가시와 연접을 이루는 빈도가 높았다. 표식종말이 세포체 및 이에 인접한 근심부 가지돌기와 연접하는 경우는 드물었으며, 소수의 표식종말에서 p-ending과 연접하는 경우를 보였다. 표식종말의 체적, 표면적, 사립체의 체적, neurofile과 접하는 면적, 활성부위의 면적, 단위표식종말당 연접소포의 수 및 연접소포의 밀도등은 넓은 범위의 계측치를 나타내었으며, 이는 5명 및 LDCV형 표식종말 사이에 유의한 차이가 없었다. 이상의 결과로 미루어보아 연수후각에서 치수유래 구심성 신경섬유 종말의 연접양식은 고유의 특징을 보이며 이는 신경회로의 기능과 밀접한 상관관계를 가지는 것으로 판단되었다. Little is known about processing mechanism of pain sensation of the oral cavity at the 1st synapse of trigeminal sensory nuclei. Serial ultrathin sections of tooth pulp afferent terminals, identified by the transganglionic transport of 1% wheatgerm agglutinin conjugated horseradish peroxidase, were investigated wih electron microscope. Quantitative ultrastructural analysis was performed on digitizing tablet connected to Macintoshi personal computer (software: NIH Image 1.60, NIH, Bethesda, MD). Labeled boutons could be classified into two types by the shapes of containing vesicles : S bouton which contained mainly spherical vesicles (Dia. 45-55 nm) and few large dense cored vesicles (Dia. 80-120nm), and LDCV bouton, which contained spherical vesicles as well as large number of large dense coredd vesicles. Most of the parameters on the ultrastruotural characteristic and synaptic organization of labeled boutons were similar between S and LDCV boutons, except shapes of containing vesicles. Majority of the labeled boutons showed simple synaptic arrangement. The labeled bouton were frequency presynaptic to dendritic spine, and to a lesser extent, dendritic shaft. They rarely synapsed with soma and adjacent proximal dendrite. A small proportion of labeled boutons made synaptic contacts with presynaptic pleomorphic vesicless containing endings and synaptic triad. Morphometric parameters of labeled boutons including volume and surface area, total apposed area, mitochondrial volume, active zone area, vesicle number and density showed wide variation and theme were not significantly different between S and LDCV boutons. The present study revealed characteristic features on ultrastructure and synaptic connection of pulpal afferents which may involved in transmission of oral pain sensation.
치아 재식 후 시간경과에 따른 치수조직의 재혈관화와 신경재지배의 변화를 관찰하기위해 생후 35일된 흰쥐(Sprague dawley) 56마리를 대상으로 상악우측 제1대구치를 발치 즉시 재식한 후 1일, 2일, 3일, 1주, 2주, 4주, 6주 간격으로 희생시켜 먹물을 이용한 혈관조영술과 CGRP를 이용한 면역조직화학적방법으로 각기 시행하여 다음과 같은 결론을 얻었다. 1. 재혈관화와 CGRP 면역반응신경섬유의 재지배는 재식후 1일에서 근심측 치수조직에서는 이미 이루어졌으나 원심측은 미약했다. 재식후 2일에 전치수조직에서 재혈관화와 신경재지배가 이루어졌으며 이후 6주까지 시간경과에 따라 분포밀도가 증가하였으나 대조군에 비해서는 약하게 나타났다. 2. 재식후 1주에서부터 술후 상아질이 형성되기 시작하였으며 재식후 6주에서는 대조군에 비해 상대적으로 치수강이 좁아진 양상을 보였다. 3. 재혈관화와 신경재지배는 거의 같은 시기에 이루어지는 것으로 나타났으며 밀접한 관련성이 있는 것으로 보인다. The purpose of this study was to investigate the revascularization and reinnervation of calcitonin gene-related peptide immunoreactive nerves in immediately replanted rat molars. First maxillary right molars in 56 rats(35days old) were extracted and immediately replanted. The rats were killed 1, 2, 3, 7, 14, 28 and 42 days after replantation and revascularization of pulpal blood vessels were examined microangiogram with korean traditional ink and reinnervation of pulpal nerve were examined immunohistochemical method using calcitonin gene-related peptide(CGRP) antiserum. The results were as follows; 1. Revascularization and reinnervation of CGRP immunoreactive nerve fibers were observed mesial side whole pulp tissue of replanted teeth. Revascularization and reinnervation of CGRP immunoreactive fiber were made at 2days after replantation in entire pulp of replanted teeth and the distribution density of blood vessels were gradually increased according time elapsed, but did not achieve the density of control. 2. Postoperative dentin formation in replanted teeth revealed at 1 week after replantaton and gradually increased according to time elapsed. 3. Revascularization and Reinnervation of CGRP immunoreactive nerve fibers were established at the same time and it seems to be closed relatationship between revascularization and reinnervation.
This study has been undertaken to see the variation of the weight loss, dyeing property, and the tensile strength of the polyethylene terephthalate (PET) fabrics under the influence of the heat setting during the finishing of the fabrics. The fabrics were heat set for 40,80 and 120 seconds, then alkali treated with 5%, caustic soda solution for 40 minutes on temperature of 80℃, and then dyed with blue and red disperse for 30 minutes of the temperature of 130℃, Using these treated materials, color differences and tensile strength were measured. The results were as follows; 1. The weight loss of PET fabrics increased as the heat setting temperature was elevated. 2. weight loss of PET fabrics decreased as heat setting time increased on the temperature over 220℃ 3. The dyeing property of PET fabrics became stable on the temperature below 180℃ not influenced by heat setting time. 4. The tensile strength decreased as the weight loss increased. Consequently, the temperature influences greatly on the weight loss and the dyeing property during the finishing of PET fabrics.
The purpose of this study was to investigate the distribution of CGRP immunoreactive nerve fibers in rat squamosomandibular joint with postnatal development. Squamosomandibular joint with adjacent tissue of 8 groups of rats(1,5,10,15,20,25,35-postnatal day and adult groups) were removed en bloc and processed for immunohistochemistry and were subjected to light microscopic examination. The results obtained were as follows; 1. The anterior portion of the articular disk was most densely innervated, followed by the posterior, lateral, and medial portions in each group. 2. Increase of CGRP immunoreactive nerve fibers was evident in 10,15,20 postnatal day groups. 3. Almost no CGRP immunoreactive nerve fibers were observed in articular surface of disk proper, mandibular fossa and condyle head of each group. These result suggest that CGRP immunoreactive nerve fibers increased in synovial membrane and peripheral portion of articular disk during 10-20 postnatal day may play a important role in squamosomandibular joint function after weaning period.
In a recent industry development, the area and the length of the inclined plane are have been increased. It is needed to make use of mountain and inclination area as the site of structures because the use rate of these areas is enlarged by the large constructions. Therefore, in this study, some model experiments were performed to check the characteristics of the uplift capacity of inclined plate anchors which were embedded in the model of sloped air - dried sandy ground. The results of the uplift experiment are as follows : 1. The failure occurring in the shallow plate anchor which was embedded in sloped ground was local shear failure. The Peak point of displacement curve increased as the embedment ratio increased. 2. The ultimate uplift capacity was increased as the inclination angle and the embedment ratio of an anchor increased. It was much more influenced by the embedment ratio than by the inclination angle. 3. It was showed that the increasing ratio (K) of the ultimate uplift capacity was about 0.11 according to the inclination angle and embedment ratio of an anchor. 4. It was showed that the increasing ratio of the ultimate uplift capacity was changed linearly according to the inclination angle and embedment ratio of an anchor. 5. It was showed that the ultimate uplift capacity of an anchor was much more influenced the small of embedment ratio more than large one.
이 논문은 MOSFET로 구성된 등가 Half-bridge형 고주파공진형 인버어터에 대해 기술하고 있다. 시분할 방식에 의한 게이트회로를 구성하여 구동함으로써 출력단에는 두개의 인버어터에서 동작되는 순시위상이 합성되어 있어 나타나므로 부하단 출력주파수는 소자의 수위칭주파수에 대해 두배가 되고 수위칭 손실이 경감되어 소자의 평균전류가 증가한다. This paper proposes a high frequency resonant inverter consisting of equivalent half bridge model using MOSFET. In this paper time-sharing control method is applied. as a result the output frequency is two times as high as switching frequency of device and average current of device is increased because of decreasing switching loss.