급성 골수성 백혈병 환자에서 발생한 침습성 아스페르길루스중에 대한 수술적치료 1 예

배영환;어원식;어상민;김승만 김태영;박수영;서영경;정은주;안효정 인제대학교 2011 仁濟醫學 Vol.32 No.-

Invasive pulmonary aspergillosis is known to have a poor prognosis and major cause of morbidity and motality in patients with hematologic disease. Without adequate therapy, invasive pulmonary aspergillosis will almost always progress to fatal pneumonia. Early administration of antifungal agents in patient with invasive pulmonary aspergillosis is most important. And surgical resection of aspergillous-infected tissue may be useful in patients with lesions that are contiguous with great vessel and lesions causing hemoptysis. We reported a rare case of surgical resection as curative treatment for invasive pulmonary aspergillosis patient in 58-year-old man who had the history of acute myeloid leukemia.

장기간 항갑상선제 투여 후 임의 중단 뒤 재복용시 발생한 무과립구증 1 예

김승만;김태영;박수영;배영환;서영경 정은주;김태균;권민정;박정현;이순희 인제대학교 2011 仁濟醫學 Vol.32 No.-

Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.

Preparation of new natural silk non-woven fabrics by using adhesion characteristics of sericin and their characterization

Lee, Ji Hye,Bae, Yeon Su,Kim, Su Jin,Song, Dae Woong,Park, Young Hwan,Bae, Do Gyu,Choi, Jin Hyun,Um, In Chul ELSEVIER 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.106 No.-

<P><B>Abstract</B></P> <P>Electro-spun regenerated silk webs have been extensively studied for biomedical applications because of the simplicity of their fabrication methods However, the productivity of the electro-spinning process is low for web fabrication and the mechanical properties of the electro-spun silk web are not satisfactory, which restricts its commercialization. In this study, a new silk non-woven fabric was successfully fabricated by wetting and hot press treatments using the excellent binding characteristic of sericin. The effects of the press temperature and residual sericin content on the preparation, structure, and properties of the silk non-woven fabric were examined. A press temperature of 200°C was optimum for obtaining non-woven fabrics with best mechanical properties, without yellowing. The silk non-woven fabric could not be fabricated without sericin, and a minimum of 8% sericin was required to fabricate it. As the sericin content was increased, the strength and Young’s modulus of the silk non-woven fabric increased, while the tensile elongation remained constant. Regardless of the press temperature and sericin content, all the silk non-woven fabrics showed good cell viability, comparable to that of the tissue culture plate (TCP) used as a control until 4days, which however decreased compared to that of TCP after 7days.</P>

연령대별 요추 추간판탈출증 환자의 요근과 척추주위근 단면적에 대한 분석

공덕현 ( Deok Hyun Kong ),배광호 ( Kwang Ho Bae ),고호연 ( Ho Yeon Go ),강명진 ( Myung Jin Kang ),김준수 ( Jun Su Kim ),양기영 ( Kee Young Yang ),이재훈 ( Jae Hoon Lee ),은영준 ( Young Jun Eun ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :This study was designed to evaluate the correlation of the cross-sectional areas(CSA) of paraspinalis(iliocostalis lumborum, multifidus, longissimus thoracis parts lumborum) and psoas muscle and sex, age, change of the VAS(visual analogue scale) and past history of chronic low back pain in patients suffering from HIVD(herniation of intervertebral disc). Methods :Medical records of 140 subjects with HIVD were retrospectively reviewed. The MRI(magnetic resonance imaging) findings on the patients were scanned and analyzed by PiView program to find the paraspinal and psoas muscle CSA and were evaluated by the correlation of sex, age, change of the VAS, and past history of chronic low back pain. Results :There was significant difference between groups in male and female, young-adults age and middle age, middle age and old age, young-adults age and old age. But the correlation of the paraspinal and psoas muscle CSA and past history of chronic low back pain were partially significant. On the other hand, the correlation of the paraspinal and psoas muscle CSA and change of the VAS were not significant. Conclusions :These results suggest that the cross-sectional areas(CSA) of paraspinalis and psoas muscle have relevance to sex and age.

CART를 이용한 분류

배상현,손영수 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.2

Recently, nonparametric methods of curve estimation have become useful technique in applied statistics. Among the methods, nonparametric regression using various splines have been focused due to its flexibility. In this paper, we develop a classifier in classification problem using CART. Also, various classification methods are compared with the proposed method.

족관절 삼과골절에서 후과골절편이 외상후 관절통증에 미치는 영향

배서영,신동훈 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 족관절 삼과골절에서 후과 골절편의 정복과 고정 여부에 관하여는 논란이 있으나 골절편의 크기가 관절면의 25~30% 이상을 차지하는 경우 고정이 필요하다는 주장이 일반적으로 받아들여지고 있다. 저자들은 후과 골절편의 크기 및 고정 여부가 실제로 임상결과에 영향을 주는 가장 중요한 인자인지 알아보고자 하였다. 대상 및 방법 : 본원에서 동반손상이 없는 족근관절 삼과골절로 치료받았으면서 내과 및 외과의 해부학적 정복이 이루어진 73명중 2년 이상 추시 가능하였던 30명을 대상으로 하였다. 수상 직후와 정복 직후의 측면사진에서 후과 골절편의 크기를 관절면을 차지하는 정도(%)로 측정하고 정복 직후 사진에서 잔존하는 전위 정도를 골편 간극과 관절면의 층짐으로 나누어 측정하였다. 또한 의무기록의 조사를 통해 후과의 고정 여부, 관절운동의 시작시기, 체중부하 시작시기를 조사하였다. 임상 결과는 AOFAS(American Orthopaedic Foot and Ankle Society)의 기준에 따라 통증, 기능, 정렬에 대해 점수를 매기고 추시상 관절의 통증이 남은 군과 통증이 없는 군으로 나누어 각 인자들 중 어떤 인자에 의해 좌우되는지 로지스틱 회귀분석과 Chi-square교차분석을 통해 유의수준 5%로 알아보았다. AOFAS 점수 중 기능이나 정렬 면에서는 차이가 없었으며 관절 불안정을 보이는 경우도 없었으며 운동범위의 제한을 보이는 경우가 1예 있었다. 관절통을 호소하는 군은 7명, 통증이 없는 군은 23명이었고 두 군간에 잔존하는 골절편의 간극과 관절면의 층짐 정도는 유의한 인자였으나 골편의 크기나 고정여부, 관절운동 시작시기, 체중부하 시작시기 등에서는 유의성을 검증할 수 없었다. 결 론 : 삼과골절에서 후과 골절편은 크기나 고정 여부보다도 정복 후 골절편의 간극이나 층짐이 임상결과, 특히 관절통증에 더 영향을 미치므로 고정 여부에 상관없이 정복후 정복 상태에 대한 정확한 평가가 필요하고 골편의 크기에 상관없이 해부학적 정복이 필요할 것으로 사료된다. 또한 후과의 부정위는 내외 양과의 골절이 해부학적으로 정복된다면 족관절 기능이나 불안정보다는 통증을 유발하는 것으로 사료된다. Purpose : There are some criticisms of indication for internal fixation of the posterior malleolar fragments in trimalleolar fractures. We tried to find out clinical and radiologic factors which affect on a clinical outcome of triballerolar fractures. Materials and Methods : Thirty three patients who were treated for trimalleolar fractures and given anatomical reduction of lateral and medial malleolus were included. We divided patients into two groups, a group without the pain and the other group with the pain. Preoperative and postoperative lateral plain radiographic films were used to estimate fragment size, post-reduction gap and step off. By reviewing the medical records, other factors such as the time of ankle motion, weight loading and whether posterior malleolus was fixed. Or not were studied. A clinical outcome was evaluated by ASFAS(American Orthopaedic Foot and Ankle Society) scaling system. We performed statistical analysis using Logistic regression analysis and Chi-square test on each factors. Results : There was no definite difference between two groups on the functional outcome. There was one case showing limited ankle motion. Seven patients were involved in the group with the pain and 23 in the group without the pain. The remnant fracture gap and step off of joint surface statistically showed the meaningful corellation with the pain but a fragment size and a surgical fixation, time of motion and weight loading did not show any significances. Conclusion : We doubt the significance of the size of posterior malleolar fragment. We concluded that anatomical reduction of posterior malleolus is the most significant factor of a clinical outcome regardless of the size or internal fixation, especially the pain after trimalleolar injuries.

증권분석 전문가시스템에서 전향추론에 관한 설계

배상현,손영수 조선대학교 기초과학연구소 1993 自然科學硏究 Vol.16 No.1

The Expert system is a field of the artificial intellegence which enables the problem of a special territory to be solve by using model imitating an expert, that is, The Expert system is the computer system which infers a problem by using the knowledge base made up by means of inputting the knowledge of an expert. This paper designs the process of inference using forward chaining method, which to Pick up the knowledge data from knowledge base of stock analysis system.

광중합형 복합레진 제조시의 압축강도에 관한 실험적 연구

배태성,추용호,채민수 大韓齒科器材學會 1995 대한치과재료학회지 Vol.22 No.2

This study was performed to elaluate the effect of matrix resins and fillers on the compressive strength of light-activated composite resins. Four different types of composites were made by mixing the inorganic fillers of armorphous spherical silica and crushed quartz with resins of BisGMA/TEGDMA and UTeMA/TEGDMA. The specimens of 3mm in diameter and 6mm in length were prepared. Compressive test was subjected to a crosshead speed of 0.5mm/min and fracture surfaces were examined by SEM. The results obtained were summarized as follows; 1. Compressive strength of the UTeMA-based composite resin with spherical filler was superior to the other composite resins(p<0.01). 2. Compressive strength of the BisGMA-based composite resins with significantly decreased after immersion in water for 7 days(p<0.05). 3. UTeMA-based composite resins showed the aspect of decrease in compressive strength after cold storage at 5℃.

치수유래 구심성 신경섬유의 삼차신경 감각핵군에서의 연접특성

배용철,이은희,최민기,홍수형,김현정,남순현,김영진 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.2

일차연접부위에서 악안면 영역에서 유래하는 유해자극의 전달 및 처리기전을 이해하고자 horseradish pe개xidase를 치수지배 구심성 신경섬유를 표식한 후 연수후각에서 미세구조 및 연절 양상을 분석하여 다음과 같은 결과를 얻었다. 표식종말은 소수의 큰 치밀소포가 관찰되는 종말 (S형) 및 다수의 치밀소포를 함유하는 종말 (LDCV형)등 2종류로 분류할 수 있었다. S형 및 LDCV형 표식종말의 연접양식은 유사하였으며, 다수의 표식종말이 1개 혹은 2개의 neurofile과 연접을 이루어 대단히 단순한 연접양상을 보였다. 표식종말은 가지돌기체 보다는 다수의 가지돌기가시와 연접을 이루는 빈도가 높았다. 표식종말이 세포체 및 이에 인접한 근심부 가지돌기와 연접하는 경우는 드물었으며, 소수의 표식종말에서 p-ending과 연접하는 경우를 보였다. 표식종말의 체적, 표면적, 사립체의 체적, neurofile과 접하는 면적, 활성부위의 면적, 단위표식종말당 연접소포의 수 및 연접소포의 밀도등은 넓은 범위의 계측치를 나타내었으며, 이는 5명 및 LDCV형 표식종말 사이에 유의한 차이가 없었다. 이상의 결과로 미루어보아 연수후각에서 치수유래 구심성 신경섬유 종말의 연접양식은 고유의 특징을 보이며 이는 신경회로의 기능과 밀접한 상관관계를 가지는 것으로 판단되었다. Little is known about processing mechanism of pain sensation of the oral cavity at the 1st synapse of trigeminal sensory nuclei. Serial ultrathin sections of tooth pulp afferent terminals, identified by the transganglionic transport of 1% wheatgerm agglutinin conjugated horseradish peroxidase, were investigated wih electron microscope. Quantitative ultrastructural analysis was performed on digitizing tablet connected to Macintoshi personal computer (software: NIH Image 1.60, NIH, Bethesda, MD). Labeled boutons could be classified into two types by the shapes of containing vesicles : S bouton which contained mainly spherical vesicles (Dia. 45-55 nm) and few large dense cored vesicles (Dia. 80-120nm), and LDCV bouton, which contained spherical vesicles as well as large number of large dense coredd vesicles. Most of the parameters on the ultrastruotural characteristic and synaptic organization of labeled boutons were similar between S and LDCV boutons, except shapes of containing vesicles. Majority of the labeled boutons showed simple synaptic arrangement. The labeled bouton were frequency presynaptic to dendritic spine, and to a lesser extent, dendritic shaft. They rarely synapsed with soma and adjacent proximal dendrite. A small proportion of labeled boutons made synaptic contacts with presynaptic pleomorphic vesicless containing endings and synaptic triad. Morphometric parameters of labeled boutons including volume and surface area, total apposed area, mitochondrial volume, active zone area, vesicle number and density showed wide variation and theme were not significantly different between S and LDCV boutons. The present study revealed characteristic features on ultrastructure and synaptic connection of pulpal afferents which may involved in transmission of oral pain sensation.

슬라이딩 섹터에 근거한 제어기 설계

배상현,손영수,한종길 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.2

A sliding sector is defined as a subset the state space, inside which some norm of state decreases with zero control input. The variable structure controller with sliding sector is designed to transfer the system state from the outside to the inside of the sliding sector in a finite time and enable the system state stay inside the sliding sector, and the resulted VS control system is quadratically stable. The simulation results are its effectiveness.