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FC 1-13 : Expression of extracellular superoxide dismutase protein in diabetes
( Bum Joon Ko ),( Han Eul Lee ),( Gang Mo Lee ),( Je Min An ),( You In Bae ),( Sung Yul Lee ),( Moon Kyun Cho ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Diabetes is characterized by chronic hyperglycemia, which can increase reactive oxygen species (ROS) production by the mitochondrial electron transport chain. The formation of ROS induces oxidative stress and activates oxidative damage-inducing genes in cells. No research has been published on oxidative damage-related extracellular superoxide dismutase (EC-SOD) protein levels in human diabetic skin. We investigated the expression of EC-SOD in diabetic skin compared with normal skin tissue in vivo. Objectives: To compare the expression of EC-SOD in normal skin versus diabetic skin. Methods: The expression of EC-SOD protein was evaluated by western blotting in 6 diabetic skin tissue samples and 6 normal skin samples. Immunohistochemical staining was also carried out to confirm the EC-SOD expression level in the 6 diabetic skin tissue samples. Results: The western blotting showed significantly lower EC-SOD protein expression in the diabetic skin tissue than in the normal tissue. Immunohistochemical examination of EC-SOD protein expression supported the western blotting analysis. Conclusion: Diabetic skin tissues express a relatively small amount of EC-SOD protein and may not be protected against oxidative stress. We believe that EC-SOD is related to the altered metabolic state in diabetic skin, which elevates ROS production.
Bilateral Bipartite Carpal Scaphoid
Sang-Bum Kim(김상범),Woo-Sik Kim(김우식),Whan-Yong Chung(정환용),Taek-Soo Jeon(전택수),In-Tak Bae(배인탁) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.5
이분 주상골은 드문 기형이며 아직도 그 선천성 혹은 외상성의 논란의 여지는 있으나 대부분의 보고가 선천성의 가능성을 시사 하고 있다. 현재 까지 이분 주상골에 대한 국내 증례보고는 없었으며 이에 저자들은 38세 남자의 이분 주상골의 증례를 경험하였기에 문헌 고찰과 함께 보고하고자 한다. Bipartite scaphoid is a rare anomaly and it has been questioned as whether it is of congenital origin or traumatic. However, many authors have reported that congenital origin is more probable. There was no case report in Korea about bipartite scaphoid, but this article reports a case of a 38-year-old male with bilateral bipartite scaphoid.
Non-Lithographic Growth of Core–Shell GaAs Nanowires on Si for Optoelectronic Applications
Bae, Myung-Ho,Kim, Bum-Kyu,Ha, Dong-Han,Lee, Sang Jun,Sharma, Rahul,Choi, Kyoung Jin,Kim, Ju-Jin,Choi, Won Jun,Shin, Jae Cheol The American Chemical Society 2014 CRYSTAL GROWTH AND DESIGN Vol.14 No.4
<P>We demonstrated a nonlithographic method for integrating GaAs nanowire (NW) array-based light-emitting diodes (LEDs) on silicon (Si) substrates. A sub-100 nm hole array on a deposited SiO<SUB>2</SUB> layer was patterned on an entire 2 in. Si wafer based on a sacrificed self-assembled InAs NW array. Then, a core–shell <I>n</I>–<I>p</I> junction GaAs NW array was grown on exposed Si windows via the selective-area growth method. The electrical properties of the core–shell <I>n</I>–<I>p</I> junction GaAs NW has been measured and compared to those of the core–shell junction NWs formed via the self-assembled growth method. Room temperature electroluminescence was successfully observed from the fabricated GaAs NW array-based LEDs. The core–shell junction III–V NW array epitaxially grown on a ubiquitous Si platform could be applied to future low-cost optical devices.</P><P>We demonstrated a nonlithographic method for integrating GaAs nanowire (NW) array-based light-emitting diodes on Si. For the NW growth, a sub-100 nm SiO<SUB>2</SUB> hole was patterned on a Si wafer based on a sacrificed self-assembled InAs NW array. Then, a core−shell <I>n</I>−<I>p</I> junction GaAs NW array was grown on exposed Si windows via the selective-area growth method.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cgdefu/2014/cgdefu.2014.14.issue-4/cg401520q/production/images/medium/cg-2013-01520q_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cg401520q'>ACS Electronic Supporting Info</A></P>
A Study on Wavelet-based Denoising Algorithm for Signal Reconstruction in Mixed Noise Environments
Bae, Sang-Bum,Kim, Nam-Ho The Korea Institute of Information and Commucation 2007 Journal of information and communication convergen Vol.5 No.1
In the process of the acquisition, storage, transmission of signals, noises are generated by various causes and the degradation phenomenon by noises tends to generate serious errors for the signal with information. So, in order to analyze and remove these noises, studies on numerous mathematical methods such as the Fourier transform have been implemented. And recently there have been many ongoing wavelet-based denoising algorithms representing excellent characteristics in time-frequency localization and multiresolution analysis, but the method to remove additive white Gaussian noise (AWGN) and the impulse noise simultaneously was not given. So, to reconstruct the corrupted signal by noises, in this paper a novel wavelet-based denoising algorithm was proposed and using signal-to-noise ratio (SNR) this method was compared to conventional methods.
A Phase 1 Study Using Autologous Natural Killer Cells in Patients with HAIC-Hepatocellular Carcinoma
( Sung Bum Cho ),( Chung Hwan Jun ),( Sung Kyu Choi ),( Woo Kyun Bae ),( Je Jung Lee ),( Yang Jun Kang ),( Cheol Kyun Cho ),( Yang Seok Ko ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Natural killer (NK) cell-based immunotherapy has recently been tried with advances of understanding the role of immune defense against hepatocellular carcinoma (HCC). To improve NK cells therapy, we focused to increasing delivery of NK cells and synergic effect combined with hepatic arterial infusion chemotherapy (HAIC). Methods: We did a prospective, open label, phase 1 trial of the safety and efficacy of autologous NK cells through hepatic arterial infusion as sequential therapy after HAIC in advanced HCC patients. Between March 2016 and July 2017, 11 patients were included who showed favorable response more than stable disease (SD) after 2 sessions of HAIC in advanced HCC patients with child A. A total 4 sessions of HAIC were performed the protocols of infusion of cisplatin (25/m2) and 5-fluorouracil (750/m<sup>2</sup>) for 4 days every 3-4 weeks interval. The peripheral blood mononuclear cells of patients by leukapheresis were ob-tained after 3<sup>rd</sup> HAIC and NK cells were expanded for 2 weeks under Current Good Manufacturing Practices (cGMP). Patients received planned dosage of NK cells through chemoport into hepatic artery for 5 days after 4<sup>th</sup> HAIC (3 patients; 2.5x108, 3 patients; 5x10<sup>8</sup>, 5 patients; injection of 10x10<sup>8</sup> NK cells). The primary end point was safety of NK cell injection; secondary endpoint included objective response rate (modified Response Evaluation Criteria In Solid Tumors), time to progression, dura-tion of response and immunologic efficacy. Results: Any adverse events of NK cells injection were none according to dosage. An objective response was observed in 7 patients (63.6%) included three complete responses and four partial responses. Stable disease was observed in 2 patients and progressive disease was in 2 patients and thus disease control rate was 81.8%. The mean duration of time to progression was 9.7±5.3 month and duration of response without chemotherapy was 6.1±5.2 month. The newly metastatic lesion was occurred in 3 patents (27.2%; lymph node 1 patients, Lung 2 patients). Two patients were died by tumor progression and others were still alive. The increasing immunologic response was observed in 5 patients (55 %) to evaluate cytotoxicity and NK cell proportion of peripheral mononuclear cells after NK cell injection. Conclusions: The HAIC and NK cells immunotherapy is safe and effective treatment in the advance HCC patient with favorable liver function. The additional studies are urgently required to establish the new novel treatment.
Cytomegalovirus Induced Interstitial Nephritis and Ureteral Stenosis in Renal Transplant Recipient
Bae, Sung Ha,Chung, Byung Ha,Park, Yun Kyung,Jo, Kwanhoon,Yang, Chul Woo,Kim, Yong-Soo,Choi, Bum Soon The Korean Association of Internal Medicine 2012 The Korean Journal of Internal Medicine Vol.27 No.4
A case of malignant otitis externa caused by Candida glabrata in a patient receiving haemodialysis
Bae, Woo Kyun,Lee, Kyun Sang,Park, Jeong Woo,Bae, Eun Hui,Kwon, Seong,Kim, Nam Ho,Choi, Ki Chul,Shin, Jong Hee,Cho, Hyong Ho,Cho, Yong Bum,Kim, Soo Wan Informa Healthcare 2007 Scandinavian journal of infectious diseases Vol.39 No.4
<P> A 74-y-old male receiving haemodialysis presented with right-sided otalgia, otorrhoea and diffuse swelling on the right external auditory canal. Following an initial successful treatment with prolonged intravenous antibiotics, the patient relapsed with a secondary infection in the same site due to Candida glabrata. We report an unusual case of malignant otitis externa caused by the fungus C. glabrata.</P>
Sang Gon Kim,Seonghyu Shin,Hwan Hee Bae,Jin-Seok Lee,Jung-Tae Kim,Min Jung Seo,Beom-Young Son,Jeom Ho Lee,Seong-Bum Baek 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Understanding the response of a crop to water deficiency is the first step towards breeding drought-tolerant varieties. In this study, inbred maize (Zea mays L.) lines KS140 and KS141 were subjected to drought stress by withholding water for 10 days at the V5 or V6 leaf stage. Water-deficient plants experienced a decrease in relative leaf water content, stomatal conductance, net CO2 assimilation rate, and water use efficiency compared to well-watered plants. This was accompanied by a decrease in the relative leaf water content that resulted in severe growth retardation in KS140 and KS141. However, leaf chlorophyll content in KS140 was unchanged. To understand the proteome dynamics during the 10-day drought stress in maize leaves, comparative proteome analysis was carried out between the well-watered and water-withheld leaves. Differential expression was observed for 29 protein spots from KS140 and 14 protein spots from KS141, and these were identified using MALDI-TOF mass spectrometry. Among identified proteins, metabolism and stress related proteins were highly were increased by drought stress. This study provides a protein profile of a Korean maize inbred line during drought stress, which will be valuable for future studies of the molecular mechanisms underlying drought resistance and for development of selective breeding markers for drought tolerance in maize.