人蔘의 配合에 따른 數種 韓藥材의 抗酸化作用에 關한 硏究 (Ⅱ)

朴時興,康秉秀,朴涌基 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2

This study was carried out in order to investigate the anti-oxidant effect of main tonic medicine, Ginseng Radix with combination of other well-known herb medicines such as Rehmammiae Radix Preparat, Astragali, Poria, Aconiti lateralis Preparata Radix, Gecko and Bupleuri Radix. These herbs were mixed with Ginseng Radix to measure inhibitory activity lipid peroxidation of linoleic acid mixture and rat liver and hydrogen-giving-temper effect by DPPH. The study showed the following valuable results. 1. In inhibitory activity of water extract against lipid peroxidation of linoleic acid mixture, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity. Ginseng Radix -Rehmammiae Radix Preparat compound herbal medicine showed the lowest anti-oxidant activity when compared with the examined samples. 2. In inhibitory activity of water extract against lipid peroxidation of rat liver, Ginseng Radix-Gecko showed the highest anti-oxidant activity. Ginseng Radix-Rehmammiae Radix Preparat showed the lowest anti-oxidant activity. 3. In hydrogen-giving-temper effect of water extract by DPPH, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity. 4. In the linoleic acid mixture, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity in Butanol fraction. 5. In the lipid peroxidation of rat liver, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity in Butanol fraction. 6. In hydrogen-giving-temper effect of water extract by DPPH, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity in Butanol fraction. From the above results, it was concluded as follows. All the six compound herbal medicine including Ginseng Radix showed the anti-oxidant activity. Especially, Ginseng Radix-Gecko compound herbal medicine showed the highest anti-oxidant activity among them.

국내에서 생산 판매되는 담배 각초에 존재하는 보습제 함량 비교

박병주,임흥빈,이학수 충북대학교 연초연구소 2006 煙草硏究 Vol.20 No.-

This study was carried out to compare humectant contents existed in tobacco shred from 69 cigarette brands being on sale in Korea. Humectant in tobacco shred were extracted by AOAC official method and analysed by gas chromatography. Mean value of glycerol, propylene glycol, and triethylene glycol contents from 69 cigarette brands were 13.6 ± 4.5 mg/g, 6.5 ± 2.6 mg/g, and 0.8 ± 0.2 mg/g, respectively. Humectant contents existed in tobacco shred of cigarette brands manufactured by small tobacco companies were relatively lower than that of the other four major tobacco companies in Korea. These results indicates that humectant contents in tobacco shred from cigarette have to determine periodically in order to give a basic information for quality evaluation of cigarette smoke in connection with smoking and healths, because it plays an important role the formation toxic cigarette smoke components. 본 실험은 국내에서 시판되고 있는 69종의 궐련담배 각초를 재료로 하여 실시하였다. 궐련담배 각초에 함유되어 있는 보습제의 함량을 측정하고 궐련담배 주류연의 tar 및 nicotine 함량을 측정하여 비교분석한 결과는 다음과 같다. 1. 국내에서 시판되는 귈련담배 각초 보습제 성분의 평균함량은 glycerol 13.6±4.5 mg/g, propylene glycol 6.5±2.6 mg/g, triethylene glycol 0.8±0.2 mg/g이었다. 2. 군소업체 귈련담배 각초에 존재하는 보습제 함량은 대규모업체에 비해 상대적으로 매우 낮은 수준을 유지하고 있었다

人蔘의 配合에 따른 抗酸化作用에 關한 硏究 (1) : 人蔘과 配合하는 數種 韓藥制의 抗酸化 作用에 對한 比較 硏究 Study on comparative anti - oxidative effects of some herbal medicine frequently combined with Ginseng Radix

朴時興,康秉秀,朴涌基 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

This study was carried out in order to investigate the anti-oxidative effects of main tonic herb medicine, Ginseng Radix, Rehmammiae Radix Preparat, Astragali Radix, Poria, Aconiti Iateralis Preparata Radix, Gecko and Bupleuri Radix. These herbs were measured on inhibitory activity against lipid peroxidation of linoleic acid mixture and rat liver and hydrogen-giving-temper effect by DPPH. The study showed the following valuable results: 1. In inhibitory activity of water extract against lipid peroxidation of linoleic acid mixture, Gecko showed the highest anti-oxidant activity among the some herbal medicine and Rehmammiae Radix Preparat showed the lowest anti-oxidant activity when compared with the examined samples. 2. In inhibitory activity of water extract against lipid peroxidation of rat liver, Gecko showed the highest anti-oxidant activity among the some herbal medicine and Rehmammiae Radix Preparat showed the lowest anti-oxidant activity. 3. In hydrogen-giving-temper effect of water extract by DPPH, Gecko showed the highest anti-oxidant activity. 4. In the linoleic acid mixture, Gecko showed the highest anti-oxidant activity in Butanol fraction. 5. In the lipid peroxidation of rat liver, Gecko showed the highest anti-oxidant activity in Butanol fraction. 6. In hydrogen-giving-temper effect of water extract by DPPH, Gecko showed the highest anti-oxidant activity in Butanol fraction. From the above results, it was concluded as follow: All the seven herb medicine including Ginseng Radix showed the anti-oxidant activity. Especially, Gecko showed the highest anti-oxidantactivity among them.

半夏厚朴湯을 투여하여 흉막삼출액이 소실된 환자 : 1례 1 Case

박병욱,이은,고흥 世明대학교 한의학연구소 2002 韓醫學硏究所 論文集 Vol.4 No.-

We treated a 78 year-old male patient with loculated pleural effusion. The patient complained of cough, sputum and throat discomfort. We diagnosed him as Globus hystericus (梅核氣) and gave Banhahoobak-tang three times a day. After treatment, all the main symptoms were disappeared and pleural effusion was absorbed. Therefore, we suggested that Banhahoobak-tang had a effect on the pleural effusion.

생리적 및 염증성 유치 치근 흡수면의 미세구조

박윤희,손흥규,최병재 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.4

유치 치근 흡수가 일어나는 경우는 임상에서 많이 접할 수 있다. 유치 치근 흡수는 나이에 따른 생리적 흡수와 치아우식증 및 외상 등으로 비정상적으로 흡수되는 염증성 흡수로 나눌 수 있다. 염증성 흡수는 그 시기와 양상이 생리적인 치근 흡수와는 다르며, 흡수기전이나 흡수면의 미세구조에 있어서도 많은 차이가 있을 것으로 사료된다. 유치 치근 흡수면의 미세구조에 대한 연구는 많이 있었으나, 생리적 흡수면과 염증성 흡수면의 미세구조를 비교한 연구는 드물다. 본 연구는 생리적 흡수면과 염증성 흡수면의 형태 및 인접한 세포를 연구하기 위하여 생리적 및 염증성 흡수로 인해 발거된 유치 치근의 흡수 표면을 주사전자현미경상으로, 조직학적 형태를 광학현미경상으로 관찰하여 다음과 같은 차이점을 알 수 있었다. 1.주사전자현미경상에서 생리적 유치 치근 흡수 표면은 타원형, 원형 및 다각형 모양의 흡수소와가 관찰되었고, 염증성 흡수 표면은 크기가 작으며 형태가 다양하고 매우 불규칙한 무정형 형태의 흡수소와가 관찰되었다. 2.광학현미경상에서 생리적 유치 치근 흡수면은 흡수소와로 구성된 규칙적인 큰 흡수와가 관찰되었고, 염증성 흡수면은 불규칙한 흡수소와가 관찰되었다. 3.광학현미경상에서 생리적 유치 치근 흡수면에는 다핵거대세포가 흡수소와에 직접 접하고 있었으며, 염증성 흡수면은 간엽세포 및 염증세포가 많이 관찰되었다. 4.광학현미경상에서 염증성 치근 흡수면에서는 상아질 흡수를 보상하는 부분적인 백악질 형성이 관찰되었다. Deciduous teeth can be extracted for two reasons, one due to the physiologic resorption and the other by the inflammation at the apex after traumatic injury. Physiologic resorption may be different from pathologic resorption in timing and mechanism. Therefore we resumed the different features of physiologic and pathologic resorption root surfaces. Many previous studies showed micromorphology of resorbed surface of roots of deciduous teeth. But, few studies compared physiological and pathological root resorption surfaces. In this study, we carefully observed microscopic morphologies of those two different root surfaces by scanning electron microscope and histologic features by light microscope. The resultant differences between physiologic and pathologic resorption surfaces of deciduous teeth were as follows: 1. The morphology of pathologic resorption lacunae due to inflammation varied in size and shape with irregular boundaries compared with the physiologic areas from scanning electron microscope observations. 2. From light microscope observations, several large resorption fossae containing numerous resorption lacunae were found, whereas the resorption lacunae were irregular in shape with pathologic resorption surface. 3. Numerous multinucleated giant cells were closely attached to the physiologic resorption lacunae, whereas several kinds of mesenchymal cells with numerous inflammatory cells were found in the areas adjacent to the pathologic resorption surface. 4. Light microscope findings showed that compensating cementum formation took place along some of the areas of inflammatory dentinal resorption. In conclusion, several morphological differences were between physiologic and pathologic root resorption surfaces of human deciduous teeth. The future studies should include cytochemisty to clarify the cellular roles in resorption process observations of pulpal surfaces of coronal and radicular dentin to find the changes that occur in each phase of human deciduous tooth resorption.

부적절하게 수복된 stainless steel crown에 의해 야기된 하악 제1대구치 이소맹출 치험례

박주석,손흥규,최병재 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

이소맹출이란 영구치열의 발육 과정 중에 국소적 맹출장애로 인하여 정상적 위치에서 벗어난 치아의 맹출을 말한다. 일반적으로 이소맹출은 2∼6% 정도의 이환율을 보이고, 제1대구치에서 호발하며 주로 상악에서 많이 나타나고 하악에서는 드물다. 이소맹출의 원인은 국소적 원인으로 부적절한 치열궁 길이. 상악 후방부의 성장 부족, 제1대구치의 근심 맹출, 비정상적으로 큰 제1대구치 등이 있고, 유전적인 원인으로 나타날 수도 있으며, 부적절하게 형성된 stainless steel crown에 의해서도 유발될 수 있다. 이소맹출된 치아 중 66%는 가역성이므로 3∼6개월 정도의 관찰 기간이 요구된다고 하였으며, 비가역성 이소맹출인 경우에는 brass wire 나 elastic separator를 이용한 비교적 간단한 치료 방법, 제2유구치의 distal discing, Humphrey appliance 등과 같이 제2유규치를 유지하면서 치료하는 방법 및 제2유구치 발거 후 가철식 장치나 cervical traction headgear를 이용하는 방법 등이 소개되고 있다. 본 증례는 연세대하교 치과대학병원 소아치과에 내원한 7세된 남환아로 구강 검사 및 방사선 검사 결과, 4년전 개인 치과의원에서 수복된 우측 하악 제2유구의 stainless steel crown을 제거하고, Humphrey appliance를 제작하여 장착하였으며, 약 10주 후에 고착 상태가 해소되었다. 본 증례에서와 같이 이소맹출은 부적절하게 형성된 stainless steel crown에 의해 일어날 수 있으므로, stainless steel crown의 수복 치료에 있어서, 적절한 크기의 선택, trimming 및 contouring 등이 매우 중요하다. Ectopic eruption is out of a normal position by local eruption disturbance in the developing permanent molar. The prevalence of ectopic eruption is reported to be the between 2 and 6%, most often associated maxillary first permanent molar, whereas, the occurrence for the mandibular is quite rare. The etiologic factors of ectopic eruption are inadequate arch length, lack of growth in the posterior region of the jaw, mesially inclined eruption path of first permanent molars, abnormally large first permanent molars, hereditary factor and a stainless steel crown which has been improperly restored. Ectopic eruption can be treated by the use of brass wire, separating elastics, distal disking and Humphrey appliance and the use of removable appliance and cervical traction headgear after extraction of the second primary molar. This case was that lower right first permanent molar was mesially tilted state by locking on the stainless steel crown of a lower right second primary molar. The stainless steel crown was removed and Humphrey appliance was set. Like this case, ectopic eruption could be happened by the stainless steel crown which improperly restored. In restoration of the stainless steel crown, selection of proper size, trimming and contouring are very important.

기능성 식품으로의 활용을 위한 한약자원에 관한 연구 : (Ⅱ) 인진쑥 열수 추출물이 혈관과 국소뇌혈류량에 미치는 영향 및 추출물을 이용한 건강음료의 개발 (Ⅱ) Effects of Hot Water Extracts from Artemisia capillarisin on Vessel and Regional Cerebral Blood Flow and Development of Health Drink

박성혜,임흥렬,안병용,한종현 동아시아식생활학회 2003 동아시아식생활학회지 Vol.13 No.6

As an attempt to develop new functional health beverage by using medicinal herb, Artemisia capillaris, we investigated the effect of scopoletin in Artemisia capillaris on vessel and regional cerebral blood flow (rCBF) of rats ingesting health drink prepared with Artemisia capillaris extracts and various ingredients. Artemisia capillaris extract decreased the vessel contraction and increased rCBF significantly. The extracts were grouped by heat temperature and mixed ratio and tested their respective characteristics. Then each condition was combined and produced the most effective one. The drink produced consisted of Artemisia capillaris extract 42%, honey 9.8%, citric acid 0.035%,cyclodextrin 1.47% and water. Brix, pH and acidity of the product were 9.2, 4.4 and 0.04%, respectively. This drink scored to have highest level on overall acceptance by the sensory evaluation. The above results showed that development of such functional beverage using Artemisia capillaris can be used as a functional material improving blood circulation in beverage industry.

작업장 특성에 따른 톨루엔 노출 근로자의 마뇨산 배출 특성

박흥재,김형준,정성욱,이병호 한국환경과학회 2005 한국환경과학회지 Vol.14 No.2

This study was carried out to investigate the correlation between toluene in air and hippuric acid in human urine, which is based in the results of the health check-in and measure of working environment, was investigated for five years. Toluene in air and hippuric acid in urine were checked 116 workers who exposed to toluene in five type of industry. The Mean concentration of toluene in air by type of industry and every year and sex distinction, had positive correlation.(p<0.01) The Mean concentration of hippuric acid in urine by type of industry, every year, sex distinction, disparity of age and term of duty had positive correlation.(p<0.01)

마멸입자 형태해석에 의한 유압피스톤용 모터의 상태감시

문병주,조연상,박흥식,전태옥 韓國工作機械學會 2000 한국생산제조학회지 Vol.9 No.6

Morphological analysis of wear particles is one of useful methods for machine condition monitoring because it is well reflected in machine driving state. This paper was undertaken to apply to the condition monitoring of hydraulic piston motor. The lubricating wear test was performed under different experimental conditions using the wear test device and wear specimens of the pin on disk type was rubbed in paraffinic base oil by three kinds of lubricating materials, varying applied load, sliding distance. The four shape parameters (50% volumetric diameter, aspect, roundness and reflectivity) arc used for morphological analysis of wear particles. The results showed that the four shape parameters of wear particles depend on a kind of the lubricating materials. It was capable of calculating presumed wear volume for three kinds of mate-rials on driving time to foresee a damage condition of lubricating materials.

FET형 반도체 마이크로센서 개발(Ⅲ)

손병기,이흥락,박이순,조진호,이성필,최평,서화일,박재윤,송경은,김창수 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

현재 의료진단, 화학공정의 모니터링이나 환경공학적 감시 및 제어 등의 분야에서 사용되고 있는 기존의 센서는 고가이며 용적이 클 뿐만 아니라 분석시간이 길고 사용하기 까다로운 것 등 여러 가지 문제점이 있다. 또한 측정환경에 영향을 주지 않을 만큼 충분히 작으며 빠른 분석시간을 가진 센서를 필요로 하고 있다. 본 연구에서는 기존의 센서들의 난점을 극복할 수 있는 새로운 형태의 FET형 전해질(electrolyte : H^+, K^+, Ca^2+, Na^+)센서소자 및 분석 시스템, 용존가스(O_2, CO_2)센서의 개발을 중점적으로 추진하였으며, FET형 압력센서, 습도센서 둥의 개별 FET형 센서에 관한 기초연구도 병행하였다. The conventional sensors have many problems such as high cost, large dimension, long analysis time and troublesome handling to apply to the fields of medical diagnosis, monitoring of chemical process and environmental monitoring/control. The main objects of this research are to develope a new FET type electrolyte(H^+, K^+, Ca^2+, Na^+)sensors, analysis system, and dissoved gas(O_2, CO_2)senors that can overcome the problems of the conventional sensors, and parallel basic researches on FET. type sensors such as pressure and humidity are also in progress.