Hypohidrotic Ectodermal Dysplasia Associated with Glucose-6-Phosphate Dehydrogenase Deficiency

Aylin Türel Ermertcan,Ali Yaşar,Tuba Çelebİ Kayhan,Hüseyin Gülen,Pelin Ertan 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-

Hypohidrotic ectodermal dysplasia (HED) is a syndrome characterized by hypodontia, hypotrichosis, and partial or total ecrine sweat gland deficiency. The most prevalent form of HED is inherited as an X linked pattern. Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is an X-linked recessive disease, which leads to hemolytic anemia and jaundice. It is expressed in males, while heterozygous females are usually clinically normal. A 12-year-old boy with the complaints of hair and eyebrow disturbances, teeth disfigurement, decreased sweating, and xerosis presented to the outpatient clinic. Dermatological examination revealed sparse hair and eyebrows, conical- shaped teeth, xerosis,syndactylia, transverse grooves, and discoloration of nails. Laboratory findings indicated anemia. His 3-year-old sister also had sparse hair and eyebrows, xerosis, and syndactylia. We learned that the patient had a previous history of neonatal jaundice and a diagnosis of G-6-PD deficiency. Although it has been shown that loci of ectodermal dysplasia and G-6-PD deficiency genes are near to one another, we did not find any case study reporting on occurrence of these two genetic diseases together. With the aspect of this rare and interesting case, the relationship between HED and G-6-PD deficiency was defined. (Ann Dermatol 23(S1) S8∼S10,2011)

Trimethyl Chitosan Nanoparticles Enhances Dissolution of the Poorly Water Soluble Drug Candesartan-Cilexetil

Aylin Geçer,Nuray Ylldlz,Ayla Çallmll,Belma Turan 한국고분자학회 2010 Macromolecular Research Vol.18 No.10

Candesartan-cilexetil, an angiotensin receptor blocker, exhibits low bioavailability after oral administration due to its low water solubility. Chitosan is considered one of the most promising biopolymers for drug delivery as a vehicle and trimethyl chitosan is a water soluble chitosan derivative. Trimethyl chitosan nanoparticles were prepared by the ionic crosslinking of a trimethyl chitosan solution with tripolyphosphate, at ambient temperatures during stirring. SEM and TEM (scanning and transmission electron microscopy) revealed trimethyl chitosan and trimethyl chitosan nanoparticles between 1,000-3,000 nm and 13-350 nm in size, respectively. Candesartan-cilexetil was loaded on trimethyl chitosan nanoparticles, trimethyl chitosan, gum arabic and commercial water soluble chitosan using an ultrasonic effect, and the potential of the polymers to increase the solubility of candesartan-cilexetil was investigated. Trimethyl chitosan nanoparticles are a superior vehicle for increasing the solubility of candesartan-cilexetil compared to trimethyl chitosan, gum arabic or commercial water soluble chitosan.

Effect of application factors on optimum design of reinforced concrete retaining systems

Aylin Ece Kayabekir,Zülal Akbay Arama,Gebrail Bekdaş 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.80 No.2

Retaining walls and cantilever soldier pile walls are both can be used in interchangeable manner so it is so important to evaluate the relationship between the cost and sizing. In this paper, an investigation of the effect of the design restraints and cost limits of both reinforced concrete retaining walls and cantilever soldier pile walls on optimum design is done. Pure frictional soils are evaluated as the surrounding soil medium of retaining structures and Rankine lateral earth pressure theory is used to derive the lateral thrust effected through the selected retaining systems. Fictionalized different cases are created for all retaining systems to compare optimal dimensions and minimum costs for the same project requirements. Jaya algorithm is used to perform optimization process. Parametrical analyses are conducted according to change of excavation depth, unit weight of soil, and cost of concrete, surcharge load and workmanship multiplier. The results of the parametric analysis has provided to suggest on the design and application differences of both retaining systems having regard to the effects of both cost and sizing simultaneously. As a consequence of the study, some limitations that have to be considered before design are given for the selection of proper retaining structure not to cause overinvestment.

Chia seed (Salvia Hispanica L.) added yogurt reduces short‐term food intake and increases satiety

Aylin Ayaz,Asli Akyo,Elif Inan-Eroglu,Arzu Kabasakal Cetin,Gulhan Samur,Filiz Akbiyik 한국영양학회 2017 Nutrition Research and Practice Vol.11 No.5

BACKGROUND/OBJECTIVE: Several studies have reported that consumption of Salvia Hispanica L.,commonly known as chia seed, may exert beneficial effects on health outcomes. The main purpose of this study was to examine the influence of chia seed consumption as a mid-morning snack on short-term satiety. SUBJECTS/METHODS: Subjects (n = 24) were tested using a randomized, cross-over design consisting of three mid-morning snacks. Yogurt with no chia seed, yogurt with 7 g chia seed, and yogurt with 14 g chia seed were given to subjects on different test days. After subjects were asked to report visual analog scale (VAS) scores on sensory outcomes, ad libitum lunch was served, and energy intake of individuals was measured. RESULTS: VAS scores indicated that participants reported significantly lower scores for hunger (P = 0.033), prospective food consumption (P = 0.031), amounts of food that could be consumed (P = 0.017), desire for sugary foods (P = 0.015), and higher scores for satiety (P = 0.031) on the test days with 7 g and 14 g chia seed. Energy intake of individuals during ad libitum lunch was significantly lower when they consumed yogurt with 7 g or 14 g chia seed (P = 0.037). CONCLUSIONS: The study demonstrated that chia seed consumption as a mid-morning snack may induce short-term satiety in healthy individuals.

Hypertension Induced by Aripiprazole Use in an Autistic Child Patient

Aylin Deniz Uzun,Şermin Yalın Sapmaz,Masum Öztürk,Hasan Kandemir 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.4

Atypical antipsychotics in children and adolescents are widely used for aggression, emotional variability and psychosis treatment. Aripiprazole is also an atypical antipsychotic that increasingly used in children and adolescents with schizophrenia, autism and bipolar disorder. In this case report, a medically healthy patient with autism associated with behavioral problems is presented with the development of hypertension after the onset of aripiprazole and the return of blood pressure to normal levels after withdrawal of the drug. The purpose of this case study is to discuss and report the emergence of aripiprazole-induced hypertension as a side effect of drugs in children and adolescents.

Case Reports : Hypohidrotic Ectodermal Dysplasia Associated with Glucose-6-Phosphate Dehydrogenase Deficiency

( Aylin Turel Ermertcan ),( Ali Yasar ),( Tuba Celebi Kayhan ),( Huseyin Gulen ),( Pelin Ertan ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.1S

Hypohidrotic ectodermal dysplasia (HED) is a syndrome characterized by hypodontia, hypotrichosis, and partial or total ecrine sweat gland deficiency. The most prevalent form of HED is inherited as an X linked pattern. Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is an X-linked recessive disease, which leads to hemolytic anemia and jaundice. It is expressed in males, while heterozygous females are usually clinically normal. A 12-year-old boy with the complaints of hair and eyebrow disturbances, teeth disfigurement, decreased sweating, and xerosis presented to the outpatient clinic. Dermatological examination revealed sparse hair and eyebrows, conical- shaped teeth, xerosis, syndactylia, transverse grooves, and discoloration of nails. Laboratory findings indicated anemia. His 3-year-old sister also had sparse hair and eyebrows, xerosis, and syndactylia. We learned that the patient had a previous history of neonatal jaundice and a diagnosis of G-6-PD deficiency. Although it has been shown that loci of ectodermal dysplasia and G-6-PD deficiency genes are near to one another, we did not find any case study reporting on occurrence of these two genetic diseases together. With the aspect of this rare and interesting case, the relationship between HED and G-6-PD deficiency was defined. (Ann Dermatol 23(S1) S8~S10, 2011)

Evaluation of YouTube videos as sources of information about complex regional pain syndrome

Aylin Altun,Ayhan Askin,Ilker Sengul,Nazrin Aghazada,Yagmur Aydin 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.3

Background: As the internet usage becomes easily accessible, the patients are more frequently searching about diseases and medical/non-medical treatments. Considering that complex regional pain syndrome (CRPS) is a debilitating disease, it is important to check the information that patients are accessing. Therefore, this study aimed to investigate the reliability, sufficiency, and accuracy of the YouTube videos about CRPS. Methods: This study is a descriptive research which is derived by searching videos using the keyword ‘complex regional pain syndrome’ on YouTube. Relevancebased sequencing was used to sort the videos. Sources and video parameters were documented. To evaluate the accuracy, reliability and content quality of the videos, Global Quality Score, Journal of American Medical Association Benchmark Criteria and Modified DISCERN Questionnaire scales were used. Results: A total of 167 videos were included in this study. The majority of the videos originated from USA (80.2%, n = 134). The median number of views was 639 and the viewing rate was 73.3. Most of the videos had partially sufficient data and the interaction index viewing rate parameters for videos with high content quality were greater than videos with low content quality (P = 0.010, P = 0.014). Conclusions: Our results showed that videos about CRPS on YouTube mostly had partially sufficient data and include intermediate-high quality contents. Moreover, high-content quality videos had higher viewing rates, interaction indexes, number of likes, longer durations, as well as better reliability and accuracy scores. Videos with high quality and reliable content are needed to reduce misinformation about CRPS.

Effect of plate size on meal energy intake in normal weight women

Aylin Ayaz,Asli Akyol,Cansu Cetin,H. Tanju Besler 한국영양학회 2016 Nutrition Research and Practice Vol.10 No.5

BACKGROUND/OBJECTIVES: Use of smaller plates to control food intake is a commonly recommended strategy for restricting energy intake, despite conflicting results. Therefore, the aim of this study was to examine whether or not three different sizes of plates influence energy intake during a multi-itemed buffet meal in normal weight women. SUBJECTS/METHODS: This was a cross-over study conducted on 37 female participants aged 19-25 years with normal BMI levels. Participants were recruited from Hacettepe University and the surrounding community. On experimental days, participants ate a standard breakfast and were then randomly assigned to eat lunch using a small (19 cm), medium (23 cm), or large (28 cm) diameter plate. Visual analogue scale (VAS) scores on sensory and satiety outcomes were measured for all meals. Energy and macronutrient intakes during lunch were recorded. RESULTS: There was no evidence that use of a smaller plate size reduced energy or specific macronutrient intake during the free choice lunch meal. Multiple visits to the serving table were not associated with energy or macronutrient intake. Plate size did not affect VAS scores during the test days. CONCLUSIONS: Plate size did not influence energy intake, meal composition, or palatability in normal weight women during a multi-itemed open buffet lunch. Studies in natural settings at the population level are needed to clarify current outcomes.

Can Head and Neck Cancers Be Detected with Mean Platelet Volume?

Eryilmaz, Aylin,Basal, Yesim,Omurlu, Imran Kurt Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

Background: Mean platelet volume (MPV) is a marker which has been investigated in many cancers but data for head and neck lesions are limited. We aimed to study the MPV levels in head and neck cancers as a diagnostic marker. Materials and Methods: A total of 96 head and neck cancer patients and 31 control patients who did not meet exclusion criteria were enrolled in the study. The cancer locations, the platelet and MPV levels at the first diagnosis time were collected. Results: The head and neck cancer location distribution between these patients was 2 (2.1%) buccal, 9 (9.4%) tongue, 6 (6.3) lip, 1 (1%) gingiva, 1 (1%) hypopharynx, 1 (1%) ear, 58 (60.4%) larynx, 2 (2.1%) maxilla, 2 (2.1%) nasal, 1 (1%) nasopharynx, 2 (2.1%) palatal, 3 (3.1%) primary unknown, 1 (1%) retromolar, 1 (1%) thyroid, 2 (2.1%) tonsil, and 4 (4.2%) salivary gland. MPV levels were significantly different between cancer and control group (p=0.002). The cut-off point for MPV predicting head and neck cancer is >10 fL (sensitivity=55.21, specificity=87.10). Conclusions: MPV level increase, a readily assessable parameter which does not bring extra costs can warn us regarding head and neck cancer risk.

Health Metrics and Information Behavior: How Users Estimate and Use Self-Quantifying Activity and Health Information

Ilhan, Aylin Korea Institute of Science and Technology Informat 2020 Journal of Information Science Theory and Practice Vol.8 No.3

This study focuses on users of activity tracking technologies and their related information behavior. How useful is the provided information by the trackers? Do users understand all information and explanations? We conducted a web-based survey. All in all, 631 users of a tracking device filled out the survey. From the perspective of information science, this investigation aims to analyze information needs considering different types of the provided information by activity tracking technologies. Are users satisfied by using the information on their steps, heart rates, and sleep duration? How do users assess readability about heart rate zones and sleep stages? Additionally, we investigated if users understand how to reflect on and adapt their health behavior based on the received explanations. According to the results, users mainly agree that the received information (raw data as well as - to a lesser extent - aggregated data in the form of corresponding diagrams) is useful, that the explanations are easy to understand, and that they know how to use this obtained information. This investigation enables an in-depth insight into how users are applying the self-quantifying activity and health information and which information needs are satisfied.