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Rough triple sequences in gradual normed spaces
Arulmani Indumathi,Ayhan Esi,Nagarajan Subramanian 호남수학회 2019 호남수학학술지 Vol.41 No.4
In this paper, we investigate general topological properties of rough triple sequences in a gradual normed space. We define some new notions such as rough gradual convergent of triple sequences, rough triple gradual Cauchy sequences, etc.
Brain site-specific proteome changes in aging-related dementia
Arulmani Manavalan,Manisha Mishra,Lin Feng,Siu Kwan Sze,Hiroyasu Akatsu,Klaus Heese 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.9
This study is aimed at gaining insights into the brain site-specific proteomic senescence signature while comparing physiologically aged brains with aging-related dementia brains (for example, Alzheimer’s disease (AD)). Our study of proteomic differences within the hippocampus (Hp), parietal cortex (pCx) and cerebellum (Cb) could provide conceptual insights into the molecular mechanisms involved in aging-related neurodegeneration. Using an isobaric tag for relative and absolute quantitation (iTRAQ)-based two-dimensional liquid chromatography coupled with tandem mass spectrometry (2D-LC-MS/MS) brain sitespecific proteomic strategy, we identified 950 proteins in the Hp, pCx and Cb of AD brains. Of these proteins, 31 were significantly altered. Most of the differentially regulated proteins are involved in molecular transport, nervous system development, synaptic plasticity and apoptosis. Particularly, proteins such as Gelsolin (GSN), Tenascin-R (TNR) and AHNAK could potentially act as novel biomarkers of aging-related neurodegeneration. Importantly, our Ingenuity Pathway Analysis (IPA)-based network analysis further revealed ubiquitin C (UBC) as a pivotal protein to interact with diverse AD-associated pathophysiological molecular factors and suggests the reduced ubiquitin proteasome degradation system (UPS) as one of the causative factors of AD.
ROUGH TRIPLE SEQUENCES IN GRADUAL NORMED SPACES
Indumathi, Arulmani,Esi, Ayhan,Subramanian, Nagarajan The Honam Mathematical Society 2019 호남수학학술지 Vol.41 No.4
In this paper, we investigate general topological properties of rough triple sequences in a gradual normed space. We define some new notions such as rough gradual convergent of triple sequences, rough triple gradual Cauchy sequences, etc.