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RISS 인기검색어
- 검색키워드
- 저자 : Arthur S . Hume (검색결과 1 건)
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Ma, Tangeng,Chen, Hwei Hsien,Lim, Dong K .,Arthur S . Hume,Ho, Ing K . 전남대학교 약품개발연구소 1997 약품개발연구지 Vol.6 No.1
We used the NMDA receptor non-competitive antagonist, [³H]MK-801, as a ligand for an autoradiographic study to determine the effects of lead on NMDA receptor in the rat brain. Adult male rats were administered lead acetate, 100 ㎎/㎏, or sodium acetate, 36 ㎎/㎏ (control), by i.p. for 7 days. High lead levels were detected in blood (41.1 ㎍/㎗) and in brain (16.7-29.4 ㎍/g). Concentrations of lead in brain regions were not significantly different. the [³H]MK-801 binding was heterogeneously distributed throughout the rat brain with the following order of binding densities: hippocampal formation $gt; cortex $gt; caudate-putamen $gt; thalamus $gt; brainstem. Lead exposure produced a significant decrease in [³H]MK-801 binding to the NMDA receptor in the hippocampal formation including CA2 stratum radiatum, CA3 stratum radiatun, hilus dentate gyrus and presubiculum, and in the cerebral cortex including agranular insular, cingulate, entorhinal, orbital, parietal and perirhinal areas. The hippocampal formation is known as a critical neural structure for learning and memory processes, whereas, cortical and subcortical regions have been demonstrated to be involved in the modulation of complex behavioral processes. The NMDA receptor has been demonstrated to play a key role in synaptic plasticity underlying learning and memory. Lead-induced alterations of NMDA receptors in the hippocampal formation and cortical areas may play a role in lead-induced neurotoxicity.
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