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      • Health Promoting Lifestyle Behaviour in Medical Students: a Multicentre Study from Turkey

        Nacar, Melis,Baykan, Zeynep,Cetinkaya, Fevziye,Arslantas, Didem,Ozer, Ali,Coskun, Ozlem,Bati, Hilal,Karaoglu, Nazan,Elmali, Ferhan,Yilmaze, Gulay Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

        Background: The aim of this study was to determine the predictors of health promoting lifestyle behaviour among medical students attending seven of the medical schools in Turkey. Materials and Methods: This crosssectional descriptive study was performed during the second semester of the first and last (sixth) years of study from March to May 2011. A questionnaire with two sections was specifically designed. The first section contained questions on demographic characteristics; the second consisted of the Health Promoting Lifestyle Profile II (HPLP) Scale. From a total of 2,309 medical students, 2,118 (response rate 91.7%) completed the questionnaire. Data were analyzed using descriptive statistics, t, Anova, Tukey test and binary logistic regression analysis. The research was approved by the Ethics Committee of Erciyes University. Results: The mean age was $20.7{\pm}2.9$ years and it was found that 55.1% were men, 62.3% were in the first year. The overall prevalence of smoking was 19.1%, and for drinking alcohol was 19.4%. HPLP point averages of the first year students were $129.2{\pm}17.7$, and for last year $125.5{\pm}19.0$. The overall mean score for the HPLP II was $2.5{\pm}0.4$. They scored highest on the spiritual growth subscale ($2.9{\pm}0.5$), interpersonal relations ($2.8{\pm}0.5$), health responsibility subscale ($2.3{\pm}0.5$), nutrition subscale ($2.3{\pm}0.5$), stress management subscale ($2.3{\pm}0.4$), and the lowest subscale physical activity ($2.0{\pm}0.5$). It is established that student's grade, educational level of parents, economic status of family, marital status, smoking and general health perception of the students resulted in a significant difference in HPLP Scale total score average and the mean score of majority of subscales. There was no statistically significant difference between the total HPLP when evaluated for gender, chronic disease, alcohol drinking status and BMI. Conclusions: Based on these results, particularly in the curriculum of medical students in order to increase positive health behaviours including physical activity, health promotion issues, and giving more space to aim at behaviour change in these matters is recommended.

      • SCOPUSSCIEKCI등재

        Synthesis of New Boron Derived Compounds; Anticancer, Antioxidant and Antimicrobial Effect in Vitro Glioblastoma Tumor Model

        Koldemir-Gunduz, Meliha,Aydin, Hasan Emre,Berikten, Derya,Kaymak, Gullu,Kose, Dursun Ali,Arslantas, Ali The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.6

        Objective : The aim of our study is to investigate the cytotoxic, antioxidant, and antimicrobial effects of newly synthesized boron compounds in U87MG glioblastoma cell treatment. Methods : We synthesized boron glycine monoester (BGM) and boron glycine diester (BGD) structures containing boron atoms and determined their cytotoxic activities on glioblastoma by the MTT method. The inhibitory concentration 50 (IC<sub>50</sub>) value was calculated with GraphPad Prism 5.0 program. The IC<sub>50</sub> values were administered 48 hours on U87MG glioblastoma cell. Catalase (CAT), acid phosphatase (ACP) and alkaline phosphatase (ALP) enzyme activity, malondialdehyde (MDA), total glutathione (GSH), and total protein levels were detected using spectrophotometric methods. We determined the antimicrobial activities of BGM and BGD with the disc diffusion method. Results : After 48 hours of BGM and BGD application to U87MG glioblastoma cells, we found the IC<sub>50</sub> value as 6.6 mM and 26 mM, respectively. CAT and ACP enzyme activities were decreased in BGM and BGD groups. MDA which is a metabolite of lipid peroxidation was increased in both boron compounds groups. GSH level was reduced especially in BGD group. BGM and BGD have been found to be antimicrobial effects. Conclusion : Boron compounds, especially the BGM, can provide a new therapeutic approach for the treatment of glioblastoma with their anticancer, antioxidant, and antimicrobial effects.

      • SCOPUSSCIEKCI등재

        Biomechanical Properties of the Cranial Dura Mater with Puncture Defects : An In Vitro Study

        Aydin, Hasan Emre,Kizmazoglu, Ceren,Kaya, Ismail,Husemoglu, Bugra,Sozer, Gulden,Havitcioglu, Hasan,Arslantas, Ali The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.4

        Objective : The primary aim of this investigation was to explore the nature of dura mater biomechanics following the introduction of puncture defect(s). Methods : Twenty-eight dura mater specimens were collected during autopsy from the department of forensic medicine of the authors' institution. Specimens were divided randomly into one of four groups : group I (cranial dura mater; n=7), group II (cranial dura mater with one puncture defect; n=7); group III (cranial dura mater with two puncture defects; n=7), and group IV (cranial dura mater with three puncture defects; n=7). Results : The mean${\pm}$standard deviation tensile strengths of the dura mater were $8.35{\pm}3.16$, $8.22{\pm}3.32$, $7.13{\pm}1.77$, and $6.94{\pm}1.93MPa$ for groups I, II, III, and IV, respectively. There was no statistical difference between all groups. A single, two or more punctures of the dura mater using a 20-gauge Quincke needle did not affect cranial dura tensile strength. Conclusion : This biomechanical study may contribute to the future development of artificial dura mater substitutes and medical needles that have a lower negative impact on the biomechanical properties of dura mater.

      • KCI등재

        Clientelism, partisanship, and ideology

        Arslantaş Düzgün,Arslantaş Şenol 한국외국어대학교 국제지역연구센터 2023 International Area Studies Review Vol.26 No.3

        This paper aims to highlight the role of clientelism in the Justice and Development Party's (Adalet ve Kalkınma Partisi) electoral dominance in Turkish politics. Based on intensive fieldwork in Istanbul's one of the poorest and conservative districts of Bağcılar, it argues that the expansion of clientelist networks under the Adalet ve Kalkınma Partisi government has twofold ramifications, which in turn have reproduced the cycle of dominance. First, it strengthened clients’ partisan identification. Second, it changed clients’ ideology such that they became less resistant to or even supportive of neoliberal reforms that extensively undermined their well-being.

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