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The Oxidation of Odorants from Wastewater Sludge Using Four Different Oxidants
Susana Arispe,YongJun Heor,Laura McConnell,Hyunook Kim 한국냄새환경학회 2007 실내환경 및 냄새 학회지 Vol.6 No.1
The odorants from wastewater sludge treated with four different chemical oxidants, i. e., potassium ferrate, sodium hypochlorite, sodium permanganate, and calcium nitrate, were analyzed. The release of odorants from the treated sludge was not completely eliminated, only retarded, possibly due to the low one time doseof oxidants. In a comparison of the concentration profiles of methyl mercaptan and dimethyl sulfide, calcium nitrate was the best of the four different oxidants at reducing their emission. For methyl mercaptan, calcium nitrate gave the best result, while for dimethyl sulfide, potassium permanganate was found to be the best oxidant. From this study, it was found that the oxidation-reduction potential (ORP) would be an easy and inexpensive parameter for the monitoring of the release of offensive odors.
Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells
Isabel Rivera,David M. Cauvi,Nelson Arispe,Antonio De Maio 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.4
Backgrounds: Alpha calcium channel blockers (CCB) are widely prescribed for the treatment of hypertension, including Nitrendipine (NTD). The anti-hypertension effect of NTD is related to binding and blocking the activity of the voltage-gated L-type calcium channels. These channels consist of four subunits (α1, α2/δ, γ and β subunits), localized in the plasma membrane. Methods: Cellular proliferation was determined by the XTT method and apoptosis was measured by flow cytometry. The expression of the α1c subunit (Cacna1c) of the voltage-gated L-type calcium channels was reduced by siRNA and assessed by quantitative RT-PCR. Results: NTD blocked the proliferation of murine neuroblastoma (N2a cells) and induced apoptosis in a concentration- dependent manner. A decrease in Cacna1c expression did not have a significant effect on NTD toxicity of N2a cells. Conclusion: NTD induced apoptosis on neuroblastoma cells, appears to be independent of the expression of the L-type calcium channel.