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Resolution of a Chikungunya Outbreak in a Prospective Cohort, Cebu, Philippines, 2012–2014
Srikiatkhachorn, Anon,Alera, Maria Theresa,Lago, Catherine B.,Tac-An, Ilya A.,Villa, Daisy,Fernandez, Stefan,Thaisomboonsuk, Butsaya,Klungthong, Chonticha,Levy, Jens W.,Velasco, John Mark,Roque Jr., V U.S. Department of Health and Human Services * Cen 2016 Emerging Infectious Diseases Vol.22 No.10
Immune correlates for dengue vaccine development
Srikiatkhachorn, Anon,Yoon, In-Kyu 'Informa Healthcare (Expert Reviews, LTD)' 2016 Expert review of vaccines Vol.15 No.4
<P>Dengue virus is the leading cause of vector-borne viral disease with four serotypes in circulation. Vaccine development has been complicated by the potential for both protection and disease enhancement during heterologous infection. Secondary infection triggers cross-reactive immune memory responses that have varying functional and epitope specificities that determine protection or risk. Strongly neutralizing antibodies to quaternary epitopes may be especially important for virus neutralization. Cell-mediated immunity dominated by Th1 functions may also play an important role. Determining an immune correlate of protection or risk would be highly beneficial for vaccine development but is hampered by mechanistic uncertainties and assay limitations. Clinical efficacy trials and human infection models along with a systems approach may provide future opportunities to elucidate such correlates.</P>
( Sukanya Saechow ),( Anon Thammasittirong ),( Prasat Kittakoop ),( Surasak Prachya ),( Sutticha Na-ranong Thammasittirong ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.9
Bacterial strain BAS23 was isolated from rice field soil and identified as Bacillus amyloliquefaciens. Based on dual culture method results, the bacterium BAS23 exhibited potent in vitro inhibitory activity on mycelial growth against a broad range of dirty panicle fungal pathogens of rice (Curvularia lunata, Fusarium semitectum and Helminthosporium oryzae). Cellfree culture of BAS23 displayed a significant effect on germ tube elongation and mycelial growth. The highest dry weight reduction (%) values of C. lunata, H. oryzae and F. semitectum were 92.7%, 75.7%, and 68.9%, respectively. Analysis of electrospray ionization-mass spectrometry (ESI-MS) and 1H nuclear magnetic resonance (NMR) spectroscopy revealed that the lipopeptides were iturin A with a C14 side chain (C14 iturinic acid), and a C15 side chain (C15 iturinic acid), which were produced by BAS23 when it was cultured in nutrient broth (NB) for 72 h at 30°C. BAS23, the efficient antagonistic bacterium, also possessed in vitro multiple traits for plant growth promotion and improved rice seedling growth. The results indicated that BAS23 represents a useful option either for biocontrol or as a plant growthpromoting agent.
Chowdhury Tamgid Ahmed,Anon Nusrat Zaman 한국마케팅과학회 2021 Journal of Global Fashion Marketing Vol.12 No.4
The purpose of this study is to offer an ‘employability skill index” for entry-level marketing professionals in the apparel industry and compare the skill requirements of local and multinational companies (MNCs). The study applies Structural Equation Modeling approach for index development. Primary data were collected through a structured questionnaire from 1082 managers of 18 local and 16 MNCs operating in the apparel industry in Bangladesh. Convergent and discriminant validities of the proposed index were tested. The research revealed a six-dimensional 22-item skill index with significant differences in skill requirements between local and MNCs. The skills MNCs prioritized are major courses taken, research-based internship, written communication skills, and English language ability. Local companies, on the other hand, put preferences on experience, team building ability, network skill, and effective listening. The literature review revealed that there is a lack of quantitative studies to offer employability skills for entry-level marketing managers in the apparel industry in the South Asia region. Therefore, the current study is original and adds significant value to the literature. The proposed skill index can help the universities to design their courses accordingly to increase the employability of marketing graduates in the apparel industry.
Alera, Maria Theresa,Srikiatkhachorn, Anon,Velasco, John Mark,Tac-An, Ilya A.,Lago, Catherine B.,Clapham, Hannah E.,Fernandez, Stefan,Levy, Jens W.,Thaisomboonsuk, Butsaya,Klungthong, Chonticha,Macare Public Library of Science 2016 PLoS neglected tropical diseases Vol.10 No.2
<▼1><P><B>Background</B></P><P>The mean age of dengue has been increasing in some but not all countries. We sought to determine the incidence of dengue virus (DENV) infection in adults and children in a prospective cohort study in the Philippines where dengue is hyperendemic.</P><P><B>Methodology/Principal Findings</B></P><P>A prospective cohort of subjects ≥6 months old in Cebu City, Philippines, underwent active community-based surveillance for acute febrile illnesses by weekly contact. Fever history within the prior seven days was evaluated with an acute illness visit followed by 2, 5, and 8-day, and 3-week convalescent visits. Blood was collected at the acute and 3-week visits. Scheduled visits took place at enrolment and 12 months that included blood collections. Acute samples were tested by DENV PCR and acute/convalescent samples by DENV IgM/IgG ELISA to identify symptomatic infections. Enrolment and 12-month samples were tested by DENV hemagglutination inhibition (HAI) assay to identify subclinical infections. Of 1,008 enrolled subjects, 854 completed all study activities at 12 months per-protocol undergoing 868 person-years of surveillance. The incidence of symptomatic and subclinical infections was 1.62 and 7.03 per 100 person-years, respectively. However, in subjects >15 years old, only one symptomatic infection occurred whereas 27 subclinical infections were identified. DENV HAI seroprevalence increased sharply with age with baseline multitypic HAIs associated with fewer symptomatic infections. Using a catalytic model, the historical infection rate among dengue naïve individuals was estimated to be high at 11–22%/year.</P><P><B>Conclusions/Significance</B></P><P>In this hyperendemic area with high seroprevalence of multitypic DENV HAIs in adults, symptomatic dengue rarely occurred in individuals older than 15 years. Our findings demonstrate that dengue is primarily a pediatric disease in areas with high force of infection. However, the average age of dengue could increase if force of infection decreases over time, as is occurring in some hyperendemic countries such as Thailand.</P></▼1><▼2><P><B>Author Summary</B></P><P>The average age of dengue has been increasing in some but not all dengue endemic countries. To investigate the age pattern of dengue in people of all ages ≥6 months old, a prospective community-based cohort study was undertaken in Cebu City, Philippines where dengue virus has been circulating for many decades. Active surveillance for acute fevers was performed, and acute/convalescent blood samples were tested for evidence of symptomatic dengue. Blood was also collected at enrolment and one year later, and tested serologically to identify subclinical infections. Overall, 1.62 symptomatic and 7.03 subclinical infections per 100 person-years of surveillance were detected. Among people older than 15 years, only one symptomatic dengue case occurred while 27 subclinical infections were identified. By analyzing age-specific dengue serology data, the historical infection rate among people with no prior dengue virus infection was found to be high at around 11–22% per year. Our results show that dengue is primarily a childhood disease in endemic settings where the historical infection rate has been high. However, the average age of dengue could increase if the infection rate decreases over time as is happening in some endemic countries like Thailand.</P></▼2>
Clinical Benefit of Frozen Section of Proximal Bile Duct Margin in Perihilar Cholangiocarcinoma
( Lakkana Adireklarpwong ),( Sunhawitjunrungsee ),( Anon Chotirosniramit ),( Trichak Sandhu ),( Worakitti Lapisetepun ),( Tidarat Jirapongcharoenlap ),( Kamtone Chandacham ),( Kamtone Chandacham ),( N 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: R0 resection is the best chance of prolonging the survival of cholangiocarcinoma patients. Frozen section analysis of duct margin often be used to determine bile duct in an attempt to achieve R0 resection, but the clinical benefit remains controversial. Methods: All 132 patients underwent hepatectomy for perihilar cholangiocarcinoma between January 2006, and December 2019 were analyzed into prospective and retrospective group. Resection status, the accuracy of the frozen section, surgical variables, prognostic factors, survival, and recurrence were evaluated. Results: R0 status in frozen section group was higher than non-frozen section group but not significant (48.72 vs 35.48 percent) (P=0.175). Median survival in both groups were 24 and 17 months that tend to be better in frozen section group although there were no statistically significant difference (P=0.25). And one-year survival rates were 65.38 and 67.57 percent. In all populations, the median survival of R0 resection patients was better than R1 resection patients (32 vs 13 months) (P=0.001). However, median survival of secondary R0 and R1 resection was not different (P=0.43). The median follow up time in frozen section and non frozen section group were 19.12 and 77.67 months. Conclusions: The clinical benefit of the frozen section of the proximal bile duct margin is still inconclusive. Intraoperative frozen section analysis tends to increase the number of R0 resection and prolong survival, although they were not significant. The frozen section should be done if possible for increasing R0 resection rate that has better survival.