Extracranial systemic antitumor response through the abscopal effect induced by brain radiation in a patient with metastatic melanoma

Mark A. D’Andrea,G. Kesava Reddy, 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.4

The abscopal effect is a term that has been used to describe the phenomenon in which localized radiation therapy treatment of a tumor lesion triggers a spontaneous regression of metastatic lesion(s) at a non-irradiated distant site(s). Radiation therapy induced abscopal effects are believed to be mediated by activation and stimulation of the immune system. However, due to the brain’s distinctive immune microenvironment, extracranial abscopal responses following cranial radiation therapy have rarely been reported. In this report, we describe the case of 42-year-old female patient with metastatic melanoma who experienced an abscopal response following her cranial radiation therapy for her brain metastasis. The patient initially presented with a stage III melanoma of the right upper skin of her back. Approximately 5 years after her diagnosis, the patient developed a large metastatic lesion in her upper right pectoral region of her chest wall and axilla. Since the patient’s tumor was positive for BRAF and MEK, targeted therapy with dabrafenib and trametinib was initiated. However, the patient experienced central nervous system (CNS) symptoms such as headache and disequilibrium and developed brain metastases prior to the start of targeted therapy. The patient received radiation therapy to a dose of 30 Gy delivered in 15 fractions to her brain lesions while the patient was on dabrafenib and trametinib therapy. The patient’s CNS metastases improved significantly within weeks of her therapy. The patient’s non-irradiated large extracranial chest mass and axilla mass also shrank substantially demonstrating the abscopal effect during her CNS radiation therapy. Following radiation therapy of her residual chest lesions, the patient was disease free clinically and her CNS lesions had regressed. However, when the radiation therapy ended and the patient continued her targeted therapy alone, recurrence outside of her previously treated fields was noted. The disease recurrence could be due to the possibility of developing BRAF resistance clones to the BRAF targeted therapy. The patient died eventually due to wide spread systemic disease recurrence despite targeted therapy

Travel Books and Urban Identity. British Travellers in Messina, 1770-1815: A Preliminary Study

( Diletta D`andrea ) 부산외국어대학교 지중해연구소 2014 The Mediterranean Review Vol.7 No.1

Patrick Brydone`s Tour through Sicily and Malta, first published in 1773, was a primary guide-book for all those travellers who reached Sicily from Northern Europe for the first time. Thanks to Brydone`s enthusiastic survey, Sicily and especially Messina became part of the itinerary of the Italian Grand Tour. Regular flows of travellers arrived. During the Napoleonic Wars and mostly during the British Decade (1806-1815) in Sicily, when His Majesty`s military forces occupied the Bourbons` island and protected it from a possible French invasion, Messina became the site of the British military head-quarters; at the same time, its port was either the final destination or the starting point for many travellers, whose striking descriptions helped build a new identity for Messina and put the city among the most favoured destinations of the Grand Tour in the Mediterranean. A strong connection was then created between the Sicilian town and England, a connection that lasted over ‘the long nineteenth century’.

COVID-19 Impact on the Italian Community-based System of Mental Health Care: Reflections and Lessons Learned for the Future

Andrea Amerio(Andrea Amerio ),Eleonora Vai(Eleonora Vai ),Edoardo Bruno(Edoardo Bruno ),Alessandra Costanza(Alessandra Costanza ),Andrea Escelsior(Andrea Escelsior ),Anna Odone(Anna Odone ),Domenico D 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Despite the unprecedented wave of research and publications sparked by the recent pandemic, only few studies have investigated the impact of COVID-19 on the Italian community-based system of mental health care. We aimed to summarize the available evidence from the literature also considering what we have learned from our daily clinical practice. As hospital care was restricted by COVID-19, although reducing their opening hours and activities, Community Mental Health Centers promoted continuity of care for at-risk populations, supporting them to cope with loneliness and hopelessness during quarantine and self-isolation. Ensuring continuity of care also remotely, via teleconsultation, lowered the risk of psychopathological decompensation and consequent need of hospitalization for mental health patients, with satisfaction expressed both by patients and mental health workers. Considering what we have learned from the pandemic, the organization and the activity of the Italian community-based system of mental health care would need to be implemented through 1) the promotion of a “territorial epidemiology” that makes mental health needs visible in terms of health care workers involved, 2) the increase of mental health resources in line with the other European high-income countries, 3) the formalization of structured initiatives of primary care and mental health cooperation, 4) the creation of youth mental health services following a multidimensional and multidisciplinary approach and encouraging family participation, 5) the promotion of day centers, to build competence and self-identity within a more participatory life, and programs geared to employment as valid models of recovery-oriented rehabilitation.

The clinical anatomy of the accessory submandibular gland: a comprehensive review

Andrea Yazbeck(Andrea Yazbeck ),Joe Iwanaga(Joe Iwanaga ),Jerzy A. Walocha(Jerzy A. Walocha ),Łukasz Olewnik(Łukasz Olewnik ),R. Shane Tubbs(R. Shane Tubbs ) 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.1

An accessory submandibular gland is a rare variation. As such, there is limited literature regarding the embryology, anatomy, variations, clinical imaging, and pathology of the accessory submandibular gland. In this article, we review the existing literature on the accessory submandibular gland from clinical and anatomical perspectives. The goal of this review is to provide comprehensive knowledge of this variation which can be useful for oral and maxillofacial/head and neck surgeons, radiologists, and anatomists. Within this review, the embryologic origin as well as the anatomy of the accessory submandibular gland is detailed. Several imaging modalities which can be used to visualize the accessory submandibular gland are outlined as well as its variations. Lastly, this review investigates several reported clinical considerations regarding the accessory submandibular gland including sialoliths, Wharton’s duct obstruction, and pleomorphic adenoma.

How Atypical Penile Curvature Influence Clinical Outcomes in Patients with Peyronie’s Disease Receiving Collagenase Clostridium Histolyticum Therapy?

Andrea Cocci,Fabrizio Di Maida,Giorgio Ivan Russo,Marina di Mauro,Gianmartin Cito,Marco Falcone,Andrea Minervini,Giovanni Cacciamani,Riccardo Campi,Andrea Mari,Francesco Sessa,Nicola Mondaini 대한남성과학회 2020 The World Journal of Men's Health Vol.38 No.1

Purpose: The aim of this study was to evaluate the efficacy of collagenase Clostridium histolyticum (CCH) in patients with Peyronie’s disease (PD) suffering from atypical deformities. Materials and Methods: We retrospectively collected data of patients with atypical penile curvature (PC) secondary to PD. All patients underwent a modified treatment protocol, consisting of 3 intralesional injections of 0.9 mg of CCH performed at 4-week intervals at the point of maximum PC. Patients were instructed to follow a strict routine, involving daily modeling of erect penis and stretching at the urinary toilette time, two minutes each. Success was defined as a decrease in PC of ≥20° from baseline. Results: Sixty-five patients were included in the analysis. Median age was 59.0 years (interquartile range [IQR], 53.0 to 63.0 years), median curvature 40.0° (IQR, 30.0° to 45.0°) median duration of the disease 12.0 years (IQR, 6.5 to 24.0 years). Fiftythree patients (81.54%) had ventral PC, 7 (10.77%) hourglass PC, and 5 (7.69%) shortening PC. Median changes of PC were -20.0 (IQR, -20.0 to -10.0; p<0.01) in ventral PC, -20.0 (IQR, -20.0 to 0; p<0.01) in hourglass and -15.0 (IQR, -15.0 to -15.0; p<0.01) in shortening PC. At Kruscal–Wallis test, significant differences between groups were not found. The rate of PC success was 56.60% (30/53) in ventral PC, 57.14% (4/7) in hourglass and 20.00% (1/5) in shortening PC (p=0.29). Treatment success was not influenced by characteristics of curvature (odds ratio=0.66; p=0.20). Conclusions: CCH intralesional injections could represent an effective therapeutic option for the conservative management of patients with atypical PC.

Comparison of Intralesional Hyaluronic Acid vs. Verapamil for the Treatment of Acute Phase Peyronie's Disease: A Prospective, Open-Label Non-Randomized Clinical Study

Cocci Andrea,Di Maida Fabrizio,Cito Gianmartin,Verrienti Pierangelo,Laruccia Nicola,Campi Riccardo,Mari Andrea,Di Mauro Marina,Falcone Marco,Cacciamani Giovanni E.,Garaffa Giulio,Minervini Andrea,Russ 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.2

Purpose: To compare the efficacy and safety of intralesional hyaluronic acid (HA) as compared with verapamil injection in patients with Peyronie’s disease (PD). Materials and Methods: Between January 2015 and December 2018, men in PD acute phase were prospectively recruited. This open-label, prospective study included 2 different protocols. Group A: 8-week cycle of weekly intraplaque injections with HA; Group B: 8-week cycle of weekly intraplaque injections with verapamil. Penile curvature, plaque size, International Index of Erectile Function (IIEF)-15 score and visual analogue scale (VAS) were assessed at baseline and after 3 months. Results: Two-hundred forty-four patients were enrolled. Of these, 125 received intralesional HA (Group A), 119 received intralesional verapamil (Group B). At enrollment, median age was 56.0 years (interquartile range [IQR]=47.0–63.0 years), median curvature 35.0° (IQR=25.0°–45.0°), median IIEF-15 score 19.0 (IQR=16.0–23.0), median VAS 4.0 (IQR=4.0–5.0). Median difference for IIEF-15 was 1.0 (95% confidence interval [CI]=1.12–1.94) in Group A and 0.0 (95% CI=-0.04–0.14) in Group B (p<0.05) and median difference for VAS score was -4.0 (95% CI=-4.11–-3.65) in Group A and -1.0 (95% CI=-0.50–2.01) in Group B (p<0.05). Plaque size decreased by -1.50 mm (IQR=1.60–2.10 mm) in Group A and -1.20 in Group B (p=0.10), while penile curvature decreased by -9.50° (IQR=4.50°–13.00°) in group A and -4.50 (IQR=2.50–7.50) in Group B (p<0.01). Conclusions: Intralesional HA injections could represent a reliable treatment option for the conservative management of patients with acute phase of PD.

[PE-0004] Genetic diversity and population structure of native South Sudan maize accessions using SSR markers

Emmanuel Andrea Mathiang(Emmanuel Andrea Mathiang ),Kyu Jin Sa(Kyu Jin Sa),Hyeon Park(Hyeon Park),Yeon-Jin Kim(Yeon-Jin Kim),Ju Kyong Lee(Ju Kyong Lee) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Implicit Large Eddy Simulations of a rectangular 5:1 cylinder with a high-order discontinuous Galerkin method

Andrea Crivellini,Alessandra Nigro,Alessandro Colombo,Antonio Ghidoni,Gianmaria Noventa,Andrea Cimarelli,Roberto Corsini 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.1

In this work the numerical results of the flow around a 5:1 rectangular cylinder at Reynolds numbers 3 000 and 40 000, zero angle of attack and smooth incoming flow condition are presented. Implicit Large Eddy Simulations (ILES) have been performed with a high-order accurate spatial scheme and an implicit high-order accurate time integration method. The spatial approximation is based on a discontinuous Galerkin (dG) method, while the time integration exploits a linearly-implicit Rosenbrock-type Runge-Kutta scheme. The aim of this work is to show the feasibility of high-fidelity flow simulations with a moderate number of DOFs and large time step sizes. Moreover, the effect of different parameters, i.e., dimension of the computational domain, mesh type, grid resolution, boundary conditions, time step size and polynomial approximation, on the results accuracy is investigated. Our best dG result at Re=3 000 perfectly agrees with a reference DNS obtained using Nek5000 and about 40 times more degrees of freedom. The Re=40 000 computations, which are strongly under-resolved, show a reasonable correspondence with the experimental data of Mannini et al. (2017) and the LES of Zhang and Xu (2020).

Allomorphy in the Italian Passato Remoto: A Distributed Morphology Analysis

( Andrea Calabrese ) 서강대학교 언어정보연구소 2012 언어와 정보 사회 Vol.18 No.-

Calabrese, Andrea (2012), "Allomorphy in the Italian Passato Remoto: A Distributed Morphology Analysis," Language & Information Society 18. Many Italian verbs display stem alternations with highly idiosyncratic vocalic and consonantal allomorphy in the paradigm of the simple past. Due to their complexity, these alternations are often used by linguists as evidence for models assuming rote memorization of stem alternants and endings (see the recent work by Maiden 2005, 2010 for example). In this paper, I will show that these alternations are characterized by basic regularities and that a rather simple analysis of them can be formulated in the framework of Distributed Morphology (DM) (Halle and Marantz 1993; Embick 2010; Embick and Marantz 2008). In particular, this analysis involves notions such as roots, Vocabulary Items and Readjustment Rules as predicted by DM. There is no evidence for memorized stem alternants. Instead, the allomorphy we see in the Italian Passato Remoto is readily accounted for by providing an appropriate morphosyntactic analysis of the forms and by deriving the irregular alternants from single underlying roots by means of Readjustment Rules. This paper also shows that it is crucial that the rules accounting for this allomorphy obey a strict definition of locality requiring linear adjacency. This explains why the presence of the Thematic Vowel prevents their application. In the irregular forms where these rules apply, the Thematic Vowel is removed by a special pruning rule. Crucially, Impoverishment removes a diacritic index associated with the application of this pruning rule in certain morphosyntactic contexts (in the 1st and 2nd pl., and 2ndsg.), thus the regular basic form of the root will appear in these contexts. Impoverishment in this case is motivated by a general Markedness principle that disfavors complex exponence in morphologically marked environments.

Bilateral Radiation-Induced Hypoglossal Nerve Palsy Responsive to Steroid Treatment

Andrea Rigamonti,Giuseppe Lauria,Vittorio Mantero,Lorenzo Stanzani,Andrea Salmaggi 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.2