Facile Synthesis of New Pyrazolopyrimidine Derivatives of Potential Biosignificant Interest

Aly, Aly A.,El-Karim, Iman A. Gad Korean Chemical Society 2011 대한화학회지 Vol.55 No.5

An easy and efficient route for the synthesis of some imidazo[1,2-c]pyrazolo[4,3-e]pyrimidines 3-6, imidazo[1,2-c]pyrazolo[4,3-e]triazine 8, pyrazolo[4,3-e]triazolo[1,5-c]pyrimidines 12-15 and pyrazolo-[3',4':4,5]pyrimido[1,6-b]triazines 16, 17 was described through the reaction of readily available 5-aminopyrazole-4-carbonitrile 1 with different reagents. The in vitro antimicrobial activity of some synthesized compounds was examined. Most of the tested compounds proved to be active as antibacterial and antifungal agents.

Examination of Correlations Between Several Biochemical Components and Powdery Mildew Resistance of Flax Cultivars

Aly, Aly A.,Mansour, Mahmoud T. M.,Mohamed, Heba I.,Abd-Elsalam, Kamel A. The Korean Society of Plant Pathology 2012 Plant Pathology Journal Vol.28 No.2

A field trial was conducted in 2009/2010 and 2010/2011 growing seasons at Giza Agricultural Research Station to examine correlations between some biochemical componets and powdery mildews ($PM_s$) resistance in flax cultivars. Nine flax cultivars could be divided into five distinct groups, i.e., highly susceptible (Cortland and C.I. 2008), moderately susceptible (Giza 7, and Marshall), moderately resistant (Cass), resistant (Koto, Dakota and Wilden), and highly resistant (Ottowa 770B). The cultivars showed considerable variation in PM severity ranged from 8.05 on Ottowa 770B to 97.02% on Cortland. Total soluble proteins, total phenols, antioxidant enzymes (peroxidase and polyphenoloxidase), ascorbic acid, tocopherol, and malondialdehyde (MDA), were determined in uninfected leaves of the tested cultivars. Pearson's correlation coefficient was calculated to measure the degree of association between PM severity and each component. All components showed significant (P < 0.05) or highly significant (P < 0.01) negative correlation with PM severity except MDA, which showed positive correlation (P < 0.01). Linear regression analysis was used to evaluate the causal relationship between the biochemical components (independent variables) and PM severity (dependent variable). Coefficient of determination ($R^2$) values of the generated models ranged from 48.76 to 77.15%. Tocopherol, MDA, and proteins were the most important contributors to the total variation in PM severity as the $R^2$ values of their models were 71.78, 75.28, and 77.15%, respectively. The results of the present study suggest that tocopherol, MDA, and proteins in uninfected leaves can be used as biochemical markers to predict PM resistance in flax.

Pathogenicity of Bacillus Strains to Cotton Seedlings and Their Effects on Some Biochemical Components of the Infected Seedlings

Aly A. Aly,Omima M. El-Mahdy,Marian M. Habeb,Abeer Elhakem,Amal A. Asran,Maryan M. Youssef,Heba I. Mohamed,Rania S. Hanafy 한국식물병리학회 2022 Plant Pathology Journal Vol.38 No.2

Pathogenicity of eight Bacillus strains to seedlings of four cotton cultivars was evaluated under greenhouse conditions. Each of the tested cultivars was individually treated with powdered inoculum of each bacterial strain. Untreated seeds were planted as control treatments in autoclaved soil. Effects of the tested strains on levels and activities of some biochemical components of the infected seedlings were also assayed. The biochemical components included total soluble sugars, total soluble proteins, total free amino acids, peroxidase, polyphenol oxidase, phenols, and lipid peroxidation. ANOVA showed that Bacillus strain (B) was a very highly significant source of variation in damping-off and dry weight. Cotton cultivar (V) was a nonsignificant source of variation in damping-off while it was a significant source of variation in dry weight. B × V interaction was a significant source of variation in damping- off and a nonsignificant source of variation in dry weight. Bacillus strain was the most important source of variation as it accounted for 59.36 and 64.99% of the explained (model) variation in damping-off and dry weight, respectively. The lack of significant correlation between levels and activities of the assayed biochemical components and incidence of damping-off clearly demonstrated that these biochemical components were not involved in the pathogenicity of the tested strains. Therefore, it was hypothesized that the pathogenicity of the tested strains could be due to the effect of cell wall degrading enzymes of pathogenic toxins. Based on the results of the present study, Bacillus strains should be considered in studying the etiology of cotton seedling damping-off.

Control of wind-induced motion in high-rise buildings with hybrid TM/MR dampers

Aly Mousaad Aly 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.5

In recent years, high-rise buildings received a renewed interest as a means by which technical and economic advantages can be achieved, especially in areas of high population density. Taller and taller buildings are being built worldwide. These types of buildings present an asset and typically are built not to fail under wind loadings. The increase in a building\'s height results in increased flexibility, which can lead to significant vibrations, especially at top floors. Such oscillations can magnify the overall loads and can be annoying to the top floors\' occupants. This paper shows that increased stiffness in high-rise buildings may not be a feasible solution and may not be used for the design for comfort and serviceability. High-rise buildings are unique, and a vibration control system for a certain building may not be suitable for another. Even for the same building, its behavior in the two lateral directions can be different. For this reason, the current study addresses the application of hybrid tuned mass and magneto-rheological (TM/MR) dampers that can work for such types of buildings. The proposed control scheme shows its effectiveness in reducing floors\' accelerations for both comfort and serviceability concerns. Also, a dissipative analysis carried out shows that the MR dampers are working within the possible range of optimum performance. In addition, the design loads are dramatically reduced, creating more resilient and sustainable buildings. The purpose of this paper is to stimulate, shape, and communicate ideas for emerging control technologies that are essential for solving wind related problems in high-rise buildings, with the objective to build the more resilient and sustainable infrastructure and to optimally retrofit existing structures.

Wind loading on trees integrated with a building envelope

Aly Mousaad ALY,Fabio Fossati,Tommaso Argentini,Girma Bitsuamlak,Alberto Franchi,Nicola Longarini,Pietro Crespi,Arindam Gan Chowdhury 한국풍공학회 2013 한국풍공학회지 Vol.17 No.1

With the sustainability movement, vegetated building envelopes are gaining more popularity. This requires special wind effect investigations, both from sustainability and resiliency perspectives. The current paper focuses on wind load estimation on small- and full-scale trees used as part of green roofs and balconies. Small-scale wind load assessment was carried out using a wind tunnel testing in a global-effect study to understand the interference effects from surrounding structures. Full-scale trees were investigated at a large open-jet facility in a local-effect study to account for the wind-tree interaction. The effect of Reynolds number combined with shape change on the overall loads measured at the base of the trees (near the roots) has been investigated by testing at different model-scales and wind speeds. In addition, high-speed tests were conducted to examine the security of the trees in soil and to assess the effectiveness of a proposed structural mitigation system. Results of the current research show that at relatively high wind speeds the load coefficients tend to be reduced, limiting the wind loads on trees. No resonance or vortex shedding was visually observed.

Vibration control of high-rise buildings for wind: a robust passive and active tuned mass damper

Aly, Aly Mousaad Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.13 No.3

Tuned mass dampers (TMDs) have been installed in many high-rise buildings, to improve their resiliency under dynamic loads. However, high-rise buildings may experience natural frequency changes under ambient temperature fluctuations, extreme wind loads and relative humidity variations. This makes the design of a TMD challenging and may lead to a detuned scenario, which can reduce significantly the performance. To alleviate this problem, the current paper presents a proposed approach for the design of a robust and efficient TMD. The approach accounts for the uncertain natural frequency, the optimization objective and the input excitation. The study shows that robust design parameters can be different from the optimal parameters. Nevertheless, predetermined optimal parameters are useful to attain design robustness. A case study of a high-rise building is executed. The TMD designed with the proposed approach showed its robustness and effectiveness in reducing the responses of high-rise buildings under multidirectional wind. The case study represents an engineered design that is instructive. The results show that shear buildings may be controlled with less effort than cantilever buildings. Structural control performance in high-rise buildings may depend on the shape of the building, hence the flow patterns, as well as the wind direction angle. To further increase the performance of the robust TMD in one lateral direction, active control using LQG and fuzzy logic controllers was carried out. The performance of the controllers is remarkable in enhancing the response reduction. In addition, the fuzzy logic controller may be more robust than the LQG controller.

Wind profile management and blockage assessment for a new 12-fan Wall of Wind facility at FIU

Aly, Aly Mousaad,Chowdhury, Arindam Gan,Bitsuamlak, Girma Techno-Press 2011 Wind and Structures, An International Journal (WAS Vol.14 No.4

Researchers at the International Hurricane Research Center (IHRC), Florida International University (FIU), are working in stages on the construction of a large state-of-the-art Wall of Wind (WoW) facility to support research in the area of Wind Engineering. In this paper, the challenges of simulating hurricane winds for the WoW are presented and investigated based on a scale model study. Three wind profiles were simulated using airfoils, and/or adjustable planks mechanism with and without grids. Evaluations of flow characteristics were performed in order to enhance the WoW's flow simulation capabilities. Characteristics of the simulated wind fields are compared to the results obtained from a study using computational fluid dynamics (CFD) and also validated via pressure measurements on small-scale models of the Silsoe cube building. Optimal scale of the test model and its optimal distance from the WoW contraction exit are determined - which are two important aspects for testing using an open jet facility such as the WoW. The main objective of this study is to further the understanding of the WoW capabilities and the characteristics of its test section by means of intensive tests and validations at small scale in order to apply this knowledge to the design of the full-scale WoW and for future wind engineering testing.

Proposed approach for determination of tributary areas for scattered pressure taps

Aly, Aly Mousaad Techno-Press 2013 Wind and Structures, An International Journal (WAS Vol.16 No.6

In wind load calculations based on pressure measurements, the concept of 'tributary area' is usually used. The literature has less guidance for a systematic computational methodology for calculating tributary areas, in general, and for scattered pressure taps, in particular. To the best of the author's knowledge, there is no generic mathematical equation that helps calculate the tributary areas for irregular pressure taps. Traditionally, the drawing of tributary boundaries for scattered and intensively distributed taps may not be feasible (a time and resource consuming task). To alleviate this problem, this paper presents a proposed numerical approach for tributary area calculations on rectangular surfaces. The approach makes use of the available coordinates of the pressure taps and the dimensions of the surface. The proposed technique is illustrated by two application examples: first, quasi-regularly distributed pressure taps, and second, taps that have scattered distribution on a rectangular surface. The accuracy and the efficacy of the approach are assessed, and a comparison with a traditional method is presented.

Proposed approach for determination of tributary areas for scattered pressure taps

Aly Mousaad ALY 한국풍공학회 2013 Wind and Structures, An International Journal (WAS Vol.16 No.6

In wind load calculations based on pressure measurements, the concept of ‘tributary area’ is usually used. The literature has less guidance for a systematic computational methodology for calculating tributary areas, in general, and for scattered pressure taps, in particular. To the best of the author’s knowledge, there is no generic mathematical equation that helps calculate the tributary areas for irregular pressure taps. Traditionally, the drawing of tributary boundaries for scattered and intensively distributed taps may not be feasible (a time and resource consuming task). To alleviate this problem, this paper presents a proposed numerical approach for tributary area calculations on rectangular surfaces. The approach makes use of the available coordinates of the pressure taps and the dimensions of the surface. The proposed technique is illustrated by two application examples: first, quasi-regularly distributed pressure taps, and second, taps that have scattered distribution on a rectangular surface. The accuracy and the efficacy of the approach are assessed, and a comparison with a traditional method is presented.

The Use of Bracing Systems with MR Dampers in Super Tall Buildings

Aly, Aly Mousaad Council on Tall Building and Urban Habitat Korea 2016 International journal of high-rise buildings Vol.5 No.1

High-rise buildings are increasingly viewed as having both technical and economic advantages, especially in areas of high population density. Increasingly taller buildings are being built worldwide. Increased heights entail increasing flexibility, which can result in serviceability problems associated with significant displacements and accelerations at higher floors. The purpose of this paper is to present the concept of a versatile vibration control technology (MR dampers with bracings) that can be used in super tall buildings. The proposed technology is shown to be effective, from a serviceability point of view, as well as resulting in dramatically reduced design wind loads, thus creating more resilient and sustainable buildings.