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In the published article “Comparison of physicochemical traits of dry-cured ham from purebred Berkshire and crossbred Landrace × Yorkshire × Duroc (LYD) pigs. J Anim Sci Technol 2019;61(1):35- 40. https://doi.org/10.5187/jast.2019.61.1.35,” the author’s name is given incorrectly. The spelling of Md. Mahabbat Ali’s name was incorrectly given as Md. Mhahbbat Ali. The editorial office would like to correct the author’s name.
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This study was conducted to investigate whether adding different levels of raw or differently processed chickpea into different diets of laying quails affected live weight, feed intake, feed efficiency, egg weight and internal and external egg quality. Chickpea was used as raw, autoclaved or microwave-processed, and it was involved in the diets on two different levels (20% and 40%). The sample was divided into 7 groups including the control, 20% and 40% raw, 20% and 40% autoclaved, and 20% and 40% microwaveprocessed groups. 336 ten-week-old female laying quails were used in the study, and the experiment continued for 19 weeks. In the study, the differences among the groups were insignificant in terms of live weight, feed intake, feed efficiency, egg weight and egg quality characteristics such as shell thickness, shell weight, yolk weight, yolk color and albumin index. The differences were significant in terms of the shape index, Haugh unit (p<0.05) and yolk index (p<0.01). Consequently, it was observed that different thermal processes on chickpeas did not usually have a significant effect on the yield performance of the quails, and the results that were obtained were similar to the other groups. However, it was determined that some egg quality characteristics were affected by the autoclaving and microwaving processes. Between the thermal processes, it may be stated that autoclaving provided better results.
Objective: Schizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in schizophrenia, adequate information is not available on these issues. The aim of this study is to determine the changes in oxidative status and thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs. Methods: Thirteen schizophrenic patients using atypical antipsychotic drugs and 30 healthy controls were included this study. The concentrations of total oxidant status (TOS), total antioxidant status (TAS), native thiol, total thiol, and disulfide levels were determined in the study population. Results: The TAS (p=0.001), total thiol, and native thiol levels (p<0.001) were higher in the patients compared to the controls, whereas the TOS and disulfide levels were lower in the patients than in the controls (p<0.001). Conclusion: These results may suggest that atypical antipsychotic drugs have a useful therapeutic effect by reducing oxidative stress via the inhibition of the formation of disulfide bonds. The study population number was one of the limitations of this study. Therefore, further studies are needed to establish the association between thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs
Purpose: The promoter methylation status of cell cycle regulatory genes plays a crucial role in the regulation of the eukaryotic cell cycle. CpG cytosines are actively subjected to methylation during tumorigenesis, resulting in gain/loss of function. E2F5 gene has growth repressive activities; various studies suggest its involvement in tumorigenesis. This study aims to investigate the epigenetic regulation of E2F5 in breast cancer to better understand tumor biology. Methods: The promoter methylation status of 50 breast tumor tissues and adjacent normal control tissues was analyzed. mRNA expression was determined using SYBR® green quantitative polymerase chain reaction (PCR), and methylation- specific PCR was performed for bisulfite-modified genomic DNA using E2F5-specific primers to assess promoter methylation. Data was statistically analyzed. Results: Significant (p<0.001) upregulation was observed in E2F5 expression among tumor tissues, relative to the control group. These samples were hypo-methylated at the E2F5 promoter region in the tumor tissues, compared to the control. Change in the methylation status (Δmeth) was significantly lower (p=0.022) in the tumor samples, indicating possible involvement in tumorigenesis. Patients at the postmenopausal stage showed higher methylation (75%) than those at the premenopausal stage (23.1%). Interestingly, methylation levels gradually increased from the early to the advanced stages of the disease (p<0.001), which suggests a putative role of E2F5 methylation in disease progression that can significantly modulate tumor biology at more advanced stage and at postmenopausal age (Pearson’s r=0.99 and 0.86, respectively). Among tissues with different histological status, methylation frequency was higher in invasive lobular carcinoma (80.0%), followed by invasive ductal carcinoma (46.7%) and ductal carcinoma in situ (20.0%). Conclusion: Methylation is an important epigenetic factor that might be involved in the upregulation of E2F5 gene in tumor tissues, which can be used as a prognostic marker for breast cancer.
Larik, Fayaz Ali,Faisal, Muhammad,Saeed, Aamer,Channar, Pervaiz Ali,Korabecny, Jan,Jabeen, Farukh,Mahar, Ihsan Ali,Kazi, Mehar Ali,Abbas, Qamar,Murtaza, Ghulam,Khan, Gul Shahzada,Hassan, Mubashir,Seo, Academic Press 2019 Bioorganic chemistry Vol.86 No.-
<P><B>Abstract</B></P> <P>The increasing resistance of pathogens to common antibiotics, as well as the need to control urease activity to improve the yield of soil nitrogen fertilization in agricultural applications, has stimulated the development of novel classes of molecules that target urease as an enzyme. In this context, the newly developed compounds on the basis of 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity to validate their role as potent inhibitors of this enzyme. 1-Heptanoyl-3-arylthioureas were obtained in excellent yield and characterized through spectral and elemental analysis. All the compounds displayed remarkable potency against urease inhibition as compared to thiourea standard. It was found that novel compounds fulfill the criteria of drug-likeness by obeying Lipinski’s rule of five. Particularly compound <B>4a</B> and <B>4c</B> can serve as lead molecules in 4D (drug designing discovery and development). Kinetic mechanism and molecular docking studies also carried out to delineate the mode of inhibition and binding affinity of the molecules.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new family of 1-heptanoyl-3-arylthioureas (<B>4a-4j</B>) was synthesized in excellent yield. </LI> <LI> The synthesized 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity. </LI> <LI> Particularly compound <B>4a</B> and <B>4c</B> can serve as lead molecules in 4D (drug designing discovery and development). </LI> <LI> Kinetic mechanism and molecular docking studies also carried out to delineate the mode of inhibition and binding affinity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
In recent years, high-rise buildings received a renewed interest as a means by which technical and economic advantages can be achieved, especially in areas of high population density. Taller and taller buildings are being built worldwide. These types of buildings present an asset and typically are built not to fail under wind loadings. The increase in a building's height results in increased flexibility, which can lead to significant vibrations, especially at top floors. Such oscillations can magnify the overall loads and can be annoying to the top floors' occupants. This paper shows that increased stiffness in high-rise buildings may not be a feasible solution and may not be used for the design for comfort and serviceability. High-rise buildings are unique, and a vibration control system for a certain building may not be suitable for another. Even for the same building, its behavior in the two lateral directions can be different. For this reason, the current study addresses the application of hybrid tuned mass and magneto-rheological (TM/MR) dampers that can work for such types of buildings. The proposed control scheme shows its effectiveness in reducing floors' accelerations for both comfort and serviceability concerns. Also, a dissipative analysis carried out shows that the MR dampers are working within the possible range of optimum performance. In addition, the design loads are dramatically reduced, creating more resilient and sustainable buildings. The purpose of this paper is to stimulate, shape, and communicate ideas for emerging control technologies that are essential for solving wind related problems in high-rise buildings, with the objective to build the more resilient and sustainable infrastructure and to optimally retrofit existing structures.
<P>In recent days, vehicles have been equipped with smart devices that offer various multimedia-related applications and services, such as smart driving assistance, traffic congestions, weather forecasting, road safety alarms, and many entertainment and comfort applications. Thus, these smart vehicles produce a large amount of multimedia-related data that require fast and real-time processing. However, due to constrained computing and storage capacities, such huge amounts of multimedia-related data cannot be processed in on-board standalone devices. Thus, multimedia cloud computing (MCC) has emerged as an economical and scalable computing technology that can process multimedia-related data efficiently while providing improved Quality of Service (QoS) to vehicular users from anywhere, at any time and on any device, at reduced costs. However, there are certain challenges, such as fast service response time and resource cost optimization, that can severely affect the performance of the MCC. Therefore, to tackle these issues, in this paper, we propose a dynamic priority-based architecture for the MCC. In the proposed scheme, we divide multimedia processing into four different subphases, while computing resources to each computing server are assigned dynamically, according to the workload, in order to process multimedia tasks according to the multimedia user Quality of Experience (QoE) requirements. The performance of the proposed scheme is evaluated in terms of service response time and resource cost optimization using the CloudSim simulator.</P>