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      • KCI등재SCOPUS

        Aberrant Promoter Methylation at CpG Cytosines Induce the Upregulation of the E2F5 Gene in Breast Cancer

        Arshad,Ali,Farman,Ullah,Irum,Sabir,Ali,Ahmad,Faraz,Mumtaz,Khan,Syed,Tahir,Ali,Shah,Nawab,Ali,Muhammad,Saeed 한국유방암학회 2016 Journal of breast cancer Vol.19 No.2

        Purpose: The promoter methylation status of cell cycle regulatory genes plays a crucial role in the regulation of the eukaryotic cell cycle. CpG cytosines are actively subjected to methylation during tumorigenesis, resulting in gain/loss of function. E2F5 gene has growth repressive activities; various studies suggest its involvement in tumorigenesis. This study aims to investigate the epigenetic regulation of E2F5 in breast cancer to better understand tumor biology. Methods: The promoter methylation status of 50 breast tumor tissues and adjacent normal control tissues was analyzed. mRNA expression was determined using SYBR® green quantitative polymerase chain reaction (PCR), and methylation- specific PCR was performed for bisulfite-modified genomic DNA using E2F5-specific primers to assess promoter methylation. Data was statistically analyzed. Results: Significant (p<0.001) upregulation was observed in E2F5 expression among tumor tissues, relative to the control group. These samples were hypo-methylated at the E2F5 promoter region in the tumor tissues, compared to the control. Change in the methylation status (Δmeth) was significantly lower (p=0.022) in the tumor samples, indicating possible involvement in tumorigenesis. Patients at the postmenopausal stage showed higher methylation (75%) than those at the premenopausal stage (23.1%). Interestingly, methylation levels gradually increased from the early to the advanced stages of the disease (p<0.001), which suggests a putative role of E2F5 methylation in disease progression that can significantly modulate tumor biology at more advanced stage and at postmenopausal age (Pearson's r=0.99 and 0.86, respectively). Among tissues with different histological status, methylation frequency was higher in invasive lobular carcinoma (80.0%), followed by invasive ductal carcinoma (46.7%) and ductal carcinoma in situ (20.0%). Conclusion: Methylation is an important epigenetic factor that might be involved in the upregulation of E2F5 gene in tumor tissues, which can be used as a prognostic marker for breast cancer.

      • KCI등재

        Facile Synthesis of New Pyrazolopyrimidine Derivatives of Potential Biosignificant Interest

        Aly,A.,Aly,A.,Gad,El-Karim 대한화학회 2011 대한화학회지 Vol.55 No.5

        An easy and efficient route for the synthesis of some imidazo[1,2-c]pyrazolo[4,3-e]pyrimidines 3-6, imidazo [1,2-c]pyrazolo[4,3-e]triazine 8, pyrazolo[4,3-e]triazolo[1,5-c]pyrimidines 12-15 and pyrazolo-[3',4':4,5]pyrimido[1,6-b]triazines 16, 17 was described through the reaction of readily available 5-aminopyrazole-4-carbonitrile 1 with different reagents. The in vitro antimicrobial activity of some synthesized compounds was examined. Most of the tested compounds proved to be active as antibacterial and antifungal agents.

      • SCIESCOPUSKCI등재후보

        Wind profile management and blockage assessment for a new 12-fan Wall of Wind facility at FIU

        Aly,,Aly,Mousaad,Chowdhury,,Arindam,Gan,Bitsuamlak,,Girma Techno-Press 2011 Wind and Structures, An International Journal (WAS Vol.14 No.4

        Researchers at the International Hurricane Research Center (IHRC), Florida International University (FIU), are working in stages on the construction of a large state-of-the-art Wall of Wind (WoW) facility to support research in the area of Wind Engineering. In this paper, the challenges of simulating hurricane winds for the WoW are presented and investigated based on a scale model study. Three wind profiles were simulated using airfoils, and/or adjustable planks mechanism with and without grids. Evaluations of flow characteristics were performed in order to enhance the WoW's flow simulation capabilities. Characteristics of the simulated wind fields are compared to the results obtained from a study using computational fluid dynamics (CFD) and also validated via pressure measurements on small-scale models of the Silsoe cube building. Optimal scale of the test model and its optimal distance from the WoW contraction exit are determined - which are two important aspects for testing using an open jet facility such as the WoW. The main objective of this study is to further the understanding of the WoW capabilities and the characteristics of its test section by means of intensive tests and validations at small scale in order to apply this knowledge to the design of the full-scale WoW and for future wind engineering testing.

      • KCI등재

        Model Determination of Delayed Causes of Analgesics Prescription in the Emergency Ward in Arak, Iran

        ( Ali Cyrus ), ( Mehrdad Moghimi ), ( Abolfazle Jokar ), ( Mohammad Rafeie ), ( Ali Moradi ), ( Parisa Ghasemi ), ( Hanieh Shahamat ), ( Ali Kabir ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.2

        According to the reports of the World Health Organization 20% of world population suffer from pain and 33% of them suffer to some extent that they cannot live independently. Methods: This is a cross-sectional study which was conducted in the emergency department (ED) of Valiasr Hospital of Arak, Iran, in order to determine the causes of delay in prescription of analgesics and to construct a model for prediction of circumstances that aggravate oligoanalgesia. Data were collected during a period of 7 days. Results: Totally, 952 patients participated in this study. In order to reduce their pain intensity, 392 patients (42%) were treated. Physicians and nurses recorded the intensity of pain for 66.3% and 41.37% of patients, respectively. The mean (SD) of pain intensity according to visual analogue scale (VAS) was 8.7 (1.5) which reached to 4.4 (2.3) thirty minutes after analgesics prescription. Median and mean (SD) of delay time in injection of analgesics after the physician``s order were 60.0 and 45.6 (63.35) minutes, respectively. The linear regression model suggested that when the attending physician was male or intern and patient was from rural areas the delay was longer. Conclusions: We propose further studies about analgesics administration based on medical guidelines in the shortest possible time and also to train physicians and nurses about pain assessment methods and analgesic prescription. (Korean J Pain 2014; 27: 152-161)

      • KCI등재SCOPUS

        Continuous biosorption of U(VI) and Fe(II) using Cystoseira indica biomass packed bed column: Breakthrough curves studies in single, binary and multi-component systems

        Ali,Reza,Keshtkar,Ali,Talebian,Mohammad,Ali,Moosavian 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7

        Ca-pretreated Cystoseira indica algae was used as a biosorbent for the biosorption of U(VI) and Fe(II) ions in single, binary and multi-component systems by using a packed bed column. Experiments were conducted to study the effect of important design parameters such as bed height and flow rate. FTIR and XRF analyses and pH and Ca2+ ion concentration recordings showed that the biosorption of U(VI) and Fe(II) proceeded through ion-exchange mechanism. BDST, Thomas and Modified dose-response models were used for predicting breakthrough curves and for estimations of the parameters necessary for the design of a large-scale packed bed column.

      • KCI등재SCIESCOPUS

        Vibration control of high-rise buildings for wind: a robust passive and active tuned mass damper

        Aly,,Aly,Mousaad Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.13 No.3

        Tuned mass dampers (TMDs) have been installed in many high-rise buildings, to improve their resiliency under dynamic loads. However, high-rise buildings may experience natural frequency changes under ambient temperature fluctuations, extreme wind loads and relative humidity variations. This makes the design of a TMD challenging and may lead to a detuned scenario, which can reduce significantly the performance. To alleviate this problem, the current paper presents a proposed approach for the design of a robust and efficient TMD. The approach accounts for the uncertain natural frequency, the optimization objective and the input excitation. The study shows that robust design parameters can be different from the optimal parameters. Nevertheless, predetermined optimal parameters are useful to attain design robustness. A case study of a high-rise building is executed. The TMD designed with the proposed approach showed its robustness and effectiveness in reducing the responses of high-rise buildings under multidirectional wind. The case study represents an engineered design that is instructive. The results show that shear buildings may be controlled with less effort than cantilever buildings. Structural control performance in high-rise buildings may depend on the shape of the building, hence the flow patterns, as well as the wind direction angle. To further increase the performance of the robust TMD in one lateral direction, active control using LQG and fuzzy logic controllers was carried out. The performance of the controllers is remarkable in enhancing the response reduction. In addition, the fuzzy logic controller may be more robust than the LQG controller.

      • SCOPUSKCI등재

        Facile Synthesis of New Pyrazolopyrimidine Derivatives of Potential Biosignificant Interest

        Aly,,Aly,A.,El-Karim,,Iman,A.,Gad Korean Chemical Society 2011 대한화학회지 Vol.55 No.5

        An easy and efficient route for the synthesis of some imidazo[1,2-c]pyrazolo[4,3-e]pyrimidines 3-6, imidazo[1,2-c]pyrazolo[4,3-e]triazine 8, pyrazolo[4,3-e]triazolo[1,5-c]pyrimidines 12-15 and pyrazolo-[3',4':4,5]pyrimido[1,6-b]triazines 16, 17 was described through the reaction of readily available 5-aminopyrazole-4-carbonitrile 1 with different reagents. The in vitro antimicrobial activity of some synthesized compounds was examined. Most of the tested compounds proved to be active as antibacterial and antifungal agents.

      • KCI등재SCIESCOPUS

        Vibration control of high-rise buildings for wind: a robust passive and active tuned mass damper

        Aly,Mousaad,Aly 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.13 No.3

        Tuned mass dampers (TMDs) have been installed in many high-rise buildings, to improve their resiliency under dynamic loads. However, high-rise buildings may experience natural frequency changes under ambient temperature fluctuations, extreme wind loads and relative humidity variations. This makes the design of a TMD challenging and may lead to a detuned scenario, which can reduce significantly the performance. To alleviate this problem, the current paper presents a proposed approach for the design of a robust and efficient TMD. The approach accounts for the uncertain natural frequency, the optimization objective and the input excitation. The study shows that robust design parameters can be different from the optimal parameters. Nevertheless, predetermined optimal parameters are useful to attain design robustness. A case study of a high-rise building is executed. The TMD designed with the proposed approach showed its robustness and effectiveness in reducing the responses of high-rise buildings under multidirectional wind. The case study represents an engineered design that is instructive. The results show that shear buildings may be controlled with less effort than cantilever buildings. Structural control performance in high-rise buildings may depend on the shape of the building, hence the flow patterns, as well as the wind direction angle. To further increase the performance of the robust TMD in one lateral direction, active control using LQG and fuzzy logic controllers was carried out. The performance of the controllers is remarkable in enhancing the response reduction. In addition, the fuzzy logic controller may be more robust than the LQG controller.

      • KCI등재

        Examination of Correlations Between Several Biochemical Components and Powdery Mildew Resistance of Flax Cultivars

        Aly,A.,Aly,Kamel,A.,Abd-Elsalam,Mahmoud,T.,M.,Mansour,Heba,I.,Mohamed 한국식물병리학회 2012 Plant Pathology Journal Vol.28 No.2

        A field trial was conducted in 2009/2010 and 2010/2011growing seasons at Giza Agricultural Research Station to examine correlations between some biochemical componets and powdery mildews (PMs) resistance in flax cultivars. Nine flax cultivars could be divided into five distinct groups, i.e., highly susceptible (Cortland and C.I. 2008), moderately susceptible (Giza 7, and Marshall),moderately resistant (Cass), resistant (Koto, Dakota and Wilden), and highly resistant (Ottowa 770B). The cultivars showed considerable variation in PM severity ranged from 8.05 on Ottowa 770B to 97.02% on Cortland. Total soluble proteins, total phenols, antioxidant enzymes (peroxidase and polyphenoloxidase), ascorbic acid, tocopherol, and malondialdehyde (MDA), were determined in uninfected leaves of the tested cultivars. Pearson's correlation coefficient was calculated to measure the degree of association between PM severity and each component. All components showed significant (P < 0.05) or highly significant (P < 0.01) negative correlation with PM severity except MDA, which showed positive correlation (P < 0.01). Linear regression analysis was used to evaluate the causal relationship between the biochemical components (independent variables)and PM severity (dependent variable). Coefficient of determination (R2) values of the generated models ranged from 48.76 to 77.15%. Tocopherol, MDA, and proteins were the most important contributors to the total variation in PM severity as the R2 values of their models were 71.78, 75.28, and 77.15%, respectively. The results of the present study suggest that tocopherol,MDA, and proteins in uninfected leaves can be used as biochemical markers to predict PM resistance in flax.

      • The Use of Bracing Systems with MR Dampers in Super Tall Buildings

        Aly,,Aly,Mousaad Council on Tall Building and Urban Habitat Korea 2016 International journal of high-rise buildings Vol.5 No.1

        High-rise buildings are increasingly viewed as having both technical and economic advantages, especially in areas of high population density. Increasingly taller buildings are being built worldwide. Increased heights entail increasing flexibility, which can result in serviceability problems associated with significant displacements and accelerations at higher floors. The purpose of this paper is to present the concept of a versatile vibration control technology (MR dampers with bracings) that can be used in super tall buildings. The proposed technology is shown to be effective, from a serviceability point of view, as well as resulting in dramatically reduced design wind loads, thus creating more resilient and sustainable buildings.

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