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We show that roots of log-concave Alexander knot polynomials are dense in C. This in particular implies that the log-concavity and Hoste's conjecture on the Alexander polynomial of alternating knots are (essentially) independent.
Levada,Kateryna,Pshenichnikov,Stanislav,Omelyanchik,Alexander,Rodionova,Valeria,Nikitin,Aleksey,Savchenko,Alexander,Schetinin,Igor,Zhukov,Dmitry,Abakumov,Maxim,Majouga,Alexander,Lunova,Mariia,Jirsa,Mi 나노기술연구협의회 2020 Nano Convergence Vol.7 No.17
Iron oxide nanoparticles (IONs) are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver imaging. Indeed, number of IONs have been withdrawn due to their poor clinical performance. Yet comprehensive understanding of their interactions with hepatocytes remains relatively limited. Here we investigated how iron oxide nanocubes (IO-cubes) and clusters of nanocubes (IO-clusters) affect distinct human hepatic cell lines. The viability of HepG2, Huh7 and Alexander cells was concentration-dependently decreased after exposure to either IO-cubes or IO-clusters. We found similar cytotoxicity levels in three cell lines triggered by both nanoparticle formulations. Our data indicate that different expression levels of Bcl-2 predispose cell death signaling mediated by nanoparticles. Both nanoparticles induced rather apoptosis than autophagy in HepG2. Contrary, IO-cubes and IO-clusters trigger distinct cell death signaling events in Alexander and Huh7 cells. Our data clarifies the mechanism by which cubic nanoparticles induce autophagic flux and the mechanism of subsequent toxicity. These findings imply that the cytotoxicity of ION-based contrast agents should be carefully considered, particularly in patients with liver diseases.
We show that roots of log-concave Alexander knot polyno- mials are dense in C. This in particular implies that the log-concavity and Hoste's conjecture on the Alexander polynomial of alternating knots are (essentially) independent.
The safety and efficiency of nuclear reactors largely depend on the monitoring and control of nuclear radiation. Due to the unique nuclear-physical characteristics, Hf is one of the most promising materials for the manufacturing of the control rods and the emitters of neutron detectors. It is proposed to use the Compton neutron detector with the emitter made of Hf in the In-core Instrumentation System (ICIS) for monitoring the neutron field. The main advantages of such a detector in comparison the conventional β-emission sensors are the possibility of reaching of a higher cumulative radiation dose and the absence of signal delays. The response time of the detection is extremely important when a nuclear reactor is operating near its critical operational parameters. Taking Hf as an example, the general principles for calculating the chains of materials transformation under neutron irradiation are reported. The influence of <sup>179m1</sup>Hf on the Hf composition changing dynamics and the process of transmutants' (Ta, W) generation were determined. The effect of these processes on the absorbing properties of Hf, which inevitably predetermine the lifetime of the detector and its ability to generate a signal, is estimated.
This project is dedicated to the elaboration of a man-machine system for monitoring the non spread of nuclear weapons, technologies, raw materials. The main purpose of such a system depends on the customer requirements and may be : - control of non proliferation of nuclear technologies, especially those that can be used to manufacture a nuclear explosive device; - the appraisal of the possibility of production of nuclear weapons by a certain country on the basic of its intellectual and scientific-technical potential, its raw material resources, its export-import potential and other parameters.
Background: Our objectives were to review our institutional early and midterm experience with primary tetralogy of Fallot (TOF) repair, and identify predictors of intensive care unit (ICU) morbidity. Methods: We analyzed perioperative and midterm follow-up data for all cases of primary TOF repair from 2001 to 2012. The primary endpoint was early mortality and morbidity, and the secondary endpoint was survival and functional status at follow-up. Results: Ninety-seven patients underwent primary repair. The median age was 4.9 months (range, 1 to 9 months), and the median weight was 5.3 kg (range, 3.1 to 9.8 kg). There was no early surgical mortality. The incidence of junctional ectopic tachycardia and persistent complete heart block was 2% and 1%, respectively. The median length of ICU stay was 6 days (range, 2 to 21 days), and the median duration of mechanical ventilation was 19 hours (range, 0 to 136 hours). By multiple regression analysis, age and weight were independent predictors of the length of ICU stay, while the surgical era was an independent predictor of the duration of mechanical ventilation. At the 8-year follow-up, freedom from death and re-intervention was 97% and 90%, respectively. Conclusion: Primary TOF repair is a safe procedure with low mortality and morbidity in a medium-sized program with outcomes comparable to national standards. Age and weight at the time of surgery remain significant predictors of morbidity.
This erratum is being published to correct the printing error on pages 82 and 88 of the article entitled ‘Evaluation of the Impact of Automated Specimen Inoculation, Using Previ Isola, on the Quality of and Technical Time for Stool Cultures' by Alexander Mischnik, Marlies Trampe, and Stefan Zimmermann in Ann Lab Med 2015;35:82-8, DOI 10.3343/alm.2015.35.1.82 as follows.
The reaction was controlled by sampling the melt, as well as by analysis of the resulting precipitate. The process was shown to proceed according to several parallel reactions. The summary reaction was determined to have two stages: a fast one and a slow one. The 19–53% UN → UCl3 conversion was obtained for the molar ratio of CdCl2/UN = 1.22–14.9. The rest of UN converts into the precipitate of complex composition (UNCl + U2N3 + U4N7 + UN2). The increase in the CdCl2/UN molar ratio from 1.22 to 14.9 resulted in the decrease in duration of the first “fast” stage of the process from 18 h to 1 h.