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RISS 인기검색어
- 검색키워드
- 저자 : Albrektsson, Tomas (검색결과 4 건)
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Sul, Young-Taeg,Johansson, Carina,Albrektsson, Tomas The Royal Society 2010 Journal of the Royal Society, Interface Vol.7 No.42
<P> Quantifying the <I>in vivo</I> interfacial biochemical bond strength of bone implants is a biological challenge. We have developed a new and novel <I>in vivo</I> method to identify an interfacial biochemical bond in bone implants and to measure its bonding strength. This method, named biochemical bond measurement (BBM), involves a combination of the implant devices to measure true interfacial bond strength and surface property controls, and thus enables the contributions of mechanical interlocking and biochemical bonding to be distinguished from the measured strength values. We applied the BBM method to a rabbit model, and observed great differences in bone integration between the oxygen (control group) and magnesium (test group) plasma immersion ion-implanted titanium implants (0.046 versus 0.086 MPa, <I>n</I> =10, <I>p</I> =0.005). The biochemical bond in the test implants resulted in superior interfacial behaviour of the implants to bone: (i) close contact to approximately 2 μm thin amorphous interfacial tissue, (ii) pronounced mineralization of the interfacial tissue, (iii) rapid bone healing in contact, and (iv) strong integration to bone. The BBM method can be applied to <I>in vivo</I> experimental models not only to validate the presence of a biochemical bond at the bone-implant interface but also to measure the relative quantity of biochemical bond strength. The present study may provide new avenues for better understanding the role of a biochemical bond involved in the integration of bone implants. </P>
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Sul, Young-Taeg,Jeong, Yongsoo,Johansson, Carina,Albrektsson, Tomas Blackwell Publishing Ltd 2006 Clinical oral implants research Vol.17 No.5
<P>Abstract</P><P>Objectives</P><P>The study presented was designed to investigate the speed and the strength of osseointegration of oxidized implants at early healing times in comparison which machined, turned implants.</P><P>Material and methods</P><P>Screw-shaped titanium implants were prepared and divided into two groups: magnesium ion incorporated, oxidized implants (Mg implants, <I>n</I>=10) and machined, turned implants (controls, <I>n</I>=10). Mg implants were prepared using micro-arc oxidation methods. Surface oxide properties of implants such as surface chemistry, oxide thickness, morphology/pore characteristics, crystal structures and roughness were characterized with various surface analytic techniques. Implants were inserted into the tibiae of ten New Zealand white rabbits. After a follow-up period of 3 and 6 weeks, removal torque (RTQ), osseointegration speed (ΔRTQ/Δhealing time) and integration strength of implants were measured. Bonding failure analysis of the bone-to-implant interface was performed.</P><P>Results</P><P>The speed the and strength of osseointegration of Mg implants were significantly more rapid and stronger than for turned implants at follow-up periods of 3 and 6 weeks. Bonding failure for Mg implants dominantly occurred within the bone tissue, whereas bonding failure for turned implants mainly occurred at the interface between implant and bone.</P><P>Conclusions</P><P>Oxidized, bioactive implants are rapidly and strongly integrated in bone. The present results indicate that the rapid and strong integration of oxidized, bioactive Mg implants to bone may encompass immediate/early loading of clinical implants.</P>
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Sul, Young-Taeg,Kang, Byung-Soo,Johansson, Carina,Um, Heung-Sik,Park, Chan-Jin,Albrektsson, Tomas Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of biomedical materials research. Part A Vol.a89 No.4
<P>The present study investigated the effects of surface chemistry and topography on the strength and rate of osseointegration of titanium implants in bone. Three groups of implants were compared: (1) machine-turned implants (turned implants), (2) machine-turned and aluminum oxide-blasted implants (blasted implants), and (3) implants that were machine-turned, aluminum oxide-blasted, and processed with the micro-arc oxidation method (Mg implants). Three and six weeks after implant insertion in rabbit tibiae, the implant osseointegration strength and rate were evaluated. Surface chemistry revealed characteristic differences of nine at.% Mg for Mg implants and 11 at.% Al for blasted implants. In terms of surface roughness, there was no difference between Mg implants and blasted implants in developed surface ratio (Sdr; p = 0.69) or summit density (Sds; p = 0.96), but Mg implants had a significantly lower arithmetic average height deviation (Sa) value than blasted implants (p = 0.007). At both 3 and 6 weeks, Mg implants demonstrated significantly higher osseointegration strength compared with turned (p = 0.0001, p = 0.0001) and blasted (p = 0.0001, p = 0.035) implants, whereas blasted implants showed significantly higher osseointegration than turned implants at 6 weeks (p = 0.02) but not at 3 weeks (p = 0.199). The present results not only support the hypothesis that biochemical bonding facilitates rapid and strong integration of implants in bone, but also provide evidence for biochemical bonding theory previously proposed by Sul. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</P>
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