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Alba Francesca Battista(알바 프란체스카 바티스타),Nicola Monopoli(니콜라 모노폴리) 한국전자음악협회 2015 에밀레 Vol.13 No.-
최대 범주의 규칙 보완적 카논Regular Complementary Canons of Maximal Category (RCCM) 혹은 뷰자 카논Vuza canons은 댄 튜더 뷰자Dan Tudor Vuza가 1990년대 피엔엠Perspectives of New Music 저널에 괄목할만한 논문을 발표하면서 음악계에 소개되었다. 그의 독창적인 견해가 알려진 후 이 중대한 개념은 많은 발전과 대중화 과정을 거쳤다. 음악가들은 늘 캐논의 구성에 많은 관심을 가지고, 플랑드르악파인 조스캥 데프레Josquin Desprez의 복합다성음악이나 요한 세바스찬 바하Johann Sebastian Bach의 대위 기법의 특성들은 공식적인 대수학algebraic 용어로 설명된다. 올리비에 메시앙Olivier Messiaen이 아마 처음으로 리듬 카논의 개념을 소개하고 연구한 이론가 겸 작곡가일 것이다. 수학적 관점에서 봤을 때, 리듬 카논의 구성은 다른 20세기 작곡가들처럼 메시앙도 몰랐을 개념인 두 하위집합의 합으로서 유한하게 순환하는 그룹들의 인수분해로 공식화될 수 있을 것이다. 요즈음 모자이크 카논mosaic canons을 만드는 과정에는 프로그래밍 언어가 적용될 수 있다: 작곡가들이 창조적 음악 작품을 지을 때 형식적 시스템formal architectures의 기초로 이를 활용하여 극도로 복잡하고 거대한 구조를 다룰 수 있다. 이 글에서는 프랑크 예드르제브스키Franck Jedrzejewski의 것에서 비롯된, 작곡가가 알시시엠 카논을 만들고 직접 다룰 수 있게 해주는 알고리듬으로 울프람 매스마티카Wolfram Mathematica에서 저자들이 시행한 것을 보여주고자 한다. 덧붙여 이 알고리듬은 실시간 공간화를 위한 특정 패턴을 구성하는 데 사용된다. Regular Complementary Canons of Maximal Category (RCCM) or Vuza canons were introduced to the musical world with Dan Tudor Vuza’s seminal papers in PNM in the 1990s. Since their original exposition, this important notion has known many developments and generalizations. Musicians have always been intrigued by canon construction, q.v. the complex polyphony of the Flemish composer Josquin Desprez or the contrapuntal techniques of Johann Sebastian Bach, whose properties have been translated into formal algebraic terms. Olivier Messiaen is maybe the first theorist and composer who introduced and studied the concept of rhythmic canon. From a mathematical point of view, the construction of rhythmic canons is formalized in terms of factorizations of finite cyclic groups as the sum of two subsets, a concept that probably Messiaen, like many other composers of the twentieth century, did not know. Nowadays the process of building mosaic canons can be implemented using programming languages: composers can access extremely complex macro-structures that can be taken as the basis for formal architectures of original music compositions. In this paper, we would like to show our implementation in Wolfram Mathematica, with an algorithm, that moves from the Franck Jedrzejewski one, which allows the composer to create and directly manage RCCM Canons. In addition, we use our algorithm to construct special patterns for real-time spatialization.
Alba A. Trespalacios,William Otero,Jorge E. Caminos,Marcela M. Mercado,Jenny Ávila,Liliana E. Rosero,Azucena Arévalo,Raúl A. Poutou-Piñales,David Y. Graham 한국미생물학회 2013 The journal of microbiology Vol.51 No.4
Resistance of Helicobacter pylori to clarithromycin is the most common cause of treatment failure in patients with H. pylori infections. This study describes the MICs and the presence of 23S rRNA mutations of H. pylori isolates from Bogotá, D.C., Colombia. H. pylori were isolated from gastric biopsies from patients with functional dyspepsia. Clarithromycin susceptibility was investigated by agar dilution and strains were considered resistant if the MIC was ≥1 μg/ml. DNA sequences of the 23S rRNA gene of strains resistant and sensitive to clarithromycin were determined to identify specific point mutations. Clarithromycin resistance was present in 13.6% of patients by agar dilution. The A2143G,A2142G and A2142C mutations were found in 90.5, 7.1, and 2.4% of H. pylori strains with resistance genotype.The resistant phenotype was associated with 23S rRNA resistance genotype in 85.7% of isolates. The point mutations in 23S rRNA were well correlated with MICs values for clarithromycin.
Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
( Alba Herrero ),( Aitor Benedicto ),( Irene Romayor ),( Elvira Olaso ),( Beatriz Arteta ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.3
Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE2 secretion. To elucidate the role of the LSEC intercellular adhesion molecule-1 (ICAM-1) in the prometastatic response exerted by tumor and stromal COX-2, we utilized celecoxib (CLX) as a COX-2 inhibitory agent. We analyzed the in vitro proliferative and secretory responses of murine C26 colorectal cancer (CRC) cells to soluble ICAM-1 (sICAM-1), cultured alone or with LSECs, and their effect on LSEC and hepatic stellate cell (HSC) migration and in vivo liver metastasis. CLX reduced sICAM-1-stimulated COX-2 activation and PGE2 secretion in C26 cells cultured alone or cocultured with LSECs. Moreover, CLX abrogated sICAM-1-induced C26 cell proliferation and C26 secretion of promigratory factors for LSECs and HSCs. Interestingly, CLX reduced the protumoral response of HSC, reducing their migratory potential when stimulated with C26 secretomes and impairing their secretion of chemotactic factors for LSECs and C26 cells and proliferative factors for C26 cells. In vivo, CLX abrogated the prometastatic ability of sICAM-1-activated C26 cells while reducing liver metastasis. COX-2 inhibition blocked the creation of a favorable tumor microenvironment (TME) by hindering the intratumoral recruitment of activated HSCs and macrophages in addition to the accumulation of fibrillar collagen. These results point to COX-2 being a key modulator of processes initiated by host ICAM-1 during tumor cell/LSEC/HSC crosstalk, leading to the creation of a prometastatic TME in the liver.
( Alba Beas Catena ),( Asterio Sanchez Miron ),( Francisco Garcia Camacho ),( Antonio Contreras Gomez ),( Emilio Molina Grima ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.12
The aim of this paper was to study the effect of spent medium recycle on Spodoptera exigua Se301 cell line proliferation, metabolism, and baculovirus production when grown in batch suspension cultures in Ex-Cell 420 serum-free medium. The results showed that the recycle of 20% of spent medium from a culture in mid-exponential growth phase improved growth relative to a control culture grown in fresh medium. Although both glucose and glutamine were still present at the end of the growth phase, glutamate was always completely exhausted. The pattern of the specific glucose and lactate consumption and production rates, as well as the specific glutamine and glutamate consumption rates, suggests a metabolic shift at spent medium recycle values of over 60%, with a decrease in the efficiency of glucose utilization and an increase in glutamate consumption to fuel energy metabolism. Baculovirus infection provoked a change in the metabolic pattern of Se301 cells, although a beneficial effect of spent medium recycle was also observed. Both growth rate and maximum viable cell density decreased relative to uninfected cultures. The efficiency of glucose utilization was dramatically reduced in those cultures containing the lowest percentages of spent medium, whereas glutamine and glutamate consumption was modulated, thereby suggesting that infected cells were devoted to virus replication, retaining their ability to incorporate the nutrients required to support viral replication. Recycle of 20% of spent medium increased baculovirus production by around 90%, thus showing the link between cell growth and baculovirus production.
Alba Rita Valenzuela-Briseno,Jeanette Guadalupe Arredondo-D,Antonio Rascon-Careaga,Humberto stiazaran-Garcia,Agustin Gomez-Alvarez,Reynaldo Esquivel-Gonzalez,Roberto Carlos Carrillo-Torres,Enrique Alv 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.4
This study aimed to evaluate whether aluminum chloride (AlCl₃) causes hematological changes in the peripheral blood of Sprague–Dawley (SD) rats. Five groups of female SD rats were intragastrically administered with 4 different concentrations of AlCl₃ for 5 days a week for a total of 90 days. The aluminum concentration was determined via graphite furnace atomic absorption spectroscopy. Analysis of serum iron-kinetic profiles, blood cytometry outcomes, and blood smears of the blood samples. Scanning electron microscopy (SEM) and Raman spectroscopy were used to search for structural and ultrastructural changes, respectively. Blood aluminum concentration ranged 12.38-16.24 μg/L with no significant difference between experimental treatments. At the AlCl₃ concentration of 40 mg Al/kg bw of rats/day, the mean ferritin value in the serum iron kinetic profile was 29.81±6.1 ng/mL, and this value showed a significant difference between experimental treatments. Blood cytometry revealed that there were 6.45-7.11×10<SUP>6</SUP> cells/μL erythrocytes, 8.91-9.32×10³ cells/μL leukocytes, and 477.2-736.3×10³ cells/μL platelets along with a hemoglobin of 37.38-41.93 g/dL and hematocrit level of 37.38-41.93%; the experimental treatments showed no significant differences. Erythrocyte structural analysis using SEM showed no differences between experimental treatments, whereas ultrastructural evaluation using Raman spectroscopy made it possible to identify the following bands: 741, 1123, 1350, 1578, and 1618 cm<SUP>−1</SUP>, which were respectively associated with the following vibrational modes and compounds: vibration of the tryptophan ring, asymmetric C-O-C stretching of glucose, C-H curve of tryptophan, C=C stretching of the heme group, and C-N stretching of the heme group, with no significant differences between experimental treatments. Therefore, AlCl₃ administration does not induce ultrastructural changes in the erythrocyte membrane. This study revealed that serum ferritin concentration was the only parameter affected by AlCl₃ exposure at 40 mg of Al/kg bw of rats/day.