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Genetic aberrations on the short arm of chromosome 8 (8p) in tongue carcinomas
Akiyuki Murano,Kanae Ono,Hirofumi Koike,Yosuke Endo,Ken Shimada,Kenshi Kawasaki,Hitomi Nomura,Masashi Shiiba,Katsuhiro Uzawa,Hideki Tanzawa 대한구강악안면외과학회 2016 대한구강악안면외과학회지 Vol.38 No.2
Aberrations on the short arm of chromosome 8 (8p) are frequently observed in several human cancers. In this study, 20 squamous cell carcinoma (SCC) specimens from the tongue were examined in order to evaluate the role of 8p in SCC of the tongue. Microsatellite analysis using 14 markers demonstrated two commonly deleted regions (CDRs) on 8p. Reverse transcription-polymerase chain reaction (RT-PCR) revealed frequent downregulation of the FEZ1 gene, mapped to 8p22, and frequent over-expression of the cathepsin B gene, mapped to 8p-21-22. These results suggested that genetic aberrations are involved in the development of SCC of the tongue. However, no significant relationship was observed to be established between the genetic alterations and clinicopathological features. Thus, further investigation is necessary in order to clarify the clinical role of 8p in carcinoma of the tongue.
EST analysis of regenerating newt retina
Hisatomi, Osamu,Hasegawa, Akiyuki,Goto, Tatsushi,Yamamoto, Shintaro,Sakami, Sanae,Kobayashi, Yuko,Tokunaga, Fumio Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
A vertebrate retina is an organ belonging to the central nerve system (CNS), and is usually difficult to regenerate except at an embryonic stage in life. However, certain species of urodele amphibians, such as newts and salamanders, possess the ability to regenerate a functional retina from retinal pigment epithelial (RPE) cells even as adults. After surgical removal of neural retinas from adult newt eyes, the remaining RPE cells lose their pigment granules, transdifferentiate into retinal progenitor cells, which further differentiate into various retinal neurons, and then finally reform a functional neural network. To understand the molecular mechanisms of CNS regeneration, we attempted to investigate the genes expressing in regenerating newt retina. mRNAs were isolated from regenerating retinas at 18-19 days after the surgical removal of the normal retina, and a cDNA library (regenerating retinal cDNA library) were constructed. Our EST analysis of 112 clones in the regenerating cDNA library revealed that about 70% clones are closely related to the genes previously identified. About 40% clones are housekeeping genes, and about 15% clones encode proteins related to the regulation of gene expression and to the proliferation of the cells. Sequences similar to neural retina- and RPE-specific genes were not detected at all. These results led us to suppose that the regenerating retinal cells are in a state considerably different from those of neither neural retina nor RPE cells.
Ippei Kojima,Yushi Naito,Akiyuki Yamamoto,Yasuhiro Terashima,Norie Sho,Jun Nagayama,Yurika Okada,Tatsuya Nagai 대한골다공증학회 2019 Osteoporosis and Sarcopenia Vol.5 No.4
Objectives: The purpose of this study is to evaluate the efficacy of annual zoledronic acid treatment in Japanese patients with nonmetastatic prostate cancer during androgen deprivation therapy (ADT). Methods: This is a single institution 12-month study. Between 2016 and 2019, patients aged 70 years or older on ADT for nonmetastatic prostate cancer had bone mineral density (BMD) measured and 10-year probability of fracture calculated using fracture risk assessment tool (FRAX). Patients who showed osteopenia or had a 10-year hip fracture risk 3% or a 10-year probability of major osteoporotic fracture 20% were offered treatment with zoledronic acid 5 mg intravenously (ZA group). The patients who did not receive treatment were set as the control group. Lumbar and hip BMD were measured 6 and 12 months after treatment in the ZA group and 12 months after baseline in the control group. The yearly BMD change of both groups was compared. Results: The mean ages of the ZA group (n ¼ 26) and control group (n ¼ 12) were 80.5 ± 9.1 and 76.1 ± 6.7 years, respectively. In the ZA group, lumbar and hip BMD changes at 12 months were þ2.1% and þ0.8%, respectively. In the control group, lumbar and hip BMD changes were 0.9% and 4.9%, respectively. There were statistically significant differences between the 2 groups in BMD percent changes (P < 0.05). Conclusions: Without intervention, BMD tends to continue to decrease during ADT. Our findings suggest that administration of zoledronic acid enables maintenance of BMD in the older adults.
Sasaki, Keisuke,Ishihara, Kenji,Oyamada, Chiaki,Sato, Akiyuki,Fukushi, Akihiko,Arakane, Tomohiro,Motoyama, Michiyo,Yamazaki, Makoto,Mitsumoto, Mitsuru Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.7
Effects of fucoxanthin (FX), a major carotenoid in algae, on lipid peroxidation and meat colour in ground chicken breast meat were investigated. FX and/or ${\alpha}$-tocopherol (Toc) were added to ground samples at a content level of 200 mg/kg. The samples were subjected to a chilling storage test before and after cooking. In the storage test before cooking, neither FX nor Toc affected the thiobarbituric acid reactive substances (TBARS) on days 1 and 6, and FX decreased the L* value and increased the a* and b* values. In the storage test after cooking, both FX and Toc decreased TBARS values on days 1 and 6. FX decreased the L* value and increased the a* and b* values, similar to what occurred in the storage test before cooking. Based on these results, we concluded that FX is a potent ingredient for improvement of the appearance and shelf life of chicken meat and its products.
Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
Motohiro Nishida,Tomohiro Tanaka,Supachoke Mangmool,Kazuhiro Nishiyama,Akiyuki Nishimura 한국지질동맥경화학회 2020 지질·동맥경화학회지 Vol.9 No.1
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response to changes in the vessel environment. Abnormal phenotypic switching of VSMCs is a distinctive characteristic of vascular disorders, including atherosclerosis, pulmonary hypertension, stroke, and peripheral artery disease; however, how the control of VSMC phenotypic switching is dysregulated under pathological conditions remains obscure. Canonical transient receptor potential (TRPC) channels have attracted attention as a key regulator of pathological phenotype switching in VSMCs. Several TRPC subfamily member proteins—especially TRPC1 and TRPC6—are upregulated in pathological VSMCs, and pharmacological inhibition of TRPC channel activity has been reported to improve hypertensive vascular remodeling in rodents. This review summarizes the current understanding of the role of TRPC channels in cardiovascular plasticity, including our recent finding that TRPC6 participates in aberrant VSMC phenotype switching under ischemic conditions, and discusses the therapeutic potential of TRPC channels.
( Teppei Komiya ),( Takuma Maeda ),( Yuki Kajino ),( Hirofumi Nakayama ),( Takayuki Shimaoka ),( Takayuki Hirao ),( Shuji Watanabe ),( Makoto Takemoto ),( Naoya Maeda ),( Akiyuki Ukai ),( Fumihiro Kas 한국폐기물자원순환학회(구 한국폐기물학회) 2019 한국폐기물자원순환학회 심포지움 Vol.2019 No.1
Approximately 20% of solid waste in Japan is disposed of at coastal landfill sites. It is an issue that it takes long-term to stabilize coastal landfill sites. Municipal solid waste incineration bottom ash (BA) is one of main wastes landfilled at coastal landfill sites. It is known that finer particles contain more contaminants in BA1), and it was demonstrated that the removal of finer particles from BA produced the lowering pH of leachate as well as the increase of permeability of the landfilled waste layer2). In this study, open channel (OC) classification was focused on as a feasible technique to remove finer particles from BA on a coastal landfill site, and its demonstrational experiment was carried out in order to clarify if the fine particle fraction (d<0.425mm) (FPF) could be removed from BA by OC classification and the settling characteristics of BA in OC. Fig. 1 shows the experimental apparatus. The sea water in a coastal landfill site was pumped up and flowed in OC, and BA is supplied on the surface of the flowing water. After completions of the settling and outflow of BA, saucers on the bottom of OC was collected, and the dry weight and particle size distribution of the BA sediment in each saucer were measured. Table 1 shows the experimental condition. The settling section means the part of OC from the BA supply point to the end of OC. Fig. 2 shows the removal ratio of FPF by OC classification, which is the ratio of the dry weight of FPF in the BA sediment to that in the BA supplied. The largest removal ratio was 61% in Case 3 with the largest water flow velocity and the shortest length of settling section. Fig. 3 shows the median of the settling velocity of BA in OC (MSV) compared with the theoretical settling velocity by Allen’s and Newton’s laws (TSV). The MSV of BA particles greater than 3mm was almost 50% of TSV, and MSV became closer to TSV as BA’s particle size became smaller. The MSV of BA particles with a diameter of 0.425mm was approximately 80% of TSV.
Variety of the Wave Change in Compound Muscle Action Potential in an Animal Model
Zenya Ito,Shiro Imagama,Kei Ando,Akio Muramoto,Kazuyoshi Kobayashi,Tetsuro Hida,Kenyu Ito,Yoshimoto Ishikawa,Mikito Tsushima,Akiyuki Matsumoto,Satoshi Tanaka,Masayoshi Morozumi,Yukihiro Matsuyama,Naok 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.6
Study Design: Animal study. Purpose: To review the present warning point criteria of the compound muscle action potential (CMAP) and investigate new criteria for spinal surgery safety using an animal model. Overview of Literature: Little is known about correlation palesis and amplitude of spinal cord monitoring. Methods: After laminectomy of the tenth thoracic spinal lamina, 2–140 g force was delivered to the spinal cord with a tension gage to create a bilateral contusion injury. The study morphology change of the CMAP wave and locomotor scale were evaluated for one month. Results: Four different types of wave morphology changes were observed: no change, amplitude decrease only, morphology change only, and amplitude and morphology change. Amplitude and morphology changed simultaneously and significantly as the injury force increased (p <0.05) Locomotor scale in the amplitude and morphology group worsened more than the other groups. Conclusions: Amplitude and morphology change of the CMAP wave exists and could be the key of the alarm point in CMAP.