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Magnetic Resonance Imaging with Intermolecular Double Quantum Coherences
Ahn, Sang-Doo Korean Magnetic Resonance Society 2004 Journal of the Korean Magnetic Resonance Society Vol.8 No.2
Recently a new method for magnetic resonance imaging based on the detection of relatively strong signal from intermolecular multiple quantum coherences (iMQCs) is reported. Such a signal would not be observable in the conventional framework of magnetic resonance; it originates in long-range dipolar couplings that are traditionally ignored. In this paper, we present the results of experimental studies to assess the feasibility of intermolecular double quantum coherences (iDQCs) imaging in humans. We show that the iDQC images are readily observable at 4T and that they do indeed provide different contrast than appears in conventional images.
( Doo Sun Sim ),( Myung Ho Jeong ),( Weon Kim ),( Jay Young Rhew ),( Ju Hyup Yum ),( Ju Han Kim ),( Jeong Gwan Cho ),( Young Keun Ahn ),( Jong Chun Park ),( Byoung Hee Ahn ),( Sang Hyung Kim ),( Jung 대한내과학회 2003 The Korean Journal of Internal Medicine Vol.18 No.3
Background: High-risk percutaneous coronary interventions (PCIs) are associated with a high complication rate, a low procedural success rate and a high restenosis rate, especially in diabetics. We sought to determine whether abciximab (ReoPro(R)) therapy
Ahn, Sang-Woon,Kim, Hyung-Doo,Park, Eui-Suh Korean Chemical Society 1986 Bulletin of the Korean Chemical Society Vol.7 No.2
The dipole moments for some coordination compounds with organic ligands have been calculated adopting the molecuar orbitals obtained from EHT calculation with modified technique. Adopting the molecular orbitals with the modified technique, the calculated dipole moments for all the coordination compounds with organic ligands give closer agreements with experimental values than those using the molecular orbitals obtained from EHT calculation. The calculated dipole moments suggest that $(C_2H_5)_2SO,\;(C_6H_5)_2SO,\;and\;(C_6H_5)_2SeO$ may have a trigonal planar structure and $(C_6H_5)_3AsO,\;and\;(C_6H_5)_3PBCl_3$ a square planar structure and $(C_2H_5)_2OZrCl_4$ may be distorted markedly. This work may also indicate that the modified technique is superior to the EHT calculation as far as the dipole moment calculation is concerned.
Ahn, Byung Yoon,Shin, Hang Cheol,Choi, Ki Doo,Chang, Seung Gu,Kim, Key Sun,Cho, Yoon Sang 생화학분자생물학회 2001 BMB Reports Vol.33 No.2
M2PI is an active single chain mini-proinsulin with a 9-residue linker containing the turn-forming sequence `YPGDV' between the B- and A-chains, but which retains about 50% of native insulin receptor binding activity The refolding efficiency of M2PI is higher than proinsulin by 2040% at alkaline pH, and native insulin is generated by the enzymatic conversion of M2PI. The solution structure of M2PI was determined by NMR spectroscopy The global structure of M2PI is similar to that of native insulin, but the flexible linker between the B- and A-chains perturbed the N-terminal A-chain and C-terminal B-chain. The helix in the N-terminal A-chain is partly perturbed and the β-turn in the B-chain is disrupted in M2PI. However, the linker between the two chains was completely disordered indicating that the designed turn was not formed under the experimental conditions (20% acetic acid). Considering the fact that an insulin analogue, directly cross-linked between the C-terminus of the B-chain and the N-terminus of the A-chain, has negligible binding activity, a flexible linker between the two chains is sufficient to keep binding activity of M2PI, but the perturbed secondary structures are detrimental to receptor binding.
Sang-Rae Moon,Doo-Jin Noh,Jeong-Oh Yang,Changmann Yoon,Ki-Su Ahn,Gil-Hah Kim 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05
This study was performed to investigate the seasonal occurrence, developmental characteristics of each nymphal stages with different temperatures (20, 25, 30℃), longevity and fecundity of ussur brown katydid, Paratlanticus ussuriensis, damaging by outbreaks in the orchard areas of Bitan-ri, Yeongdong, Chungbuk. Paratlanticus ussuriensis occurred from late-March to late-August with peak of mid-May. Newly emerged nymphs appeared from March and do damaged fruit orchards with peak of mid-May when P. ussuriensis existed as 4th and 5th nymphal stages. P. ussuriensis adult occurred from early-June to mid-Aug. with peak of mid-July. Total density of P. ussuriensis was showed highest in mid-May. P. ussuriensis goes through nymphal stages to 7th nymph, the ovipositor began exposed to outside from the 4th instar and the body weight increased heavily from this stage and the wings were observed from 6th instar. Developmental period was longer as increased the nymphal stages. Sex ratio of collected insect was showed as 0.57; females more than males. As increased the temperature, developmental period was to be short. Preoviposition was also to be short as 5.0, 4.3, and 3.4 days at 20, 25, 30℃, respectively, and fecundity increased as 69.0, 87.1, and 104.3 at 20, 25, 30℃, respectively. Longevity of male and female at 25℃ was showed the longest with 35.7, and 32.9 days and showed the shortest with 30.1 and 28.1 days at 30℃, respectively. The difference of developmental period in male and female were showed longer in female without relation of temperature. The eggs laid were frequently distributed 3 to 4 cm from soil surface, and showed the behavior laying eggs intensively when early oviposition period.
Ahn, Youngkeun,Kim, Yongcheol,Chang, Kiyuk,Kim, Weon,Rhee, Moo-Yong,Cha, Kwang Soo,Hyon, Min Su,Shim, Chi Young,Lee, Sung Yun,Kim, Doo Il,Kim, Sang Wook,Lim, Sang-Wook,Han, Kyoo-Rok,Jo, Sang-Ho,Lee, N Williams & Wilkins Co 2018 Medicine Vol.97 No.37
<P><B>Abstract</B></P><P><B>Background:</B></P><P>To determine whether the effectiveness and safety of fixed-dose combinations (FDCs) of amlodipine orotate/valsartan (AML/VAL) 5/160 mg are noninferior to those of valsartan/hydrochlorothiazide (VAL/HCTZ) 160/12.5 mg in hypertensive patients with inadequate response to valsartan 160 mg monotherapy.</P><P><B>Methods:</B></P><P>This 8-week, active-controlled, parallel-group, fixed-dose, multicenter, double-blind randomized controlled, and noninferiority trial was conducted at 17 cardiovascular centers in the Republic of Korea. Eligible patients had mean sitting diastolic blood pressure (msDBP) ≥90 mm Hg despite monotherapy with valsartan 160 mg for 4 weeks. Patients were randomly assigned to treatment with AML/VAL 5/160 mg FDC (AML/VAL) group or VAL/HCTZ 160/12.5 mg FDC (VAL/HCTZ) group once daily for 8 weeks. A total of 238 patients were enrolled (AML/VAL group, n = 121; VAL/HCTZ group, n = 117), of whom 228 completed the study.</P><P><B>Results:</B></P><P>At 8 weeks after randomization, msDBP was significantly decreased in both groups (−9.44 ± 0.69 mm Hg in the AML/VAL group and −7.47 ± 0.71 mm Hg in the VAL/HCTZ group, both <I>P</I> < .001 vs baseline). Between group difference was −1.96 ± 1.00 mm Hg, indicating that AML/VAL 5/160 mg FDC was not inferior to VAL/HCTZ 160/12.5 mg FDC at primary efficacy endpoint. Control rate of BP defined as the percentage of patients achieving mean sitting SBP (msSBP) <140 mm Hg or msDBP <90 mm Hg (target BP) from baseline to week 8 was significantly higher in the AML/VAL group than that in the VAL/HCTZ group (84.3% [n = 102] in the AML/VAL group vs 71.3% [n = 82] in the VAL/HCTZ group, <I>P</I> = .016). At 8 weeks after randomization, mean uric acid level was significantly increased in the VAL/HCTZ group compared to that at baseline (0.64 ± 0.08 mg/dL; <I>P</I> < .001). However, it was slightly decreased from baseline in the AML/VAL group (−0.12 ± 0.08 mg/dL; <I>P</I> = .085). The intergroup difference was significant (<I>P</I> < .001).</P><P><B>Conclusion:</B></P><P>The effectiveness and safety AML/VAL 5/160 mg FDC are noninferior to those of VAL/HCTZ 160/12.5 mg FDC in patients with hypertension inadequately controlled by valsartan 160 mg monotherapy.</P>
Ahn, Doo-Sik,Kim, So-Yeon,Lim, Goo-Il,Lee, Sungyul,Choi, Young S.,Kim, Sang Kyu WILEY-VCH Verlag 2010 Angewandte Chemie Vol.49 No.7
<B>Graphic Abstract</B> <P>Lights, spectrometer, action: Crucial information about the detailed shape of the potential-energy surface in the vicinity of the transition state is obtained from the Fano resonances in the photodissociation cross-section of diazirine in the S<SUB>1</SUB> state. The excitation along the asymmetric C&n.bond;N stretching mode accelerates the ring-opening reaction, suggesting that two C&n.bond;N bonds of the excited diazirine break in a stepwise manner (see scheme). <img src='wiley_img_2010/14337851-2010-49-7-ANIE200905619-content.gif' alt='wiley_img_2010/14337851-2010-49-7-ANIE200905619-content'> </P>