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Anti-Toxoplasma Activities of Zea Mays and Eryngium Caucasicum Extracts, In Vitro and In Vivo
Ahmadpour, Ehsan,Ebrahimzadeh, Mohammad Ali,Sharif, Mehdi,Edalatian, Sara,Sarvi, Shahabeddin,Montazeri, Mahbobeh,Mehrzadi, Saeed,Akbari, Mohammad,Rahimi, Mohammad Taghi,Daryani, Ahmad KOREAN PHARMACOPUNCTURE INSTITUTE 2019 Journal of pharmacopuncture Vol.22 No.3
Objectives: Toxoplasmosis is a worldwide health problem that caused by intracellular apicomplexan parasite, Toxoplasma gondii (T. gondii). Considering that the available drugs for toxoplasmosis have serious host toxicity, the aim of the current study was to survey the in vitro and in vivo anti-Toxoplasma activity of Zea mays (Z. mays) and Eryngium caucasicum (E. caucasicum) extracts. Methods: Four concentrations (5, 10, 25, and $50mg\;mL^{-1}$) of Z. mays and E. caucasicum methanolic extracts for 30, 60, 120, and 180 min were incubated with infected macrophages and then the viability of RH strain of T. gondii tachyzoites was evaluated by trypan blue staining method. Also, we evaluated the survival rate of acutely infected mice with the extracts (100 and $200mg\;kg^{-1}\;day^{-1}$) intraperitoneally for 5 days after infection with $2{\times}104$ tachyzoites of T. gondii. Results: The anti-Toxoplasma effect of the methanolic extracts were extremely significant compared to the negative control group in all exposure times (P < 0.05). The Z. mays (10, 25 and $50mg\;mL^{-1}$) killed 100% of the parasites after 180 and 120 min exposure, respectively. Also, high toxoplasmacidal activity was observed with E. caucasicum extract. Furthermore, treatment of experimentally infected mice with the Z. mays (100, $200mg\;kg^{-1}\;day^{-1}$) and E. caucasicum ($100mg\;kg^{-1}\;day^{-1}$) significantly increased their survival rate compared to untreated infected control (P < 0.05). Conclusion: These extracts are promising candidates for further medicine development on toxoplasmosis. However, further investigations are necessary to clarify effective fractions of the Z. mays and E. caucasicum extracts and the mechanisms of action.
Anti-Toxoplasma Activities of Zea Mays and Eryngium Caucasicum Extracts, In Vitro and In Vivo
Ehsan Ahmadpour,Mohammad Ali Ebrahimzadeh,Mehdi Sharif,Sara Edalatian,Shahabeddin Sarvi,Mahbobeh Montazeri,Saeed Mehrzadi,Mohammad Akbari,Mohammad Taghi Rahimi,Ahmad Daryani 대한약침학회 2019 Journal of pharmacopuncture Vol.22 No.3
Objectives: Toxoplasmosis is a worldwide health problem that caused by intracellular apicomplexan parasite, Toxoplasma gondii (T. gondii). Considering that the available drugs for toxoplasmosis have serious host toxicity, the aim of the current study was to survey the in vitro and in vivo anti-Toxoplasma activity of Zea mays (Z. mays) and Eryngium caucasicum (E. caucasicum) extracts. Methods: Four concentrations (5, 10, 25, and 50 mg mL -1 ) of Z. mays and E. caucasicum methanolic extracts for 30, 60, 120, and 180 min were incubated with infected macrophages and then the viability of RH strain of T. gondii tachyzoites was evaluated by trypan blue staining method. Also, we evaluated the survival rate of acutely infected mice with the extracts (100 and 200 mg kg -1 day -1 ) intraperitoneally for 5 days after infection with 2× 104tachyzoites of T. gondii. Results: The anti-Toxoplasma effect of the methanolic extracts were extremely significant compared to the negative control group in all exposure times (P < 0.05). The Z. mays (10, 25 and 50 mg mL -1 ) killed 100% of the parasites after 180 and 120 min exposure, respectively. Also, high toxoplasmacidal activity was observed with E. caucasicum extract. Furthermore, treatment of experimentally infected mice with the Z. mays (100, 200 mg kg -1 day -1 ) and E. caucasicum (100 mg kg -1 day -1 ) significantly increased their survival rate compared to untreated infected control (P < 0.05). Conclusion: These extracts are promising candidates for further medicine development on toxoplasmosis. However, further investigations are necessary to clarify effective fractions of the Z. mays and E. caucasicum extracts and the mechanisms of action.
Shahriar Ahmadpour,Khadijeh Foghi 대한해부학회 2014 Anatomy & Cell Biology Vol.47 No.4
We report on an extremely rare case of multiple absences of the branches of abdominal aorta with congenital absence of the portal vein, unilateral adrenal agenesis and persistent ductus arteriosus in an adult female cadaver. Specifically, instead of celiac trunk, superior and inferior mesenteric arteries, solely a single arterial trunk aroused from the anterior aspect of abdominal aorta, inferior phrenic and ovarian arteries were absent in both sides. Left kidneys drained by two veins. There were not superior, splenic and mesenteric veins, while left renal vein received an additional vein, which run downward and drained primarily all parts of digestive tract and its associated glands (portal vein did not exist). Right adrenal gland was absent. To the best of our knowledge, it is the only reported case with such widespread anomalies. We think the importance of this case is beyond the surgical consideration and needs more profound developmental studies.
Shahram Manoochehry(Shahram Manoochehry ),Hamid Reza Rasouli(Hamid Reza Rasouli ),Fathollah Ahmadpour(Fathollah Ahmadpour ),Alireza Keramati(Alireza Keramati ) 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.2
Purpose: This study aimed to evaluate the role of inflammatory blood markers in predicting the pathological response rate after neoadjuvant chemoradiation (neo-CRT) in patients with locally advanced rectal cancer (LARC). Materials and Methods: In this prospective cohort study, we analyzed the data of patients with LARC who underwent neo-CRT and surgical removal of the rectal mass between 2020 and 2022 in a tertiary medical center. Patients were examined weekly during chemoradiation and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune inflammation index (SII) were calculated from weekly laboratory data. Wilcoxon signed-ranks and logistic regression analysis were utilized to determine whether any laboratory parameters during different time point assessments or their relative changes could predict the tumor response based on a permanent pathology review. Results: Thirty-four patients were recruited for the study. Eighteen patients (53%) achieved good pathologic response. Statistical analysis by Wilcoxon signed-ranks method indicated significant rises in NLR, PLR, MLR, and SII on weekly assessments during chemoradiation. Having an NLR over 3.21 during chemoradiation was correlated with the response on a Pearson chi-squared test (p = 0.04). Also, a significant correlation was found between the PLR ratio over 1.8 and the response (p = 0.02). NLR ratio over 1.82 marginally missed a significant correlation with the response (p = 0.13). On multivariate analysis, a PLR ratio over 1.8 showed a trend for response (odds ratio = 10.4; 95% confidence interval, 0.9–123; p = 0.06). Conclusion: In this study, PLR ratio as an inflammatory marker showed a trend in the prediction of response in permanent pathology to neo-CRT.
Behravan, Javad,Ahmadpour, Hassan The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.7
Interferons are cytokines that confer resistance to viral infection and inhibit cellular proliferation. The interferon alpha gene from human blood samples was amplified, cloned and expressed in E. coli (BL21). Leukocyte chromosomal DNA was used as a source of template DNA. Using specific primers, the gene for HulFN$\{alpha}$-2b was amplified and inserted into the E. coli vector, pET21b, by ligation of the HindIII and BamHI linkers of the vector and insert. The insert was further analyzed by PCR, DNA restriction mapping and sequencing, and expressed in a suitable E. coli strain. The production of this important cellular protein in the laboratory has significant applications in production of the recombinant pharmaceutical proteins.
Morteza Davarpanah,ALI AHMADPOUR,Tahereh Rohani-Bastami,Hossein Dabir 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.30 No.-
Polystyrene resin was functionalized by diethanolamine for the efficient removal of p-toluenesulfonicacid (p-TSA) from aqueous solution. Functionalized adsorbent (DEA-PS) was characterized by elementalanalysis, Fourier transform infrared spectroscopy, point of zero charge measurement and field-emissionscanning electron microscopy. According to the results, maximum removal of p-TSA was observed at thepH range of 2.5–5. The adsorption kinetics of p-TSA onto DEA-PS was represented by pseudo-first-ordermodel and the equilibrium data followed Langmuir model well. The adsorption process wasendothermic and spontaneous, along with the positive change of entropy. The regeneration of DEAPSwas also conducted by 1 M NaOH solution.
A. Hafizi,A. AHMADPOUR,M. Koolivand-Salooki,M.M. Heravi,F.F. Bamoharram 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.6
Design of experiments (DOE) and artificial neural networks (ANNs) were successfully applied for studying the operating parameters of benzene alkylation with 1-decene over H14[NaP5W30O110]/SiO2catalyst. In this reaction catalyst loading, catalyst weight percent and benzene to 1-decene molar ratio (Bz/C10) were chosen as independent variables in experimental design. Prediction of 1-decene conversion and 2-phenyldecane selectivity was performed applying response surface method (RSM) and ANN models. Final selected multi-layer (3-6-2-2) ANN model resulted a coefficient of determination (R2)of 0.95 for 1-decene conversion and 0.99 for 2-phenyldecane selectivity, while the R2 of RSM was 0.93and 0.92 for these two parameters.
The effect of Al2O3 nano additions on failure of GFRP plate with two parallel pin loaded holes
Mohammadmahdi Attar,S. Mahdi Ahmadpour,S. Shahin Banisadr,Arash Mohammadi,S. Zahra Mirmoradi,Zohreh Shirazi 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.6
The aim of this study is to scrutinize the effect of nano-additions on failure modes and loads of glass-epoxy laminate subjected two parallel pin-loaded holes, experimentally and numerically. Furthermore, the effect of physical and geometrical parameters such as the ratio of free edge distance of laminated composite to holes diameter (e/d) and the ratio of centre to centre distances of holes to holes diameter (M/d) have been investigated. Afterwards, to exactly prognosticate failure modes and the ultimate load obtained from the experimental procedure, a numerical simulation in finite element software was implemented. There have found a close agreement between two methods. It should be acknowledged that after augmenting glass-epoxy laminate with nano-addition Al 2 O 3 , there was seen to be a clear difference between the two samples while the bearing strength of reinforced samples has been improved.
Functionalized magnetite / silica nanocomposite for oily wastewater treatment
Hakimabadi, Seyfollah Gilak,Ahmadpour, Ali,Mosavian, Mohammad T. Hamed,Bastami, Tahereh Rohani Techno-Press 2015 Advances in environmental research Vol.4 No.2
A new magnetite-silica core/shell nanocomposite ($Fe_3O4@nSiO_2@mSiO_2$) was synthesized and functionalized with trimethylchlorosilane (TMCS). The prepared nanocomposite was used for the removal of diesel oil from aqueous media. The characterization of magnetite-silica nanocomposite was studied by X-ray diffraction (XRD), Fourier transform infrared (FTIR), transmission electron microscopy (TEM), surface area measurement, and vibrating sample magnetization (VSM). Results have shown that the desired structure was obtained and surface modification was successfully carried out. FTIR analysis has confirmed the presence of TMCS on the surface of magnetite silica nanocomposites. The low- angle XRD pattern of nanocomposites indicated the mesoscopic structure of silica shell. Furthermore, TEM results have shown the core/shell structure with porous silica shell. Adsorption kinetic studies indicated that the nanocomposite was able to remove 80% of the oil contaminant during 2 h and fit well with the pseudo-second order model. Equilibrium studies at room temperature showed that the experimental data fitted well with Freundlich isotherm. The magnetic property of nanocomposite facilitated the separation of solid phase from aqueous solution.
Tahereh Rohani Bastami,ALI AHMADPOUR,Fatemeh Ahmadi Hekmatikar 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.51 No.-
Magnetic Fe3O4/Bi2WO6 nanohybrids were prepared via a two-step approach. Fe3O4 nanospheres weresynthesized using a solvothermal method in polyol media and Bi2WO6 nanocrystals were formed by thesubsequent hydrothermal process. In the preparation process of Bi2WO6 nanoparticles, tungstophos-phoric acid hydrate (H3PW12O40) was used as an acidic agent. The activity of the photocatalyst wasevaluated by the photocatalytic degradation of ibuprofen (IBP) from an aqueous solution with solar light. The as-prepared nanohybrid, which could be easily recovered by a magnet, showed high efficiency inphotocatalytic degradation of IBP, especially at pH = 4.7.