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Optimization of binary and ternary concrete composed of fly ash and ultra-fine slag using GRA
Agrawal, Vinay Mohan,Savoika, Purnanand P. Techno-Press 2021 Advances in concrete construction Vol.12 No.4
The paper presents the study of concrete made with supplementary cementitious materials such as Fly Ash (FA) and Ultra Fine Slag (UFS). Ordinary Portland Cement (OPC) is partially replaced with 20%, 30%, and 40% of FA by weight of cementitious content in three FA binary combinations. OPC is further replaced with 5%, 10%, 15%, and 20% of UFS to all three binary combinations forming twelve ternary combinations. The paper assesses workability, strength behaviour, chloride migration, water permeability, and cost aspect of all mixes. The results indicate that the use of FA binary combinations improves the workability but mechanical and durability properties are compromised. In case of FA-UFS ternary combinations, the compressive, flexural, and split tensile strengths have been observed to improve up to 36%, 13%, and 22%, respectively. Chloride migration and water permeability of ternary mix improve by 92% and 94% compared to reference concrete. An optimization technique using Taguchi-grey relational analysis (GRA) suggested that a ternary combination with 55% OPC, 30% FA, and 15% UFS qualify as an optimum mix combination.
Improved Mechanical Fault Identification of an Induction Motor Using Teager-Kaiser Energy Operator
Agrawal, Sudhir,Giri, V.K. The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.5
Induction motors are a workhorse for the industry. The condition monitoring and fault analysis are the main concern for the engineers. The bearing is one of the vital segment of the induction machine and the condition of the whole machine is decided based on the condition of the bearing. In the present paper, the vibration signal of the bearing has been used for the analysis. The first line of action is to perform a statistical analysis of the vibration signal which gives trends in signal. To get the location of a fault in the bearing the second action is to develop an index based on Wavelet Packet Transform node energy named as Bearing Damage Index (BDI). Further, Teager-Kaiser Energy Operator (TKEO) has been calculated from higher index value to get the envelope and finally Power Spectral Density (PSD) has been applied to identify the fault frequencies. A performance index has also been developed to compare the usefulness of the proposed method with other existing methods. The result shows that the strong amplitude of fault characteristics and its side bands help to decide the type of fault present in the recorded signal obtained from the bearing.
Agrawal, Kapil S,Pabari, Mansi,Shrotriya, Raghav Korean Society of Plastic and Reconstructive Surge 2016 Archives of Plastic Surgery Vol.43 No.6
"A smile is happiness you'll find right under your nose"- Tom Wilson. This quote holds true just for patients, not for surgeons. The correction of the nose always poses a challenge to the cosmetic surgeon. Deformities of the external and internal nose may be congenital or acquired and may be secondary to soft tissue and/or osseo-cartilaginous abnormalities, leading to aesthetic and/or functional consequences. Alar flare poses a common problem, sometimes alone and sometimes in conjunction with other external deformities. Alar base reduction is generally considered when the interalar distance exceeds the intercanthal distance. It has been well documented that this simple additional procedure brings about a substantial enhancement in the nose. Various techniques have been described and used in the past, each having their benefits and drawbacks, with the modified Weir wedge excision, Aufricht nasal sill excision, and Bernstein V-Y advancement being the common ones. We hereby describe a technique that is simple yet effective in achieving the desired results and at the same time aims at preventing relapse to obtain satisfactory long term results.
Agrawal Pankaj,Newbold Sally,Busaidi Ayisha Al,Kapoor Ritika R,Thomas Nick,Aylwin Simon JB,Buchanan Charles R,Arya Ved Bhushan 대한소아내분비학회 2022 Apem Vol.27 No.4
Pituitary apoplexy typically presents with acute headache, vomiting, visual disturbance, and confusion. Herein, we report a rare presentation of ischemic stroke due to pituitary apoplexy. A 16.5-year-old male presented with reduced Glasgow Coma Scale (GCS) score, slurred speech, right-sided hemiparesis, and bitemporal hemianopia. Magnetic resonance imaging of the brain showed a large hemorrhagic sellar/suprasellar mass and an area of cortical T2/FLAIR hyperintensity with corresponding diffusion restriction in the middle cerebral artery territory. Computed tomography (CT) intracranial angiogram showed luminal occlusion of the clinoid and ophthalmic segments of both internal carotid arteries (ICAs, left>right) due to mass pressure effect. Biochemical investigations confirmed hyperprolactinemia and multiple pituitary hormone deficiencies. Stress-dose hydrocortisone was commenced with cabergoline, followed by urgent endoscopic transsphenoidal debulking of the tumor (subsequent histology showing prolactinoma). Postoperative CT angiogram showed improved caliber of ICAs. Intensive neurorehabilitation was implemented and resulted in complete recovery of motor and cognitive deficits. At the last assessment (18.8 years), the patient remained on complete anterior pituitary hormone replacement without cabergoline. Pituitary apoplexy is a medical emergency requiring prompt recognition and treatment and should be suspected in patients presenting with sudden, severe headache; nausea; or visual disturbance and meningism. Ischemic stroke is a rare manifestation of pituitary apoplexy in the pediatric population.
An Exploration on physiology of Vasa, Meda, Majja in Ayurveda w.s.r. to adipose tissue.
Agrawal, Sonam,Verma, Vandana,Gehlot, Sangeeta Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.3
Recent researches on adipocytes in human and mice model have reported that the adipocytes are not only the fat depots but having role in maintenance of physiology and metabolism through adipokines released by them in accordance to their anatomical location. Ayurveda scholars too have mentioned different tissues like Vasa (inter muscular fat), Meda (visceral fat) and Majja (bone marrow) which are predominantly rich in adipocytes similar to adipose tissues, with a different sites, functions, compositions and pathological outcomes. The metabolic effect of Meda and Majja Dhatu on other tissues like muscle (Mamsa Dhatu), bone (Asthi Dhatu) and reproductive tissue (Shukra Dhatu) shows their functional interdependence. The detailed description of therapeutic indications of Vasa and Majja under Snehakarma (oleation therapy) illustrates that clinical physiology of these tissues have been elaborated rather than general physiology. This article is an attempt to comprehend the physiological aspect of Vasa, Meda and Majja retrospectively on the basis of their therapeutic indication for the management of variety of disorders, in the form of Sneha through different therapeutic procedures. An effort has been also taken to distinguish Vasa, Meda, Majja based on the functional peculiarities of adipocytes present in different sites of body like omentum, muscle and bone marrow. Critical observation of explanations of Vasa, Meda and Majja in Ayurveda compendia and advanced research in field of adipocytes reflected that Ayurveda scholars had deep insights regarding the various dimensions of adipocytes, most of which are in consistent with the advanced physiology and biomolecular studies of adipocytes.
Nonlinear interaction behaviour of plane frame-layered soil system subjected to seismic loading
Agrawal, Ramakant,Hora, M.S. Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.6
The foundation of a tall building frame resting on settable soil mass undergoes differential settlements which alter the forces in the structural members significantly. For tall buildings it is essential to consider seismic forces in analysis. The building frame, foundation and soil mass are considered to act as single integral compatible structural unit. The stress-strain characteristics of the supporting soil play a vital role in the interaction analysis. The resulting differential settlements of the soil mass are responsible for the redistribution of forces in the superstructure. In the present work, the nonlinear interaction analysis of a two-bay ten-storey plane building frame- layered soil system under seismic loading has been carried out using the coupled finite-infinite elements. The frame has been considered to act in linear elastic manner while the soil mass to act as nonlinear elastic manner. The subsoil in reality exists in layered formation and consists of various soil layers having different properties. Each individual soil layer in reality can be considered to behave in nonlinear manner. The nonlinear layered system as a whole will undergo differential settlements. Thus, it becomes essential to study the structural behaviour of a structure resting on such nonlinear composite layered soil system. The nonlinear constitutive hyperbolic soil model available in the literature is adopted to model the nonlinear behaviour of the soil mass. The structural behaviour of the interaction system is investigated as the shear forces and bending moments in superstructure get significantly altered due to differential settlements of the soil mass.
Radiological Downstaging with Neoadjuvant Therapy in Unresectable Gall Bladder Cancer Cases
Agrawal, Sushma,Mohan, Lalit,Mourya, Chandan,Neyaz, Zafar,Saxena, Rajan Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: Gall bladder cancer (GBC) usually presents as unresectable or metastatic disease. We conducted a feasibility study to evaluate the effect of neoadjuvant therapy (NAT) on radiologic downstaging and resectability in unresectable GBC cases. Materials and Methods: Patients with locally advanced disease were treated with chemoradiotherapy [CTRT] ( external radiotherapy (45Gy) along with weekly concurrent cisplatin $35mg/m^2$ and 5-FU 500 mg) and those with positive paraaortic nodes were treated with neoadjuvant chemotherapy [NACT (cisplatin $25mg/m^2$ and gemcitabine $1gm/m^2$ day 1 and 8, 3 weekly for 3 cycles). Radiological assessment was according to RECIST criteria by evaluating downstaging of liver involvement and lymphadenopathy into complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Results: A total of 40 patients were evaluated from January 2012 to December 2014 (CTRT=25, NACT=15). Pretreatment CT scans revealed involvement of hilum (19), liver infiltration (38), duodenum involvement (n=22), colon involvement (n=11), N1 involvement (n=11), N2 disease (n=8), paraaortic LN (n=15), and no lymphadenopathy (n=6). After neoadjuvant therapy, liver involvement showed CR in 11(30%), PR in 4 (10.5%), SD in 15 (39.4%) and lymph node involvement showed CR in 17 (50%), PR in 6 (17.6%), SD in 4 (11.7 %). Six patients (CTRT=2, NACT=4) with 66.6 % and 83% downstaging of liver and lymphnodes respectively underwent extended cholecystectomy. There was 16.6 % and 83.3% rates of histopathological CR of liver and lymph nodes. All resections were R0. Conclusions: Neoadjuvant therapy in unresectable gall bladder cancer results in a 15% resectability rate. This approach has a strong potential in achieving R0 and node negative disease. Radiologic downstaging (CR+PR) of liver involvement is 40.5% and lymphadenopathy is 67.5%. Nodal regression could serve as a predictor of response to neoadjuvant therapy.
Agrawal, Meenakshi,Jain, Sonika,Agarwal, Anshu,Dwivedi, Jaya,Sharma, Swapnil,Kishore, D. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.2
Exceedingly facile protocols based on the reactivity of corresponding oxoketenedithioacetal (4), 2-(dimethylaminomethylene) ketone (5), ${\beta}$-oxoenolether (6) and ${\alpha}$, ${\beta}$-unsaturated ketone (7) resulted from 7-ethyl-3,4 dihydroazepino[3,2-b] carbazole-2,5 (1H,7H)-dione (3) on its reaction with base catalyzed condensation of (a) $CS_2+$ MeI (b) DMF-DMA (c) H-COOEt and (IV) $C_6H_5CHO$ respectively, has been explored to provide an easy access of their isoxazole and pyrazole annulated analogues (8-13) of medicinal interest. The key compound 3 from which, the synthesis proceeded was in turn realized on the reaction of commercial 3-amino-9-ethyl carbazole (1) with ethyl succinyl chloride, under the conditions of Friedel-Crafts acylation followed by cyclocondensation of the resulting intermediate 2 with PPA. Isoxazolo and pyrazolo annulated analogues of carbazolo condensed azepinone derivatives (8-13) were screened for their in-vitro antimicrobial potential against various bacterial and fungal species. Besides this pyrazole derivative (8) was also evaluated for its CNS depressant potential in mice using photoactometer.