Cariprazine — an Alternative Treatment for Clozapine-resistant Schizophrenia?

Adam Montgomery(Adam Montgomery ),Marianna Rogowska(Marianna Rogowska ),Luiz Dratcu(Luiz Dratcu ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients’ symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients’ compliance with the treatment. Although clozapine augmentation options are available, there is currently no alternative monotherapy proven to be effective in TRS. We present a case of a young man with TRS who failed to respond to appropriate trials of risperidone, aripiprazole and also clozapine, and who experienced impairing adverse effects of clozapine that made further clozapine treatment not only futile but also detrimental to his health. He was successfully treated with cariprazine monotherapy, which culminated in the remission of his both positive and negative symptoms of psychosis as well as in the marked improvement in social functioning. Cariprazine, a newer atypical antipsychotic endowed with a D3-preferring mode of action, may offer a better tolerated and more acceptable treatment option for patients with difficult-to-treat psychotic symptoms.

Patterns of failure for hypopharynx cancer patients treated with limited high-dose radiotherapy treatment volumes

Adam Burr(Adam Burr ),Paul Harari(Paul Harari ),Aaron Wieland(Aaron Wieland ),Randall Kimple(Randall Kimple ),Gregory Hartig(Gregory Hartig ),Matthew Witek(Matthew Witek ) 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.4

Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the effectiveness of a direct 3-mm high-dose gross tumor volume to planning target volume expansion on clinical outcomes for hypopharynx cancers. Materials and Methods: We performed a retrospective analysis of patients with hypopharynx carcinoma treated between 2004 and 2018 with primary radiotherapy using a direct high-dose gross tumor volume to planning target volume expansion and with or without concurrent systemic therapy. Diagnostic imaging of recurrences was co-registered with the planning CT. Spatial and volumetric analyses of contoured recurrences were compared with planned isodose lines. Failures were initially defined as in field, marginal, elective nodal, and out of field. Each failure was further classified as central high-dose, peripheral high-dose, central intermediate/low-dose, peripheral intermediate/low-dose, and extraneous. Clinical outcomes were analyzed by Kaplan-Meier estimation. Results: Thirty-six patients were identified. At a median follow-up at 52.4 months, estimated 5-year overall survival was 59.3% (95% confidence interval [CI], 36.3%–74.1%), 5-year local and nodal control was 71.7% (95% CI, 47.1%–86.3%) and 69.9% (95% CI, 57.0%–82.6%), respectively. The most common failure was in the high-dose primary target volume. The gastrostomy tube retention rate at 1 year among patients without recurrence was 13.0% (95% CI, 3.2%–29.7%). Conclusion: Minimal high-dose target volume expansions for hypopharynx cancers were associated with favorable locoregional control. This approach may enable therapy intensification to improve clinical outcomes.

Korean Plum(Maesil) Deseeder

( Adam Chung ) 한국기초조형학회 2018 한국기초조형학회 작품집 Vol.2018 No.2

Local Knowledge on Trees Utilization and Their Existing Threats in Rashad District of Nuba Mountains, Sudan

Adam, Yahia Omar Institute of Forest Science 2014 Journal of Forest Science Vol.30 No.4

Rural people of Sudan are endowed with a deep knowledge concerning the utilization of different tree species. However research on the local knowledge related to tree species utilization still lacks adequate attention. The study objectives were to identify the existing local knowledge related to the utilization of the tree species and the existing threats to the availability of the trees. A total of 300 respondents were selected randomly from Rashad district in Nuba Mountains in 2011. Semi-structured interview, direct observation, group discussion, preference ranking and direct matrix ranking were used to collect the data. The study results revealed that people of Nuba Mountains utilize different tree species for food, medicinal purposes, fodder, firewood, construction and cultural ceremonies. The study results also indicated that the availability of trees is negatively influenced by firewood collection, agricultural expansion, drought, overgrazing and charcoal production. The study concluded that local knowledge has crucial role in tree species utilization in Nuba Mountains. Further researches to document and substantiate the local knowledge on useful tree species are highly recommended.

“Everyone Deserves a Family”: The Triple Bind of Family in Ari Aster’s Horror

Adam F. Braun 전남대학교 인문학연구원 2020 가족과 커뮤니티 Vol.0 No.1

This paper reviews Ari Aster’s two full-length feature films, Hereditary and Midsommar, by examining its use of its representations of “the family” in its narrative relationship with neoliberal ideology. While Hereditary fits with recent trends in gender and anti/oedipal relations within the horror genre, Midsommar reimagines an “otherwise” to neoliberal family relations. However, this new family still adheres to neoliberalism’s “triple bind” (melancholy for the Good family, hetero-futurity, and familial language), evidencing once again neoliberalism’s power in limiting our collective imagination of a possible otherwise.

Shifting Maritime Cultures and Economies in Kalaallit Nunaat(Greenland)

Adam Grydehøj(아담 그뤼데오이) 한국해양대학교 국제해양문제연구소 2018 해항도시문화교섭학 Vol.0 No.19

이 논문에서는 그린란드의 칼라틀리트 누나트에서 나타난 해양문화와 경제의 변화에 대해서 살펴보았다. 칼라틀리트 누나트(그린란드)의 원주민들은 전통적으로 해양 포유류의 사냥에 중점을 둔 유목적이며, 생존 위주의 생활방식으로 살아왔다. 1700년대 초에 덴마크는 칼라틀리트 누나트에서 덴마크로 바다표범의 가죽을 운송하기 위한 ‘식민도시’를 건설했다. 시간이 흐르면서 칼라틀리트(그린란드의 에스키모)는 어업에 기반한 시장경제로 발전해 나갔는데, 점점 더 많은 사람들이 도시와 어촌에 정착했다. 오늘날 칼라틀리트 누나트는 덴마크로부터 정치적 독립을 향해 나아가고 있지만, 그것의 도시들(칼라틀리트 누나트 상황에서 도시들)은 바다와 관련된 다른 문화적 경제적 가치들과 균형을 맞추기 위해서 싸우고 있다. 칼라틀리트 누나트의 도시에 더 큰 항구와 공항이 건설되고 있는 동안, 새로운 세계적인 기후와 경제 측면에서 칼라틀리트 누나트에 기회가 주어지면서, 칼라틀리트는 다시 한 번 새로운 해양문화로 나아가고 있다. The Indigenous people of Kalaallit Nunaat(Greenland) traditionally engaged in a nomadic, subsistence lifestyle focused on the hunting of marine mammals. Beginning in the early 1700s, the Danish state established ‘colony towns’ for shipping seal skins from Kalaallit Nunaat to Denmark. Over time, Kalaallit(Greenlandic Inuit) were drawn into a fishing-based market economy, and more and more people settled in towns and fishing stations. Today, Kalaallit Nunaat is advancing toward political independence from Denmark, yet its towns(‘cities’ in a Kalaallit Nunaat context) struggle to balance different cultural and economic values related to the sea. As larger sea ports and airports are being built in Kalaallit Nunaat’s towns, and as opportunities are opening up for Kalaallit Nunaat in the new global climate and economy, Kalaallit may once again be moving toward a new kind of maritime culture.

Corruption, Rule-Breaking, and Sanctions: The Case of the NCAA

Adam G. Pfleegor,Brian P. Soebbing,Chad Seifried 글로벌지식마케팅경영학회 2019 Journal of Global Sport Management Vol.4 No.1

Corruption in organizations is commonplace across the globe in many industries, including sport. Despite the immense ramifications stemming from corrupt and unethical behavior and interest by sport organizations to comprehend the effects of corruption and employ tools to discourage unethical actions, literature in this area has been limited. In order to curb corrupt and unethical activities, governing bodies often implement penalties or sanctions to deter similar actions in the future. Through a review of rule-breaking, corruption, and sanction literature, and utilizing ethical climate theory (ECT), we examine what features of organizations encourage corrupt types of behaviors, and what tenets of sanctions allow for the greatest effectiveness. The present research used the National Collegiate Athletic Association (NCAA) as a conceptual setting. We present a series of propositions for consideration to improve the viability of the sanctioning process in the NCAA applicable to other third-party regulators.

Rings in which every ideal contained in the set of zero-divisors is a d-ideal

Adam Anebri,Najib Mahdou,Abdeslam Mimouni 대한수학회 2022 대한수학회논문집 Vol.37 No.1

In this paper, we introduce and study the class of rings in which every ideal consisting entirely of zero divisors is a d-ideal, considered as a generalization of strongly duo rings. Some results including the characterization of AA-rings are given in the first section. Further, we examine the stability of these rings in localization and study the possible transfer to direct product and trivial ring extension. In addition, we define the class of $d_E$-ideals which allows us to characterize von Neumann regular rings.

Fatal Cerebral Air Embolism Due to a Patent Foramen Ovale during Endoscopic Retrograde Cholangiopancreatography

Adam Bastovansky,Claudia Stöllberger,Josef Finsterer 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.3

Fatal air embolism to the cerebrum during an endoscopic retrograde cholangiopancreatography (ERCP) has not been reported in a patientwith a biliodigestive anastomosis and multiresistant extended-spectrum β-lactamase Escherichia coli (ESBL) bacteremia. A 59-yearoldwoman with a history of laparoscopic cholecystectomy and iatrogenic injury of the right choledochal duct, choledochojejunostomy(biliodigestive anastomosis), recurrent cholangitis, revision of the biliodigestive anastomosis, recurrent liver abscesses, and recurrentstenting of stenotic bile ducts, was admitted because of fever and tenderness of the right upper quadrant. On ERCP, a previously deployedcovered Wallstent was replaced. Blood cultures grew ESBL. After stent removal 8 days later, the patient did not wake up and developedarterial hypotension and respiratory insufficiency, requiring mechanical ventilation. Computed tomography scans showed extensiveair embolism to the liver, heart, and cerebrum. She died 1 day later. Although the exact pathogenesis of the fatal cerebral air embolism remainsspeculative, the nonphysiological anatomy and chronic infection with ESBL may have been contributory factors.

Measuring displacements of a railroad bridge using DIC and accelerometers

Adam Hoag,Neil A. Hoult,W. Andy Take,Fernando Moreu,Hoat Le,Vamsi Tolikonda 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.2

Railroad bridges in North America are an integral but aging part of the railroad network and are typically only monitored using visual inspections. When quantitative information is required for assessment, railroads often monitor bridges using accelerometers. However without a sensor to directly measure displacements, it is difficult to interpret these results as they relate to bridge performance. Digital Image Correlation (DIC) is a non-contact sensor technology capable of directly measuring the displacement of any visible bridge component. In this research, a railroad bridge was monitored under load using DIC and accelerometers. DIC measurements are directly compared to serviceability limits and it is observed that the bridge is compliant. The accelerometer data is also used to calculate displacements which are compared to the DIC measurements to assess the accuracy of the accelerometer measurements. These measurements compared well for zero-mean lateral data, providing measurement redundancy and validation. The lateral displacements from both the accelerometers and DIC at the supports were then used to determine the source of lateral displacements within the support system.