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女仕牌固体饮料对左甲状腺素钠诱导肾阴虚小鼠模型内分泌系统的影响
류석(刘硕),마사요(马思遥),주문이(朱文驿),양가(梁佳),Yujing Shi,Hong Meng 한국피부과학연구원 2020 아시안뷰티화장품학술지 Vol.18 No.2
Purpose: To observe the effects of Nv Shi solid drink on thyroid hormone, sex hormones and cyclic nucleotide of kidney-yin deficiency hyperthyroid mice induced by levothyroxine sodium. Methods: ICR mice were randomly grouped into normal control group, model group, Nv Shi solid drink high dose group, the middle dose group and low dose group, male and female in half. The kidney-yin deficiency mice models were established by intragastric administration of levothyroxine sodium before intragastric administration of corresponding drugs once a day for 10 consecutive days. One day after the last administration, the effects were observed by measuring weight. And tetraiodothyronine (T4), triiodothyronine (T3), thyrotropin (TSH), testosterone (T), estradiol (E2), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) were tested by ELISA method. Results: Compared with the model group, the body weight increased significantly (p<0.05), T3 level decreased significantly in high and medium dose group (p<0.01, p<0.05), and serum T4 and cAMP decreased significantly (p<0.01, p<0.05), TSH increased significantly (p<0.01, p<0.05) in all dose groups, and cAMP/cGMP decreased in the low dose group (p<0.05). The expression of E2 in female decreased significantly in all does groups, the same as the ratio of E2/T in high dose group (p<0.05). There was no significant change in the expression of sex hormones in male in all dose groups (p>0.05). Conclusion: Nv Shi solid drink may improve the kidney-yin deficiency syndrome by adjusting T3, T4, TSH, cAMP and E2 level in the endocrine system of the body and exert the function of nourishing yin and tonifying kidney. 目的: 观察女仕牌固体饮料对左甲状腺素钠致肾阴虚模型小鼠体内甲状腺激素、性激素及环核苷酸的影响。方 法: ICR小鼠随机分为正常组、模型组、女仕牌固体饮料大、中、小剂量组,雌雄各半,采用左甲状腺素钠片灌 胃造成小鼠肾阴虚模型,造模当天灌胃给予样品,每天1次,连续10天。末次给药后1天,观察小鼠体征及体 重,取血,采用Elisa方法检测血清中甲状腺素(thyroxine, T4)、三碘甲状原氨酸(triiodothyronine, T3)、 促甲状腺激素(thyroid-stimulating hormone, TSH)、睾酮(testosterone, T)、雌二醇(estradiol, E2)、 环磷酸腺苷(cyclic Adenosine monophosphate, cAMP)、环磷酸鸟苷(cyclic guanosine monophosphate, cGMP)的表达。结果: 与模型组比较,女仕牌固体饮料大剂量组和中剂量组小鼠体重显著升高(p<0.05);大 剂量和中剂量组T3显著降低(p<0.01,p<0.05),各剂量组血清T4、cAMP均显著降低(p<0.01,p<0.05), TSH均显著升高(p<0.01,p<0.05),小剂量组cAMP/ cGMP比值降低(p<0.05),各剂量组雌鼠E2表达显著 降低,大剂量组雌鼠E2/T比值降低,各剂量组雄鼠性激素表达无显著改变(p>0.05)。结论: 女仕牌固体饮料 可能通过调整机体内神经分泌系统中T3、T4、TSH、cAMP、雌鼠E2这些共同的潜在物质基础,改善HPT轴和 HPG轴功能、平衡环核苷酸系统,从而改善肾阴虚证,发挥滋阴补肾功效。
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류석(刘硕),마사요(马思遥),주문이(朱文驿),양가(梁佳),Yujing Shi,Hong Meng 한국피부과학연구원 2020 아시안뷰티화장품학술지 Vol.18 No.2
Purpose: To study the regulatory effect of Lanshi tonic on kidney-yang deficiency model and its related mechanism. Methods: ICR mice were randomly divided into five groups according to body weight: normal group, model group, Lanshi tonic high, medium and low dose group. Mice with kidney-yang deficiency syndrome were induced by hydrocortisone sodium succinate by intraperitoneal injection, 50 mg/ kg for 7 days. At the same time, all groups were given corresponding medicine by oral administration for 10 days. The body mass, hair color and body shape of mice were observed and recorded. Spleen index, thymus index and adrenal index were calculated. Level of urine 17-OHCS was measured by ELISA. Level of serum Cortisol, ACTH, cAMP, cGMP and ratio of cAMP/cGMP were measured by ELISA. Results: Compared with the normal group, the above indexes of the model group mice were significantly lower (p<0.05, p<0.01), except the serum cGMP was significantly higher (p<0.01). Compared with the model group, Lanshi tonic at high and medium doses had no significant change in urine 17-OHCS content (p>0.05), but had different improvement effects on the other indicators mentioned above (p<0.05, p<0.01). Conclusion: Lanshi tonic can regulate the state of kidney-yang deficiency, which may be related to the regulation of adrenocortical secretion function and the imbalance of cyclic nucleotide levels. 目的: 研究澜仕口服液对肾阳虚状态的调节作用及相关机制。方法: 将ICR小鼠按体质量随机分为5组:正常组、 模型组、澜仕口服液高、中、低剂量组。小鼠腹腔注射氢化可的松琥珀酸钠,50 mg/kg,连续7天,停止注射3 天造成肾阳虚证候小鼠模型。造模同时给予各剂量澜仕口服液,正常组和模型组在同等条件下给予蒸馏水。观 察并记录小鼠体质量、毛色、体态等一般体征状态,解剖、称量并计算脾指数、胸腺指数和肾上腺指数,ELISA 法检测尿液17-OHCS含量,ELISA法检测血清Cortisol、ACTH、cAMP、cGMP含量、计算cAMP/cGMP比值。结 果: 与正常组比较,模型组小鼠除血清cGMP显著升高外,上述其他指标均显著降低(p<0.05, p<0.01)。与模 型组比较,澜仕口服液高剂量和中剂量除对尿液17-OHCS含量无显著改变(p>0.05)外,对上述其他指标均有 不同程度的改善作用(p<0.05, p<0.01)。结论: 澜仕口服液对肾阳虚状态具有调节作用,可能与调节肾上腺皮 质分泌功能和调整环核苷酸水平失衡相关。
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