Calcium Phosphate Glass가 마우스 두개골 세포에 미치는 영향

김민경,김창성,이덕연,이용근,조규성,채중규,김종관,최성호,Kim, Min-Kyoung,Kim, Chang-Sung,Lee, Doug-Youn,Lee, Yong-Keun,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.1

The goal of periodontal treatment is not only to arrest the progression of the disease but also to promote the functional, esthetic regeneration of the periodontium. Flap operation, bone graft, guided tissue regeneration, growth factors and bone morphogenetic protein have been used for this purpose. Among these techniques of regeneration, alloplastic graft, especially calcium phosphate is getting more attention recently. The purpose of this study was to evaluate the effects of calcium phosphate glass on mouse calvarial cell in vitro. The toxicity of calcium phosphate glass was measured using MTT assay, the synthesis of collagen was measured using collagen assay, and ALP activity was measured. The experimental groups were cultured with calcium phosphate glass(both AQ-, and HT-CPG) in concentration of 0.01, 0.02, 0.1, 0.2g/ml. The results are as follows 1. In concentrations not exceeding 0.02g/ml, both the groups(AQ-CPG, HT-CPG) didn't show any toxicity on mouse calvarial cell(p<0.05). 2. In both the experimental groups are the concentration of 0.02g/ml, collagen expressions were significantly up-regulated (p<0.05). 3. In both the experimental groups are the concentration of 0.02g/ml, ALP activity was not significantly up-regulated, but ALP activity in both experimental groups were greater than control group(p<0.05). The results suggested that the use of calcium phosphate glass may promotes periodontal regeneration. Ongoing studies are necessary in order to determine their regeneration effects.

전용면적 60 m², 85 m² 아파트 평면 유형에서 실 치수의 통계적 특성에 관한 연구

김민경,윤재신,Kim, Min-Kyoung,Yoon, Chae-Shin 한국주거학회 2010 한국주거학회 논문집 Vol.21 No.1

Apartment buildings represent the most typical patterns of housing in Korea. The present plans are very different from the previous ones when they appeared for the first time. Although apartment unit plans has changed drastically, they can be classified into several categories. Apartment unit plans reflects the demands of living activities and space dimensions of unit plans have the characteristics of diachronic continuity and carry the values of living culture. Thus this study aims to provide the statistical dimensional data of each room that can be actually used for the design of unit plans by sub-grouping typical unit plans. The statistical data of this study showed that apartment unit plans are shifting from 2bay/3room type to 3bay/3room type in 1990s. It is very peculiar that the typical unit plan of $60\;m^2$ area becomes to resemble that of $85\;m^2$ area. The space arrangement of typical unit plans of both $60\;m^2$ and $85\;m^2$ area is almost identical while only their space dimensions differ slightly. As the mean/mode/median values of space dimensions in a typical unit plan are converging into a range of narrow margin, space dimensions of typical unit plan are contended to be strictly regular. The statistical numeric data of various space dimensions provided in this paper can be applied practically to the design of apartment unit plans for low income class people who are disprivileged in the society.

Modified Photo-Fenton Reaction을 이용한 Methyl Tert-butyl Ether (MTBE)의 분해 Kinetic 및 메커니즘 규명에 관한 연구

김민경,공성호,Kim, Min-Kyoung,Kong, Sung-Ho 한국지하수토양환경학회 2006 지하수토양환경 Vol.11 No.6

지하 저장 탱크로부터의 유류 유출로 인하여 전세계적으로 넓은 지역의 토양 및 지하수가 오염되고 있다. Methyl tert-butyl ether(MTBE)는 대기 오염 감소를 위하여 널리 사용되고 있는 유류 첨가제이지만 토양 및 지하수로 유입되어 섭취 되었을 때 발암 가능성이 있는 유독 물질이다. 본 연구는 고도 산화 처리 기법 중 유기 오염물의 분해에 높은 효율을 나타내는 고전적 Fenton reaction의 최대 단점인 강한 산성(pH 2.5-3) 의존성을 극복한 새로운 산화 처리 기법을 개발하여 고농도의 MTBE를 효과적으로 분해 하는 것을 그 목적으로 하여 자연 친화적인 chelating agents를 사용하여 중성 영역에서 Fenton reaction을 가능하게 하는 기법인 Modified Fenton reaction과 Ultra Violet light(UV)를 이용하여 분해효율을 극대화 하는 Photo-assisted Fenton reaction을 응용한 Modified Photo-Fenton reaction system을 개발하여 최적 반응 조건 및 반응 차수, 반응 메커니즘을 밝혀내었다. 낮은 독성과 높은 생분해성을 나타낸 Citrate ion을 chelating agents로 선정하였으며 최적 반응 조건은 [$Fe^{3+}$] : [Citrate] = 1 mM : 4 mM, 3% $H_2O_2$, 17.4 kWh/L UV dose, 초기 pH 6.0이며 이 조건에서 1000 ppm MTBE를 분해한 결과 6시간 후 86.75%, 16시간 후 99.99%의 높은 분해율을 나타냈으며 최종 pH는 6.02로 안정적이었다. 또한 Modified Photo-Fenton reaction을 이용한 MTBE 분해 반응은 유사 1차 반응을 나타내었으며 methoxy group이 ${\cdot}OH$ radical과 주로 반응하여 tert-butyl formate(TBF)가 주요 분해 산물이 되는 분해 경로를 따른 다는 것이 밝혀졌다. 본 연구로 개발된 Modified Photo-Fenton reaction에서 발생되는 산화제인 ${\cdot}OH$ radical의 비선택적 반응성을 고려할 때 본 system은 다른 종류의 유기 오염물 분해에도 효과적일 것으로 판단된다. Improper disposal of petroleum and spills from underground storage tanks have created large areas with highly toxic contamination of the soil and groundwater. Methyl tert-butyl ether (MTBE) is widely used as a fuel additive because of its advantageous properties of increasing the octane value and reducing carbon monoxide and hydrocarbon exhausts. However, MTBE is categorized as a possible human carcinogen. This research investigated the Modified Photo-Fenton system which is based on the Modified Fenton reaction and UV light irradiation. The Modified Fenton reaction is effective for MTBE degradation near a neutral pH, using the ferric ion complex composed of a ferric ion and environmentally friendly organic chelating agents. This research was intended to treat high concentrations of MTBE; thus, 1,000 mg/L MTBE was chosen. The objectives of this research are to find the optimal reaction conditions and to elucidate the kinetic and mechanism of MTBE degradation by the Modified Photo-Fenton reaction. Based on the results of experiments, citrate was chosen among eight chelating agents as the candidate for the Modified Photo-Fenton reaction because it has a relatively higher final pH and MTBE removal efficiency than the others, and it has a relatively low toxicity and is rapidly biodegradable. MTBE degradation was found to follow pseudo-first-order kinetics. Under the optimum conditions, [$Fe^{3+}$] : [Citrate] = 1 mM: 4 mM, 3% $H_2O_2$, 17.4 kWh/L UV dose, and initial pH 6.0, the 1000 ppm MTBE was degraded by 86.75% within 6 hours and 99.99% within 16 hours. The final pH value was 6.02. The degradation mechanism of MTBE by the Modified Photo-Fenton Reaction included two diverse pathways and tert-butyl formate (TBF) was identified to be the major degradation intermediate. Attributed to the high solubility, stability, and reactivity of the ferric-citrate complexes in the near neutral condition, this Modified Photo-Fenton reaction is a promising treatment process for high concentrations of MTBE under or near a neutral pH.

저장온도를 달리한 밀감과육 통조림의 품질특성

김민경,이택수,최진영,박성오 ( Min Kyoung Kim,Taik Soo Lee,Jin Young Choi,Sung Oh Park ) 한국응용생명화학회 1997 Applied Biological Chemistry (Appl Biol Chem) Vol.40 No.3

The canned fruit flesh of orange (Onju, Citrus unshi Marc.) was stored at 5℃, 15℃ and 30℃ for 4 months and the contents of sugar, organic acids and vitamin C of stored orange were investigated. The contents of reducing sugar of orange stored for 4 months slightly increased from 4.91% to 5.39∼7.95% and decreased as the temperature rised. The sugar was composed of 6.63∼18.09% sucrose, 3.86∼9.12% glucose and 3.59∼9.51% fructose. The content of sucrose used in manufacturing process was the highest and decreased as the temperature rised and as the storage period prolonged, whereas the contents of glucose and fructose increased as the storage period prolonged. The content of citric acid in the sample was the highest (50.41∼90.15 ㎎%) among the-citric, malic, malefic, α-ketoglutaric and oxalic acids. The organic acids decreased as the temperature riled after storage for 4 months. The content of vitamin C was 8.28∼14.29 ㎎% and decreased most pronouncedly at 30℃ after storage. The color of the samples did not change significantly, but the degree of transparency, L was 20.41∼23.01 after storing the sample.

키토산 함유 치약의 임상적 효과;Multicenter study

김민경,최성호,신승윤,류인철,허익,박준봉,조규성,Kim, Min-Kyoung,Choi, Seong-Ho,Shin, Seung-Yun,Rhyu, In-Chul,Herr, Yeek,Park, Joon-Bong,Cho, Kyoo-Sung 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.2

Many researches are being done to study the effect of toothpaste containing natural extracts. The aim of this study was to evaluate the plaque control effect and therapeutic effect of toothpaste products containing chitosan extract. 120 healthy subjects with gingivitis or early periodontitis were divided into two groups. Subjects in the experimental group only used toothpaste containing chitosan and subjects in the control group used toothpaste without chitosan. At first, subjects received scaling and tooth brushing instruction. Gingival index, bleeding index, probing pocket depth, probing attachment level were scored at baseline, 2 months, and 3 months, and plaque index were scored at baseline, 1 month, 2 months, 3 months. Gingival index of experimental group and control group at baseline, 2 months, and 3 months use were 0.71${\pm}$0.66, 0.49${\pm}$0.55, 0.36${\pm}$0.49 and 0.62${\pm}$0.58, 0.51${\pm}$0.52, 0.48${\pm}$0.50 (mean${\pm}$SD), respectively (statistically significant different at p <0.05 ). Plaque index of experimental group and control group at baseline, 1 month, 2 months, and 3 months were 0.52${\pm}$0.50, 0.43${\pm}$0.50, 0.39${\pm}$0.49, 0.29${\pm}$0.46 and 0.49${\pm}$0.50, 0.50${\pm}$0.50, 0.51${\pm}$0.50, 0.45${\pm}$0.50, respectively (statistically significant different at p<0.05 ). Bleeding index of experimental group and control group were 0.40${\pm}$0.49, 0.33${\pm}$0.47, 0.24${\pm}$0.43 and 0.40${\pm}$0.49,0,38${\pm}$0.49,0.30${\pm}$0.46, respectively (statistically significant different at p<0.05). Probing depth of experimental group and control group were 2.41${\pm}$0.64, 2.31${\pm}$0.60, 2.28${\pm}$0.55 and 2.51${\pm}$0.67, 2.47${\pm}$0.63,2.42${\pm}$0.62, respectively (statistically significant different at p<O.05 ). Attachment level of experimental group and control group were, 2.46f0.70, 2.36${\pm}$0.66, 2.32${\pm}$0.62 and 2.54${\pm}$0.70, 2.51${\pm}$0.69,2.46${\pm}$0.66, respectively (statistically significant different at p<0.05 ). From these finding, it can be concluded that toothpaste containing chitosan have better plaque control effect and therapeutic effect on gingivitis and early periodontitis compared to conventional toothpastes.

클라우드 기반의 공개의료 빅데이터 분석을 통한 삶의 질에 영향을 미치는 요인분석

김민경,조영복,Kim, Min-kyoung,Cho, Young-bok 한국정보통신학회 2018 한국정보통신학회논문지 Vol.22 No.6

본 연구에서 공개 의료 빅데이터 분석을 지역사회건강조사 2012~2014년 자료를 이용해 개인의 건강관련 삶의 질 차이와 삶의 질에 영향을 미치는 요인을 분석하였다. 제안논문에서는 공개의료 빅데이터 분석을 위해 Hadoop 기반의 Spack을 이용해 병렬처리 지원을 위한 클라우드 메니저를 구성하고 개인의 삶의 질에 영향을 미치는 요인을 하드웨어의 제약없이 빠르게 분석하였다. 건강관련 삶의 질에 미치는 영향을 개인적 특성과 지역사회 특성으로 구분하여 단계별 다수준 회귀분석(ANOVA, t-test)을 실시하였다. 연구결과 개인별 삶의 질에 영향을 미치는 요인으로는 남자 평균 73.8점, 여자 평균 70.0점으로 남자가 여자보다 건강관련 삶의 질이 높은 것으로 나타났다. In this study, we analyzed public health data analysis using the hadoop-based spack in the cloud environment using the data of the Community Health Survey from 2012 to 2014, and the factors affecting the quality of life and quality of life. In the proposed paper, we constructed a cloud manager for parallel processing support using Hadoop - based Spack for open medical big data analysis. And we analyzed the factors affecting the "quality of life" of the individual among open medical big data quickly without restriction of hardware. The effects of public health data on health - related quality of life were classified into personal characteristics and community characteristics. And multiple-level regression analysis (ANOVA, t-test). As a result of the experiment, the factors affecting the quality of life were 73.8 points for men and 70.0 points for women, indicating that men had higher health - related quality of life than women.

한국인의 사회경제적 불평등에 따른 주관적 건강수준의 차이와 건강행태 기여요인 분석

김민경,정우진,임승지,윤수진,이자경,김은경,고난주,Kim, Min-Kyung,Chung, Woo-Jin,Lim, Seung-Ji,Yoon, Soo-Jin,Lee, Ja-Kyoung,Kim, Eun-Kyung,Ko, Lan-Ju 대한예방의학회 2010 예방의학회지 Vol.43 No.1

Objectives: The study is investigated socioeconomic variations in self-rated health status and contribution of health behavioral factors in Korea. Methods: A nationally representative sample (2,800 men and 3,230 women aged 20-64 years) from the 2005 Korea National Health and Nutrition Surveys was analyzed using logistic regression. Results: Self-rated health was lower among lower socioeconomic groups compared with higher socioeconomic groups, with gender being irrelevant. This association was attenuated when health behavioral and socio-demographic factors were adjusted. When each health behavioral factor was considered separately, mediators such as smoking in men, and stress or exercise in women explained a large part of the decreased socioeconomic health inequalities. Conclusions: In Korea, subjective health inequalities arise from different socioeconomic status, but this difference is decreased by health behavioral factors. Therefore, socioeconomic inequity in self-rated health status can be corrected more effectively by promotional health behaviors.

장애아 보육시설의 물리적환경 실태조사

김민경,주서령,Kim, Min-Kyoung,Ju, Seo-Ryeung 한국주거학회 2007 한국주거학회 논문집 Vol.18 No.5

Eater Seal, the child care experts, observes that children with disability significantly benefit from receiving appropriated care along side their peers. Typically developing children serve as role models from which children with disabilities team age-appropriated communications and social behavior. Therefore the children with disability can actively participate in well-designed child care settings. But unfortunately in Seoul, Korea, only 2% of children with disability are taken care of in child care centers. And even the disabled children at the child care centers are mostly mentally or emotionally disabled because the building, programs and services of the centers are restrictive to the children with severe physical disabilities. This study reviewed Korean domestic physical environment of child care centers for children with disabilities. 15 centers located in Seoul were surveyed. Our survey revealed that the accessibility to buildings is poor. There are many places with difference in height of floors. Also, there are no elevators in all buildings surveyed. Accessibility to toilet is noted as significant problem, especially wet floors in toilets. In a nursing room, a space for psychological rest and special education is needed for children with mental disability. Technical specifications on how to make buildings and facilities accessible for the children with disability should be developed. The goal of this study is to provide basic information to develop domestic design guidelines to ensure that the child care centers are safe, convenient, and usable for everyone possible.

빅데이터 기반 만성질환자의 삶의 질에 미치는 영향분석

김민경,조영복,Kim, Min-kyoung,Cho, Young-bok 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.11

The purpose of this study is to investigate the effect of personal factors and community factors on the quality of life based on the presence of chronic patients based on the Big Data Platform. As a method of study, second data of 2017 community health survey and Statistics Korea by City·Gun·Gu public office were used and a multi-level analysis was conducted after separating EQ-5D index, individual factor and community factor. As a result, men, age, education level, monthly household income, having economic activity, the number of sports infrastructure were positively associated with the quality of life, and subjective health not good, extremely perceived stress were negatively associated with the quality of life. Research will continue to provide a platform independent of hardware that can utilize the cloud and open source for medical big data analysis in the future. 본 연구는 빅데이터 플랫폼을 이용해 만성질환자에 따른 개인적 요인과 지역사회요인이 삶의 질에 미치는 영향을 알아보는데 목적이 있다. 연구방법은 2017년 지역사회건강조사 자료와 통계청 시군구별 2차 자료를 사용하였고, EQ-5D 지수와 개인요인 및 지역사회요인을 구분하여 다수준분석을 실시하였다. 연구결과 남자의 경우, 나이가 어릴수록, 학력이 높을수록, 월가구소득이 많을수록, 경제활동을 하는 경우, 스포츠 인프라가 많은 경우 삶의 질이 높았다. 또한 주관적 건강감이 나쁠수록, 스트레스가 많을수록 삶의 질이 낮았다. 향후 의료 빅데이터 분석을 위해 클라우드와 오픈소스를 활용할 수 있는 하드웨어에 독립적인 플랫폼 제공을 위한 연구가 지속되어야 할 것이다.

전산화학 모델링 분자생물학 분야에서의 계산화학의 응용과 그 현황

김민경 ( Min Kyoung Kim ),이태범 ( Tae Bum Lee ),최승훈 ( Seung Hoon Choi ) 한국공업화학회 2005 공업화학전망 Vol.8 No.3