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Surgical Animal Models for Bone and Cartilage Regeneration
Gonhyung Kim(김근형) 한국실험동물학회 2008 한국실험동물학회 학술발표대회 논문집 Vol.2008 No.-
Tissue engineering for bone and cartilage which fail to treat effectively by severe damage and degeneration is still in the experimental stage. Stem cells, growth factors and scaffolds have been suggested as candidate therapeutic methods to develop neo-tissue during the last decade. A number of experimental surgical animal models are studied on different species of animals to treat the bone and cartilage defects. Rat, rabbit, dog, sheep and pig are frequently used for animal models. Partial or segmental defects are created in long bones such as femur, tibia, humerus, radius and ulna. However, orthopaedic experimental studies are more sensitive to infection and painful to the animals. It is therefore essential for accurate results to find suitable and successful surgical method in animal models.