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Jae-Hoon Lee(이재훈),Dai-Jung Chung,Eun-Hee Kang,Hwa-Seok Chang,Chi-Bong Choi,Hwi-Yool Kim 한국실험동물학회 2008 한국실험동물학회 학술발표대회 논문집 Vol.2008 No.-
We developed a minimally-invasive canine model of spinal cord injury (SCI). A balloon catheter was inserted into the epidural space via the lumbosacral space, and inflated between L2 and L3 for 30 or 60 minutesunder fluoroscopic guidance. Motor function after SCI was assessed using modified Tarlov scale. All seven dogs showed complete paraplegia after the procedure, neurological problems were evident and the modified Tarlov scores remained at zero after the SCI procedure; no improvement in clinical signs was observed. The dogs underwent 3T MR imaging at 3 days and 1 year after SCI. Histopathologic examinations were conducted at 2 weeks, 12 weeks and 1 year after SCI. Two pig also underwent 60-minute compression, These pigs underwent 3T MR imaging at 3 days. The pigs also showed paraplegia for 1 week. In the present study, we described an animal model of minimally invasive spinal cord injury using a balloon catheter without laminectomy under fluoroscopic guidance. And, this percutaneous spinal cord compression injury model has many potential applications.