http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Piperlongumine 유도체 합성과 $Aflatoxin\;B_1$ 생성 억제 효과
이성은,최원식,이현상,이영행,박병수,Lee, Sung-Eun,Choi, Won-Sik,Lee, Hyun-Sang,Lee, Young-Haeng,Park, Byeoung-Soo 한국응용생명화학회 2003 한국농화학회지 Vol.46 No.4
Anti-aflatoxigenic studies on synthetic pyridione alkaloids were conducted. Seven derivatives using piperlongumine as a leading compound were prepared from 3,4,5-trimethoxycinnamic acid (TMCA). These derivatives were analyzed for their structural confrmation and purity by HPLC, GC, GC/MS and $1^H-NMR$. 1-piperidin-1-yl-3-(3,4,5-trimethoxyphenyl)propenone (1) reaction with piperidine; 1-morpholin-4-yl-3-(3,4,5-trimethoypenyl)propenone (2) with morpholine; 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (3) with 3,5-dimethylpiperdine; 1-(2-methylpiperidine-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (4) with 2-methylpiperidine; 1-(3-hydroxypiperidin-1-yl)-3- (3,4,5-trimethoxyphenyl)propenone (5) with 3-hydroxypiperidine hydrochloride; 1-[3- (3,4,5-trimethoxyphenyl)acryloyl]piperidin-2-one (6) with ${\delta}-valerolactam;\; and\;ethyl\;1-[3-(3,4,5-trimethoxyphenyl)acyloyl]piperidine-4-carboxylate$ (7) with ethyl isonipectotate were synthesized respectively. All derivatives showed an inhibitory activity on aflatoxin $B_1$ production. In conclusion, we believe that they might be an agent for the control of mycotoxin in agricultural commodities. 필발 열매로부터 추출 및 분리한 piperlongurnine (1-[3-(3,4,5-trimethoxyphenyl)acryloyl]-5,6-dihydro-1H-pyridin-2-one)이 aflatoxin $B_1\;(AFB_1)$ 생성억제에 있어서 탁월한 효과가 입증되어 3,4,5-trimethoxycinnamic acid (TMCA)를 모체로 하여 1-piperidin-1-yl-3-(3,4,5-trimethoxyphenyl)propenone (1), 1-morpholin-4-yl-3-(3,4,5-trimetholfrphenyl)propenone (2), 1- (3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (3), 1-(2-methylperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (4), 1- (3-hydroxypiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)propenone (5), 1-[3-(3,4,5-trimethoxy-phenyl)acryloyl]piperidin-2-one (6) 및 ethyl 1-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperidin-4-carboxylate (7)의 유도체를 합성하여 구조를 확인하고, 이 화합물들을 이용하여 $AFB_1$ 생성저해 효과를 측정하였다. Aspergillus flavus NRRL 2061로부터 생성되는 $AFB_1$ 생성저해에 대한 실험한 결과 모든 유도체 화합물에서 활성을 나타내었으며, 특히 화합물 (3)이 1000, 500, 250, 100및 $50\;{\mu}g/ml$에서 100, 95, 90, 53 및 10%의 생성저해를 나타냈다. 이러한 연구 결과 유도체 화합물 (3)은 항진균 독소제 개발을 위한 선도화합물로 이용하여 새로운 농약으로 개발이 가능할 것이라고 판단된다.
코로나 방전 또는 상용화제가 처리된 폴리프로필렌/케나프 섬유 펠트의 물성 연구
구선교(Sun Gyo Ku),박병수(Byeoung-Soo Park),김동원(Dong Won Kim),김기성(Ki Sung Kim),김연철(Youn Cheol Kim) 한국고분자학회 2016 폴리머 Vol.40 No.5
폴리프로필렌(polypropylene, PP)/케나프 섬유(kenaf fiber, KF) 펠트와 폴리우레탄(polyurethane, PU) 바인더의 계면 접착특성 향상을 위해 코로나 방전처리와 상용화제로 말레인산 무수물(maleic anhydride, MAH)이 그래프트된 PP-g-MAH가 적용되었다. PU 바인더의 반응온도와 시간 선정을 위해 DSC를 이용하여 등온 실험을 수행하였다. 코로나 방전처리와 상용화제 적용에 따른 PP/KF/PU 복합체의 기계적 물성 변화를 고찰하기 위해 인장, 굴곡 및 충격 특성을 평가하였다. 코로나 방전처리 및 PP-g-MAH 처리의 경우 인장특성과 충격특성이 개선되는 경향을 나타내었다. 기계적 물성의 증가는 코로나 방전처리 및 PP-g-MAH에 의한 PP의 산소기 도입으로 mPP/KF와 PU 바인더간의 상용성이 개선되었기 때문으로 해석할 수 있고, 파단면의 SEM 사진으로부터 확인되었다. In order to improve the interfacial adhesion property between polypropylene (PP)/kenaf fiber (KF) felt and polyurethane (PU) binder, corona discharge treatment and PP-g-MAH grafted maleic anhydride (MAH) were applied as a compatibilizer to PP/KF felt. Isothermal experiments were carried out by using differential scanning calorimetry (DSC) to determine the reaction temperature and time for PU binder. Tensile, flexural and impact properties were evaluated to analyze the mechanical properties of PP/KF/PU treated by corona discharge and PP-g-MAH. In case of modified-PP (mPP)/KF/PU composite treated by corona discharge and PP-g-MAH, the tensile and impact properties were improved. It may be because when the corona discharge was applied to the mPP/KF felt, the compatibilizing ability between the mPP/KF and PU binder increased due to the insertion of oxygen group in PP chain. The interface adhesion properties of the mPP/KF/PU composites were identified by SEM images of the fracture after the tension test.
박병수,최원식,염윤기 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.1
New cephalosporin antibiotics, 7-[(5-ethylthio-3-hydroxyisothiazol-4-yl)acetamido]-3-(hetero-cyclothiomethyl)-3-cephem-4-carboxylic acid derivatives(2a-2d) and 7-[(5-ethyl-thio-3-hydroxyisothiazol-4-yl)acetamido]-3-[(4-carbonyl-5-ethylthioisothiazol-3-yl)oxymethyl]-3-cephem-4-carboxylic acid(2e) and 7-[(5-ethylthio-3-hydroxyisothiazol-4-yl)acetamido]-3-(pyridinummethyl)-3-cephem-4-carboxylate(2f) were synthesized. The structure of these compound(2a-2f) were confirmed by means of IR and ¹H-NMR-spectrum.