PncA 유전자의 염기 서열 결정에 의한 결핵균의 Pyrazinamide 내성 진단

황지윤 ( Hwang Ji Yun ),곽경록 ( Gwag Gyeong Log ),박혜경 ( Park Hye Gyeong ),이지석 ( Lee Ji Seog ),박삼석 ( Park Sam Seog ),김윤성 ( Kim Yun Seong ),이정유 ( Lee Jeong Yu ),장철훈 ( Jang Cheol Hun ),이민기 ( Lee Min Gi ),박순규 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.1

질적 연구를 통한 삶의 맥락적 관점에서의 노인의 도시락 및 밑반찬 배달 서비스에 대한 수용 태도 및 적응에 대한 이해

황지윤(Ji Yun Hwang),김보경(Bok Young Kim),김기랑(Ki Rang Kim) 대한지역사회영양학회 2014 대한지역사회영양학회지 Vol.19 No.5

The purpose of this study was to suggest the strategies for improvement ofhome-delivered meal services for the elderly, to identify reasons for recipients to getstarted with the services and to evaluate the attitude, acceptability and adaptation ofrecipients to the services from the perspective of life context. Methods: The data was collected through face-to-face in-depth interviews with eighteenlow-income elderly recipients of home-delivered meals and analyzed using a qualitativeresearch method. Results: The results were deduced as four themes which comprised of long-termvulnerable socioeconomic contexts resulted in entry to the services, conflicting acceptabilityto the services, passive adaptation to taking the services, and positive practices to copewith supplement free meals or other services. The service participation was initiatedbecause of a combination of prolonged, vulnerable socioeconomic contexts, includingpoverty and unexpected life events such as diseases, disability, living alone, aging andunemployment. With regard to taking the services, conflicting acceptability wasobserved: positive aspects including saving living cost and good quality of meals, andnegative aspects including lack of a tailored service and feeling of stigma. Although therecipients needed an individualized service, they did not express their needs anddemands for the services and they accepted the unavailability as an accustomed,prolonged vulnerable socioeconomic context. With regard to lack of tailored services,either self-solution such as modification of eating patterns or community-based networkand services were used. Conclusions: We suggest that a system to concretely identify recipients’ attitude,acceptability and adaptation for home-delivered meal services should be developed inthe establishment of a tailored nutrition support system for the low-income elderly.

서울지역 저소득층 여성의 비만 및 영양소 섭취 부족과 관련된 사회경제적 요인

황지윤(Hwang Ji-Yun),류성엽(Ru Sung Yeap),유한경(Ryu Han Kyoung),박희정(Park Hee Jung),김화영(Kim Wha Young) 韓國營養學會 2009 Journal of Nutrition and Health Vol.42 No.2

본 연구에서는 도시 저소득층 여성을 대상으로 비만 및 영양소 섭취 부족과 관련된 사회경제적 요인을 분석하고자 했다. 대상자는 저소득층 가구를 대상으로 한 무료건강검진 센터를 방문한 여성 중 연구 참여에 동의한 41~87세 125명의 여성이었다. 대상자들의 72%가 초등학교 이하의 교육, 70%가 50만원 미만의 수입, 68%가 집을 소유하지 않고 있는 것으로 나타났다. 대상자들을 65세 미만, 이상으로 나누어 봤을 때 65세 미만군의 비만유병율은 BMI (≥ 25 ㎏/㎡) 기준으로 44%, WHR (≥ 0.85) 기준으로 48%, 허리둘레 (≥ 80 ㎝) 기준으로 50%이었다. 65세 이상군에서는 이보다 높아 BMI (≥ 25 ㎏/㎡) 기준 57%, WHR (≥ 0.85) 기준 81%, 허리둘레 (≥ 80 ㎝) 기준으로 79%였다. 대상자는 주로 채소류, 곡류, 과일류를 많이 섭취했다. 모든 대상자에서 열량 및 영양소 섭취 상태는 대체적으로 불량했고 특히 65세 이상 노인에서 더욱 불량한 것으로 나타나 여자노인에서 EAR을 충족시키지 못하는 비율은 철을 제외한 모든 영양소에서 50% 이상이었다. 대부분의 대상자들의 영양소 섭취량은 RI 수준에 미치지 못했고 그러한 사람의 비율은 65세 미만의 경우 단백질과 Vitamin B6 제외한 65세 이상에서는 모든 영양소에서 50% 이상이었다. 65세 미만에서는 비만 및 영양불량과 사회경제적 지표와의 관련성이 없었다. 그러나 65세 이상에서 비만의 경우 수입과 영양불량의 경우 학력과 집소유 여부와 관련이 있었다. 따라서, 65세 이상에서 연령을 보정한 후에, 사회경제적 수준에 따른 비만 및 영양부족의 위험도를 살펴본 결과, BMI 기준 비만의 위험도 (OR = 12.601; 95% CI = 2.338-67.911)와 WC 기준 복부 비만의 위험도(OR = 4.778; 95% CI = 1.103-20.696)는 월평균 가구 수입 50만원 미만인군에서 그 이상인 군보다 높았다. 영양섭취불량의 경우, 교육 수준이 낮은 사람들 (무학)에게서 Vitamin A (OR = 4.555; 95% CI = 1.491-13.914)를 EAR보다 적게 섭취할 위험이 높았고 자기 집을 소유하지 않은 사람의 경우, 단백질 (OR = 3.660; 95% CI = 1.118-11.981), 인 (OR = 3.428; 95% CI = 1.157-10.158), 철분 (OR = 3.765; 95% CI = 1.205-11.766)섭취가 EAR보다 부족할 위험이 집을 소유한 사람들보다 높았다. 저소득층 노인여성에서 사회경제적 수준은 비만 (소득수준) 및 영양불량 [교육수준(Vitamin A), 자가집 소유 여부(단백질, 인, 철)] 위험과 관련이 있는 것으로 보여진다. 따라서 이러한 여성들의 비만 및 영양불량을 예방하기 위한 노력이 필요할 것으로 사료된다. This study was performed to investigate socioeconomic factors relating to obesity and inadequate nutrient intake in women in low income families residing in Seoul. The subjects were 125 women (aged 41-87 y) recruited from the local health center for free health examination for low income families. The socioeconomic status such as educational level, income level, and housing condition were poor. For subjects aged less than 65 years, the prevalence of obesity was 44% based on BMI (≥ 25 ㎏/㎡), 48% based on WHR (≥ 0.85), and 50% based on waist circumference (≥ 80 ㎝) and for those more than 65 years, these were greater and 57%, 81%, and 79%, respectively. The main food sources of daily diet were vegetables, grains, and fruits. Energy and other nutrient intake was not adequate for all subjects and the inadequacy was more profound in the elderly, showing percentages of subjects whose intake was less than EAR were greater than 50% for all nutrients except for iron and below RI were also greater than 50% for all nutrients. The prevalence of obesity and nutrient inadequacy were not associated with socioeconomic status in subjects aged less than 65 years, however, obesity was associated with household income and nutrient inadequacy was related to education (vitamin A) and housing status (protein, phosphate, and iron) in the elderly. After adjustment for ages, in the elderly, OR for obesity (BMI ≥ 25, OR = 12.601; 95% CI = 2.338-67.911) and central obesity (WC ≥ 80 ㎝, OR = 4.778; 95% CI = 1.103-20.696) were greater in subjects who earned less than 500 thousand Won per month than who earned more. For inadequate nutrient intake, the OR for inadequate intake of Vitamin A (OR = 4.555; 95% CI = 1.491-13.914) was greater in subjects with no education than those educated. Subjects without her own house had greater risk for inadequate intake for protein (OR = 3.660; 95% CI = 1.118-11.981), phosphate (OR = 3.428; 95% CI = 1.157-10.158), and iron (OR = 3.765; 95% CI = 1.205-11.766) than subjects possessing her house. In elderly females in low income families, the socioeconomic status was associated with the risk for obesity (income level) and inadequate nutrient intake (education level and housing status). More attention on these groups should be given for prevention of obesity and inadequate nutrient intake.

인공전위장과 회전력장을 이용한 자율비행체의 충돌 회피 궤적/자세 동시 제어

황지윤(Jiyoon Hwang),이광원(Kwangwon Lee),박찬덕(Chandeok Park) 한국항공우주학회 2017 한국항공우주학회 학술발표회 논문집 Vol.2017 No.11

복수의 자율 우주비행체의 대형유지비행을 위한 충돌 회피 궤적 제어

황지윤(Jiyoon Hwang),이광원(Kwangwon Lee),박찬덕(Chandeok Park) 한국항공우주학회 2018 한국항공우주학회 학술발표회 논문집 Vol.2018 No.4

인구통계학적 요인 및 나트륨 섭취와 건강관련 삶의 질 간의 연관성: 경주지역 성인을 중심으로

이승우,황지윤,김인선,이수진,정경식,고광필,백영화,Lee, Seung-Woo,Hwang, Ji-Yun,Kim, In Seon,Lee, Sujin,Jeong, Kyungsik,Ko, Kwang-Pil,Beak, Younghwa 한국식생활문화학회 2021 韓國食生活文化學會誌 Vol.36 No.1

Sodium intake has been associated with the health-related quality of life (HRQoL). This study examined the demographic factors related to HRQoL and whether there is an association between sodium intake and HRQoL in adults residing in rural areas. A total of 1,980 adults (aged ≥20 years) were selected from a cross-sectional study conducted between December 2013 and February 2014 in Gyeongju, South Korea. The sodium intake and HRQoL were measured using a validated food frequency questionnaire and the EuroQol Five-Dimension (EQ-5D) (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), respectively. The education levels (<5 years) were inversely associated with all five dimensions of HRQoL. Men had better EQ-5D scores for each of the five components examined. Adults living with spouses had better scores related to usual activities and anxiety/depression, whereas widowers had decreased scores of mobility and self-care. Unlike older adults aged 70-79 years, adults aged <60 years were more likely to have greater scores related to mobility, usual activities, and pain/discomfort. The income levels were also inversely related to the scores for self-care, usual activities, pain/discomfort, and anxiety/depression. Sodium intake was positively associated with the HRQoL related to self-care, usual activities, and pain/discomfort, but it was negatively associated with anxiety/depression. In conclusion, these findings suggest that the demographic factors and sodium intake were independently associated with HRQoL. The results highlight the need to provide tailored, targeted policies and interventions that consider personal characteristics and dietary intake to improve the overall HRQoL in adults residing in rural areas.

베트남 결혼이민여성의 영양플러스 수혜 여부에 따른 영양지식 및 식습관, 식사섭취상태 비교

조미영(Mee-Young Joe),황지윤(Ji-Yun Hwang) 한국식품영양과학회 2019 한국식품영양과학회지 Vol.48 No.6

본 연구는 2012년 11월부터 2014년 4월까지 베트남 결혼이민여성 233명을 대상으로 신체계측 및 설문조사를 통해 일반사항, 식습관 및 식생활 현황, 영양지식 수준, 식사섭취상태 등을 조사하고 영양플러스 수혜 여부에 따른 유의적인 차이를 분석하였다. 결혼이민여성 중 영양플러스 수혜자는 비수혜자보다 식습관, 식생활, 영양지식 점수에서 모두 유의적으로 높은 점수를 나타냈다. 영양플러스 사업을 통해 더욱 바람직한 식습관과 건전한 식생활을 영위하고 있는 것으로 판단되며, 영양소 섭취에서도 영양플러스 수혜자가 비수혜자보다 섭취상태가 양호하였다. 수혜자는 철(P=0.009), 나트륨(P=0.008), 비타민 A(P=0.029), 리보플라빈(P=0.047), 비타민 C(P=0.012), 콜레스테롤(P=0.037) 등 6가지 영양소에서 비수혜자보다 유의적으로 많이 섭취하고 있었다. 칼슘의 경우 평균필요량 이하 섭취자 비율이 두 그룹 모두에서 50%가 넘었으며(65.9%), 영양플러스 비수혜자의 경우 엽산도 평균필요량 이하 섭취자 비율이 54.1%로 조사되었다. 영양플러스 수혜자는 비수혜자보다 비교적 규칙적인 식습관과 바람직한 식생활을 영위하고 있으며, 상대적으로 높은 영양지식 수준 및 영양소 섭취상태를 나타냈다. 따라서 결혼이민여성 중 영양플러스 대상자를 적극적으로 발굴하고 정보가 차단되지 않도록 할 필요가 있다. 영양플러스 사업을 통한 결혼이민여성 대상 영양교육의 진행은 타국 생활에 있어 순조로운 정착을 도우며, 주부로서의 역할 수행 능력을 함양하고 나아가 다문화가정 구성원 전체의 바람직한 식생활 영위에 도움이 될 것으로 기대한다. This study investigated the dietary habits, nutritional knowledge and nutrient intakes of married Vietnamese immigrant women according to participation in the Nutrition-Plus program. A total of 233 Vietnamese marriage immigrants were recruited from public health centers and multicultural family support centers in Seoul metropolitan areas and the Seoul Immigration Office. The methods of data collection included anthropometric measurements and face-to-face interviews using a structured questionnaire. The mean weight and body mass index (BMI) of those who underwent the Nutrition-Plus program were higher than those who did not (P=0.002, P=0.007, respectively). Additionally, those who received the Nutrition-Plus program showed a more balanced diet and higher total scores on the mini dietary assessment than those who did not receive the program (P<0.001). Furthermore, subjects who underwent the Nutrition-Plus program showed higher scores regarding questions about functions of cereals (P=0.010) and meat and fish (P=0.010), as well as higher overall scores (P=0.004) than those who did not participate in the program. With regard to nutrient intake, those who received the Nutrition-Plus program showed more intake of iron (P=0.034), sodium (P=0.007), vitamin A (P=0.049), riboflavin (P=0.025), vitamin C (P=0.019), and cholesterol (P=0.063) after adjusting for length of residence in Korea, number of children and BMI. Subjects who received the Nutrition-Plus program had more balanced dietary habits and nutrition knowledge, as well as greater food and nutrient intake than those who did not. These findings indicate the Nutrition-Plus program should be provided to married immigrant women to establish a healthy diet.

게잡이 원숭이에서 Recombinant Human Erythropoietin의 4주간 투여 후 비장 유전자 발현 연구

윤석주(Seokjoo Yoon),황지윤(Ji-Yoon Hwang),임정선(Jung-Sun Lim),정선영(Sun-Young Jeong),김용범(Yong-Bum Kim),김달현(Dal-Hyun Kim),권명상(Myung-Sang Kwon),한상섭(Sang-Seop Han),김충용(Choong-Yong Kim) 한국독성학회 2005 Toxicological Research Vol.21 No.3

We investigated effects of recombinant human erythropoietin (rHuEPO) on profiles of mRNA transcripts in 6 male cynomolgus (M. fascicularis) monkey’s spleen for 4 weeks. Six monkeys, composed of control and treatment group (Control : M1, M2, M3; Treatment : M4, M5, M6) were intravenously administered 3 times per week without or with a dose of rHuEPO 2730 IU/0.1 ㎖/㎏. After 4 weeks rHuEPO treatment, spleen was removed for RNA isolation. Splenic gene expression was assessed using Affymetrix U133A 2.0 arrays containing 18,400 transcripts and variants, including 14,500 well-characterized human genes. Gene expression pattern was very different between individuals even in same treatment. In rHuEPO treated groups showed number of genes were up-or downregulated (M4: 79; M5: 48; M6: 73 genes). Six genes (epidermal growth factor receptor, calgranulin A, estrogen receptor binding site associated antigen, matrix metalloproteinase 19, zinc finger and BTB domain containing 16, progestin and adipoQ receptor) were commonly expressed in rHuEPO treated group. The different individual response could be major considering factor in monkey experiment. Further study is needed to clarify the different individual response to rHuEPO in molecular level. This study will be valuable in the fundamental understanding and validation of molecular toxicology for biogeneric drugs including rHuEPO in cynomolgus monkey.

식품보장 기준선 마련을 위한 기본 개념과 세부 영역 설정 및 관련 지표 탐색

박소현(Sohyun Park),황지윤(Ji-Yun Hwang),심재은(Jae Eun Shim),김기랑(Kirang Kim) 대한지역사회영양학회 2021 대한지역사회영양학회지 Vol.26 No.6

질적연구조사를 통한 베트남 결혼이민여성과 한국인 배우자의 영양불량 원인 규명

조미영 ( Mee-young Joe ),황지윤 ( Ji-yun Hwang ) 대한영양사협회 2019 대한영양사협회 학술지 Vol.25 No.1

This study examined the possible causes of nutritional inadequacy in Vietnamese immigrant women married to Korean husbands. Qualitative in-depth interviews were conducted with a sample of 34 Vietnamese marriage immigrant women and 17 Korean spouses participating in or having experienced Nutrition Plus from four Community Health Centers in Seoul, Korea. The study results showed that the nutritional staus of the Vietnamese marriage immigrant women was affected by the unfamiliar Korean food (cultural factor), low household income (economical factor), difficulty in purchasing Vietnamese food (environmental factor), and low accessibility to nutrition support systems (social factor). The Korean husbands’ nutritional status was affected by the unfamiliar Vietnamese food (cultural factor), low household income (economic factor), and irregular working conditions (social factors). Nutritional interventions as a public service to the community needs to be developed and applied. Suggestions are presented regarding the future efforts to better understand and meet the nutrition needs of intermarried couples to respond to their heterogeneous needs and deliver adequate nutrition service to ever increasing intermarried families.