나를 '의사학'으로 이끈 역사읽기

황상익,Hwang, Sang-Ik 대한출판문화협회 1997 출판저널 Vol.208 No.-

책이있는 에세이

황상익,Hwang, Sang-Ik 대한출판문화협회 2000 출판저널 Vol.277 No.-

바람직한 교수 임용은 대학의 자율적.민주적 운영에서만 가능하다

황상익,Hwang, Sang-Ik 한국대학교육협의회 2002 大學敎育 Vol.117 No.-

칼슘, 베라파밀, 란타눔이 흰쥐 자궁근의 자발적 수축과 칼륨 경축에 미치는 효과

황상익,Hwang, Sang-Ik 대한생리학회 1984 대한생리학회지 Vol.18 No.1

The effects of $Ca^{++}$ and its antagonists (verapamil and $La^{+++}$) upon the spontaneous contraction and the contracture induced by 60 mM K-Tyrode solution were studied in the isolated uterine muscle. Longitudinal muscle strips were prepared from the rat uteri at estrous stage. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100% $O_2$ and kept at 35^{\circ}$. The results obtained were as follows: 1) In the uterine strips contracting spontaneously, both the amplitude of peak tension and the area of contraction curve increased dose-dependently in the range of $0.5${\sim}8$ mM $Ca^{++}$. The frequency of contraction increased as the concentration of $Ca^{++}$ increased up to 2 mM, but above this concentration the frequency decreased. In $Ca^{++}-free$ media, however, contraction did not develop. In the contracture induced by 60 mM K-Tyrode solution, the developed tension increased dose-dependently as the concentration of external $Ca^{++}$ increased to 8 mM. In the absence of external $Ca^{++}$ K-contracture appeared, but it was not sustained. 2) The spontaneous contraction of rat uterus was suppressed by verapamil in proportion to an increase of its concentration and totally abolished at the concentration of $3{\times}10^{-4}\;g/l$, but the spontaneous contraction re-appeared by addition of $Ca^{++}$. The amplitude of peak tension recovered completely but the recovery of frequency was incomplete. K-contracture decreased in a dose-dependent manner after the treatment with verapamil and totally disappeared at its concentration of $3{\times}10^{-4}\;g/l$. Even in this case contracture developed again by extra $Ca^{++}$. 3) The spontaneous contractile activity was inhibited by $La^{+++}$. At the concentration of $10^{-4}$M $La^{+++}$, fibrillation appeared. In the strip inhibited by $10^{-5}M\;La^{+++}$, contractility recovered completely by extra $Ca^{++}$ while in the $10^{-4}M\;La^{+++}$ treated preparation, the rhythmic spontaneous contraction did not develop even at the concentration of 16 mM $Ca^{++}$. After the initial transient depression of contracture tension by $10^{-3}M$ of $La^{+++}$, the strip stowed considerably large size of contracture, hardly influenced by external $Ca^{++}$ or verapamil. The results obtained in this experiment suggest that in the rat uterine muscle there would be some competitive actions between $Ca^{++}$ and its antagonists. It is speculated that $Ca^{++}$ plays an important role in the conduction of excitation, and $La^{+++}$ influences upon cellular $Ca^{++}$ mobilization and re-uptake process as well as transmembrane $Ca^{++}$ transport in a K-depolarized state.

혈액과 조직의 $CO_2$완충능 및 세포막을 통한 $H^+$농도 경사

황상익,박영배,민병구,김우겸,Hwang, Sang-Ik,Park, Young-Bae,Min, Byoung-Ku,Kim, Woo-Gyeum 대한생리학회 1983 대한생리학회지 Vol.17 No.2

The in vivo and in vitro buffer capacities of true plasma and tissue buffer capaciies were compared on dogs. Intracellular pH was determined on skeletal muscle by a modification of the method of Schloerb and Grantham using $C^{14}$ DMO. The in vivo curve for plasma or extracellular fluid has a much lower slope than the in vitro curve. The in vivo slope of skeletal muscle in the dog is approximately 20 sl. The slope for skeletal muscle in vivo falls between the in vitro and in vivo slopes of true plasma. It appears that intracellular hydrogen ion varies linearly with extracellular hydrogen ion when $CO_2$ tension is changed. Both hydrogen ion gradient and Hi/He ratio vary in skeletal muscle, with an increase in $CO_2$ tension. Infusion of 0.3N HCl gave two distinct patterns, the $H_i-H_e$ gradient decreased; and it would appear that very little hydrogen ion as such penetrated to the inside of the cells during the time of observation. Although lactic acid presumably enters the cell and the same of larger load was given as was used for hydrochloric acid, only very mild intracellular acidosis resulted, ostensibly due to metabolism of this substrate. Gluconic acid produced a more severe acidosis, both intracellularly and extracellularly, but with both of these acids the hydrogen ion gradient decreased and the $H_i/H_e$ ratio also decreased. The experiments on the dogs with hemorrhagic shock the hydrogen ion increase producing the acidosis originates inside the cells. Even so, the hydrogen ion gradient increased only very slightly in the acute experiments. This may suggest that even over short intervals of time skeletal muscle cells have a capacity to pump out hydrogen ions at a rate which maintains approximately the normal $H_i/H_e$ gradient when the source of the hydrogen ion is in the interior of the cell.

확대서평 - "한국 의료 대논쟁"

황상익,Hwang, Sang-Ik 대한출판문화협회 2000 출판저널 Vol.280 No.-

장기간의 신체 단련에 따른 체지방, 심폐기능 및 혈액화학상의 변화

황상익,Hwang, Sang-Ik 대한생리학회 1986 대한생리학회지 Vol.20 No.2

줄넘기 운동의 신체 단련 효과를 측정하기 위하여 사병 9명에게 9주동안 규칙적으로 줄넘기 운동을 시킨 후 체격, 심폐기능, 혈액화학적인 변화를 관찰, 단련전과 비교하여 다음과 같은 결과를 얻었다. 효과를 검사하기 위해 부하한 운동은 트레드밀 달리기 운동이었다. 1) 단련에 의해 몸무게, 체표넓이, 피부두겹두께 및 총지방량이 유의하게 감소하였다. 2) 안정시 폐기능검사 값 중 최대환기능과 노력성 호기유속 25%가 단련후에 유의하게 증가하였다. 3) 심장박동수는 단련에 의해 안정시와 운동시, 회복기 전 시간대를 통해 매우 유의하게 증가하였다. 4) 단련으로 수축기 동맥혈압은 안정시와 회복기 전 시간대에서 거의 유의하게 감소한 반면, 이완기 동맥혈압은 회복기 전체를 통해 유의하게 증가하였다. 5) 안정시와회복기의 호흡회수는 단련에 의해 변화가 없었다. 6) 안정시와 회복 초기의 혈중 총 콜레스테롤 농도는 단련 후에 유의하게 감소하였지만 혈당, HDL-콜레스테롤 농도는 약간의감소에 그쳤다. 7) 단련전에 비해 단련후의 혈중 젖산 농도는 회복기에 대체로 감소하엿고 20분과 60분 값의 감소는 뚜렷하였다. 이상의 결과로 보아 9주 동안의 규칙적인 줄넘기 운동으로 체내 지방이 감소하고 순환기계 기능에 뚜렷한 향상을 가져오며 혈액화학적인 변화가 생긴다고 할 수 있겠다. In an attempt to observe the to long-term training effects, the exercise of rope-skipping was regularly loaded to nine soldiers for nine weeks. And some physical characteristics, cardiopulinonary functions. some blood constituents were measured before, during and after the load of test exercise. treadmill running, and were compared with the pre-trained values. The results obtained were as follows: 1) Body weight, body surface area, skinfold thickness and total body fat decreased sifnificantly after the training. 2) The post-trained values of MVV and $FEF_{25%}$, increased significantly. 3) By the training, heart rates decreased very significantly in the resting, exercising and recovery periods. 4) After the training, the systolic blood pressures of the resting and recovery periods decreased meaningfully, while diastolic blood pressures increased significantly through the recovery stages. 5) In spite of the training, the respiration rates never change in both the resting and the recovery periods. 6) After the training, total cholesterol concentration of the venous blood decreased significantly in the resting the early recovery phases while the blood levels of glucose and HDL-cholesterol decreased very slightly. 7) Blood lactate concentration decreased through the recovery periods and the value of the recovery 20 and 60 minutes decreased obviously, in comparison with the pre-trained values. The above results suggest that the 9 week-training of the rope-skipping brings about the decrease of the body fat contents, the enhancement of cardiopulmonary functions and some changes in the blood constituents.

줄넘기 운동 훈련이 심폐기능 항진에 미치는 효과

황상익,Hwang, Sang-Ik 대한생리학회 1986 대한생리학회지 Vol.20 No.1

줄넘기 운동의 신체 단련 효과를 측정하기 위하여 사병 9명에게 9주 동안 규칙적으로 줄넘기 운동을 시키면서 심폐기능의 변화를 관찰하여 다음과 같은 결과를 얻었다. 효과를 측정하기 위해 부하한 운동은 줄넘기, 40 cm 및 45 cm 높이의 계단운동이었다. 1) 심장박동수는 단련에 의해 안정시와 운동후 회복기 전 시간대를 통해 매우 유의하게 감소하였으며 효과는 단련 시작 1주후부터 나타났다. 2) 단편으로 수축기 동맥혈압은 안정시와 회복기 전 시간대에서 거의 유사하게 감소하였는데 이러한 효과는 단련 한달경부터 나타났다. 3) 회복기의 호흡회수는 단련에 의해 별 변화가 없었으나 단지 줄넘기 운동 회복 초기에만 유의하게 감소하였다. 4) 심폐기능 상의 단련 효과는 검사시 부하하는 운동량이 경할수록 더욱 뚜렷하였다. 이상의 결과로 보아 9주간의 줄넘기 운동으로 심폐기능 특히 심장순환계 기능에 뚜렷한 향상이 온다고 할 수 있겠다. In an attempt to observe the effects obtained by the regular physical training, nine soldiers performed regularly the rope-skipping for nine weeks. All subjects were healthy and did not experience any special military training Programs. During the course of the training, their cardiopulmonary functions were measured in the resting and the Post-exercise recovery periods, and the values were compared with ones of the pre-trained. The test exercises loaded to the subjects were rope-skipping and step-rising & falling. The results obtained were as follows: 1) By the training, heart rates decreased very significantly in the resting and post-exercise recovery periods. And the effects began to bring out at the early stage, about the 7th day. 2) As the duration of the training increased, the systolic blood pressures decreased meaningfully in the resting and recovery periods. 3) Only in the early recovery phase after the exercise of the rope·skipping, the respiration rates decreased significantly by the training. 4) The lighter the intensity of the test exercise loaded was, the more prominent the effect of the physical training on the cardiopulmonary functions was. The above results suggest that the 9 week training of the rope-skipping would bring about the enhancement of the cardiopulmonary functions.

과학기술의 두 얼굴 - 시급한 "생명윤리기본법" 제정 연구자들도 관심갖고 참여를

황상익,Hwang, Sang-Ik 한국과학기술단체총연합회 2001 과학과 기술 Vol.34 No.4

의학교육과 의료개혁

황상익,Hwang, Sang-Ik 한국대학교육협의회 1995 大學敎育 Vol.76 No.-