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RISS 인기검색어
- 검색키워드
- 저자 : 홍승길 ( Seung Kil Hong ) (검색결과 48 건)
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홍승길,Hong, Seung-Kil 대한생리학회 1973 대한생리학회지 Vol.7 No.2
It has been reported that vasopressin disperse the melanophore granule of frog skin. The author used hypophysectomized and adrenergic receptor blockaded animals in order to define the mechanism of vasopressin on the melanopore pigment of frog skin. The Rana niglomaculata which could be found in the Seoul area were used on this experiment. The amount of the following drugs were injected into the lymphatic sac of the frog; vaospressin $(0.05\;{\mu}g/g\;B.W.)$, dibenzylin $(0.05\;{\mu}g/g\;B.W.)$, and propranolol $(0.01\;{\mu}g/g\;B.W.)$. The following results were observed; 1. Vasopressin dispersed the melanin granules of melanocyte of frog skin. 2. The melanin granule dispersion activity of vasopressin was observed on the hypophysectomized frog. 3. The melanin granule dispersion was observed on the adrenergic receptor blockaded frog with dibenzylin or propranolol respectively, especially the later one was found to be more obvious. 4. The melanin granule dispersion was observed on the frog which was injected with vasopressin after alpha-receptor or beta-receptor blockade and the later one was found to be more obvious. 5. The melanin granule dispersion was more effective with the blockade of beta-receptor after the treatment with vasopressin on hypophysectomized frog.
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고양이 허파에서 산소재유입 손상을 결정하는 저산소증의 정도
남현정,김유경,홍승길,나흥식,Nam, Hyun-Jung,Kim, Yoo-Kyung,Hong, Seung-Kil,Na, Heung-Sik 대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.6
Although reoxygenation is the best way to salvage hypoxic tissues, reduced oxygen species (ROS) generated during reoxygenation are blown to cause further tissue injuries and the induction of heat shock proteins (HSPs). The present study was undertaken to determine any causal relationship between the severity of hypoxia and the opposite outcomes, either beneficial or detrimental, of the subsequent reoxygenation by measuring the HSP72. To this aim, one group (6 male cats, $2.5{\sim}3.5\;kg$) was subjected to a 5-min episode of hypoventilation (H, ventilation rate: 5/min) for the induction of slight hypoxia and the other group (6 male cats, $2.4{\sim}3.7\;kg$) was subjected to a 5-min episode of apnea (A) for severe hypoxia. Each 3 animals from both groups received a 10-min episode of ventilation with $(95%\;O_2\;(0)$, whereas the remainder did not. After these procedures, all animals were allowed to be ventilated within physiological range for 1, 4, or 8 hours (1H, 1HO, 4H, 4HO, 8H, 8HO, 1A, 1AO, 4A, 4AO, 8A and 8AO groups). Control animals did not receive any manipulation. The arterial blood $pCO_2$ was significantly higher just after apnea than hypoventilation, while $pCO_2$ and pH were significantly lower just after apnea than hypoventilation. Western blot analysis revealed that the magnitude of HSP72 synthesis is larger in 1H, 4H and 8H groups than in 1HO, 4H and 8HO groups, respectively. In contrast, 1AO, 4AO and 8AO groups more induced HSP72 than 1A, 4A and 8A groups, respectively. These results suggest that the reoxygenation is beneficial after slight hypoxia but detrimental after severe hypoxia.
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이계열,지선호,홍승길,성양호,Lee, Kae-Yol,Chee, Sun-Ho,Hong, Seung-Kil,Sung, Yang-Ho 대한생리학회 1972 대한생리학회지 Vol.6 No.2
Contrary to most of European and American investigators failed to find out the seasonal variations of basal metabolic rate in man, Japanese and Korean investigators reported the increase in winter, decrease in summer season. But the causes of variation were not found clearly. To find out whether metabolic acclimatization to climate could be arise or not in human being, the basal metabolic rate was determined monthly for a period of one year in Airmen volunteers who live in Seoul, with 9 l Collins spirometer. The results obtained were as follows: 1. The average ambient temperature was lowest in February $(-5.88^{\circ}C)$ and highest in July $(27.34^{\circ}C)$. 2. Basal metabolic rate was lowest in June and highest in December showing seasonal variations. Interestingly, the increase of basal metabolic rate followed after the drop of ambient temperature below $0^{\circ}C$ (December) and the decrease followed after the elevation of ambient temperature from optimum to hot (June) or cold to warm (March). 3, Mean skinfold thickness increased in spring, decreased in winter. 4. These findings indicate that the basal metabolic rate of Korean reveals the seasonal variation affected by ambient temperature highly.
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홍승길,이계열,박용덕 최신의학사 1972 最新醫學 Vol.15 No.9
To investigate the effects of hypothalamic lesion on the erythropoietic function and the regulation of body temperature, bilateral preoptic regions of rabbit hypothalamus were destroyed electrolytically. The reticulocytes count, hematocrit and rectal temperature were evaluated to these lesioned animals and exposed to 8% oxygen environment for erythopoietic response to hypoxia. The results obtained were as follows: 1. The reticulocytes and hematocrit values were decreased in the lesioned animals of preoptic region of hypothalamus. 2. Destruction of preoptic region of hypothalamus leads to decrease of rectal temperature. 3. There were no changes of erythropoietic responses to hypoxia in the preoptic lesioned ainmals. 4. Destruction of preoptic region of hypothalamus can not inhibit the erythropoietic response to hypoxia. It was suggested that the regulating center for erythropoiesis and body temperature did not exist in a local point but in scattered area of hypothalamus.
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고양이 식도에서 장력 - 감수성 구심성 미주신경의 특성에 대한 연구
홍승길,방윤경,송치욱,현진해,한희철 대한소화기학회 1997 대한소화기학회지 Vol.29 No.6
Background/Aims: Activation of tension-sensitive receptors in the esophagus evokes spike discharges in vagal and sympathetic afferent axons. These tension-sensitive afferent fibers play irnportant roles in esophageal reflex activities, including the activation of peristalsis and contraction of the upper esophageal sphincter, as well as in the central mediation of esophageal pain. To understand the properties of vagal esophageal tension-sensitive afferents we studied the response of vagal afferents to balloon distension in the lower esophagus of the cat using the single fiber recording technique. We also studied whether these afferent fibers were sensitized by acid infusion or not. Methods: Under an alpha-chloralose anesthesia, the cat was dissected along the aidline of the neck and 21 vagal afferent fibers were separated. Electrophysiological activity was then measured during rest and during latex balloon distentions. Next, acid(0.1N HC1) was infused into the lurnen of the esopahgus and changes in baseline discharges and response to distention of vagal afferents were compared before and after the acid infusion. Results: Of the 21 esophageal afferents, 18 were A6 and 3 were C fibers. During the resting state, 19 of the 21 fibers showed spontaneous discharge activity, the mean was found to be 3.6±5.4 imp/second. Esophageal distention produced a reproducible increase in discharge rate that adapted slowly to sustained distention. The average threshold pressure of the endings was 10.4±5 mmHg. The saturation pressure was 97.8±10.2 mmHg with graded, discrete distentions. After intraesophageal acid infusion, the discharge rate showed no significant changes when compared to base line discharges. Conclusions: Esophageal tension-sensitive vagal afferent fibers showed a reproducible re:sponse to distention, which may provide a new objective methodology in studying afferent sensory nerve fibers. Furthermore these fibers were also not sensitized by intraesophageal acid infusion.
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홍승길 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1
The present experiments were preformed in order to determine whether an increased activity of group Ⅳ units evoked by pain producing substances influences the dischrage of motoneurones. In decerebrate cats, the discharge of alpha and gamma motoneurones of the gastrocnemius-soleus muscle were studied. Extracellular recordings were made from thin filaments of the L6, L7, or S1 ventral roots obtained by microdissection. 1. Group Ⅳ (unmyelinated fiber) muscle afferent fibers were activated by administration of bradykinin, KCl, and 5-HT. 2. Bradykinin has the inhibitory effect to alpha-motoneurones and excitatory effect to gamma-motoneurones. 3. KCl has the inhibitory effect to alpha-motoneurones and excitatory effect to gamma-motoneurones. 4. 5-HT has the inhibitory effect to alpha-motoneurones and excitatory effect to gamma-motoneurones. 5. Succinylcholine has no effect to both alpha-and gamma-motoneurones. It is concluded that motoneurones receive and input from group Ⅳ muscle afferents which possesses chemo-nociceptive properties.
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박동빈,홍승길 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.1
The present experiment was done to determine the influence of pH changes on muscle spindle excitability by in jection of acidic and alkalic substances of different pH through the intra-arterial canulation to gastrocnemius-soleus muscle of the cat and examined the changes of the excitability of muscle spindle from group Ia muscular afferents. The changes of the impulse discharges were recorded from peripheral sensory nerve fibers of sciatic nerve and the results are as follows: 1) Among 46 group Ia muscular afferents, 8 showed enhancement, 17 showed decrement and 21 showed initial enhancement followed by decrement of the impulse discharges by lactate(pH 3.2). 2) Among 35 group Ia muscular afferents, 4 showed enhancement, 9 showed decrement and 13 showed initial enhancement followed by decrement of the impulse discharges by acetic acid(pH 3.2). 3) Among 15 group Ia muscular afferents, 2 showed enhancement, 5 showed decrement and 8 showed initial enhancement followed by decrement of the impulse discharges by acetate(pH 6.6). 4) Almost all the group Ia muscular afferents, there were no changes of the impuslse discharge to Tyrode solution(pH 7.4), however, a few of them showed slight decrement of the impulse discharges. 5) Among 21 group Ia muscular afferents, 2 showed enhancement, 7 showed decrement, and 12 showed initial enhancement followed by decrement of the impulse discharges by ammonia buffer solution(pH 8.1). 6) Among 27 group Ia muscular afferents, 5 showed enhancement and 22 showed initial enhancement followed by decrement of the impulse discharges by NaHCO₃ solution(pH 8.1).
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