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만성신부전에서 염류코르티코이드 투여가 포타시움 평형과 요 암모늄 배설에 미치는 효과
한진석(Jin Suk Han),이정상(Jung Sang Lee),김강석(Kang Seock Kim),허우성(Woo Seong Huh),전은실(Un Sil Jeon),이서진(Seo Jin Lee),주권욱(Kwon Wook Joo),김성권(Suhnggwon Kim),진호준(Ho Jun Chin),조윤숙(Yun Suk Cho) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2
N/A Mineralocorticoids influences on acid-base homeo-stasis by the regulation of urine acidification. But its mechanism of acion is not well known in human. This study compared the acid-base status and the indices of urine acidification before and after mineralocorticoid administration in human, and analyzed the effect of mineralocorticoids on human acid-base homeostasis. We administered 9a-fludrocortisone in 6 chronic renal failure patients and 6 normal controls 0.5mg daily for 7 days. The results were as following ' 1) After administration of 9a-fludrocortisone in patients group, serum aldosterone level changed from 120.2±71.0pg/mL to 44.8±32.2pg/mL(mean±SD, p< 0.05). Serum HCO- level was not changed. Urine ammonium excretion was incresed from 24.6±12.3 mmol/day to 43.7±19.0(p<0.05), but there were no change in urine pH and urine anion gap, Serum potassium level decreased from 5.5±0.7mBq/L to 4.1±0.5mEq/L(p<0.05), and TTKG increased from 3.9 to 8.9(p<0.05). 2) After administration of 9a-fludrocortisone in control group, serum aldosterone level changed from 99.7±44.5pg/mL to 25.1±3 mL(p<0.05). Serum HCO- level was not changed. Urine ammonium ex-cretion was incresed from 44.3±21.6mmoVday to 76.3±19.6(p<0.05), but there were no change in urine pH and urine anion gap. Serum potassium level decreased from 4.8±0.5mEq/L to 3.9±0.2mHq/L(p< 0.05), but there was no change in TTKG. 3) No patient or control showed any discomfort after 9-fludrocortisoneadministration, and there was no elevation in diastolic blood pressure, increase in body weight, electrolyte abnormality. In summary, after 9α-fludrocortisane administration, urinary ammonium excretion increased in both patients and control group, and this phenomenon occured with correction of hyperkalemia without urine pH change. This result implies urinary ammonium excretion increase by mineralocorticoid. In human increase in renal distal acidification by mineralocorticoid is due to increase in renal ammo- niagenesis rather than stimulation on proton excretion.
증식성 및 비증식성 사구체신염에서 Cytokine 과 Chemokine 유전자의 발현 양상
이서진(Seo Jin Lee),김강석(Kang Suk Kim),정수환(Shou Huan Zheng),임춘수(Chun Soo Lim),윤형진(Hyung Jin Yoon),김연수(Yon Su Kim),안규리(Cu Rie Ahn),한진석(Jin Suk Han),노정우(Jung Woo Noh),채동완(Dong Wan Chae),이정상(Jung Sang Lee),김 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.4
Backgroud : Intraglomerular cellular proliferation is one of the major determinants for dividing various glomerulonephritis(GN) into two groups, such as proliferative versus nonproliferative. We hypothesized that this morphological difference could be based on the differential expression of various cytokines and chemokines. To elucidate this hypothesis we quantified the intrarenal gene expression of various cytokines and chemokines, and correlated it with clinical and histological parameters. Methods: Total RNA was extracted from 54 proliferative GN(PGN) core biopsy specimens and 42 nonproliferative GN(NPGN) specirnens. Using the internal competitors RT-PCR was instituted to quantify mRNAs. Results: The magnitude of the gene expressions of IL-2, IFN- r, and IFN- r /IL-10 ratio were signi- ficantly higher in PGN. RANTES and IL-8 had more abundant gene messages in PGN than in NPGN. It was shown that Thl cytokine was upregulated if GN was mediated by immune complexes regardless of cellular proliferation. Upregulation of the IFN- r / IL-10 ratio and TNF- αwas associated with renal dysfunction at the time of renal biopsy. Conclusion Thl, proinflammatory cytokines, and chemokines were more abundant in proliferative GN, and correlated with unfavorable clinical and histologic parameters. We propose that the clinical manifestations and diverse histologic features of human GN are associated with differential expressions of specific cytokines and chemokines. A new way of blocking the actions of these cytokines should be instituted for the treatment and prevention of the progression of GN.
구진회(Gu, Jin-Hoi),이재원(Lee, Jae-Won),서충열(Seo, Chung-Youl),장성기(Jang, Seong-Ki),최경희(Choi, Kyung-Hee),한진석(Han, Jin-Seok) 한국소음진동공학회 2012 한국소음진동공학회 논문집 Vol.22 No.3
The noise emitted from an excavator has long been a cause of environmental disputes, while causing displeasure to the nearby residents. So, the ministry of environment adopted the construction machinery noise labeling system to encourage the construction machinery manufacturing companies to develop the low noise construction machinery voluntarily. But, as the quality of life improves, a growing number of people desire the comfortable and quite environment to live in. Under the situation, noise from the construction machinery has been a major cause for stress and complaints. When the noise dispute happened in the construction site, the sound pressure level of the construction machinery like a excavator was measured at the lot boundary of the noise victim's residence to judge how much noise damage occur. But the sound pressure level of the construction machinery is measured differently according to the acoustic environment of construction site and the measuring position, respectively, which makes it difficulty to judge whether the noise damage occur or not. As the sound power level of noise source is not affected by the acoustic environment of construction site and the measuring position, if we use the information of the sound power level, it will be easy to judge whether the noise damage occur and to establish the soundproofing measures. Therefore, we derive the sound power level regression model of the excavator to judge whether the noise emitted from the excavator damages to residents near the construction site. Also, the sound power level regression model of the excavator drawn in this paper will help construction companies to plan the noise reduction program in the construction sites.
구진회(Gu, Jin-Hoi),이재원(Lee, Jae-Won),이우석(Lee, Woo-Seok),최경희(Choi, Kyung-Hee),서충열(Seo, Chung-Youl),박형규(Park, Hyung-Kyu),김삼수(Kim, Sam-Soo),한진석(Han, Jin-Seok) 한국소음진동공학회 2012 한국소음진동공학회 논문집 Vol.22 No.9
The global warming caused the changes of our environment like an increasing tropical night phenomenon in the middle latitude areas. Especially, in Korea, the habitats of tropical Korean blockish cicada have changed from Jeju island located in Southern part of Korea to the whole of Korea because of the increasingly warming weather. The cicadas crying sound have been social problem because the tropical Korean blockish cicadas cry at middle of the night owing to the various outdoor lights. The cicada is positive phototaxis insect. So, the cicada is not cry at night. But if the outdoor light is very bright, then the cicada confuse the night as a day and start to cry. As a result, the cicadas crying noise has caused the resident living in downtown to an unpleasure and sleeplessness. In this research, we have measured three kinds of cicada singing noise at 16 points of urban area(Incheon, Gwangju, Busan, Gyeonggido Anyang). And then we analyzed the sound quality of the three kinds of cicada singing noise using by CADA-X signal process program. And we analyzed the acoustical characteristics by STFT(short time Fourier transform) which is a time-frequency analysis method. The characteristics of the cicada singing noise in terms of the sound quality and the time-frequency variation will be usefull to discover the relations between the human annoyance about the cicada singing noise and the acoustical characteristics.
수도권 지역 대기 중 카보닐화합물의 시ㆍ공간적 농도 분포 특성
서영교(Young-Kyo Seo),정은희(Eun-Hui Jeong),서석준(Seok-Jun Seo),황윤정(Yun-Jeong Hwang),한진석(Jin-Seok Han),백성옥(Sung-Ok Baek) 한국대기환경학회 2008 한국대기환경학회지 Vol.24 No.2
The purpose of this study is to evaluate concentrations of carbonyl compounds during summer season in Seoul metropolitan area. The air samples were collected at 7 sites in this area from June 2001 to June 2003. The carbonyl compounds were analyzed by DNPH/HPLC method. The analytical method applied in this study showed good repeatability, linearity, and sensitivity. The most abundant carbonyl was formaldehyde (average 4.48 ppb), and followed by acetone, acetaldehyde, methyl ethyl ketone, butyraldehyde, propionaldehyde and benzaldehyde, respectively. Concentrations of carbonyl compounds in June were higher than those in August. There was not only higher solar radiation but also higher ozone concentration in June than in August. As a result of photochemical reactions, carbonyl compounds from both primary and secondary sources are likely to contribute to the formation of ozone. The contributions to photochemical ozone creation of two carbonyl compounds such as formaldehyde and acetaldehyde were estimated to be about 70%. Ratios of formaldehyde to acetaldehyde in this study ranged from 1.13 to 4.26, which are generally equivalent levels to those of other urban areas in domestic and foreign countries.
신부전 만성도 평가에 있어 혈중 carbamylated hemoglobin 치의 유용성
김연수(Yon Su Kim),한진석(Jin Suk Han),진호준(Ho Jun Chin),이서진(Seo Jin Lee),조윤숙(Yun Suk Cho),안규리(Ahn Cu Rie),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee),장인진(In Jin Jang),신상구(Sang Gu Shin),허우성(Woo Seong Huh) 대한내과학회 1996 대한내과학회지 Vol.51 No.3
N/A Objective: Differentiation of acute from chronic renal failure is an important but difficult task in treating the azotemic patients. It is known that the degree of carbamylation reflects the duration and the severity of the uremia. To assess the usefulness in differentiating acute(ARF) from chronic reanl failure (CRF), we measured the carbamylated hemoglobin (CarHb). Methods: We measured CarHb(measured as ㎍ of carbamyl valine per g hemoglobin) prospectively in 64 patients with azotemia (24 ARF, 40 CRF) referred to the Seoul National University Hospital. High performance liquid chromatography was used for measuring CarHb. Thirteen normal controls were also studied to match 64 patients. Results: Patients with ARF had lower median (range) CarHb concentration than those with CRF [56.0(24.6-97.1) ㎍CV/gHb vs 120.4(31.7-286.5) p<0.01]. It is not different from normal control [56.0 (24.6-97.1) vs 40.9(19,9-62.9); p<0.05]. The ratio of CarHb to serum creatinine(mg/dl) was lower in ARF than in CRF [10.5(4.9-34A) vs 18.2(4.7-52.2) p<0.01]. The cut-off value for CarHb to be CRF is 80 ㎍CV/gHb(sensitivity 70%, specificity 71%, positive predictive value 80%). Conclusion: The carbamylated hemoglobin is useful in determining the chronicity of the renal failure and it could be of clinical value in deciding the further management.