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      • KCI등재

        과채류, 과수류 및 벼 재배지역에서 농약사용 실태

        하헌영(Ha Huen-Young), 나동수(Ra Dong-Soo), 신욱철(Shin Wook-Cheol), 임건재(Im geon-Jae), 박재읍(Park Jae-Eup) 한국농약과학회 2012 농약과학회지 Vol.16 No.4

        농약의 오남용을 방지하고 안전한 농산물을 생산하기 위한 일환으로 농약 등록 후에 농가에서의 사용되는 농약사용실태 및 작물별 단위면적당 농약사용량을 조사하기 위하여 2009년부터 2011년까지 작물별 주산단지별, 재배면적을 감안하여 390농가를 선정하여 조사하였다. 농약안전사용 준수사항은 과채류, 과수류, 벼 재배농가 모두가 대체적으로 잘 지키고 있었다. 작물별 단위면적당 농약사용량은 주성분 기준으로 노지고추 11.6 kg/ha, 시설고추 2.0 kg/ha, 딸기 2.3 kg/ha, 수박 2.2 kg/ha, 오이 4.8 kg/ha, 참외 1.5 kg/ha, 토마토 2.1 kg/ha, 사과 12.5 kg/ha, 배 12.5 kg/ha, 복숭아 7.7 kg/ha, 포도 4.5 kg/ha, 감귤 40 kg/ha, 단감 5.4 kg/ha이었으며, 벼는 3.46 kg/ha이었다. 고추, 딸기, 오이, 참외, 토마토, 사과, 배, 포도, 감귤, 단감, 벼는 4년 전에 비해 농약사용량이 감소하였으나 수박, 복숭아는 다소 증가하는 경향을 보였다. In order to survey the actual pesticide usage, this survey was carried out on the growers of 3 plant groups, fruit vegetables, fruits and rice field, from 2009 to 2011. 390 farmers were selected from main production areas to investigate their pesticide application during the growing seasons. Input amounts per area of domestic fruit vegetables was surveyed as 11.6 kg a.i./ha for red pepper of field culture, 2.0 kg a.i./ha for red pepper of greenhouse, 2.3 kg a.i./ha for strawberry, 2.2 kg a.i./ha for watermelon, 4.8 kg a.i./ha for cucumber, 1.5 kg a.i./ha for oriental melon and 2.1 kg a.i./ha for tomato, respectively. Input amounts per area on fruits and on rice field were surveyed as 11.7 kg a.i./ha for apple, 12.5 kg a.i./ha for pear, 7.7 kg a.i./ha for peach, 4.5 kg a.i./ha for grape, 40.0 kg a.i./ha for citrus 5.4 kg a.i./ha for persimmon, and 3.46 kg a.i./ha for rice, respectively. As a result of the actual pesticide usage survey, The safety guideline for pesticide use is generally kept well by all farmers of fruits vegetables, fruits and rice.

      • 오차드그라스의 예취빈도에 따른 무기태질소의 단기시용 효과

        조익환,이용세,전하준 대구대학교 과학기술연구소 1998 科學技術硏究 Vol.5 No.2

        A study was made to estimate the economic level(Necon.) of mineral nitrogen and a proper cutting frequency for the dry matter production of Orchardgrass (Dactlyis glomerata L.) during the harvested years in 1993∼1995. Annual mineral nitrogen was applied at the levels of 0, 90, 180, 270 and 360 kg ha^(-1) in 3 cuttings, 0, 120, 240. 360 and 480 kg ha^(-1) in 4 cuttings, and 0. 150. 300. 450 and 600 kg ha^(-1) in 5 cuttings, respectively. The dry matter yields of all cutting frequencies in 1993 were significantly higher than in the other harvested years. Mean dry matter yield were 13.1, 12.7 and 14.3 tons ha-1 in 3, 4 and 5 cuttings, respectively. Higher efficiencies of dry matter production in response to mineral nitrogen application were recorded as 12.9 kg at level of 360 kg ha^(-1) yr-1 in 3 cuttings. 27.3 kg at level of 240 kg ha-1 yr^(-1) in 4 cuttings, and 20.5 kg at level of 150 kg ha-1 yr-1 in 5 cuttings, respectively. Significantly higher dry matter yields appeared as 4.6 tons ha-1 at 1st cut in 3 cuttings, 3.7 tons and 4.1 tons ha^(-1) at 2nd cut in 4 and 5 cuttings, respectively. The estimated marginal dry matter yields(Ymar.) were 11.7∼12.3 tons ha^(-1) at ranges of economic N level of 285.5∼316.6 kg ha^(-1) yr^(-1) in 3 cuttings, 10.4∼10.5 tons ha-1 at ranges of 176.7∼196.6 kg ha^(-1) yr^(-1) in 4 cuttings, and 11.2∼11.6 tons ha^(-1) at ranges of 246.1∼286.0 kg ha^(-1) yr^(-1) in 5 cuttings, respectively. Maximun dry matter yields(Ymax.) were 14.3 tons at the level of limiting N(Nmax.) of 379.5 kg ha^(-1) yr^(-1) in 3 cuttings. 11.1 ton at level of limiting N of 298.4 kg ha^(-1) yr^(-1) in 4 cuttings, and 12.3 ton at level of limiting N of 467.7 kg ha^(-1) yr^(-1) in 5 cuttings, respectively. Economic N level in all cuts were in the ranges of 85.1∼116.1 kg ha^(-1) cut^(-1) in 3 cuttings, 31.3∼69.7 kg ha^(-1) cut^(-1) in 4 cuttings, and 30.8∼81.4 kg ha^(-1) cut^(-1) in 5 cuttings, respectively.

      • SCOPUSKCI등재

        수용액중의 수은전극에서 바나듐-디에틸렌트리아민 펜타아세트산염의 환원 및 평형연구

        정기석,손세철,하영경,엄태윤,윤석승,Ki-Suk,Jung,Se,Chul,Sohn,Young,Kyung,Ha,Tae,Yoon,Eom,Sock,Sung,Yun 대한화학회 1989 대한화학회지 Vol.33 No.1

        0.5M $NaClO_4$ 수용액중의 수은전극에서 바나듐-디에틸렌트리아민펜타아세트산(DTPA)염의 전기화학적 환원 및 평형을 온도 25$^{\circ}C$와 3.2 < pH < 10.5 에 걸쳐서 연구하였다. 바나듐(III)-DTPA착물은 모든 pH에 걸쳐서 V${\cdot}A^{3-}$-(A=DTPA)로서 존재하고 EDTA같은 다른 디아민카르복시산과의 착물들과 달리 수소첨가가 일어나지 않고 $OH^-$도 배위되지 않으며 가역적으로 바나듐(II)-DTPA착물로 환원된다. 3.2 < pH < 5.9에서는 전극반응이 $V{\cdot}A^{2-}+H^++e^-=V{\cdot}HA^{2-}$와 같이 진행하며 $V{\cdot}HA^{3-}$ 의 안정도상수는 $3.09{\times}10^{14}$과 같이 구하여졌다. $VO^{2+}$이온의 경우 pH적정결과 착화반응은 $VO^{2+}+H_2A^{3-}=VO{\cdot}HA^{2+}H^{+}$ 및 $VO{\cdot}HA^{2-}=VO{\cdot}A^{3+}+H$ 와 같이 2단계에 걸쳐서 진행되며, $VO{\cdot}HA{2-}$의 산해리상수는 pKa=7.15이다. $VO{\cdot}HA^{2-}$와 $VO{\cdot}A^{3-}$ 의 안정도상수는 각각 $1.41{\times}10^{14}$ 및 $3.80{\times}10^{17}$과 같이 구하여졌다. 바나듐(IV)-DTPA착물은 비가역적으로 바나듐(III)-DTPA착물로 환원되며 이때 전이상수 ${\alpha}$=0.43이다. 더 큰 음의 과전압에서는 2단계에 걸쳐서 환원된다. 이 때 첫째 단계의 환원은 3.2 < pH < 10.5에서 $VO{\cdot}A^{3-}+e{\to}VO{\cdot}A^4$인 것으로 판단되었다. 두번째 단계의 환원은 V(III)의 환원과 같다. $VO{\cdot}HA^{2-}$ 와 $VO{\cdot}A^{3-}$의 확산계수로서 각각 $(9.0{\pm}0.4){\times}10^{-6}cm^2/s$ 및 $(5.9{\pm}0.4){\times}10^{-6}cm^2/s$ 을 구하였다. Reduction and equilibrium of vanadium-DTPA (DTPA = diethylenetriaminepentaacetic acid, $H_5A$) complexes at mercury electrodes are studied in 0.5M $NaClO_4$ aqueous solution at 3.2 < pH < 10.5 and 25$^{\circ}$C. At 3.2 < pH < 5.9, the reduction reaction is $V{\cdot}A^{2-}+H^-+e^-=V{\cdot}HA^{2-}$, while at 5.9 < pH < 10.5 it is $V{\cdot}A^{2-}+H^-+e^-=V{\cdot}A^{3-}$. The stability constants of $V{\cdot}HA^{2-}$ and $V{\cdot}A^{3-}$ are found to be $6.46{\times}10^{9}$ and $3.09{\times}10^{14}$, respectively. V(IV)-DTPA undergoes stepwise complexation as $VO^{2+}+H_2A^{3-}=VO{\cdot}HA^{2+}H^{+}$ and $VO{\cdot}HA^{2-}=VO{\cdot}A^{3+}+H$, where acidity constant of $VO{\cdot}HA^{2-}$- is pKa = 7.15. Stability constants of $VO{\cdot}HA^{2-}$ and $VO{\cdot}A^{3-}$ are found to be $1.41{\times}10^{14}$ and $3.80{\times}10^{17}$, respectively. It is detected that $VO^{2+}-DATA$ is reduced irreversibly to $VO^{2-}$ with the transfer coefficient of $\alpha$ = 0.43. At more cathodic overpotential, the reduction is stepwise as V(IV)${\to}$V(III)${\to}$V(II). The first one corresponds to $VO{\cdot}HA^{2-}+e^{-}{\to}VO{\cdot}HA{3+}$ at 3.2 < pH < 7.2 and $VO{\cdot}A^{3-}+e^{-}{\to}VO{\cdot}A^{4-}$ at 7.2 < pH < 10.5. The second is identical to that of V(III). Diffusion coefficients of $VO{\cdot}HA^{2-}$ and $VO{\cdot}A^{3-}$ are found to be $(9.0{\pm}0.3){\times}10^{-6}cm^2/s$ and $(5.9{\pm}0.4){\times}10^{-6}cm^2/ses$, respectively.

      • KCI등재

        An Approach for the Estimation of NPS Pollutant Discharge

        Choi,,Eui,So,Kim,,Geon,Ha,Yun,,Zu,Whan 한국물환경학회 1994 한국물환경학회지 Vol.10 No.3

        The pollutant generation and discharge rates from the nonpoint sources(NPS) in selected areas were evaluated. An urban area as well as a typical agricultural area with feedlot farming region were considered for evaluation. The pollutant generation rate from the NPS in urban area was estimated as 4,822 ㎏COD/ha/year, 24,651 ㎏SS/ha/year, 203 ㎏T-N/ha/year, and 56 ㎏T-P/ha/year. Approximately 47% of the pollutants was discharged to the Han River during the flooding season of July to August. The NPS pollutant discharge rates from the urban area to the Han river were computed as 98 ㎏ COD/ha/year, 1,437 ㎏SS/ha/year, 76 ㎏T-N/ha/year, and 1.22 ㎏ T-P/ha/year, which were significantly less than the generation rates. The pollutant: generation rates fron the NPS in agricultural area was estimated as 53 ㎏BOD/ha/year, 175 ㎏COD/ha/year, 51 ㎏SS/ha/year, 12.6 ㎏T-N/ha/year. and 8.1 ㎏T-P/ha/year. The feedlot farming region in the agricultural area generated similar amount of pollutants per unit area compared to the urban area.

      • SCOPUSKCI등재

        Preparation of Thermo-Responsive and Injectable Hydrogels Based on Hyaluronic Acid and Poly(N-isopropylacrylamide) and Their Drug Release Behaviors

        Ha,Dong,In,Lee,Sang,Bong,Chong,Moo,Sang,Lee,Young,Moo,Kim,So,Yeon,Park,Young,Hoon The Polymer Society of Korea 2006 Macromolecular Research Vol.14 No.1

        Copolymers composed of hyaluronic acid (HA) and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to create temperature-sensitive injectable gels for use in controlled drug delivery applications. Semi-telechelic PNIPAAm, with amino groups at the end of each main chain, was synthesized by radical polymerization using 2-aminoethanethiol hydrochloride (AESH) as the chain transfer agent, and was then grafted onto the carboxyl groups of HA using carbodiimide chemistry. The result of the thermo-optical analysis revealed that the phase transition of the PNIPAAm-grafted HA solution occurred at around 30$\∼$33$^{circ}C$. As the graft yield of PNIPAAm onto the HA backbone increased, the HA-g-PNIPAAm copolymer solution exhibited sharper phase transition. The short chain PNIPAAm-grafted HA ($M_{w}$=6,100) showed a narrower temperature range for optical turbidity changes than the long chain PNIPAAm-grafted HA ($M_{w}$=13,100). PNIPAAm-grafted HA exhibited an increase in viscosity above 35$^{circ}C$, thus allowing the gels to maintain their shape for 24 h after in vivo administration. From the in vitro riboflavin release study, the HA-g-PNIPAAm gel showed a more sustained release behavior when the grafting yield of PNIPAAm onto the HA backbone was increased. In addition, BSA released from the PNIPAAm-g-HA gels showed a maximum concentration in the blood 12 h after being injected into the dorsal surface of a rabbit, followed by a sustained release profile after 60 h.

      • 포스터 발표 제1분과: 식물상 및 식생 관리 ; 한라산 아고산대 구상나무군락의 물질생산과 탄소수지

        장래하 ( Rae Ha Jang ), 최재윤 ( Jae Yun Choi ), 유영한 ( Young Han You ) 한국환경생태학회 2014 한국환경생태학회 학술대회지 Vol.2014 No.2

        본 연구는 우리나라 한라산 아고산대에서 구상나무림의 물질생산, 탄소분포와 탄소수지에 대하여 알아보기 위해 수행되었다. 구상나무림의 현존량은 2009, 2010, 2011, 2012 와 2013에 각각 98. 88, 106. 42, 107. 67, 108. 31와 91. 48ton/ha 유기탄소량은 44. 5, 47. 89, 48. 45, 48. 74와 41. 17 ton C/ha 이었다. 순생산량은 2009, 2010, 2011, 2012 년에 각각 11. 40, 7. 41, 0. 05 와 -9. 46 ton ha-1yr-1 이었고, 유기탄소 순생산량은 5. 13, 3. 33, 0. 02와 -4. 25 ton C ha-1yr-1 이었다. 2009~2013년 연간 낙엽생산량은 각각 2. 42, 4. 02, 2. 94, 5. 47, 2. 67 ton ha-1yr-1이었고, 낙엽생산량의 유기탄소량은 1. 09, 1. 80, 1. 32, 2. 46, 1. 20 ton C ha-1yr-1. 연간 임상낙엽량 6. 09, 5. 40, 4. 45, 2. 57 ton/ha 임상냑엽량의 유기탄소량은 2. 74, 2. 43, 2. 00, 1. 16 ton C/ha. 토양 20cm까지의 유기탄소축척량은 각각 55. 77, 54. 90, 50. 69, 44. 42, 41. 87 ton C ha-120cm-1. 2012년 토양호흡을 통해 배출된 유기탄소량은 2011, 2012년에 각각 4. 42, 4. 14 ton Cha-1yr-1 이었다. 한라산 구상나무림에서는 2011년에 총 0. 01 ton C ha-1yr-1의 유기탄소를 대기로 방출하였고 2012년에 -8. 39 ton C ha-1yr-1의 유기탄소를 대기로 배출하였다.

      • KCI등재

        한라산 아고산대 구상나무림에서 연간 물질생산과 유기탄소량 변화1a

        장래하 ( Rae Ha Jang ), 조규태 ( Kyu Tae Cho ), 유영한 ( Young Han You ) 한국환경생태학회 2014 한국환경생태학회지 Vol.28 No.6

        국가장기생태사업(LTER)의 일환으로 한라산 아고산대 구상나무림의 물질생산과 탄소분포의 특성을 밝히고자 2009년부터 2013년까지 현존량, 유기탄소분포, 낙엽생산, 임상낙엽량과 토양 유기탄소 축척량을 조사하였다. 식물현존량은 상대생장법에 의해 보고된 물질생산 식을 이용하여 측정하고 이를 이산화탄소의 고정량으로 환산하였다. 2009, 2010, 2011, 2012 와 2013년의 현존량은 각각 98.88, 106.42, 107.67, 108.31 와 91.48 ton ha-1 였다. 이 기간 동안의 유기탄소는 지상부 생물량에 35.95, 38.69, 38.96, 39.46, 33.2 ton C ha-1, 지하부 생물량에 8.54, 9.2, 9.49, 9.28, 7.97 ton C ha-1 이 각각 분포하였다. 5년 동안 낙엽 생산을 통해 1.09, 1.80, 1.32, 2.46 와 1.20 ton C ha-1 의 유기탄소가 생태계로 유입되었다. 2010, 2011, 2012와 2013년의 임상낙엽층의 유기탄소량은 2.74, 2.43, 2.00 와 1.16 ton Cha-1였고, 토양 20cm깊이까지의 유기탄소 축적량은 55.77, 54.90, 50.69, 44.42 와 41.87 ton C ha-120cm-1였다. 이와 같이 현존량과 유기탄소량이 2009~2012년까지 매년 증가하였지만 태풍이 있었던 2013년에는 감소하였다. 이러한 현상은 자연적 교란이 한국의 아고산대 생태계에 크게 영향을 미친다는 것을 의미한다. Annual biomass production and amount of organic carbon in Abies koreana forest at Mt. Halla were conducted as a part of Korea National Long-Term Ecological Research (KNLTER). We measured standing biomass change of litter, soil production and organic carbon amounts of the forest floor and soil layer of A. koreana forest in Mt. Halla from 2009 to 2013 in permanent plots. Standing biomass, which was determined by allometric method, was converted into CO2. The standing biomass in A. koreana forest was 98.88, 106.42, 107.67, 108.31, 91.48 ton ha-1 in 2009, 2010, 2011, 2012 and 2013 year, respectively. The amount of annual carbon allocated to above ground was 35.95, 38.69, 38.96, 39.46, 33.2 ton C ha-1 and below ground biomass was 8.54, 9.2, 9.49, 9.28, 7.97 ton C ha-1 in 2009, 2010, 2011, 2012 and 2013 year, respectively. Amount of organic carbon returned to the forest via litterfall was 1.09, 1.80, 1.32, 2.46 and 1.20 ton C ha-1 in 2009, 2010, 2011, 2012 and 2013. Amount of organic carbon in annual litter layer on forest floor was 2.74, 2.43, 2.00 and 1.16 ton C ha-1 in 2010, 2011, 2012 and 2013 year, respectively. Amount of organic carbon within 20cm soil depth was 55.77, 54.9, 50.69, 44.42 and 41.87 ton C ha-120cm-1 in 2009, 2010, 2011, 2012 and 2013 year, respectively. Then standing biomass and organic carbon distribution increased steadily until 2012. But there declined in 2013 because of the typhoon Bolaven. Thus, standing biomass and organic carbon distribution of this subalpine forest were largely affected by natural disturbance factor.

      • KCI등재

        논문 : 산불로 인한 지표층 연소량 및 온실가스 배출량 추정

        이병두 ( Byung Doo Lee ), 윤호중 ( Ho Jung Youn ), 구교상 ( Kyo Sang Koo ), 김경하 ( Kyong Ha Kim ) 한국임학회 2012 한국산림과학회지 Vol.101 No.2

        산불은 전 세계적으로 다량의 온실가스를 배출하여 지구온난화에 기여한다. 본 연구에서는 산불로 인한 지표층 연료의 연소량과 이로 인한 온실가스 배출량을 분석하고자 하였다. 이를 위해 51개 산불을 대상으로 소나무림과 활엽수림으로 구분하고, 다시 지표화와 수관화 피해 지역으로 나누어 잔존 연료량을 채취하여, 미연소 지역의 연료량과 일원분산분석을 수행하였다. 그 결과 활엽수 지표화 지역은 8,361 kg/ha, 소나무 지표화 지역은 8,055 kg/ha, 소나무 수관화 지역은 12,333 kg/ha이 연소되어, 수종별·산불행태별로 차이가 있었다. 이때의 연소율은 각각 78, 59, 90%이었다. 이산화탄소, 메탄, 아산화질소 등의 온실가스 배출량은 활엽수 지표화 연소지역 15,856 kg/ha, 소나무 지표화 연소지역 14,834 kg/ha, 소나무 수관화 연소지역은 약 22,709 kg/ha이었다. Globally, the forest fires are a significant contributor of carbon dioxide and other greenhouse gases in the atmosphere. In this study, fuel load consumed by forest fire and emission of green house gases were analysed in the surface layer. For this, remaining fuel was collected and weighed with the species (Japanese red pine, deciduous) and the forest fire types (surface fire, crown fire) in the 51 forest fires. 8,361 kg/ha fuel load was consumed in deciduous forest damaged by surface fire, and 8,055 kg/ha, 12,333 kg/ha in Japanese red pine burned by surface fire and crown fire. The combustion ratios were 78, 59, and 90%, respectively. 15,856 kg/ha the green house gases such as CO2, CH4, CH4 in deciduous forest burned by surface fire was emitted and 14,834 kg/ha, 22,709 kg/ha in Japanese red pine burned by surface fire and crown fire.

      • KCI등재

        새만금간척지에서 사료맥류의 파종량에 따른 생육과 수량 특성

        류진희 ( Jin Hee Ryu ), 김영주 ( Young Joo Kim ), 이수환 ( Su Hwan Lee ), 오양열 ( Yang Yeol Oh ), 김영두 ( Young Doo Kim ), 홍하철 ( Ha Cheol Hong ), 양창휴 ( Chang Hyu Yang ), 김선림 ( Sun Lim Kim ) 한국국제농업개발학회 2015 韓國國際農業開發學會誌 Vol.27 No.4

        본 연구는 새로 조성된 간척지에서 사료맥류 종자의 안정생산을 위한 적정 파종량을 구명코자 2011년부터 2013년까지 수행하였다. 청보리와 트리티케일은 ha당 200, 300 및 400 kg 호밀과 귀리는 ha당 100, 200 및 300 kg을 파종하고 토양화학성과 작물별 수량성을 조사 하였다. 사료맥류의 출현율과 입모율은 호밀, 트리티케일, 청보리, 귀리 순으로 높았다. 사료맥류 종실의 질소 함량은 트리티케일, 호밀, 보리, 귀리 순으로 높았고 트리티케일과 호밀은 파종량 증가에 따라 질소함량이 높아지는 경향을 나타냈다. 사료맥류의 종실수량은 트리티케일, 귀리, 호밀, 청보리 순으로 많았다. 파종량에 따른 종실수량은 청보리와 트리티케일은 ha당 300 kg에서, 호밀과 귀리는 200 kg에서 많았다. 수량구성요소 중 m2당 이삭수가 종실수량에 큰 영향을 미쳤고 수당립수와 천립중은 파종량 감소에 따라 증가하는 경향을 나타냈다. 연구 결과 새로 조성된 간척지에서 동계 사료맥류 종자의 안정생산을 위한 적정 파종량은 ha당 청보리는 320 kg, 트리티케일은 290 kg, 호밀은 220 kg, 귀리는 210 kg으로 나타났다. This study was carried out to investigate the optimum seeding rate of winter cereal forage crops(WCFC) for stable seed production in newly reclaimed land. Plots of barley and triticale were treated with seeding rate of 200, 300, and 400 kg ha-1. And, plots of rye and oat were treated with seeding rate of 100, 200, and 300 kg ha-1. Emergence rate and seedling establishment were higher in order of rye, triticale, barley and oat. Plant height of triticale and rye was increased with decreasing seeding rate. Number of panicles was increased with increasing seeding rate. Grain yield was higher in order of triticale, oat, rye, and barley. Grain yield of barley and triticale were the highest at seeding rate of the 300 kg ha-1. Grain yield of rye and oat were the highest at seeding rate of the 200 kg ha-1. Number of panicles per unit area (m2) greatly influenced on grain yield. Thousand grain weight and number of grains per panicle increased with decreasing seeding rate. As the result, the seeding rate of barley (320 kg ha-1), triticale (290 kg ha-1), rye(220 kg ha-1), and oat(210 kg ha-1) would be recommendable for seed production of WCFC in newly reclaimed land.

      • P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

        ( Jie Hyun Jeon ), ( Joo Ha Kim ), ( Jung Woo Lee ), ( Kui Young Park ), ( Seong Jun Seo ), ( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

        Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

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